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2022: In rats with nausea from THC, CBD lessened the effects via a serotonin receptor

Cannabidiol Interferes with Establishment of Δ 9-Tetrahydrocannabinol-Induced Nausea Through a 5-HT 1A Mechanism

https://pubmed.ncbi.nlm.nih.gov/33998876/

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2022: In an animal model of colitis, CBD reduced pain responses

NON-PSYCHOTROPIC PHYTOCANNABINOIDS ATTENUATE VISCERAL HYPERSENSITIVITY IN DEXTRAN SULFATE SODIUM (DSS)-INDUCED COLITIS

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859311/

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2022: In heart cells stressed by high levels of glucose (a model of diabetes), CBD protected them from arrythmia & cytotoxicity via inhibition of the sodium channels

Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels

https://pubmed.ncbi.nlm.nih.gov/32077098/

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2022: In a mouse model of obesity, treatment with CBD & omega 3 (fish oil) improved the gut microbiome as well as reducing anxiety & memory impairment

High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies

https://www.scirp.org/journal/paperinformation.aspx?paperid=115157

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2022: In a rat model of obesity, CBD treatment protected their hearts via several measures

Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity

https://pubmed.ncbi.nlm.nih.gov/35216351/

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2022: In a mouse model of obesity, PEA restored the plasticity of their white & brown fat cells, leptin sensitivity, tissue hormone sensitivity & rewired the energy storing white into energy-consuming brown fat cells

Palmitoylethanolamide Promotes White-to-Beige Conversion and Metabolic Reprogramming of Adipocytes: Contribution of PPAR-α

https://www.mdpi.com/1999-4923/14/2/338

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2022: In mice, a combination of diet & exercise improved their ECS & their metabolic function

Effect of diet and physical exercise on endocannabinoid system and energy homeostasis in obese mice

https://e-century.us/files/ijcem/14/3/ijcem0118169.pdf

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2022: In mice, CB1 receptors may form heteromer complexes with a ghrelin receptor, stressing the importance of the ECS & the regulation of metabolism

Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB 1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet

https://pubmed.ncbi.nlm.nih.gov/34955755/

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2021: In obese mice, alterations to their orexin system & to their 2-AG/CB1 signaling led to problems with episodic memory

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

https://pubmed.ncbi.nlm.nih.gov/34675233/

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2021: In neurons of the hypothalamus related to feeding, endocannabinoids are required for the proper control of energy homeostasis

Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis

https://pubmed.ncbi.nlm.nih.gov/34654741/

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2021: In male rats, CBD treatment when they are teenagers leads to later changes in metabolism

Juvenile cannabidiol chronic treatments produce robust changes in metabolic markers in adult male Wistar rats

https://pubmed.ncbi.nlm.nih.gov/34478689/

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2021: In rats fed a high-fat diet, CBD reduced insulin resistance & decreased the tau protein associated with Alzheimer’s disease

Cannabidiol - A phytocannabinoid that widely affects sphingolipid metabolism under conditions of brain insulin resistance

https://pubmed.ncbi.nlm.nih.gov/34435590/

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2021: In rats, mothers being fed a high-fat diet altered the CB1 levels in the brains of their sons & led to depressive symptoms in early life

Maternal High-Fat Diet Modulates Cnr1 Gene Expression in Male Rat Offspring

https://pubmed.ncbi.nlm.nih.gov/34445045/

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2021: In cells that produce cholecystokinin (CCK - a hormone that regulates the pancreas, gastric motility & appetite), the endocannabinoid 2-AG caused increased CCK secretion via the CB1 receptor

2-Arachidonoyl glycerol potently induces cholecystokinin secretion in murine enteroendocrine STC-1 cells via cannabinoid receptor CB1

https://pubmed.ncbi.nlm.nih.gov/34533218/

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2021: In humans undergoing a caloric restriction diet for 12 weeks & taking 100 mg of capsicum extract, they saw important alterations in their fecal microbiome

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity

https://www.mdpi.com/2227-9059/9/9/1246

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2021: In a cellular culture mimicking the gut microbiome, probiotics engineered to produce butyrate downregulated the ECS

Engineered probiotics modulate the endocannabinoid system

https://www.sciencedirect.com/science/article/pii/S2665906921000040

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2021: In zebrafish, CBD oil had little impact on the microbiome

