top of page

Psoriasis

psoriasis (1).jpg

Best reviews

 

2022: A summary of a survey of cannabinoids for psoriasis
Practices and perspectives on medical cannabis and cannabinoids: A survey of the National Psoriasis Foundation Medical Advisory Board
https://pubmed.ncbi.nlm.nih.gov/36017106

2017: A review of how psoriasis might help via suppression of angiogenesis and inflammation
Cannabinoids: Possible agents for treatment of psoriasis via suppression of angiogenesis and inflammation

https://www.ncbi.nlm.nih.gov/pubmed/28110689

2016: A review covering the various mechanisms of cannabis for psoriasis

Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review

https://www.ncbi.nlm.nih.gov/pubmed/27164964

Timeline of Research

2023: In a mouse model of psoriasis & skin inflammation, activating the CB1 receptor significantly lessened scratching behavior & skin inflammation
The key role of CB1R in the sensory neurons to regulate psoriasiform skin inflammation and pruritus
https://pubmed.ncbi.nlm.nih.gov/36410425/

2023: Using a cannabis patch for psoriasis symptoms
Efficacy and Safety of Cannabis Transdermal Patch for Alleviating Psoriasis Symptoms: Protocol for a Randomized Controlled Trial (CanPatch)
https://www.medrxiv.org/content/medrxiv/early/2023/03/09/2023.03.08.23286926.full.pdf

2022: In mice with psoriasis, enhancing the action of NAAA (an enzyme that breaks down PEA) worsened the disease progress

N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation
https://pubmed.ncbi.nlm.nih.gov/36244543

2022: In a survey of rheumatoid & psoriatic arthritis patients, medical cannabis gave them significant relief from short & long-term pain as well as reduced stiffness – and for some patients, total pain relief
PARE Patient-Reported Outcome Measures of Pain Alleviation With Cannabinoid Usage in Rheumatoid and Psoriatic Arthritis: a Cross-Sectional Study
https://ard.bmj.com/content/81/Suppl_1/1132.3.abstract

2021: In skin stem cells from psoriasis patients, the application of CBD restored levels of protective enzymes, lowered inflammation from UVB radiation & protected healthy skin stem cells

Cannabidiol Decreases Metalloproteinase Activity and Normalizes Angiogenesis Factor Expression in UVB-Irradiated Keratinocytes from Psoriatic Patients

https://www.hindawi.com/journals/omcl/2021/7624389/

2020: In humans with psoriasis, the antioxidant effects of CBD caused less formation of neutrophil extracellular traps (NET)

Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients

https://pubmed.ncbi.nlm.nih.gov/32947961/

2020: In humans with psoriasis, CBD helped treatment with UVB light to work better & causes the psoriatic keratinocytes (skin stem cells) to die while protecting the healthy keratinocytes

Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients

https://pubmed.ncbi.nlm.nih.gov/32916896/

2020: In skin stem cells of patients with psoriasis, CBD increased CB1 & CB2 receptor levels - reduced oxidative stress in healthy patients but might increase it in patients with psoriasis

Cannabidiol Effects on Phospholipid Metabolism in Keratinocytes from Patients with Psoriasis Vulgaris

https://www.ncbi.nlm.nih.gov/pubmed/32121131

2019: In humans with psoriasis & atopic dermatitis, topical CBD improved skin parameters (20 patients in a spontaneous, anecdotal, retrospective study)

A therapeutic effect of cbd-enriched ointment in inflammatory skin diseases and cutaneous scars

https://www.ncbi.nlm.nih.gov/pubmed/30993303

2007: On the mechanisms of potential therapeutic value of cannabinoids for psoriasis

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis

https://www.ncbi.nlm.nih.gov/pubmed/17157480

https://www.alchimiaweb.com/blogfr/wp-content/uploads/2015/11/cannabinoids_inhibit_keratinocytes.pdf

2005: Cannabinoids as a new tool against psoriasis

Cannabinoids, loratadine and allopurinol as novel additions to the antipsoriatic ammunition

https://www.ncbi.nlm.nih.gov/pubmed/15857457

bottom of page