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Research Roundup: Apr 4, 2022



Best of the Week...


In patients with traumatic brain injury, the use of THC before their injury led to no negative changes in outcome & was correlated to a decreased rate of hemorrhagic stroke Thromboembolic Outcomes in Tetrahydrocannabinol-Positive Trauma Patients With Traumatic Brain Injury https://pubmed.ncbi.nlm.nih.gov/35305485/


A review suggests exploring the cannabinoids & psychedelics for the symptoms of Alzheimer’s Cannabinoids and Psychedelics for Neuropsychiatric Symptoms of Alzheimer's: Addressing Disparities Through Clinical Trials https://www.ajgponline.org/article/S1064-7481(22)00280-9/pdf


A review looks at how exercise activates the endocannabinoid system & prevents metabolic disorders The Endocannabinoid System and Physical Activity-A Robust Duo in the Novel Therapeutic Approach against Metabolic Disorders https://pubmed.ncbi.nlm.nih.gov/35328503/


In a mouse model of Parkinson’s, CBD significantly improved motor deficits & protected the midbrain via the gut-brain axis Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis https://pubmed.ncbi.nlm.nih.gov/35360659/


In a rat model of neuropathic pain, CBD & THCV worked together to reduce pain & protect the neurons via the CB1 receptor & a serotonin receptor Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents https://pubmed.ncbi.nlm.nih.gov/35303507/


A new method for synthesizing CBD from the readily available starting material limonene Stereoselective Synthesis of Nonpsychotic Natural Cannabidiol and Its Unnatural/Terpenyl/Tail-Modified Analogues

https://pubmed.ncbi.nlm.nih.gov/35289168/

Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In a survey of medical cannabis patients in Oklahoma, they found cannabis to provide ‘extreme relief’ from anxiety, sleep problems, nausea & depression Characteristics of adults with a medical cannabis license, reasons for use, and perceptions of benefit following medical cannabis legalization in Oklahoma https://www.sciencedirect.com/science/article/pii/S2211335522000845


In a survey of Greek-Cypriot nurses & midwives, they reported cannabis helpful for a number of conditions including persistent muscle spasm, insomnia, mental health conditions & terminal illness Greek-Cypriot nurses and midwives attitudes, beliefs and knowledge on medical cannabis: A cross-sectional descriptive correlational study https://assets.researchsquare.com/files/rs-1400459/v1/9e95c21a-336b-4a9a-ab54-e862c3f63fd0.pdf


A retrospective study finds that in people 18-36 years old, cannabis smoking was associated with a 5x risk of acute coronary syndrome (sudden decreased blood flow to the heart, a category including heart attacks) Relationship Between Marijuana Use and Hospitalization for Acute Coronary Syndrome https://www.cureus.com/articles/42342-relationship-between-marijuana-use-and-hospitalization-for-acute-coronary-syndrome


In a study of why New Zealand patients used CBD, the primary reason was non-cancer-related pain Cannabidiol Prescription Requests in NZ: Describing Patients and Indications Seen in a New Zealand Cannabis Clinic https://assets.researchsquare.com/files/rs-1215517/v1/22708d47-b46d-419e-85d3-b969b76e6c28.pdf


Using an app to look at cannabis products for nausea, the most relief was reported for sativas in smokeable form & with higher THC The Effectiveness of Common Cannabis Products for Treatment of Nausea

https://pubmed.ncbi.nlm.nih.gov/35258504/

For more on nausea, see our science archive here.