Passive exposure to cannabidiol oil does not cause microbiome dysbiosis in larval zebrafish

https://www.sciencedirect.com/science/article/pii/S2666517421000262

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2021: In diabetic humans with painful neuropathy in their feet, 20 mg of water solubilized CBD reduced pain, improved sleep & reduced anxiety

Cannabidiol (CBD) For the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet: A Placebo-Controlled, Double-Blind, Randomized Trial

https://www.longdom.org/abstract/cannabidiol-cbd-for-the-treatment-of-painful-diabetic-peripheral-neuropathy-of-the-feet-a-placebocontrolled-doubleblind--77161.html

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2021: A study in tissues supports CBD’s anti-diabetic effects

Evaluation of cannabidiol's inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids

https://pubmed.ncbi.nlm.nih.gov/34162444/

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2021: In diabetic mice, injections of 2-AG protected their hearts from the cardiac pathology of the disease

2-Arachidonoylglycerol Attenuates Fibrosis in Diabetic Mice via the TGF-β1/Smad Pathway

https://europepmc.org/article/ppr/ppr344998

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2021: In rats fed an obesity-inducing diet, the endocannabinoid oleoylethanolamide protected their livers from oxidative stress

Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats

https://www.mdpi.com/2076-3921/10/8/1289/htm

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2021: In mice with a hole in their intestines, activating the CB2 receptor protected from inflammation & sepsis

Activation of CB2 receptor inhibits pyroptosis and subsequently ameliorates cecal ligation and puncture-induced sepsis

https://pubmed.ncbi.nlm.nih.gov/34364304/

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2021: In rats on an obesity diet, PEA as well as oleamide (OEA – another endocannabinoid) functioned as anti-obesity nutritional interventions

Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity

https://www.mdpi.com/2072-6643/13/8/2589

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2021: In mice, CBD helped to reduce binge eating behavior

Cannabidiol reduces binge eating behavior in mice

https://helda.helsinki.fi/handle/10138/332343

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2021: In female mice with no CB1 receptor, a high-fat diet caused their offspring to be susceptible to later metabolic challenges

MATERNAL OBESITY REVERSES THE RESISTANCE TO LPS-INDUCED ADVERSE PREGNANCY OUTCOME AND INCREASES FEMALE OFFSPRING METABOLIC ALTERATIONS IN CANNABINOID RECEPTOR 1 KNOCKOUT MICE

https://pubmed.ncbi.nlm.nih.gov/34147601/

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2021: In rats, the ECS & the dopamine system are linked to the changes associated with obesity

The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach

https://pubmed.ncbi.nlm.nih.gov/34165614/

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2021: In mice, they find that the CB1 receptors in the brain’s ventromedial hypothalamus regulates glucose homeostasis

CB1Rs in VMH Neurons Regulate Glucose Homeostasis but not Body Weight

https://pubmed.ncbi.nlm.nih.gov/34097543/

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2021: In humans, the Mediterranean diet modulates the endocannabinoid system

Mediterranean diet consumption affects the endocannabinoid system in overweight and obese subjects: possible links with gut microbiome, insulin resistance and inflammation

https://pubmed.ncbi.nlm.nih.gov/33763720/

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2021: In a rat model of obesity, chronic CBD reduced oxidative stress, lowered inflammation & improved the ratio of fatty acids in the skeletal muscle

Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved n-6/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity

https://www.mdpi.com/2072-6643/13/5/1603

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2021: In a rat model of irritable bowel syndrome, treatment with a ketogenic diet caused the upregulation of CB1 & CB2 receptors

Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet

https://www.mdpi.com/1422-0067/22/6/2880

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2021: In mice with metabolic syndrome, blocking the CB1 receptor in the body improved symptoms

Peripherally Selective CB1 Receptor Antagonist Improves Symptoms of Metabolic Syndrome in Mice

https://pubs.acs.org/doi/full/10.1021/acsptsci.0c00213

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2021: In mice, the CB1 receptor in neurons producing glutamate (the brain's basic excitatory neurotransmitter) drives the overconsumption of food & obesity

Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity

https://pubmed.ncbi.nlm.nih.gov/33558679/

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2021: In a rat model of anxiety from colitis, the increase in the FAAH enzyme led to lower levels of AEA & more anxiety

Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase

https://pubmed.ncbi.nlm.nih.gov/33452437/

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2021: In diabetic rats, CBD helped with depression & anxiety by multiple pathways

