Full Spectrum Hemp Extract
studies

2021: This survey of epilepsy patients shows several improvements for users of “artisanal CBD products” including “higher quality of life, lower psychiatric symptom severity, and improved sleep”

Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

https://pubmed.ncbi.nlm.nih.gov/34311183/

2021: In humans with Crohn’s disease, CBD-rich cannabis extracts caused significant improvements to the quality of life though no significant changes to inflammatory scores

Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/33858011/

2021: In a mouse model of pain, the combination of full-spectrum hemp extracts & PEA reduced pain greatly

Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain

https://pubmed.ncbi.nlm.nih.gov/33722712/

2021: In ovarian cancer cells, full-spectrum hemp extract found to have anticancer effects

Hemp Extract with Specific Anti-Cancer Properties against Ovarian Cancer

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.02877

2020: In humans, CBD hemp extract helped to delay the onset of muscle soreness

The influence cannabidiol on delayed onset of muscle soreness

http://www.kheljournal.com/archives/2020/vol7issue2/PartB/7-2-4-412.pdf

2020: In mouse model of Lafora disease (progressive infantile epilepsy), CBD-rich extracts helped with the dementia but not the seizures

Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model

https://pubmed.ncbi.nlm.nih.gov/32656347/

2020: Great pilot study in 32 dogs with osteoarthritis finds that CBD-rich hemp extracts help almost all of them with their pain & allowed almost all of them taking gabapentin to reduce or eliminate that drug

The Use of Cannabidiol-Rich Hemp Oil Extract to Treat Canine Osteoarthritis-Related Pain: A Pilot Study

https://www.semanticscholar.org/paper/The-Use-of-Cannabidiol-Rich-Hemp-Oil-Extract-to-A-Kogan-Hellyer/94d216f37b94965863e33bda278cb31adcf1f5ea?p2df

2020: Epilepsy patients vastly prefer natural CBD over synthetic CBD

Plant Derived Versus Synthetic Cannabidiol: Wishes and Commitment of Epilepsy Patients

https://pubmed.ncbi.nlm.nih.gov/32554292/

2020: In mice, full-spectrum help oil was effective for chronic neuropathic pain

The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model
https://www.mdpi.com/2075-1729/10/5/69

2020: A GRAS safety study of CBD-rich hemp extracts in rats

Safety Assessment of a Hemp Extract using Genotoxicity and Oral Repeat-Dose Toxicity Studies in Sprague-Dawley Rats

https://www.sciencedirect.com/science/article/pii/S2214750019305207

2020: In humans, the use of CBD-rich extract reduced or eliminated opioids with significant improvement in their quality of life indices

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

https://pubmed.ncbi.nlm.nih.gov/31711352/

2020: Observational study to find pharmacokinetic data of CBD rich extracts in children with epilepsy - prospective observational study of 29 patients

Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy

https://pubmed.ncbi.nlm.nih.gov/32048179/

2020: In mice, CBD extracts increased good bacteria but increased inflammation signals

Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract

https://pubmed.ncbi.nlm.nih.gov/32400224/

2019: Hemp extracts for antimicrobial effects

Hemp (Cannabis Sativa L.) Extract: Anti-Microbial Properties, Methods of Extraction, and Potential Oral Delivery

https://www.tandfonline.com/doi/abs/10.1080/87559129.2019.1600539

2019: Cannabis extracts were more effective than THC or CBD alone in reducing severe side effect of bone marrow transplantation – but all treatments inhibited lymphocyte recovery

Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation

https://www.ncbi.nlm.nih.gov/pubmed/30720730

2019: In a mouse model of multiple sclerosis, CBD extracts helped with neurological disability & behavioral assessments via TNF-α & BDNF

Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis

https://pubmed.ncbi.nlm.nih.gov/31213295/

2019: A liver health safety study

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model

https://www.mdpi.com/1420-3049/24/9/1694

2019: Out of 15 autism patients, only one failed to show improvements with CBD-rich cannabis extracts (18 person observational study)

Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate Use

https://pubmed.ncbi.nlm.nih.gov/31736860/

2019: In mice, CBD & the plant extract significantly reduced the fear response while THC did not

Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation

https://pubmed.ncbi.nlm.nih.gov/31417379/

2019: In mice using a CBD rich extract, a drug interaction of CBD at 116 mg/kg followed by acetaminophen caused toxicity with 37.5% mortality – but CBD at 290 mg/kg saw no problems

Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

https://pubmed.ncbi.nlm.nih.gov/31212965/

2018: In humans with epilepsy, CBD-rich extracts found effective & safe (108 patients in a retrospective study)

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center

https://www.ncbi.nlm.nih.gov/pubmed/29429908

2018: A metareview finds more help from CBD extracts than isolated CBD - 11 references covering 670 patients

Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis

https://pubmed.ncbi.nlm.nih.gov/30258398/

(correction of a table: https://pubmed.ncbi.nlm.nih.gov/30687209/)

2018: A CBD-rich extract for ulcerative colitis patients didn’t improve primary endpoints but did suggest beneficial symptom treatment (39 patients in a randomized, double-blind, placebo-controlled, parallel-group pilot study)

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis

https://pubmed.ncbi.nlm.nih.gov/29538683/

2018: A toxicity study from CV Sciences

An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp

https://www.hindawi.com/journals/jt/2018/8143582/abs/

2018: In humans, 800 mg of CBD did not improve working or spatial memory or improve impulsivity during tobacco abstinence (30 participants in a randomized control trial)

The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers

https://www.ncbi.nlm.nih.gov/pubmed/29765102

2018: In humans who use tobacco, 800 mg of CBD “reduced the salience and pleasantness of cigarette cues” but “did not influence tobacco craving or withdrawal or any subjectively rated side effects” (30 participants in a randomized, double-blind cross-over study)

Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal

https://www.ncbi.nlm.nih.gov/pubmed/29714034

2018: In a mouse model of multiple sclerosis, CBD rich extracts (from Avidekel cannabis) work as well as the common drug copaxone in suppressing symptoms

Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice

https://pubmed.ncbi.nlm.nih.gov/30291491/

2018: In docking studies, CBD/CBDA extracts & CBG/CBGA extracts reduced aldose reductase activity for diabetes

Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or Cannabigerol

https://pubmed.ncbi.nlm.nih.gov/29427593/

2017: In a survey of parents in Mexico, CBD extracts very helpful for seizures (53 parents)

Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy

https://pubmed.ncbi.nlm.nih.gov/28392943/

2016: In a mouse model of colitis, CBD extract decreased damage and reduced intestinal hypermotility better than isolated CBD

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

https://pubmed.ncbi.nlm.nih.gov/27757083/

2016: In 5 Israeli children with intractable epilepsy, CBD-rich extracts caused “significant positive effect on seizure load”

CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience

https://pubmed.ncbi.nlm.nih.gov/26800377/

2016: Two case reports of children using CBD-rich extracts getting intoxicated by the THC – improvements when switched to CBD isolate

Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol

https://pubmed.ncbi.nlm.nih.gov/27746737/

2015: In a survey of 117 parents of children with epilepsy, CBD-rich extracts saw “eighty-five percent of all parents reported a reduction in seizure frequency, and 14% reported complete seizure freedom”

Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome

https://pubmed.ncbi.nlm.nih.gov/25935511/

2014: In colon cancer tissue culture & xenograft animal model, CBD extract reduced tumor cell proliferation more than isolated CBD – the extract also showed a much higher binding affinity to CB1 & CB2

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

https://pubmed.ncbi.nlm.nih.gov/24373545/

2013: In a survey, reports from parents on treatment with high CBD cannabis for epilepsy

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy

https://www.ncbi.nlm.nih.gov/pubmed/24237632

2011: In human & rat bladder samples, CBD extract & isolated CBD reduced the contractions induced by acetylcholine (but not those induced with electrical field stimulation, KCl, or α,β-methylene adenosine triphosphate) via TRPV1 in rats

Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility

https://pubmed.ncbi.nlm.nih.gov/21310467/

2006: In cultures of hippocampal neurons and glial cells, the extracts of THC & CBD did better than the isolated cannabinoids at elevating calcium levels

Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

https://pubmed.ncbi.nlm.nih.gov/16997463/

2006: In mice, CBD extracts did not reverse memory deficits caused by cholinergic  (scopolamine) or glutamatergic (MK801) insults

Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

https://pubmed.ncbi.nlm.nih.gov/16406104/

2004: Many ‘n of 1’ studies on THC/CBD combos found that CBD did not help with the pain or sleep duration but did improve sleep quality (24 participants in a double‐blind, 4‐way cross‐over, RCT)

Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies

https://pubmed.ncbi.nlm.nih.gov/15096238/

2004: In rats, THC extracts caused problems for spatial working/short-term memory but CBD extracts did not

Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

https://www.ncbi.nlm.nih.gov/pubmed/15567426