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Best reviews

2022: A review of using CBD to treat autism

Cannabidiol for the treatment of autism spectrum disorder: hope or hype?

2022: On autism, a review of the clinical evidence shows that the cannabinoids, and especially CBD, can help with common comorbidities as well as the central symptoms
Clinical Data on Canabinoids: Translational Research in the Treatment of Autism Spectrum Disorders

2022: A review of autism & why using cannabinoids seems to help with a number of the behavioral, cognitive, social interaction, hyperactivity, anxiety & sleep symptoms
Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review

2022: This thorough review of autism spectrum disorders looks at the overlap between the endocannabinoid system & the microbiome’s effect on the gut-brain axis
The Endocannabinoids-Microbiota Partnership in Gut-Brain Axis Homeostasis: Implications for Autism Spectrum Disorders

2022: A review of the promise of cannabinoids for early neurodevelopmental disorders such as intellectual disability, autism spectrum disorders, tics & attention/deficit hyperactivity disorder
The role of cannabinoids in neurodevelopmental disorders of children and adolescents

2022: A specialist on using cannabis for autism
Medical cannabis in autism spectrum disorder: a specialist perspective

2022: In autism, a review of why the endocannabinoid control of lipid signaling helps to balance inflammation & oxidation & why this makes it a treatment target
Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

2021: This review of the ECS & autism looks at all of the human studies & finds that AEA levels are lower in people with autism

Endocannabinoid Markers in Autism Spectrum Disorder: a Scoping Review of Human Studies

2021: A review of targeting the ECS for the treatment of autism - with lessons from animal models

The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models

2021: CBD & neurodevelopmental disorders like autism

Cannabidiol and Neurodevelopmental Disorders in Children

2021: A review of using medical cannabis in children & teens with autism

Medicinal Cannabis in Children and Adolescents with Autism Spectrum Disorder: A Scoping Review

2021: This review looks at PEA for autism & looks at its several different mechanisms

Palmitoylethanolamide and Its Biobehavioral Correlates in Autism Spectrum Disorder: A Systematic Review of Human and Animal Evidence

2021: For treating epilepsy & autism, this review suggests cannabidivarin (CBDV - a phytocannabinoid similar to CBD but with a shorter tail)

Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder

2021: A review of how to treat autism spectrum disorder by targeting neuroinflammation via the endocannabinoid system

Healing autism spectrum disorder with cannabinoids: a neuroinflammatory story

2021: This review looks at the potential of using cannabinoids for the treatment of autism

Potential of Cannabinoids as Treatments for Autism Spectrum Disorders

2020: This meta-review of CBD for children with autism included ten studies

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

2020: Clinical review of cannabis & CBD for autism

Autism Spectrum Disorder and Medical Cannabis: Review and Clinical Experience

2019: A review of microglia, the ECS & autism

The Endocannabinoid System as a Window Into Microglial Biology and Its Relationship to Autism

2019: A review of CBD & autism

Cannabidiol as a suggested candidate for treatment of autism spectrum disorder

2017: The endocannabinoids and the neuroinflammation of autism

Role of Endocannabinoids on Neuroinflammation in Autism Spectrum Disorder Prevention

2017: A look at the endocannabinoids & autism

Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders

2017: How the ECS is dysregulated in autism

Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations

Timeline of Research

2022: In kids with autism, CBD-rich cannabis extracts for 6 months most showed improvement in repetitive behaviors & social communication abilities, especially those with more severe starting symptoms
Children and adolescents with ASD treated with CBD-rich cannabis exhibit significant improvements particularly in social symptoms: an open label study

2022: In a survey of pediatric autism patients, the caregivers administered cannabis most frequently for repetitive behaviors & irritability & found high levels of CBD paired with low levels of THC tended to work best
A natural history study of medical cannabis consumption in pediatric autism in the United States

2022: For people with autism in the UK Medical Cannabis Registry, they saw “significant improvements in general health-related quality of life and sleep”
Clinical outcome analysis of patients with autism spectrum disorder: analysis from the UK Medical Cannabis Registry

2022: A case study of full-spectrum CBD for autism
Cannabidiol in Treatment of Autism Spectrum Disorder: A Case Study

2022: In a double-blind study of children with autism, CBD-rich hemp extracts increased social interaction & concentration while decreasing anxiety & psychomotor agitation & led to less caregiver distress
Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial

2022: In a case study where isolated CBD stopped being effective for autism once the patient hit puberty, the power of enriching with terpenes
Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report

2022: In a safety study of children with autism, treatment with a 20:1 CBD:THC solution caused no significant differences in the safety biomarkers measured
Medical cannabis for the treatment of comorbid symptoms in children with autism spectrum disorder: An interim analysis of biochemical safety

2022: In a study of autistic children, researchers looked at how biomarkers in the saliva could be used to measure the effectiveness of cannabis treatment
The Potential of Salivary Lipid-Based Cannabis-Responsive Biomarkers to Evaluate Medical Cannabis Treatment in Children with Autism Spectrum Disorder

