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Tourette Syndrome & Tic Disorders

Best reviews

2021: A review of the available studies of using cannabis for treating Tourette syndrome

Cannabis-based medicine in treatment of patients with Gilles de la Tourette syndrome

https://pubmed.ncbi.nlm.nih.gov/34708399/

2019: A cautious review of cannabinoids for Tourette syndrome
The Potential of Cannabinoid-Based Treatments in Tourette Syndrome
https://pubmed.ncbi.nlm.nih.gov/30977108/

2013: Muller-Vahl's review
Treatment of Tourette syndrome with cannabinoids
https://pubmed.ncbi.nlm.nih.gov/23187140/

 

Timeline of Research

 

2023: In a clinical trial of people with Tourette syndrome or chronic tic disorders, nabiximols (1:1 THC:CBD sprays) did not help everyone, but seemed to work best in males with more severe tics as well as with comorbid ADHD
CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders - Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study
https://pubmed.ncbi.nlm.nih.gov/36878177/

2023: In patients with severe Tourette syndrome, treatment with THC & CBD reduced tics as well as impairments due to tics, anxiety & obsessive compulsive disorder
Tetrahydrocannabinol and Cannabidiol in Tourette Syndrome
https://evidence.nejm.org/doi/pdf/10.1056/EVIDoa2300012

2023: In a long term follow up of 25 patients with Tourette syndrome, a subset of them found cannabis to help improve control of their symptoms
Licensed Medical Cannabis Use in Gilles de la Tourette Syndrome: A Retrospective Long-term Follow-Up
https://pubmed.ncbi.nlm.nih.gov/37172308/

2022: In a mouse model of Tourette Syndrome, acupuncture helped with behavioral symptoms via the effects of CB1 receptors on dopamine neurons in parts of the basal ganglia (a center for movement, learning, emotions & addiction)
Acupuncture alleviates behavioral stereotypies of Tourette Syndrome via CB1 receptors in dopaminergic neurons of nigrostriatal system
https://assets.researchsquare.com/files/rs-2265002/v1/b07486c3-ae85-4884-99b4-bc861f26cdb9.pdf

2022: In this study of cannabis for Tourette syndrome, it did not lower the tics but did help on secondary measures like the urge to tic & the level of distress
A Double-Blind, Randomized, Controlled Crossover Trial of Cannabis in Adults with Tourette Syndrome
https://pubmed.ncbi.nlm.nih.gov/36040329

2022: In a survey of humans with Tourette syndrome, while THC & CBD did not help with tics, it did help to improve several other areas such as OCD, anxiety, employment status & general quality of life
Use of Medical Cannabis in Patients with Gilles de la Tourette's Syndrome in a Real-World Setting
https://pubmed.ncbi.nlm.nih.gov/36342913

 

2022: In some people with Tourette syndrome, medical cannabis helped to control tics

Medical Cannabis for Gilles de la Tourette Syndrome: An Open-Label Prospective Study

https://www.hindawi.com/journals/bn/2022/5141773/

2022: In humans with Tourette syndrome, a MAGL inhibitor (which raises 2-AG levels) caused tic reduction with just a single dose

Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study

https://pubmed.ncbi.nlm.nih.gov/34847610/

2021: In patients with Tourette syndrome, a pharmaceutical inhibitor of the MAGL enzyme (which breaks down 2-AG) had no significant differences from the placebo
Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study
https://pubmed.ncbi.nlm.nih.gov/34117788

2021: A case report of a 1:1 THC:CBD extract helping a young person with Tourette Syndrome

The Cannabis Extraction Product as an Adjuvant Treatment in Tourette’s Syndrome: A Case Report

http://jmatonline.com/index.php/jmat/article/view/13011

2021: In this case study of someone with Tourette syndrome, a nabiximol (1:1 THC:CBD medicine) caused a reduction of tics

Tic Reduction in Adult Onset Gilles De La Tourette Syndrome Using as Required Nabiximols Spray

https://tremorjournal.org/articles/10.5334/tohm.613/

2021: In humans with Tourette syndrome, initial promise was seen with a combination of 10 mg of THC + 800 mg of PEA

A Phase-2 Pilot Study of a Therapeutic Combination of Δ 9-Tetrahydracannabinol and Palmitoylethanolamide for Adults With Tourette's Syndrome

https://pubmed.ncbi.nlm.nih.gov/34340527/

2021: In humans, MAGL inhibitor did not help tics of Tourette Syndrome

Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A 12-Week, Randomized, Controlled Study

https://pubmed.ncbi.nlm.nih.gov/34117788/

2020: In a mouse model of Tourette (which used DOI), THC helped with some tics while CBD seemed to have a small therapeutic window in juveniles & may even exacerbate tics