Cannabidiol induces antidepressant and anxiolytic‐like effects in experimental type-1 diabetic animals by multiple sites of action

https://link.springer.com/article/10.1007/s11011-020-00667-3

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2021: In human cells, CBD disrupts cholesterol's synthesis, transport & storage

Multi-Omic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines

https://www.biorxiv.org/content/10.1101/2020.06.03.130864v2.full.pdf

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2021: A Big Data study looking at the links between obesity & the circulating levels of members of the endocannabinoidome

Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models

https://www.mdpi.com/2073-4409/10/1/71

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2021: A case report of a man using CBD to help control his type 2 diabetes

Cannabidiol (CBD) Use in Type 2 Diabetes: A Case Report

https://spectrum.diabetesjournals.org/content/early/2020/12/23/ds20-0023

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2021: In mice, the link between gut microbiome & mental health is mediated by the endocannabinoid system

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

https://www.nature.com/articles/s41467-020-19931-2

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2021: In fruit flies, cannabinoids alter what foods they prefer & how much they eat

Cannabinoids modulate food preference and consumption in Drosophila melanogaster

https://europepmc.org/article/ppr/ppr250039

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2021: In rats beginning to develop metabolic syndrome, their pancreatic islets saw differing effects on the expression of CB1 & CB2

Cannabinoid receptors are differentially regulated in the pancreatic islets during the early development of metabolic syndrome

https://pubmed.ncbi.nlm.nih.gov/33289595/

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2021: In women, this study looks at the correlation of 2-AG levels on their food habits

Blood Level of 2-arachidonoyl glycerol (2-AG), Neuropeptide Y and Omentin and Their Correlation with Food Habits in Obese Women

https://gmj.ir/index.php/gmj/article/view/1721/html

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2020: In rats, CBD protects from the gastric ulcers induced by diclofenac, an arthritis drug

Protective effect of cannabidiol on diclofenac induced gastric ulcer in rats

http://www.lifesciencesite.com/lsj/lsj170120/11_35741lsj170120_75_79.pdf

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2020: For obesity, the crosstalk between CB1 receptors & GLP-1 receptors is suggested as a therapeutic target

CB1 and GLP-1 Receptors Cross-Talk Provides New Therapies for Obesity

https://pubmed.ncbi.nlm.nih.gov/33144338/

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2020: A case study of an elderly woman getting diarrhea from CBD

Cannabidiol Oil-Associated Microscopic Colitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574987/

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2020: In mice with mood disorders induced by high-fat diets, PEA limits mood disorders & cognitive dysfunction

Palmitoylethanolamide limits mood disorders and cognitive dysfunction induced by high fat diet in obese mice

http://www.sins.it/medias/860-congress-book.pdf#page=38

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2020: In humans with intestinal problems, how diet influences the endocannabinoid components lining the gut

Endocannabinoids, endocannabinoid-like molecules and their precursors in human small intestinal lumen and plasma: does diet affect them?

https://pubmed.ncbi.nlm.nih.gov/33104865/

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2020: In mice, 2-AG protected from viral gut infections

Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens

https://pubmed.ncbi.nlm.nih.gov/33031742/

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2020: In mice with intestinal problems, fish oil combined well with CBD & CBG

Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation

https://pubmed.ncbi.nlm.nih.gov/32996187/

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2020: In mice, their ability to develop a taste for a Western diet (high fat, high sugar) requires the CB1 receptor

Cannabinoid CB 1 Receptors in the Intestinal Epithelium Are Required for Acute Western-Diet Preferences in Mice

https://pubmed.ncbi.nlm.nih.gov/32962222/

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2020: In a test of food intake & gut microbiota, the positives of the Mediterranean diet can be measured by looking at the endocannabinoid signaling (195 people)

Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat

https://pubmed.ncbi.nlm.nih.gov/32994521/

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2020: In an analysis of humans, the omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators help to regulate intuitive eating (non-pathological eating)

Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators

https://pubmed.ncbi.nlm.nih.gov/32971226/

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2020: A pilot study in obese mice found that feeding them cannabis extract helped them to lose weight

A Pilot Study on the Effect of Cannabis Extract on Weight Loss in Diet-induced Obese Mice

https://www.koreamed.org/SearchBasic.php?RID=2506220

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2020: Just like in mammals, a high-fat diet in rainbow trout causes changes in the endocannabinoid system and the intake of food

