Research Roundup: Mar 10, 2026
- 5 hours ago
- 3 min read
Best of cannabinoid science this week...
In people with lower back, cannabis caused sustained reductions in pain & disability over 4 years
Long-Term Pain Response to Cannabis Therapy in Chronic Low Back Pain: A Four-Year Prospective Observational Study Evaluating Patient-Reported Outcomes and BioWell Parameters
In people with epidermolysis bullosa (a rare condition of fragile, blistering skin), sublingual THC/CBD caused 75% of participants to report ≥30% global pain reduction, with the use of painkillers dropping by half
Sublingual tetrahydrocannabinol and cannabidiol to treat pain in epidermolysis bullosa: a randomized, placebo-controlled crossover study
In older adults, cannabis users performed modestly better on tests of numeric memory & fluid intelligence, with no associated dementia risks
Cannabis use, cognitive function and dementia risk in older adults: observational and genetic analyses
For dementia, a meta-analysis of 10 studies found that cannabinoids reduced agitation
Efficacy and Safety of Cannabinoids for Neuropsychiatric Symptoms of Dementia: A Systematic Review with Meta-analysis
In Parkinson’s disease, a meta-analysis of 6 studies found that CBD & THC helped with symptoms, including pain
The Effects of Therapeutic Cannabis and Cannabinoids in Parkinson’s Disease: An Overview of Meta-Analyses
For orofacial pain, a meta-analysis of 6 studies found cannabis caused significant pain relief in oral cancer
Cannabis-Based Therapies for Chronic Orofacial Pain: A Systematic Review and Meta-Analysis
In caregivers for older adults, a review found they used cannabis to cope with the high levels of stress or emotional burden
Cannabis Use Among Caregivers of Older Adults: A Systematic Literature Review
In drug-resistant epilepsy, a review on the potential of CBG
Elucidating the Putative Role of Cannabigerol: A Hypothesis-Generating Review of Neuroinflammatory and Neuroprotective Mechanisms with Implications for Drug-Resistant Epilepsy
For Alzheimer’s disease, a review of combining cannabis with the terpene linalool from lavender
Exploring Linalool-Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition
For Alzheimer’s, a book chapter on cannabinoids modulating the microglia (guardian immune cells of the brain)
Cannabinoids as modulators for Alzheimer’s disease: a role for microglia?
In dental stem cells, a review of how CBD improved their viability, proliferation, migration & differentiation
Bioactivity and Regenerative Potential of Cannabidiol in Human Dental Pulp Stem Cells: A Scoping Review of In Vitro Studies
In a mouse model of methamphetamine use disorder, CBD reduced anxiety & cognitive deficits via neuroprotection of the brain, especially the hippocampus (a memory center of the brain)
Cannabidiol attenuates methamphetamine-induced psychosis via anti-oxidative stress: σ1R-mediated mitochondrial dysfunction as a critical pathway
In a mouse model of Alzheimer’s disease, CBD restored their social recognition memory
Effects of Chronic 100 mg/kg Cannabidiol Treatment in Male Double Transgenic APPSwe/PS1∆E9 Mice
In a mouse model of inflammatory pain & morphine use disorder, CBD produced a significant reduction in pain behaviors
Potential effects of cannabidiol on formalin-induced inflammatory pain in morphine-dependent rats
In a mouse model of chronic pain, CBD reduced their response to chemical stimuli via their pain-sensing circuits & sodium channels
The parabss1 Drosophila melanogaster as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects
In a female rat model of liver disease from a sugar-rich diet, cannabis oil improved liver lipid metabolism, reduced fatty liver disease scores, lowered scarring, lessened oxidative stress & normalized the liver levels of the CB1 receptor & endocannabinoids
Cannabis oil modulates liver alterations and endocannabinoid system changes in a female rat model of diet-induced MASLD
In a rat model of early-stage liver inflammation from a high-fat diet, CBD reduced inflammation & prevented the development of metabolic dysfunction-associated steatohepatitis (MASH)
Therapeutic potential of cannabidiol supplementation in mitigating lipid precursors of inflammation in hepatic steatosis progression
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