2024: In a rat model of neuropathic pain, CBD helped with the pain as well as with the depressive behaviors & memory impairment via changes in the hippocampus

Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex-hippocampal connections

https://pubmed.ncbi.nlm.nih.gov/38797491/

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2024: In a mouse model of neuropathic pain, CBD improved the pain & associated depression via changes to five core genes

Neuromolecular and behavioral effects of cannabidiol on depressive-associated behaviors and neuropathic pain conditions in mice

https://pubmed.ncbi.nlm.nih.gov/39245142/

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2024: In a rat model of diabetes with neuropathic pain, CBD combined additively with tramadol for pain reduction

Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis

https://pubmed.ncbi.nlm.nih.gov/37205869/

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2024: In a mouse model of chronic neuropathic pain, the terpenes of cannabis lessened the pain via adenosine receptors in the spinal cord

Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A 2A Receptors

https://pubmed.ncbi.nlm.nih.gov/38709489/

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2024: In a rat model of neuropathic pain, cannabis modulated the levels of cannabinoid receptors but that did not fully account for the observed behavioral changes

Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat

https://pubmed.ncbi.nlm.nih.gov/39334832/

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2024: In a mouse model of chronic neuropathic pain, CBN relieved the pain while CBDV, CBG, THCV & delta-8 THC showed cannabimimetic activity (cannabis-like effects)

Select Minor Cannabinoids from Cannabis sativa are Cannabimimetic and Antinociceptive in a Mouse Model of Chronic Neuropathic Pain

https://pubmed.ncbi.nlm.nih.gov/38834356/

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2024: In a mouse model of neuropathic pain, a combination of cannabinoid & opioid drugs reduced the mechanical hypersensitivity to pain

Peripherally restricted cannabinoid and mu-opioid receptor agonists synergistically attenuate neuropathic mechanical hypersensitivity in mice

https://pubmed.ncbi.nlm.nih.gov/38815196/

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2024: In a mouse model of neuropathic pain from diabetes, the combination of CBD & the terpene beta caryophyllene prevented deterioration of the mitochondria (powerhouse of the cell) & reduced pain hypersensitivity

Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis

https://pubmed.ncbi.nlm.nih.gov/39062016/

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2024: In a mouse model of neuropathic pain, CBD reduced systemic pain via the activation of the PI3Kγ/nNOS/NO/KATP signaling pathway

Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism

https://pubmed.ncbi.nlm.nih.gov/38428514/

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2024: In a mouse model of neuropathic pain, on the use of a CBD analog

Synthesis and Antiallodynic Activity of Cannabidiol Analogue on Peripheral Neuropathy in Mice

https://pubmed.ncbi.nlm.nih.gov/38363210/

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2024: In a rat model of facial nerve pain, CBD & its analog PECS-101 reduced hypersensitivity to pain via the TRPV1 receptor

Cannabidiol and it fluorinate analog PECS-101 reduces hyperalgesia and allodynia in trigeminal neuralgia via TRPV1 receptors

https://pubmed.ncbi.nlm.nih.gov/38508408/

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2024: In a rat model of sciatic nerve injury, injection of CBD nanoparticles caused enhanced axonal restoration & remyelination as well as improvements to locomotor activities & muscle mass retention

Effectiveness of the injectable hyaluronic acid-based microparticles loaded with cannabidiol on rat sciatic nerve injury model

https://www.sciencedirect.com/science/article/abs/pii/S0141813024085908

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2024: In a mouse model of neuropathic pain, a drug that inhibited FAAH & MAGL (which break down anandamide & 2-AG respectively) led to increased endocannabinoid levels & the impairment of stress-induced pain

Disrupted stress-induced analgesia in a neuropathic pain state is rescued by the endocannabinoid degradation inhibitor JZL195

https://pubmed.ncbi.nlm.nih.gov/38922705/

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2024: In a rat model of neuropathic pain, an analysis of how the endocannabinoid system regulates the descending pain pathways

Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion

https://pubmed.ncbi.nlm.nih.gov/37463226/

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2024: In a rat model of neuropathic pain, activating the CB2 receptors in the spinal cord alleviated the pain via the microglia (immune cells of the nervous system) & by lowering P2X7 (a neural receptor that changes the electrical balance of a cell)