The endocannabinoid system is affected by a high-fat-diet in rainbow trout

https://pubmed.ncbi.nlm.nih.gov/32771417/

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2020: In mice, diet is closely linked to the endocannabinoid system

High fat diet induced obesity alters endocannabinoid and ghrelin mediated regulation of components of the endocannabinoid system in nodose ganglia

https://pubmed.ncbi.nlm.nih.gov/32659299/

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2020: In older adults, using cannabis is associated with a lower body mass index (BMI) & a higher frequency of exercise

Exercise Intervention Outcomes With Cannabis Users and Nonusers Aged 60 and Older

https://pubmed.ncbi.nlm.nih.gov/32553024/

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2020: In humans, a study on the effects of high-protein diet found that the endocannabinoids OEA & PEA might be positively associated with cholesterol levels

Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study

https://pubmed.ncbi.nlm.nih.gov/32455987/

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2020: In female rats, oleoylethanolamide (the anandamide analogue) helps with the frustration around binge eating caused by stress

Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge-eating disorder

https://www.nature.com/articles/s41386-020-0686-z

 

2020: Study of CB2 receptor expression in the intestines of prenatal sheep

Expression profile of cannabinoid receptor 2 in ovine ileum during prenatal development

https://www.researchgate.net/profile/Hidayet_Tutun/publication/336826179_Expression_profile_of_cannabinoid_receptor_2_in_ovine_ileum_during_prenatal_development/links/5e23458d92851cafc38fcfa1/Expression-profile-of-cannabinoid-receptor-2-in-ovine-ileum-during-prenatal-development.pdf

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2020: A Yale dissertation on how the ECS contributes to the habitual responses to food and alcohol

Endocannabinoid Contributions to the Formation and Expression of Habitual Responding for Food and for Alcohol

https://search.proquest.com/openview/1f01903740d9dfda529aadab507c6b04/1.pdf?pq-origsite=gscholar&cbl=18750&diss=y

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2020: In humans with MS, study looks at how THC and CBD shift glucose metabolism in various regions

The effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) use on cerebral glucose metabolism in multiple sclerosis: a pilot study

https://pubmed.ncbi.nlm.nih.gov/31841355/

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2020: In humans, a genetic variant of the CB1 receptor may be protective against metabolic syndrome & type 2 diabetes

Association Between Cannabinoid Receptor-1 Gene Polymorphism and the Risk of Diabetic Nephropathy Among Patients with Type 2 Diabetes Mellitus

https://pubmed.ncbi.nlm.nih.gov/33209051/

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2020: In rats, a CB1 neutral antagonist helped with insulin resistance in a model of metabolic syndrome

Effects of the CB1 Receptor Antagonists AM6545 and AM4113 on Insulin Resistance in a High-Fructose High-Salt Rat Model of Metabolic Syndrome

https://pubmed.ncbi.nlm.nih.gov/33138155/

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2020: In diabetic rats, activating the CB2 receptor protected the brain via increased blood flow

A cannabinoid type 2 (CB2) receptor agonist augments NOS-dependent responses of cerebral arterioles during type 1 diabetes

https://pubmed.ncbi.nlm.nih.gov/32979391/

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2020: In mice being fed an obesity inducing diet, CBD improved the insulin signaling in the skeletal muscle & helped with glycogen recovery 

Chronic Cannabidiol Administration Attenuates Skeletal Muscle De Novo Ceramide Synthesis Pathway and Related Metabolic Effects in a Rat Model of High-Fat Diet-Induced Obesity

https://pubmed.ncbi.nlm.nih.gov/32859125/

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2020: Using a CB1 receptor blocker combined with a glycemic control agonist (GLP-1R) helped mice fight obesity and diabetes

Peripheral cannabinoid–1 receptor blockade potentiates the anti–obesity and anti–diabetic effects of GLP–1 mimetics

https://www.endocrine-abstracts.org/ea/0070/ea0070ep169

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2020: In mice, blocking the CB1 receptor helped with the obesity related to a fatty liver

Cannabinoid receptor type 1 antagonist inhibits progression of obesity‐associated nonalcoholic steatohepatitis in a mouse model by remodulating immune system disturbances

https://pubmed.ncbi.nlm.nih.gov/32798334/

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2020: In rats with induced diabetes, activation of the CB1 or CB2 receptor helps with pain

