Full Spectrum Hemp Extract
studies
2023: In a mouse model of nerve injury, a cannabis extract sped up muscle function recovery
Comparative evaluation of ethyl acetate and n-Hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion
https://onlinelibrary.wiley.com/doi/pdf/10.1002/fsn3.3255
2023: A case report of using CBD-rich cannabis for a patient with hypophosphatasia (a rare genetic disorder of impaired mineralization of bones & teeth that includes muscle pain & neurological symptoms) found that it led to a significant pain reduction, a discontinuation of opioids & resumption of her work as a physician
Medical Cannabinoids as Treatment for Hypophosphatasia-Related Symptoms
https://pubmed.ncbi.nlm.nih.gov/36380652
2022: A review of pediatric patients using artisanal CBD oil for their epilepsy showed it to be effective & safe
The Long-Term Effectiveness and Safety of Cannabidiol-Enriched Oil in Children With Drug-Resistant Epilepsy
https://pubmed.ncbi.nlm.nih.gov/36049378
2022: For Alzheimer’s, a review of the advantages of using multiple cannabinoids for treatment
Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer's disease
https://pubmed.ncbi.nlm.nih.gov/36117622
2022: In a cellular model of a wound in your gum, hemp extracts & CBD decreased inflammatory factors & significantly improved wound closure
Anti-inflammation and gingival wound healing activities of Cannabis sativa L. subsp. sativa (hemp) extract and cannabidiol: An in vitro study
https://pubmed.ncbi.nlm.nih.gov/35623115
2022: In a computer analysis for diabetic effects, CBD, THC & full-spectrum extracts were found to inhibit α-glucosidase (an enzyme that breaks down glucose)
α-Glucosidase inhibitory activity of cannabidiol, tetrahydrocannabinol and standardized cannabinoid extracts from Cannabis sativa
https://pubmed.ncbi.nlm.nih.gov/35856057
2022: In a rat model of obesity, CBD-rich hemp extracts protected the heart via the inhibition of the transport of adenosine (a messenger of protein synthesis)
The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium
https://pubmed.ncbi.nlm.nih.gov/36588715/
2022: In mice with high blood pressure, one month of cannabis oil reduced their hypertension & improved their network of mitochondria (powerhouse of the cell) probably via its antioxidant effects
Cannabis oil one-month oral treatment given to spontaneously hypertensive rats (SHR): Could it be a promising therapeutic strategy for hypertensive cardiac hypertrophy?
https://www.sciencedirect.com/science/article/pii/S0022282822003959
2022: A study of the minor cannabinoids find anti-inflammatory activities for cannabielsoin, dehydrocannabielsoin, cannabimovone & 3'-epicannabimovone
Synthesis of the Cannabimovone and Cannabifuran Class of Minor Phytocannabinoids and Their Anti-inflammatory Activity
https://pubmed.ncbi.nlm.nih.gov/35476908/
2022: In a mouse model of inflammatory pain, combining CBD & β-caryophyllene (a common cannabis terpene) to produce synergistic painkilling effects via control of inflammation
Cannabidiol and Beta-Caryophyllene in Combination: A Therapeutic Functional Interaction
https://pubmed.ncbi.nlm.nih.gov/36555111/
2022: In a mouse model of nerve pain, CBD-rich extract lowered their pain sensitivity via the CB2 receptors of the microglia (immune guardian cells of the brain)
Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation
https://pubmed.ncbi.nlm.nih.gov/36583304/
2022: A case study of using THC & CBD on a patient with complex pain
Integration of Cannabis Extract Tetrahydrocannabinol:Cannabidiol in an Interdisciplinary Therapy Setting: A Case of Chronic Multilocular Pain Disorder
https://pubmed.ncbi.nlm.nih.gov/36467780
2022: In a rat model of neuropathic pain, THC worked the best for reducing pain – but high-CBD cannabis extracts was more effective than CBD alone
Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain
https://pubmed.ncbi.nlm.nih.gov/36289810
2022: Against salmonella, using CBD rich extracts to enhance the anti-bacterial activity of broad-spectrum antibiotics
Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella enterica subsp. Enterica serovar typhimurium
https://pubmed.ncbi.nlm.nih.gov/36557613
2022: In mice with gut inflammation & colitis, THC & CBD inhibited inflammatory macrophages (mobile white blood cells) & improved clinical scores - with cannabis extracts working better than isolated molecules
