Full Spectrum Hemp Extract
studies

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2022: In older medical cannabis users, CBD oils are the most common type being used & people report them helpful for pain, sleep, mood, a reduced use of opioids & a reduced use of benzodiazepines

Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects

https://pubmed.ncbi.nlm.nih.gov/34940961/

2022: In patients with Parkinson’s disease, they reported using more CBD products via oral administration for sleep, pain & mood

Higher Risk, Higher Reward? Self-Reported Effects of Real-World Cannabis Use in Parkinson's Disease

https://movementdisorders.onlinelibrary.wiley.com/doi/full/10.1002/mdc3.13414

2022: The Michael J Fox Foundation released the results of a survey on the use of cannabinoid products for Parkinson’s disease & they reported using more CBD products

Higher risk, higher reward? Self-reported effects of real-world cannabis use in Parkinson's disease

https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.13414

2022: This survey shows that most women who used cannabis or cannabinoids (THC, CBD, PEA) for gynecologic conditions found that it improved pain

Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review

https://journals.lww.com/greenjournal/Fulltext/9900/Medical_Cannabis_for_Gynecologic_Pain_Conditions_.362.aspx

2022: For chronic pain conditions, THC & CBD improved pain scores as well as quality of life

UK Medical Cannabis registry: an analysis of clinical outcomes of medicinal cannabis therapy for chronic pain conditions

https://pubmed.ncbi.nlm.nih.gov/34937477/

2022: In humans with peripheral neuropathy, a double-blind study showed topical CBD oil caused “significant improvement in pain and other disturbing sensations”

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities

https://pubmed.ncbi.nlm.nih.gov/31793418/

 

2022: Essential oil from hemp causes antimicrobial & antioxidant activity

In vitro antioxidant and antimicrobial activity of Cannabis sativa L. cv 'Futura 75' essential oil

https://pubmed.ncbi.nlm.nih.gov/32865042/

2021: This survey confirms that people find CBD effective for their anxiety

Expectancies about the effects of cannabidiol products on anxiety symptoms

https://www.tandfonline.com/doi/abs/10.1080/14659891.2021.2006341

2021: This study from Brazil suggests using CBD to prevent burnout for health care workers on the frontline of the COVID pandemic

Cannabidiol as a Treatment for Mental Health Outcomes Among Health Care Workers During the Coronavirus Disease Pandemic

https://pubmed.ncbi.nlm.nih.gov/33843818/

2021: In a study of human using cannabis, chemovars (strains) of cannabis high in CBD reduced the plasma concentrations of THC as well as the reports of paranoia & anxiety while still reporting a similar positive mood effect

Effects of cannabidiol in cannabis flower: Implications for harm reduction

https://pubmed.ncbi.nlm.nih.gov/34467598/

2021: This survey of Canadian cannabis clinics found CBD helped for pain, anxiety & depression in moderate & severe cases but not mild cases

Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic

https://pubmed.ncbi.nlm.nih.gov/34162446/

2021: A survey of caregivers of Alzheimer's patients find that they believe CBD oil to be a useful tool

Attitudes, Beliefs, and Changing Trends of Cannabidiol (CBD) Oil Use Among Caregivers of Individuals with Alzheimer’s Disease

https://www.sciencedirect.com/science/article/pii/S0965229921000017

2021: A review of patient charts suggest benefits for Parkinson’s disease & Lewy body dementia from the use of CBD or CBD/CBG extracts

Standardized extracts enriched in cannabidiol and cannabigerol: Real-world experience of cases series of Parkinson's disease and dementia with Lewy bodies

https://www.researchgate.net/profile/Flavio-Henrique-Costa/publication/355440483_Standardized_extracts_enriched_in_cannabidiol_and_cannabigerol_Real-world_experience_of_cases_series_of_Parkinson's_disease_and_dementia_with_Lewy_bodies/links/6170a5a0c10b387664c87790/Standardized-extracts-enriched-in-cannabidiol-and-cannabigerol-Real-world-experience-of-cases-series-of-Parkinsons-disease-and-dementia-with-Lewy-bodies.pdf

2021: CBD well-tolerated by patients with Parkinson's disease

Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson Disease: Interim Report on Tolerability

https://n.neurology.org/content/96/15_Supplement/1592.abstract

 

2021: A survey finds that CBD & medical cannabis are effective for insomnia across all genders & ages