2022: Among humans with autism, they were more likely to be using CBD than the rest of the population

Cannabis and cannabidiol use among autistic and non-autistic adults in the UK: a propensity score-matched analysis

2022: In children with autism, the use of low doses of CBD & trace amounts of THC decreased behavioral problems, improved cognition & increased social interactions

CBD-enriched cannabis for autism spectrum disorder: an experience of a single center in Turkey and reviews of the literature

2022: In children with autism, treatment with cannabis caused 65 biomarkers to shift towards more typical development

Cannabis-Responsive Biomarkers: A Pharmacometabolomics-Based Application to Evaluate the Impact of Medical Cannabis Treatment on Children with Autism Spectrum Disorder

2022: In a rat model of autism, increasing anandamide in the hippocampus (memory area) & blocking 2-AG in the amygdala (fear center) helped with memory tasks & social functioning respectivelyAnandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats

2021: In a mouse model of autism, long-term treatment with CBD-rich medical cannabis oil lessened anxiety & repetitive behaviors

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder

2021: According to this survey, about 20% of people caring for a child with autism give their child CBD

2021: Zynerba presents their new Phase 2 data on their transdermal CBD gel for treating autism

Longer Term Tolerability and Efficacy of ZYN002 Cannabidiol Transdermal Gel in Children and Adolescents with Autism Spectrum Disorder (ASD): An Open-Label Phase 2 Study

2021: In a mouse with no CB1 receptors, researchers looked at changes in social behavior & communication with relevance to autism

Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder

2021: In brain scans of human with autism, CBDV caused the striatum of the brain to move towards more neurotypical functionality

Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin

2021: In children with epilepsy & autism, Zynerba’s CBD transdermal gel helped with sleep

Impact of ZYN002 Cannabidiol Transdermal Gel on Sleep in Children and Adolescents With Developmental and Epileptic Encephalopathies and Comorbid Autism Spectrum Disorder

2021: Zynerba’s CBD transdermal gel helpful for those with autism including for behavior, seizures & sleep

ZYN002 Cannabidiol Transdermal Gel: Efficacy and Safety Findings in Children and Adolescents With Autism Spectrum Disorder (ASD) and Related Disorders

2021: This meta-review looks at how children with autism spectrum disorder tend to have lower levels of endocannabinoids in their blood & that their risk of developing autism may be increased by using acetaminophen because its pain-relieving properties are mediated by the endocannabinoid system

Endocannabinoid System Dysregulation from Acetaminophen Use May Lead to Autism Spectrum Disorder: Could Cannabinoid Treatment Be Efficacious?

2021: In mice, lowering the activity of their DGL-α enzyme (which produces 2-AG) creates autism-type behaviors

Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL-α, induces autism spectrum disorder-like and co-morbid phenotypes in adult C57BL/J mice

2021: A proof-of-concept trial using cannabinoids for autism

Cannabinoid treatment for autism: a proof-of-concept randomized trial

2020: Case report of a 15 year old with autism & epilepsy using low doses of CBD

A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extracts as complementary therapy: a case report

2020: In children with autism and in animal models of autism, there's less endocannabinoid signaling and this study suggests boosting 2-AG levels

The Alternations of Endocannabinoid System and its Therapeutic Potential in Autism Spectrum Disorder

2020: In a study looking at children with autism, help was seen by the addition of CBD, melatonin and oxytocin (30 patients)

A Neuroendocrine Therapeutic Approach with the Pineal Hormone Melatonin, Cannabidiol and Oxytocin (MCO regimen) in the Treatment of the Autism Spectrum disorders

2020: A brain imaging study of autistics looks at how 600 mg of CBD causes effects via the GABA & glutamate pathways

Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder

2019: In humans, 600 mg of CBD altered brain connectivity in those with autism (34 participants)

The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD)

2019: In humans with autism, 600 mg of CBDV modulated the GABA & glutamate systems (34 men in a repeated-measures, double-blind, randomized-order, cross-over design)

Effects of cannabidivarin (CBDV) on brain excitation and inhibition systems in adults with and without Autism Spectrum Disorder (ASD): a single dose trial during magnetic resonance spectroscopy

2019: In children with autism, CBD improved many behaviors (53 participants)

Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities

2019: In rats, CBDV ameliorates autism-like behaviors

Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats

2019: In patients with autism, high CBD/low THC oil found helpful (188 ASD patients)

Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy

Popular article: Israeli study finds help for autism with a 30% CBD / 1.5% THC mix

2019: CBD found helpful for autistic children (60 children in a retrospective feasibility study)

Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study

2019: Children with autism tend to have lower endocannabinoid levels circulating in their blood

Lower circulating endocannabinoid levels in children with autism spectrum disorder

2019: Out of 15 autism patients using CBD-rich cannabis extracts, only one failed to show improvements (18 person observational study)

Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate Use

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