Differences in pharmacological activities of ∆ 9 -THC and CBD on repetitive behaviours in juvenile and young adult mice may impact decision making for Tourette syndrome

https://pubmed.ncbi.nlm.nih.gov/33125731/

2020: In humans with Tourette, in their spinal fluid they had increased levels of AEA, PEA, 2-AG, AA -with 2-AG correlating to severity of symptoms

Cerebrospinal fluid endocannabinoid levels in Gilles de la Tourette syndrome

https://pubmed.ncbi.nlm.nih.gov/32272483/

2020: Genome association study found that a variant of CB1 is a risk factor for Tourette (541 participants)

Association of a Variant of CNR1 Gene Encoding Cannabinoid Receptor 1 With Gilles de la Tourette Syndrome

https://pubmed.ncbi.nlm.nih.gov/32194619/

2019: A survey with people with Tourette syndrome using cannabis found a reduction in tic severity, better sleep & improved mood
Single center experience with medical cannabis in Gilles de la Tourette syndrome
https://pubmed.ncbi.nlm.nih.gov/30292733/

 

2019: A case report of Tourette syndrome where the antipsychotics & THC did not help but 10 milligrams of THC with 20 milligrams of CBD “showed a rapid and highly significant improvement”
Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report
https://pubmed.ncbi.nlm.nih.gov/30058466/

2019: A case report of an adolescent greatly helped by a low THC high CBD vape: “tics, premonitory urges, and overall impairment significantly improved”
Vaporized Cannabis Is Effective and Well-Tolerated in an Adolescent with Tourette Syndrome
https://pubmed.ncbi.nlm.nih.gov/34676335/

2019: An online survey and retrospective analysis suggests cannabis medicines for the treatment of Tourette syndrome

Treatment of Gilles de la Tourette Syndrome with Cannabis-Based Medicine: Results from a Retrospective Analysis and Online Survey

https://pubmed.ncbi.nlm.nih.gov/31872061/

2017: In 19 adults with Tourette syndrome, cannabis decrease tic scores by 60%
Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome
https://pubmed.ncbi.nlm.nih.gov/28464701/

2016: A case report of a person with Tourette syndrome helped by Sativex (1:1 THC:CBD)
Severe motor and vocal tics controlled with Sativex®
https://pubmed.ncbi.nlm.nih.gov/27558217/

2004: In humans, imaging study in Tourette syndrome patients to look at cannabinoid binding

[123I]AM281 single-photon emission computed tomography imaging of central cannabinoid CB1 receptors before and after Delta9-tetrahydrocannabinol therapy and whole-body scanning for assessment of radiation dose in tourette patients

https://www.ncbi.nlm.nih.gov/pubmed/15110734

2004: A genome study in humans found that Tourette is not linked to a genetic variation for CB1

Tourette syndrome is not caused by mutations in the central cannabinoid receptor (CNR1) gene

https://pubmed.ncbi.nlm.nih.gov/15108190/

2003: In humans with Tourette syndrome, double-blind study finds THC safe and effective for treatment of tics

Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial

https://www.ncbi.nlm.nih.gov/pubmed/12716250

2003: In humans with Tourette syndrome, a double blind placebo study found THC caused no negative cognitive defects

Treatment of Tourette syndrome with delta-9-tetrahydrocannabinol (delta 9-THC): no influence on neuropsychological performance

https://www.ncbi.nlm.nih.gov/pubmed/12589392

2003: In humans, cannabis reduced the symptoms of Tourette (12 patients in a  single-dose, cross-over study & 24 patients in a 6-week, randomised trial)

Cannabinoids reduce symptoms of Tourette syndrome

https://pubmed.ncbi.nlm.nih.gov/14521482/

2002: A clinical trial of THC for Tourette syndrome found significant tic reduction with a correlation between blood cannabinoid level & tic reduction
Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial
https://pubmed.ncbi.nlm.nih.gov/11951146/

2002: A case report of THC augmenting the neuroleptic medication for extreme tics

Combined Treatment of Tourette Syndrome with ∆9-THC and Dopamine Receptor Antagonists

https://www.researchgate.net/publication/233205949_Combined_Treatment_of_Tourette_Syndrome_with_D9-THC_and_Dopamine_Receptor_Antagonists

http://www.cannabis-med.org/iacm/data/pdf/2002-03-04-9.pdf

1999: In humans, a clinical trial of THC by Muller-Vahl

Treatment of Tourette's syndrome with delta-9-tetrahydrocannabinol

https://pubmed.ncbi.nlm.nih.gov/10080574/

1998: In humans, a survey of 64 Tourette patients found that many of them who used marijuana saw a reduction or complete remission of tics & OCD urges

Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome

https://pubmed.ncbi.nlm.nih.gov/9879795/

1997: In humans, a survey of Tourette patients found the majority saw relief from smoked marijuana

Gilles de la Tourette syndrome. Effect of nicotine, alcohol and marihuana on clinical symptoms

https://pubmed.ncbi.nlm.nih.gov/9465342/

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