The Use of Cannabinoids for Insomnia in Daily Life: Naturalistic Study

https://pubmed.ncbi.nlm.nih.gov/34704957/ 

2021: A survey of 7 pain management clinics in SoCal found a predominantly positive attitude about CBD for pain relief

Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

https://www.dovepress.com/cannabidiol-as-a-treatment-for-chronic-pain-a-survey-of-patientsrsquo--peer-reviewed-fulltext-article-JPR

2021: A survey of spinal patients found that many of them found CBD helpful for treating their pain, improving their sleep & reducing their anxiety

Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey

https://pubmed.ncbi.nlm.nih.gov/34285125/

2021: This survey of epilepsy patients shows several improvements for users of “artisanal CBD products” (ie: not Epidiolex) including “higher quality of life, lower psychiatric symptom severity, and improved sleep”

Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

https://pubmed.ncbi.nlm.nih.gov/34311183/

2022: Case reports in women of CBD helping with heart after a concussion

Effects of phytocannabinoids on heart rate variability and blood pressure variability in female post-concussion syndrome patients: case series

https://pubmed.ncbi.nlm.nih.gov/34597522/

2022: A study in 28k people found that CBD did not find any association with negative liver function

Observed Impact of Long-term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults

https://www.liebertpub.com/doi/full/10.1089/can.2021.0114

2022: In humans, a study of how CBD enters the system via the various ingestion methods

Pharmacokinetic Profile of Δ9-Tetrahydrocannabinol, Cannabidiol, and Metabolites in Blood Following Vaporization and Oral Ingestion of Cannabidiol Products

https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkab124/6529814

2022: In two patients with hyperhidrosis (excessive sweating), CBD immediately improved their symptoms

Unexpected improvement of hyperhidrosis with cannabidiol

https://pubmed.ncbi.nlm.nih.gov/35170710/

2022: In exercising males, “CBD appears to alter some key physiological and psychological responses to aerobic exercise without impairing performance”

Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial

https://pubmed.ncbi.nlm.nih.gov/35235092/

2022: A review of CBD & cannabis for sports

Cannabis, cannabidiol and tetrahydrocannabinol in sport: An overview

https://pubmed.ncbi.nlm.nih.gov/35191178/

2022: In patients with anal fissures, a topical hemp blend significantly improved pain & quality of life

Management of Chronic Anal Fissure With A Novel Topical Hemp-Herbal Based Ointment - A Pilot Study

https://assets.researchsquare.com/files/rs-1389433/v1/1340a238-aa36-4e95-831f-71312e1b0ed5.pdf?c=1646671134

2022: White blood cells modulated by CBD as well as by cannabis extracts

Immunosuppressive activity of non-psychoactive Cannabis sativa L. extract on the function of human T lymphocytes

https://pubmed.ncbi.nlm.nih.gov/34998274/

2021: In humans with Chrohn's disease, CBD-rich cannabis extracts caused significant improvements to the quality of life - though no significant changes to inflammatory scores

Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/33858011/

2021: This survey looks at people who exercise to ask them how & why they use CBD & cannabis

Cannabis and Cannabidiol Use in Active Individuals: A Survey of Timing and Reasons for Use

https://digitalcommons.wku.edu/ijesab/vol14/iss1/53/

2021: A survey of orthopedic doctor focused on trauma about their thoughts on cannabis & CBD for postoperative pain

Knowledge and Opinion on Cannabinoids Among Orthopaedic Traumatologists

https://pubmed.ncbi.nlm.nih.gov/33872227/

2021: In humans with a psychotic disorder, CBD cigarettes improved scores & saw less antipsychotic medication used

Cannabidiol Cigarettes as Adjunctive Treatment for Psychotic Disorders - A Randomized, Open-Label Pilot-Study

https://pubmed.ncbi.nlm.nih.gov/34803760/

2021: In a case study of a man with treatment-resistant bruxism (grinding of the teeth at night), CBD capsules provided almost complete relief when he began them

Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration

https://pubmed.ncbi.nlm.nih.gov/33934685/

2021: This review looks at how aging causes our immune systems to wane & our baseline inflammation to increase – and what the cannabinoids like CBD can do to help

Inflammaging and Cannabinoids

https://pubmed.ncbi.nlm.nih.gov/34662745/

2021: A case report of a man using CBD to help control his type 2 diabetes

Cannabidiol (CBD) Use in Type 2 Diabetes: A Case Report

https://spectrum.diabetesjournals.org/content/early/2020/12/23/ds20-0023

2021: In 8 children with West syndrome (a constellation of symptoms including epileptic spasms & intellectual disability), CBD-rich medical cannabis caused half of them to see a 50% reduction in seizures