Differential Effects of D9 Tetrahydrocannabinol (THC)- and Cannabidiol (CBD)-Based Cannabinoid Treatments on Macrophage Immune Function In Vitro and on Gastrointestinal Inflammation in a Murine Model
https://pubmed.ncbi.nlm.nih.gov/35892693
2022: In a case study where isolated CBD stopped being effective for autism once the patient hit puberty, the power of enriching with terpenes
Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report
https://pubmed.ncbi.nlm.nih.gov/36386202/
2022: In kids with autism, CBD-rich cannabis extracts for 6 months most showed improvement in repetitive behaviors & social communication abilities, especially those with more severe starting symptoms
Children and adolescents with ASD treated with CBD-rich cannabis exhibit significant improvements particularly in social symptoms: an open label study
https://pubmed.ncbi.nlm.nih.gov/36085294
2022: A case study of full-spectrum CBD for autism
Cannabidiol in Treatment of Autism Spectrum Disorder: A Case Study
https://pubmed.ncbi.nlm.nih.gov/36176817
2022: In a double-blind study of children with autism, CBD-rich hemp extracts increased social interaction & concentration while decreasing anxiety & psychomotor agitation & led to less caregiver distress
Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial
https://pubmed.ncbi.nlm.nih.gov/35617670
2022: A tissue test of the antioxidative & neuroprotective properties of two cannabis extracts
Evaluation of two different Cannabis sativa L. extracts as antioxidant and neuroprotective agents
https://pubmed.ncbi.nlm.nih.gov/36176449
2022: In a cellular model of excitotoxicity (neuronal damage due to too much stimulation), a cannabis extract protected the brain cells via several mechanisms including brain-derived neurotrophic factor levels, ERK modulation & a rescue of CB1 levels
Investigation on the neuroprotective effect of a cannabidiol-enriched non-psychotropic Cannabis sativa L. extract in an in vitro model of excitotoxicity
https://pubmed.ncbi.nlm.nih.gov/36179898
2022: Individualized (magistral) cannabis formulations helpful for adults with drug-resistant focal epilepsy
Cannabis-based magistral formulation is highly effective as an adjuvant treatment in drug-resistant focal epilepsy in adult patients: an open-label prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/36129615
2022: In a roundworm model of neurodegeneration, both THC & CBD oil helped to protect their neurons
Neuroprotective potential of Cannabis sativa-based oils in Caenorhabditis elegans
https://pubmed.ncbi.nlm.nih.gov/36100636
2022: A study in former professional football players found that hemp extracts may help with cognitive performance & emotional processing
Automated Detection of Cognitive Performance and Resilience Changes in Former Professional American Football Players Following the Administration of a Hemp Extract
https://www.neuroregulation.org/article/view/22585
2022: In human sodium channels (which help control electrical signals in epilepsy), CBD-rich hemp extracts inhibited the channel at much lower doses than isolated CBD
A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function
https://pubmed.ncbi.nlm.nih.gov/35689251
2022: In a model of neuroinflammation, a CBD & terpene enriched cannabis extract lowered pro-inflammatory cytokines via several pathways
Non-psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors-, endocannabinoids-, and NF-κB-mediated signaling
https://pubmed.ncbi.nlm.nih.gov/35393641/
2022: A diary study of using cannabis for PTSD & to help with sleep with CBD-rich products helping the most to lower early awakenings
Posttraumatic stress disorder, sleep and medical cannabis treatment: A daily diary study
https://pubmed.ncbi.nlm.nih.gov/36182689
2022: In older medical cannabis users, CBD oils are the most common type being used & people report them helpful for pain, sleep, mood, a reduced use of opioids & a reduced use of benzodiazepines
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects
https://pubmed.ncbi.nlm.nih.gov/34940961/
2022: In patients with Parkinson’s disease, they reported using more CBD products via oral administration for sleep, pain & mood
Higher Risk, Higher Reward? Self-Reported Effects of Real-World Cannabis Use in Parkinson's Disease
https://movementdisorders.onlinelibrary.wiley.com/doi/full/10.1002/mdc3.13414