Spinal cannabinoid CB1 or CB2 receptors activation attenuates mechanical allodynia in streptozotocin-induced diabetic rats

https://pubmed.ncbi.nlm.nih.gov/32804775/

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2020: In a mouse model of diabetic livers, activating the CB1 receptor helped with their lipid levels being off

Simultaneous Inhibition of Peripheral CB1R and iNOS Mitigates Obesity-Related Dyslipidemia Through Distinct Mechanisms

https://pubmed.ncbi.nlm.nih.gov/32680936/

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2020: In obese women, the circulating levels of AEA & 2-AG could be correlated with body mass, waist circumference, body fat percentage, as well as insulin & leptin levels

The association of circulating endocannabinoids with appetite regulatory substances in obese women

https://pubmed.ncbi.nlm.nih.gov/32580926/

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2020: In mice with their CB1 deleted from their livers, they saw improved glucose homeostasis & this suggests the modulation of CB1 activity for obese & diabetic individuals

Nullification of Hepatic Cannabinoid 1 Receptor (CB1R) Ameliorates Fatty Liver and Improves Glucose Homeostasis via Regulation of PI3K-mTORC1 axis

https://academic.oup.com/cdn/article/4/Supplement_2/1260/5845606

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2020: In a comparison between the endocannabinoid levels in lean and obese women, it seems "the peripheral ECS may be more active than the central ECS. Indeed, the system appeared to be suppressed in the CNS of obese women."

Central and Peripheral Endocannabinoid Levels in Obese Versus Lean Women

https://academic.oup.com/jes/article/4/Supplement_1/SAT-LB100/5833488

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2020: Rats with diabetes saw a number of positive changes from 2 weeks of CBD

Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes

https://pubmed.ncbi.nlm.nih.gov/32360935/

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2020: In mice, eating meat causes obesity-type effects via alterations in the gut microbiome and the ECS

Meat Protein in High Fat Diet Induces Adipogensis and Dyslipidemia by Altering Gut Microbiota and Endocannabinoid Dysregulation in the Adipose Tissue of Mice

https://www.ncbi.nlm.nih.gov/pubmed/32148030

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2020: In a cell culture mimicking heart cells in a diabetic, CBD protected from all the negative effect of high glucose: elevated reactive oxygen species, shift of voltage by sodium channels, and prolongation of action potential (hyperexcitability)

Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels

https://www.ncbi.nlm.nih.gov/pubmed/32077098

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2020: In cultures of bone marrow stem cells, CBD (and some of the other cannabinoids) helped to promote their maturation into healthy fat cells with improved insulin sensitivity

Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets

https://www.ncbi.nlm.nih.gov/pubmed/32061773

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2020: THCV for diabetes

Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes

https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-020-0016-7

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2020: A look at using CBD for treating blindness caused by diabetes

Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955420/

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2020: In obese people, their 2-AG cycle were misaligned to the normal daily rhythm

Circadian Misalignment of the 24-hour Profile of Endocannabinoid 2-Arachidonoylglycerol (2-AG) in Obese Adults

https://pubmed.ncbi.nlm.nih.gov/31970413/

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2020: Involvement of the ECS in the liver damage caused by diabetes - seems to involve a serotonin receptor

Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: Role of 5-HT3 receptor antagonist

https://pubmed.ncbi.nlm.nih.gov/31926479/

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2020: Involvement of the ECS in the liver damage caused by diabetes - seems to involve a serotonin receptor

Involvement of endocannabinoid system, inflammation and apoptosis in diabetes induced liver injury: Role of 5-HT3 receptor antagonist

https://www.ncbi.nlm.nih.gov/pubmed/31926479

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2020: After a mouse has gastric bypass surgery (a technique for weight loss that we're still not sure of how it works), the CB1 receptor seems to be a key player in the regulation of energy after the procedure

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

https://pubmed.ncbi.nlm.nih.gov/33113371/

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2020: In patients with gastroparesis (where the stomach doesn't empty itself well), females had lower levels of AEA & 2-AG in their blood - while the males saw no change in circulating endocannabinoids

Plasma endocannabinoids and cannabimimetic fatty acid derivatives are altered in gastroparesis: A sex- and subtype-dependent observation

https://pubmed.ncbi.nlm.nih.gov/32779297/

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2020: In rats with anorexia, it appears that the CB1 receptor is downregulated

Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa

https://www.ncbi.nlm.nih.gov/pubmed/32275093