In horses, a study to help find the right dosage of CBD for their system

Pharmacokinetics, Safety, and Synovial Fluid Concentrations of Single- and Multiple-Dose Oral Administration of 1 and 3 mg/kg Cannabidiol in Horses

https://pubmed.ncbi.nlm.nih.gov/35307550/



Recent Reviews


A look at treating glaucoma with cannabinoids Cannabinoids as New Drug Candidates for the Treatment of Glaucoma https://pubmed.ncbi.nlm.nih.gov/35299275/

A book chapter in ‘Clinical Pain Management’ on using the cannabinoids for pain Cannabis and cannabinoid for pain https://onlinelibrary.wiley.com/doi/10.1002/9781119701170.ch20 & a review article on cannabinoids & pain with a more neurochemical focus Chronic Pain and the Endocannabinoid System: Smart Lipids – A Novel Therapeutic Option? https://www.karger.com/Article/FullText/522432


A review of how the endocannabinoids work with the brain’s astrocytes (the most numerous cells in the CNS, these support cells help to guide the formation of axons, protect the synapses, modulate neuroinflammation & control the blood brain barrier as well as the release of neurotransmitters) Astroglial cannabinoid signaling and behavior https://pubmed.ncbi.nlm.nih.gov/35293647/


A review of the use of the cannabinoids against cancer, neurodegeneration, dermatological diseases & viral infections Cannabinoids: Therapeutic Use in Clinical Practice

https://pubmed.ncbi.nlm.nih.gov/35328765/


Preclinical Research & Cannabinoid Chemistry


In neuronal cells, CBG slows sodium channels & leads to decreased excitability, suggesting its use as a painkiller Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitabilityI https://pubmed.ncbi.nlm.nih.gov/35297036/


In a mouse model of Alzheimer’s, a drug that blocks both the FAAH & MAGL enzyme lowered neuroinflammation, oxidative stress & levels of amyloid β plaques but did not show cognitive improvements Effect of the MAGL/FAAH Dual Inhibitor JZL-195 on Streptozotocin-Induced Alzheimer's Disease-like Sporadic Dementia in Mice with an Emphasis on Aβ, HSP-70, Neuroinflammation, and Oxidative Stress https://pubmed.ncbi.nlm.nih.gov/35316021/


In male rats, the effects of the painkiller tramadol seem to be mediated by the CB1 receptor & an orexin receptor Effects of selective orexin receptor-2 and cannabinoid receptor-1 antagonists on the response of medial prefrontal cortex neurons to tramadol https://pubmed.ncbi.nlm.nih.gov/35313383/


A study of human & monkey brains looks at the distribution of CB1 receptors across the highest levels of the brain Cell Type Specific Cannabinoid CB1 Receptor Distribution Across the Human and Non-Human Primate Cortex https://assets.researchsquare.com/files/rs-1451626/v1/9699fd25-c345-42eb-bb98-3dfdfcc96582.pdf

In a rat model of seizures, beta-caryophyllene (a predominant terpene of cannabis) reduced seizures, improved behavioral recovery & protected against blood-brain barrier breakdown Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats https://pubmed.ncbi.nlm.nih.gov/35300975/ & in male mice exposed to the toxic metal cadmium, beta-caryophyllene protected them from testicular alterations as well as their sperm’s morphology, mobility & concentration Potential protective effect of beta-caryophyllene against cadmium chloride-induced damage to the male reproductive system in mouse https://pubmed.ncbi.nlm.nih.gov/35318111/

In a mouse model of diabetes, 2-AG protected their heart & improved cardiac function 2-Arachidonoylglycerol Attenuates Myocardial Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway https://pubmed.ncbi.nlm.nih.gov/35305183/


In mice taking a strong activator of the CB1 receptor for 5 days, it profoundly altered their sleep as they began it & saw sleep disruptions when they stopped taking it

Altered sleep during spontaneous cannabinoid withdrawal in male mice

https://pubmed.ncbi.nlm.nih.gov/35288510/


A big study of the machinery of the endocannabinoid machinery across the entire phylum of nematodes (roundworms) Pan-phylum In Silico Analyses of Nematode Endocannabinoid Signalling Systems Highlight Novel Opportunities for Parasite Drug Target Discovery https://www.biorxiv.org/content/10.1101/2022.03.09.483626v1