2022: The Michael J Fox Foundation released the results of a survey on the use of cannabinoid products for Parkinson’s disease & they reported using more CBD products
Higher risk, higher reward? Self-reported effects of real-world cannabis use in Parkinson's disease
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mdc3.13414
2022: This survey shows that most women who used cannabis or cannabinoids (THC, CBD, PEA) for gynecologic conditions found that it improved pain
Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review
2022: For chronic pain conditions, THC & CBD improved pain scores as well as quality of life
UK Medical Cannabis registry: an analysis of clinical outcomes of medicinal cannabis therapy for chronic pain conditions
https://pubmed.ncbi.nlm.nih.gov/34937477/
2022: In humans with peripheral neuropathy, a double-blind study showed topical CBD oil caused “significant improvement in pain and other disturbing sensations”
The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities
https://pubmed.ncbi.nlm.nih.gov/31793418/
2022: Essential oil from hemp causes antimicrobial & antioxidant activity
In vitro antioxidant and antimicrobial activity of Cannabis sativa L. cv 'Futura 75' essential oil
https://pubmed.ncbi.nlm.nih.gov/32865042/
2021: This survey confirms that people find CBD effective for their anxiety
Expectancies about the effects of cannabidiol products on anxiety symptoms
https://www.tandfonline.com/doi/abs/10.1080/14659891.2021.2006341
2021: This study from Brazil suggests using CBD to prevent burnout for health care workers on the frontline of the COVID pandemic
Cannabidiol as a Treatment for Mental Health Outcomes Among Health Care Workers During the Coronavirus Disease Pandemic
https://pubmed.ncbi.nlm.nih.gov/33843818/
2021: In a study of human using cannabis, chemovars (strains) of cannabis high in CBD reduced the plasma concentrations of THC as well as the reports of paranoia & anxiety while still reporting a similar positive mood effect
Effects of cannabidiol in cannabis flower: Implications for harm reduction
https://pubmed.ncbi.nlm.nih.gov/34467598/
2021: This survey of Canadian cannabis clinics found CBD helped for pain, anxiety & depression in moderate & severe cases but not mild cases
Cannabidiol use and effectiveness: real-world evidence from a Canadian medical cannabis clinic
https://pubmed.ncbi.nlm.nih.gov/34162446/
2021: A survey of caregivers of Alzheimer's patients find that they believe CBD oil to be a useful tool
Attitudes, Beliefs, and Changing Trends of Cannabidiol (CBD) Oil Use Among Caregivers of Individuals with Alzheimer’s Disease
https://www.sciencedirect.com/science/article/pii/S0965229921000017
2021: A review of patient charts suggest benefits for Parkinson’s disease & Lewy body dementia from the use of CBD or CBD/CBG extracts
Standardized extracts enriched in cannabidiol and cannabigerol: Real-world experience of cases series of Parkinson's disease and dementia with Lewy bodies
2021: CBD well-tolerated by patients with Parkinson's disease
Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson Disease: Interim Report on Tolerability
https://n.neurology.org/content/96/15_Supplement/1592.abstract
2021: A survey finds that CBD & medical cannabis are effective for insomnia across all genders & ages
The Use of Cannabinoids for Insomnia in Daily Life: Naturalistic Study
https://pubmed.ncbi.nlm.nih.gov/34704957/
2021: A survey of 7 pain management clinics in SoCal found a predominantly positive attitude about CBD for pain relief
Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes
2021: A survey of spinal patients found that many of them found CBD helpful for treating their pain, improving their sleep & reducing their anxiety
Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey
https://pubmed.ncbi.nlm.nih.gov/34285125/
2021: This survey of epilepsy patients shows several improvements for users of “artisanal CBD products” (ie: not Epidiolex) including “higher quality of life, lower psychiatric symptom severity, and improved sleep”
Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy
https://pubmed.ncbi.nlm.nih.gov/34311183/
2022: Case reports in women of CBD helping with heart after a concussion
Effects of phytocannabinoids on heart rate variability and blood pressure variability in female post-concussion syndrome patients: case series
https://pubmed.ncbi.nlm.nih.gov/34597522/