Cannabidiol-enriched medical cannabis as add-on therapy in children with treatment-resistant West syndrome: A study of eight patients

https://pubmed.ncbi.nlm.nih.gov/34624613/

2021: This review looks at cannabis & CBD in treating lower back pain in older adults

The Effectiveness of Cannabis and Cannabis Derivatives in Treating Lower Back Pain in the Aged Population: A Systematic Review

https://www.karger.com/Article/FullText/518269

2021: This review of clinical studies of cannabinoids in older adults found CBD to have a low incidence of adverse events & no serious adverse events

Safety and Tolerability of Natural and Synthetic Cannabinoids in Older Adults: A Systematic Review and Meta-Analysis of Open-Label Trials and Observational Studies

https://pubmed.ncbi.nlm.nih.gov/34235645/

2021: In a mouse model of autism, long-term treatment with CBD-rich medical cannabis oil lessened anxiety & repetitive behaviors

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder

https://pubmed.ncbi.nlm.nih.gov/34645786/

2021: In a mouse model of seizures, hemp extract with CBD & terpenes worked the best

Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test

https://www.mdpi.com/1424-8247/14/12/1259

2021: In a model of tissue fibrosis (scarring), this thesis project found that high CBD extracts downregulated the activation of several key genes related to fibrosis

The effect of cannabis extracts on the expression of fibrosis-related genes

http://opus.uleth.ca/handle/10133/6095

2021: This survey of women experiencing chronic pelvic pain & fibromyalgia found that CBD helped them to reduce pain medications & improvements in sleep, anxiety, depression, fatigue & overall health

Cannabidiol Use, Substitution for Medications, and Perceptions of Effectiveness in Women with Chronic Pelvic Pain

https://www.sciencedirect.com/science/article/pii/S1553465021008955

2021: A review of cannabis concentrates rich in THC vs rich in CBD find that the CBD dominant concentrates caused positive mood effects, lowered intoxication & displayed an absence of undesirable effects

Acute objective and subjective intoxication effects of legal-market high potency THC-dominant versus CBD-dominant cannabis concentrates

https://pubmed.ncbi.nlm.nih.gov/34741088/

2021: Two hemp extracts from Chinese cultivars found to have potent antibiotic & antioxidant properties

Antioxidant and antimicrobial activity of two standardized extracts from a new Chinese accession of non-psychotropic Cannabis sativa L

https://pubmed.ncbi.nlm.nih.gov/33034400/

2021: In skin cells, hemp extracts were found to have all sorts of positive effects

Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties

https://pubmed.ncbi.nlm.nih.gov/33557174/

2021: At a cannabis social club, researchers tested various cannabis extracts with differing THC/CBD ratios & found CBD protected people from the psychotic-like symptoms caused by THC

Opposite Roles for Cannabidiol and δ-9-Tetrahydrocannabinol in Psychotomimetic Effects of Cannabis Extracts: A Naturalistic Controlled Study

https://pubmed.ncbi.nlm.nih.gov/34412109/

2021: In a case study of a man with schizophrenia & substance use disorder, high CBD-low THC cigarettes helped lessen his cannabis use & stop his cocaine use

Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder

https://pubmed.ncbi.nlm.nih.gov/34366942/

2021: In humans using alcohol & cannabis, those smoking high CBD cannabis drank less alcohol & on fewer days (the THC-rich cannabis & the CBD/THC cannabis had no effect) 

THC and CBD effects on alcohol use among alcohol and cannabis co-users

https://pubmed.ncbi.nlm.nih.gov/33764086/

2021: A survey finds topical CBD helpful for atopic dermatitis

Assessing the effects of topical cannabidiol in patients with atopic dermatitis

https://escholarship.org/content/qt8h50k2vs/qt8h50k2vs_noSplash_a5a0c93f40bf15012adc686e63eec5f7.pdf

2021: In a study in 35 humans with alopecia (patchy hair loss), 6 months of a topical CBD caused participants to experience an average of 93.5% increase in hair

Case Study of Hair Regrowth with Topical Cannabidiol (CBD)

https://www.ishrs-htforum.org/content/31/4/140

2021: This survey of epilepsy patients shows several improvements for users of “artisanal CBD products” including “higher quality of life, lower psychiatric symptom severity, and improved sleep”

Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

https://pubmed.ncbi.nlm.nih.gov/34311183/

2021: In humans with Crohn’s disease, CBD-rich cannabis extracts caused significant improvements to the quality of life though no significant changes to inflammatory scores

Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/33858011/

2021: In a mouse model of pain, the combination of full-spectrum hemp extracts & PEA reduced pain greatly

Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain

https://pubmed.ncbi.nlm.nih.gov/33722712/

2021: In ovarian cancer cells, full-spectrum hemp extract found to have anticancer effects

Hemp Extract with Specific Anti-Cancer Properties against Ovarian Cancer

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.02877

2020: In humans, CBD hemp extract helped to delay the onset of muscle soreness

The influence cannabidiol on delayed onset of muscle soreness

http://www.kheljournal.com/archives/2020/vol7issue2/PartB/7-2-4-412.pdf

2020: In mouse model of Lafora disease (progressive infantile epilepsy), CBD-rich extracts helped with the dementia but not the seizures

Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model

https://pubmed.ncbi.nlm.nih.gov/32656347/

2020: Great pilot study in 32 dogs with osteoarthritis finds that CBD-rich hemp extracts help almost all of them with their pain & allowed almost all of them taking gabapentin to reduce or eliminate that drug

The Use of Cannabidiol-Rich Hemp Oil Extract to Treat Canine Osteoarthritis-Related Pain: A Pilot Study

https://www.semanticscholar.org/paper/The-Use-of-Cannabidiol-Rich-Hemp-Oil-Extract-to-A-Kogan-Hellyer/94d216f37b94965863e33bda278cb31adcf1f5ea?p2df

2020: Epilepsy patients vastly prefer natural CBD over synthetic CBD

Plant Derived Versus Synthetic Cannabidiol: Wishes and Commitment of Epilepsy Patients

https://pubmed.ncbi.nlm.nih.gov/32554292/

2020: In mice, full-spectrum help oil was effective for chronic neuropathic pain

The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model
https://www.mdpi.com/2075-1729/10/5/69

2020: A GRAS safety study of CBD-rich hemp extracts in rats

Safety Assessment of a Hemp Extract using Genotoxicity and Oral Repeat-Dose Toxicity Studies in Sprague-Dawley Rats

https://www.sciencedirect.com/science/article/pii/S2214750019305207

2020: In humans, the use of CBD-rich extract reduced or eliminated opioids with significant improvement in their quality of life indices

Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study

https://pubmed.ncbi.nlm.nih.gov/31711352/

2020: Observational study to find pharmacokinetic data of CBD rich extracts in children with epilepsy - prospective observational study of 29 patients

Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy

https://pubmed.ncbi.nlm.nih.gov/32048179/

2020: In mice, CBD extracts increased good bacteria but increased inflammation signals

Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract

https://pubmed.ncbi.nlm.nih.gov/32400224/

2019: Hemp extracts for antimicrobial effects

Hemp (Cannabis Sativa L.) Extract: Anti-Microbial Properties, Methods of Extraction, and Potential Oral Delivery

https://www.tandfonline.com/doi/abs/10.1080/87559129.2019.1600539

2019: Cannabis extracts were more effective than THC or CBD alone in reducing severe side effect of bone marrow transplantation – but all treatments inhibited lymphocyte recovery

Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation

https://www.ncbi.nlm.nih.gov/pubmed/30720730

2019: In a mouse model of multiple sclerosis, CBD extracts helped with neurological disability & behavioral assessments via TNF-α & BDNF

Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis

https://pubmed.ncbi.nlm.nih.gov/31213295/

2019: A liver health safety study

Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model

https://www.mdpi.com/1420-3049/24/9/1694

2019: Out of 15 autism patients, only one failed to show improvements with CBD-rich cannabis extracts (18 person observational study)

Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate Use

https://pubmed.ncbi.nlm.nih.gov/31736860/

2019: In mice, CBD & the plant extract significantly reduced the fear response while THC did not

Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation

https://pubmed.ncbi.nlm.nih.gov/31417379/

2019: In mice using a CBD rich extract, a drug interaction of CBD at 116 mg/kg followed by acetaminophen caused toxicity with 37.5% mortality – but CBD at 290 mg/kg saw no problems

Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

https://pubmed.ncbi.nlm.nih.gov/31212965/

2018: In humans with epilepsy, CBD-rich extracts found effective & safe (108 patients in a retrospective study)

Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center

https://www.ncbi.nlm.nih.gov/pubmed/29429908

2018: A metareview finds more help from CBD extracts than isolated CBD - 11 references covering 670 patients

Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis

https://pubmed.ncbi.nlm.nih.gov/30258398/

(correction of a table: https://pubmed.ncbi.nlm.nih.gov/30687209/)

2018: A CBD-rich extract for ulcerative colitis patients didn’t improve primary endpoints but did suggest beneficial symptom treatment (39 patients in a randomized, double-blind, placebo-controlled, parallel-group pilot study)

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis

https://pubmed.ncbi.nlm.nih.gov/29538683/

2018: A toxicity study from CV Sciences

An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp

https://www.hindawi.com/journals/jt/2018/8143582/abs/

2018: In humans, 800 mg of CBD did not improve working or spatial memory or improve impulsivity during tobacco abstinence (30 participants in a randomized control trial)

The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers

https://www.ncbi.nlm.nih.gov/pubmed/29765102

2018: In humans who use tobacco, 800 mg of CBD “reduced the salience and pleasantness of cigarette cues” but “did not influence tobacco craving or withdrawal or any subjectively rated side effects” (30 participants in a randomized, double-blind cross-over study)

Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal

https://www.ncbi.nlm.nih.gov/pubmed/29714034

2018: In a mouse model of multiple sclerosis, CBD rich extracts (from Avidekel cannabis) work as well as the common drug copaxone in suppressing symptoms

Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice

https://pubmed.ncbi.nlm.nih.gov/30291491/

2018: In docking studies, CBD/CBDA extracts & CBG/CBGA extracts reduced aldose reductase activity for diabetes

Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or Cannabigerol

https://pubmed.ncbi.nlm.nih.gov/29427593/

2017: In a survey of parents in Mexico, CBD extracts very helpful for seizures (53 parents)

Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy

https://pubmed.ncbi.nlm.nih.gov/28392943/

2016: In a mouse model of colitis, CBD extract decreased damage and reduced intestinal hypermotility better than isolated CBD

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

https://pubmed.ncbi.nlm.nih.gov/27757083/

2016: In 5 Israeli children with intractable epilepsy, CBD-rich extracts caused “significant positive effect on seizure load”

CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience

https://pubmed.ncbi.nlm.nih.gov/26800377/

2016: Two case reports of children using CBD-rich extracts getting intoxicated by the THC – improvements when switched to CBD isolate

Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol

https://pubmed.ncbi.nlm.nih.gov/27746737/

2015: In a survey of 117 parents of children with epilepsy, CBD-rich extracts saw “eighty-five percent of all parents reported a reduction in seizure frequency, and 14% reported complete seizure freedom”

Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome

https://pubmed.ncbi.nlm.nih.gov/25935511/

2014: In colon cancer tissue culture & xenograft animal model, CBD extract reduced tumor cell proliferation more than isolated CBD – the extract also showed a much higher binding affinity to CB1 & CB2

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

https://pubmed.ncbi.nlm.nih.gov/24373545/

2013: In a survey, reports from parents on treatment with high CBD cannabis for epilepsy

Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy

https://www.ncbi.nlm.nih.gov/pubmed/24237632

2011: In human & rat bladder samples, CBD extract & isolated CBD reduced the contractions induced by acetylcholine (but not those induced with electrical field stimulation, KCl, or α,β-methylene adenosine triphosphate) via TRPV1 in rats

Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility

https://pubmed.ncbi.nlm.nih.gov/21310467/

2006: In cultures of hippocampal neurons and glial cells, the extracts of THC & CBD did better than the isolated cannabinoids at elevating calcium levels

Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

https://pubmed.ncbi.nlm.nih.gov/16997463/

2006: In mice, CBD extracts did not reverse memory deficits caused by cholinergic  (scopolamine) or glutamatergic (MK801) insults

Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

https://pubmed.ncbi.nlm.nih.gov/16406104/

2004: Many ‘n of 1’ studies on THC/CBD combos found that CBD did not help with the pain or sleep duration but did improve sleep quality (24 participants in a double‐blind, 4‐way cross‐over, RCT)

Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies

https://pubmed.ncbi.nlm.nih.gov/15096238/

2004: In rats, THC extracts caused problems for spatial working/short-term memory but CBD extracts did not

Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

https://www.ncbi.nlm.nih.gov/pubmed/15567426