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Bipolar Disorder

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Best reviews

2022: A feature article on CBD for bipolar disorder from Mary Biles on ProjectCBD

https://www.projectcbd.org/medicine/cbd-bipolar-disorder

2022: A review of bipolar disorders & the potential endocannabinoid alterations underlying it
The endocannabinoid system in borderline personality disorder and antisocial personality disorder: A scoping review
https://pubmed.ncbi.nlm.nih.gov/35575169/

2022: In a Canadian review of clinical studies with bipolar disorder & major depressive disorder, cannabis use was associated with worsening symptoms & course of the disease as well as increased suicidality & decreased functioning
Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: A Systematic Review and Recommendations of Cannabis use in Bipolar Disorder and Major Depressive Disorder
https://pubmed.ncbi.nlm.nih.gov/35711159

2021: This review looks at how inhibiting FAAH can help with alcohol use disorder

Contribution of Fatty Acid Amide Hydrolase to Alcohol Use Disorder: A Systematic Review

https://www.liebertpub.com/doi/abs/10.1089/can.2020.0158

2021: This review looks at targeting the endocannabinoid system for treating bipolar disorder

Targeting the Endocannabinoid System in Borderline Personality Disorder: Corticolimbic and Hypothalamic Perspectives

https://pubmed.ncbi.nlm.nih.gov/32351183/

2020: In this review of cannabis and cognition in people with Bipolar Disorder (BD), Overall, they found "most identified studies suggest cannabis use is not associated with significant cognitive impairment in BD"

The Relationship between Cannabis Use and Cognition in People with Bipolar Disorder: A Systematic Scoping Review

https://www.medrxiv.org/content/10.1101/2020.04.24.20078535v1

Timeline of Research

2023: In adolescents with bipolar disorder, cannabis use was associated with working memory & attention deficits
Association of cannabis use with neurocognition in adolescents with bipolar disorder
https://pubmed.ncbi.nlm.nih.gov/37497695/

2023: On people with bipolar disorder who also have cannabis use disorder
A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset
https://pubmed.ncbi.nlm.nih.gov/37626487/

2023: A case report of a young woman's bipolar disorder being exacerbated by cannabis & psychedelic use
A Nepalese female student in trap of cannabis: a case report
https://www.researchgate.net/profile/Dhana-Ratna-Shakya/publication/371079979_A_Nepalese_female_student_in_trap_of_cannabis_a_case_report/links/6471777d6a3c4c6efbe2253d/A-Nepalese-female-student-in-trap-of-cannabis-a-case-report.pdf

2023: In an analysis of public health data, cannabis use disorder was associated with the later increased risk of psychotic & nonpsychotic bipolar disorder as well as unipolar depression
Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder
https://pubmed.ncbi.nlm.nih.gov/37223912/

2023: In youth with bipolar disorder, the effects of their genetic variant of the CB1 receptor in brain scans of connectivity
The association of CNR1 genetic variants with resting-state functional connectivity in youth bipolar disorder
https://pubmed.ncbi.nlm.nih.gov/36972648/

2023: On the genetic relationship between cannabis use, schizophrenia & bipolar disorder
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
https://pubmed.ncbi.nlm.nih.gov/37208114/

2023: In people with bipolar disorder, the effects of cannabis use & insomnia on risky decision making behavior
Insomnia Symptoms, Cannabis Use, and Risky Decision-Making in Bipolar Disorder
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)00640-6/fulltext

In people with bipolar disorder, how their cannabis use patterns affect their risky decision making
Cannabis Use Patterns and Their Effects on Risky Decision-Making in Bipolar Disorder
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)00513-9/fulltext

2022: In humans with bipolar disorder, they had higher PEA levels & lower & 2-AG levels
Could serum endocannabinoid and N-acylethanolamine levels be important in bipolar disorder?
https://pubmed.ncbi.nlm.nih.gov/35950574

2022: In a detailed study of families in the DC area, they found that cannabis use disorder tends to run in families & to be associated with bipolar disorder II
Comorbidity and Coaggregation of Major Depressive Disorder and Bipolar Disorder and Cannabis Use Disorder in a Controlled Family Study
https://pubmed.ncbi.nlm.nih.gov/35648395/

2022: In veterans with bipolar disorder, current cannabis use was associated with higher working memory & higher functional capacity – but also to PTSD & suicidal ideation (though you can imagine that’s because those in worse shape were using cannabis as a treatment)
Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes
https://pubmed.ncbi.nlm.nih.gov/35430960/

2022: In a longitudinal study, they found a link between adolescent cannabis use & bipolar disorder – but this might be because of the other drugs they were taking as well
Is Early Exposure to Cannabis Associated with Bipolar disorder? Results from a Finnish Birth-Cohort Study
https://pubmed.ncbi.nlm.nih.gov/35315149/

2022: In patients with bipolar disorder in their mania phase, their blood had higher levels of the CB1 receptor
Expression of type 1 cannabinoid receptor gene in bipolar disorder
https://pubmed.ncbi.nlm.nih.gov/36323143

2022: In a detailed study of families in the DC area, they found that cannabis use disorder tends to run in families & to be associated with bipolar disorder II
Comorbidity and Coaggregation of Major Depressive Disorder and Bipolar Disorder and Cannabis Use Disorder in a Controlled Family Study
https://pubmed.ncbi.nlm.nih.gov/35648395/

2022: Cannabis use increasing manic episodes

Cannabis Use is an Independent Risk Factor for Manic Episode: A Report from 380,265 Bipolar Inpatients

https://pubmed.ncbi.nlm.nih.gov/34895014/

2021:

The Prevalence of Cannabis Use Disorder Comorbidity in Individuals With Bipolar Disorder: A Systematic Review and Meta-Analysis

https://journals.lww.com/cja/Abstract/2021/09000/The_Prevalence_of_Cannabis_Use_Disorder.4.aspx?context=LatestArticles

2021:

Bipolar disorder and cannabis use: A bidirectional two-sample Mendelian randomization study

https://pubmed.ncbi.nlm.nih.gov/33733564/

2021:

Cannabis use and medication nonadherence in bipolar disorder: A nationwide inpatient sample database analysis

https://www.sciencedirect.com/science/article/abs/pii/S0165032721013070

2015: In a diary study of 24 patients with BPD, cannabis caused a number of psychological effects

The relationship between bipolar disorder and cannabis use in daily life: an experience sampling study

https://pubmed.ncbi.nlm.nih.gov/25738578/

2010: In two patients, high levels of CBD for ~30 days was well tolerated but not effective for their bipolar disorder

Cannabidiol was ineffective for manic episode of bipolar affective disorder

https://www.ncbi.nlm.nih.gov/pubmed/18801823

1998: Grinspoon & Bakalar on cannabinoids for bipolar disorder

The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research

https://www.ncbi.nlm.nih.gov/pubmed/9692379/

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