2022: A study in 28k people found that CBD did not find any association with negative liver function
Observed Impact of Long-term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults
https://www.liebertpub.com/doi/full/10.1089/can.2021.0114
2022: In humans, a study of how CBD enters the system via the various ingestion methods
Pharmacokinetic Profile of Δ9-Tetrahydrocannabinol, Cannabidiol, and Metabolites in Blood Following Vaporization and Oral Ingestion of Cannabidiol Products
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkab124/6529814
2022: In two patients with hyperhidrosis (excessive sweating), CBD immediately improved their symptoms
Unexpected improvement of hyperhidrosis with cannabidiol
https://pubmed.ncbi.nlm.nih.gov/35170710/
2022: In exercising males, “CBD appears to alter some key physiological and psychological responses to aerobic exercise without impairing performance”
Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial
https://pubmed.ncbi.nlm.nih.gov/35235092/
2022: A review of CBD & cannabis for sports
Cannabis, cannabidiol and tetrahydrocannabinol in sport: An overview
https://pubmed.ncbi.nlm.nih.gov/35191178/
2022: In patients with anal fissures, a topical hemp blend significantly improved pain & quality of life
Management of Chronic Anal Fissure With A Novel Topical Hemp-Herbal Based Ointment - A Pilot Study
2022: White blood cells modulated by CBD as well as by cannabis extracts
Immunosuppressive activity of non-psychoactive Cannabis sativa L. extract on the function of human T lymphocytes
https://pubmed.ncbi.nlm.nih.gov/34998274/
2021: In humans with Chrohn's disease, CBD-rich cannabis extracts caused significant improvements to the quality of life - though no significant changes to inflammatory scores
Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/33858011/
2021: This survey looks at people who exercise to ask them how & why they use CBD & cannabis
Cannabis and Cannabidiol Use in Active Individuals: A Survey of Timing and Reasons for Use
https://digitalcommons.wku.edu/ijesab/vol14/iss1/53/
2021: A survey of orthopedic doctor focused on trauma about their thoughts on cannabis & CBD for postoperative pain
Knowledge and Opinion on Cannabinoids Among Orthopaedic Traumatologists
https://pubmed.ncbi.nlm.nih.gov/33872227/
2021: In humans with a psychotic disorder, CBD cigarettes improved scores & saw less antipsychotic medication used
Cannabidiol Cigarettes as Adjunctive Treatment for Psychotic Disorders - A Randomized, Open-Label Pilot-Study
https://pubmed.ncbi.nlm.nih.gov/34803760/
2021: In a case study of a man with treatment-resistant bruxism (grinding of the teeth at night), CBD capsules provided almost complete relief when he began them
Cannabidiol in the management of bruxism in behavioral variant of frontotemporal degeneration
https://pubmed.ncbi.nlm.nih.gov/33934685/
2021: This review looks at how aging causes our immune systems to wane & our baseline inflammation to increase – and what the cannabinoids like CBD can do to help
Inflammaging and Cannabinoids
https://pubmed.ncbi.nlm.nih.gov/34662745/
2021: A case report of a man using CBD to help control his type 2 diabetes
Cannabidiol (CBD) Use in Type 2 Diabetes: A Case Report
https://spectrum.diabetesjournals.org/content/early/2020/12/23/ds20-0023
2021: In 8 children with West syndrome (a constellation of symptoms including epileptic spasms & intellectual disability), CBD-rich medical cannabis caused half of them to see a 50% reduction in seizures
Cannabidiol-enriched medical cannabis as add-on therapy in children with treatment-resistant West syndrome: A study of eight patients
https://pubmed.ncbi.nlm.nih.gov/34624613/
2021: This review looks at cannabis & CBD in treating lower back pain in older adults
The Effectiveness of Cannabis and Cannabis Derivatives in Treating Lower Back Pain in the Aged Population: A Systematic Review
https://www.karger.com/Article/FullText/518269
2021: This review of clinical studies of cannabinoids in older adults found CBD to have a low incidence of adverse events & no serious adverse events
Safety and Tolerability of Natural and Synthetic Cannabinoids in Older Adults: A Systematic Review and Meta-Analysis of Open-Label Trials and Observational Studies
https://pubmed.ncbi.nlm.nih.gov/34235645/
2021: In a mouse model of autism, long-term treatment with CBD-rich medical cannabis oil lessened anxiety & repetitive behaviors
Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder
https://pubmed.ncbi.nlm.nih.gov/34645786/
2021: In a mouse model of seizures, hemp extract with CBD & terpenes worked the best
Antiseizure Effects of Fully Characterized Non-Psychoactive Cannabis sativa L. Extracts in the Repeated 6-Hz Corneal Stimulation Test
https://www.mdpi.com/1424-8247/14/12/1259
2021: In a model of tissue fibrosis (scarring), this thesis project found that high CBD extracts downregulated the activation of several key genes related to fibrosis
The effect of cannabis extracts on the expression of fibrosis-related genes
http://opus.uleth.ca/handle/10133/6095
2021: This survey of women experiencing chronic pelvic pain & fibromyalgia found that CBD helped them to reduce pain medications & improvements in sleep, anxiety, depression, fatigue & overall health
Cannabidiol Use, Substitution for Medications, and Perceptions of Effectiveness in Women with Chronic Pelvic Pain
https://www.sciencedirect.com/science/article/pii/S1553465021008955
2021: A review of cannabis concentrates rich in THC vs rich in CBD find that the CBD dominant concentrates caused positive mood effects, lowered intoxication & displayed an absence of undesirable effects
Acute objective and subjective intoxication effects of legal-market high potency THC-dominant versus CBD-dominant cannabis concentrates
https://pubmed.ncbi.nlm.nih.gov/34741088/
2021: Two hemp extracts from Chinese cultivars found to have potent antibiotic & antioxidant properties
Antioxidant and antimicrobial activity of two standardized extracts from a new Chinese accession of non-psychotropic Cannabis sativa L
https://pubmed.ncbi.nlm.nih.gov/33034400/
2021: In skin cells, hemp extracts were found to have all sorts of positive effects
Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties
https://pubmed.ncbi.nlm.nih.gov/33557174/
2021: At a cannabis social club, researchers tested various cannabis extracts with differing THC/CBD ratios & found CBD protected people from the psychotic-like symptoms caused by THC
Opposite Roles for Cannabidiol and δ-9-Tetrahydrocannabinol in Psychotomimetic Effects of Cannabis Extracts: A Naturalistic Controlled Study
https://pubmed.ncbi.nlm.nih.gov/34412109/
2021: In a case study of a man with schizophrenia & substance use disorder, high CBD-low THC cigarettes helped lessen his cannabis use & stop his cocaine use
Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder
https://pubmed.ncbi.nlm.nih.gov/34366942/
2021: In humans using alcohol & cannabis, those smoking high CBD cannabis drank less alcohol & on fewer days (the THC-rich cannabis & the CBD/THC cannabis had no effect)
THC and CBD effects on alcohol use among alcohol and cannabis co-users
https://pubmed.ncbi.nlm.nih.gov/33764086/
2021: A survey finds topical CBD helpful for atopic dermatitis
Assessing the effects of topical cannabidiol in patients with atopic dermatitis
https://escholarship.org/content/qt8h50k2vs/qt8h50k2vs_noSplash_a5a0c93f40bf15012adc686e63eec5f7.pdf
2021: In a study in 35 humans with alopecia (patchy hair loss), 6 months of a topical CBD caused participants to experience an average of 93.5% increase in hair
Case Study of Hair Regrowth with Topical Cannabidiol (CBD)
https://www.ishrs-htforum.org/content/31/4/140
2021: This survey of epilepsy patients shows several improvements for users of “artisanal CBD products” including “higher quality of life, lower psychiatric symptom severity, and improved sleep”
Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy
https://pubmed.ncbi.nlm.nih.gov/34311183/
2021: In humans with Crohn’s disease, CBD-rich cannabis extracts caused significant improvements to the quality of life though no significant changes to inflammatory scores
Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/33858011/
2021: In a mouse model of pain, the combination of full-spectrum hemp extracts & PEA reduced pain greatly
Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain
https://pubmed.ncbi.nlm.nih.gov/33722712/
2021: In ovarian cancer cells, full-spectrum hemp extract found to have anticancer effects
Hemp Extract with Specific Anti-Cancer Properties against Ovarian Cancer
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.02877
2020: In humans, CBD hemp extract helped to delay the onset of muscle soreness
The influence cannabidiol on delayed onset of muscle soreness
http://www.kheljournal.com/archives/2020/vol7issue2/PartB/7-2-4-412.pdf
2020: In mouse model of Lafora disease (progressive infantile epilepsy), CBD-rich extracts helped with the dementia but not the seizures
Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model
https://pubmed.ncbi.nlm.nih.gov/32656347/
2020: Great pilot study in 32 dogs with osteoarthritis finds that CBD-rich hemp extracts help almost all of them with their pain & allowed almost all of them taking gabapentin to reduce or eliminate that drug
The Use of Cannabidiol-Rich Hemp Oil Extract to Treat Canine Osteoarthritis-Related Pain: A Pilot Study
2020: Epilepsy patients vastly prefer natural CBD over synthetic CBD
Plant Derived Versus Synthetic Cannabidiol: Wishes and Commitment of Epilepsy Patients
https://pubmed.ncbi.nlm.nih.gov/32554292/
2020: In mice, full-spectrum help oil was effective for chronic neuropathic pain
The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model
https://www.mdpi.com/2075-1729/10/5/69
2020: A GRAS safety study of CBD-rich hemp extracts in rats
Safety Assessment of a Hemp Extract using Genotoxicity and Oral Repeat-Dose Toxicity Studies in Sprague-Dawley Rats
https://www.sciencedirect.com/science/article/pii/S2214750019305207
2020: In humans, the use of CBD-rich extract reduced or eliminated opioids with significant improvement in their quality of life indices
Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study
https://pubmed.ncbi.nlm.nih.gov/31711352/
2020: Observational study to find pharmacokinetic data of CBD rich extracts in children with epilepsy - prospective observational study of 29 patients
Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy
https://pubmed.ncbi.nlm.nih.gov/32048179/
2020: In mice, CBD extracts increased good bacteria but increased inflammation signals
Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract
https://pubmed.ncbi.nlm.nih.gov/32400224/
2019: Hemp extracts for antimicrobial effects
Hemp (Cannabis Sativa L.) Extract: Anti-Microbial Properties, Methods of Extraction, and Potential Oral Delivery
https://www.tandfonline.com/doi/abs/10.1080/87559129.2019.1600539
2019: Cannabis extracts were more effective than THC or CBD alone in reducing severe side effect of bone marrow transplantation – but all treatments inhibited lymphocyte recovery
Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation
https://www.ncbi.nlm.nih.gov/pubmed/30720730
2019: In a mouse model of multiple sclerosis, CBD extracts helped with neurological disability & behavioral assessments via TNF-α & BDNF
Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/31213295/
2019: A liver health safety study
Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
https://www.mdpi.com/1420-3049/24/9/1694
2019: Out of 15 autism patients, only one failed to show improvements with CBD-rich cannabis extracts (18 person observational study)
Effects of CBD-Enriched Cannabis sativa Extract on Autism Spectrum Disorder Symptoms: An Observational Study of 18 Participants Undergoing Compassionate Use
https://pubmed.ncbi.nlm.nih.gov/31736860/
2019: In mice, CBD & the plant extract significantly reduced the fear response while THC did not
Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation
https://pubmed.ncbi.nlm.nih.gov/31417379/
2019: In mice using a CBD rich extract, a drug interaction of CBD at 116 mg/kg followed by acetaminophen caused toxicity with 37.5% mortality – but CBD at 290 mg/kg saw no problems
Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration
https://pubmed.ncbi.nlm.nih.gov/31212965/
2018: In humans with epilepsy, CBD-rich extracts found effective & safe (108 patients in a retrospective study)
Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center
https://www.ncbi.nlm.nih.gov/pubmed/29429908
2018: A metareview finds more help from CBD extracts than isolated CBD - 11 references covering 670 patients
Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis
https://pubmed.ncbi.nlm.nih.gov/30258398/
(correction of a table: https://pubmed.ncbi.nlm.nih.gov/30687209/)
2018: A CBD-rich extract for ulcerative colitis patients didn’t improve primary endpoints but did suggest beneficial symptom treatment (39 patients in a randomized, double-blind, placebo-controlled, parallel-group pilot study)
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis
https://pubmed.ncbi.nlm.nih.gov/29538683/
2018: A toxicity study from CV Sciences
An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp
https://www.hindawi.com/journals/jt/2018/8143582/abs/
2018: In humans, 800 mg of CBD did not improve working or spatial memory or improve impulsivity during tobacco abstinence (30 participants in a randomized control trial)
The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers
https://www.ncbi.nlm.nih.gov/pubmed/29765102
2018: In humans who use tobacco, 800 mg of CBD “reduced the salience and pleasantness of cigarette cues” but “did not influence tobacco craving or withdrawal or any subjectively rated side effects” (30 participants in a randomized, double-blind cross-over study)
Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal
https://www.ncbi.nlm.nih.gov/pubmed/29714034
2018: In a mouse model of multiple sclerosis, CBD rich extracts (from Avidekel cannabis) work as well as the common drug copaxone in suppressing symptoms
Avidekel Cannabis extracts and cannabidiol are as efficient as Copaxone in suppressing EAE in SJL/J mice
https://pubmed.ncbi.nlm.nih.gov/30291491/
2018: In docking studies, CBD/CBDA extracts & CBG/CBGA extracts reduced aldose reductase activity for diabetes
Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or Cannabigerol
https://pubmed.ncbi.nlm.nih.gov/29427593/
2017: In a survey of parents in Mexico, CBD extracts very helpful for seizures (53 parents)
Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy
https://pubmed.ncbi.nlm.nih.gov/28392943/
2016: In a mouse model of colitis, CBD extract decreased damage and reduced intestinal hypermotility better than isolated CBD
An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse
https://pubmed.ncbi.nlm.nih.gov/27757083/
2016: In 5 Israeli children with intractable epilepsy, CBD-rich extracts caused “significant positive effect on seizure load”
CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience
https://pubmed.ncbi.nlm.nih.gov/26800377/
2016: Two case reports of children using CBD-rich extracts getting intoxicated by the THC – improvements when switched to CBD isolate
Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol
https://pubmed.ncbi.nlm.nih.gov/27746737/
2015: In a survey of 117 parents of children with epilepsy, CBD-rich extracts saw “eighty-five percent of all parents reported a reduction in seizure frequency, and 14% reported complete seizure freedom”
Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome
https://pubmed.ncbi.nlm.nih.gov/25935511/
2014: In colon cancer tissue culture & xenograft animal model, CBD extract reduced tumor cell proliferation more than isolated CBD – the extract also showed a much higher binding affinity to CB1 & CB2
Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
https://pubmed.ncbi.nlm.nih.gov/24373545/
2013: In a survey, reports from parents on treatment with high CBD cannabis for epilepsy
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
https://www.ncbi.nlm.nih.gov/pubmed/24237632
2011: In human & rat bladder samples, CBD extract & isolated CBD reduced the contractions induced by acetylcholine (but not those induced with electrical field stimulation, KCl, or α,β-methylene adenosine triphosphate) via TRPV1 in rats
Inhibitory effect of standardized cannabis sativa extract and its ingredient cannabidiol on rat and human bladder contractility
https://pubmed.ncbi.nlm.nih.gov/21310467/
2006: In cultures of hippocampal neurons and glial cells, the extracts of THC & CBD did better than the isolated cannabinoids at elevating calcium levels
Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia
https://pubmed.ncbi.nlm.nih.gov/16997463/
2006: In mice, CBD extracts did not reverse memory deficits caused by cholinergic (scopolamine) or glutamatergic (MK801) insults
Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts
https://pubmed.ncbi.nlm.nih.gov/16406104/
2004: Many ‘n of 1’ studies on THC/CBD combos found that CBD did not help with the pain or sleep duration but did improve sleep quality (24 participants in a double‐blind, 4‐way cross‐over, RCT)
Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies
https://pubmed.ncbi.nlm.nih.gov/15096238/
2004: In rats, THC extracts caused problems for spatial working/short-term memory but CBD extracts did not
Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats
https://www.ncbi.nlm.nih.gov/pubmed/15567426