Spinal cannabinoid receptor 2 activation alleviates neuropathic pain by regulating microglia and suppressing P2X7 receptor

https://pubmed.ncbi.nlm.nih.gov/36969555/

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2024: In a model of nerve injury, the CB1 receptors controlled the denervation & reinnervation

Cannabinoid type-1 (CB1) receptors in glial cells promote neuromuscular junction repair following nerve injury

https://www.biorxiv.org/content/biorxiv/early/2024/01/15/2024.01.12.575382.full.pdf

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2024: In a mouse model of neuropathic pain, activating the CB2 receptors in the hippocampus (memory center of the brain) reduced the cognitive impairment via the DUSP6/ERK/NFκB pathway

Hippocampal cannabinoid type 2 receptor alleviates chronic neuropathic pain-induced cognitive impairment via microglial DUSP6 pathway in rats

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202401481R

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2023: In a mouse model of peripheral nerve injuries (one of the most complex medical conditions with no effective first line treatment), the ability of cannabis leaf extract to restore muscle function & speed up recovery

Comparative evaluation of ethyl acetate and n-Hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion

https://pubmed.ncbi.nlm.nih.gov/37324902/

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2023: In a mouse model of nerve injury, a cannabis extract sped up muscle function recovery

Comparative evaluation of ethyl acetate and n-Hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion

https://pubmed.ncbi.nlm.nih.gov/37324902/

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2023: In a rat model of neuropathic pain & tolerance to morphine, a single dose of THC lowered pain transmission signals

Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine

https://pubmed.ncbi.nlm.nih.gov/37257771/

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2023: In rats with chronic neuropathic pain, CBD reduced hyperactivity of the pain neurons as well as activation in the corticolimbic system

Cannabidiol modulates chronic neuropathic pain aversion behavior by attenuation of neuroinflammation markers and neuronal activity in the corticolimbic circuit in male Wistar rats

https://pubmed.ncbi.nlm.nih.gov/37474023/

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2023: In mice with neuropathic pain, injection of CBD lowers the pain via serotonin & TRPV1 receptors

Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors

https://pubmed.ncbi.nlm.nih.gov/37068389/

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2023: In a tissue & animal model of neuropathic pain, CBD lowered pain & neuroinflammation via FKBP5 (an immunoregulation protein)

Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5

https://pubmed.ncbi.nlm.nih.gov/37196785/

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2023: In a rat model of chronic neuropathic pain, CBD worked better in the ones that had lower levels of anxiety

Systemic Chronic Treatment with Cannabidiol in Carioca High- and Low-Conditioned Freezing Rats in the Neuropathic Pain Model: Evaluation of Pain Sensitivity

https://pubmed.ncbi.nlm.nih.gov/37513915/

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2023: In a mouse model of neuropathic pain, CBD combined well with electric nerve stimulation of the skin to reduce pain, possibly via a spinal increase of the anti-inflammatory cytokine IL-10

Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice

https://pubmed.ncbi.nlm.nih.gov/36719831/

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2023: In a rat model of facial nerve pain, CBD showed a gendered relationship to painkilling effects with males having a U curve while females being dose dependent

SEX-RELATED DIFFERENCES IN THE ANTINOCICEPTIVE EFFECT OF CANNABIDIOL IN A RODENT MODEL OF TRIGEMINAL NEURALGIA.

https://www.ibroneuroreports.org/article/S2667-2421(23)01536-1/fulltext

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2023: On treating neuropathic pain with a combination of PEA & field horsetail

Novel Approach to the Treatment of Neuropathic Pain Using a Combination with Palmitoylethanolamide and Equisetum arvense L. in an In Vitro Study

https://pubmed.ncbi.nlm.nih.gov/36982577/

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2023: In a mouse model of neuropathic pain, the ability of the kratom alkaloid mitragynine to lower pain seems to be mediated by the cannabinoid receptors

Cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid mitragynine against neuropathic, but not inflammatory pain

https://pubmed.ncbi.nlm.nih.gov/37392779/

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2023: In a mouse model of neuropathic pain, two drugs that activate the CB2 receptor worked better than the common treatment drug pregabalin

Investigation of the Analgesic Properties L-759,633 and SER 601 in Experimental Neuropathic Pain Model in Rats and their Comparison with Pregabalin

http://csj.cumhuriyet.edu.tr/tr/download/article-file/2204545

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2023: In a mouse model of toxic brain damage from HIV antiretrovirals, activating the CB2 receptor protects the brain, causes painkilling effects & reverses morphine tolerance

Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of anti-retroviral toxic neuropathy

https://pubmed.ncbi.nlm.nih.gov/36417942/

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2023: In a rat model of neuropathic pain, a drug that inhibits the FAAH enzyme prevented the development of mechanical allodynia (pain due to a stimulus that does not normally provoke pain)

URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia

https://pubmed.ncbi.nlm.nih.gov/38004491/

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2023: In a mouse model of neuropathic pain, combining an inhibitor of the COX-2 enzyme with an inhibitor of FAAH (to raise anandamide levels) reduced pain behaviors & lowered the release of pro-inflammatory cytokines

Therapeutic Effects of Combined Treatment with the AEA Hydrolysis Inhibitor PF04457845 and the Substrate Selective COX-2 Inhibitor LM4131 in the Mouse Model of Neuropathic Pain

https://pubmed.ncbi.nlm.nih.gov/37174675/

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2023: In a mouse model of peripheral neuropathic pain from trauma, activating the CB2 receptor with the drug COR167 lowered pain levels via lowering the expression of HDAC1 in the microglia (guardian immune cells of the brain), reducing NF-kB activation & increasing anti-inflammatory cytokines

The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition

https://pubmed.ncbi.nlm.nih.gov/37371642/

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2023: In a mouse model of neuropathic pain from cutting a nerve, activating the CB1 receptor lowered pain via glutamate & GABA

Activation of Cannabinoid Receptor 1 in GABAergic Neurons in the Rostral Anterior Insular Cortex Contributes to the Analgesia Following Common Peroneal Nerve Ligation

https://pubmed.ncbi.nlm.nih.gov/36773215/

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2023: In a mouse model of nerve injury, the injury causes regeneration of the axons of neurons via an increase in endocannabinoid tone

Injury-induced activation of the endocannabinoid system promotes axon regeneration

https://pubmed.ncbi.nlm.nih.gov/37235048/

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2022: In a mouse model of neuropathic pain, CBD extract with a high content of terpenes outperformed the same extract without terpenes in causing rapid & long lasting relief of pain hypersensitivity via the CB2 receptor & neuroinflammatory factors of the microglial cells (guardian immune cells of the brain)

Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation

https://pubmed.ncbi.nlm.nih.gov/36583304/

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2022: In a rat model of sciatic nerve damage, PEA decreased the intensity & duration of the pain, stabilized the microglia & astroglia (brain immune cells) & lowered neuroinflammation by several mechanisms

Analgesic Activity of Palmitoylethanolamide on Neuropathic Pain in Rats

https://link.springer.com/article/10.1134/S1819712422030047

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2022: In a rat model of neuropathic pain, CBD & THCV worked together to reduce pain & protect the neurons via the CB1 receptor & a serotonin receptor

Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents

https://pubmed.ncbi.nlm.nih.gov/35303507/

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2022: In a mouse model of neuropathic pain, CBD caused the morphine’s painkilling to work better & lowered the buildup of tolerance to opioids

Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model

https://pubmed.ncbi.nlm.nih.gov/36028000

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2022: A combination of lidocaine & CBD for the topical treatment of pain

Design of Liposomal Lidocaine/Cannabidiol Fixed Combinations for Local Neuropathic Pain Treatment

https://www.mdpi.com/1999-4923/14/9/1915/html

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2022: In a rat model of neuropathic pain, a synthetic cannabinoid combined well with the painkiller tramadol

Synergistic action between a synthetic cannabinoid compound and tramadol in neuropathic pain rats

https://pubmed.ncbi.nlm.nih.gov/36651363

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2022: In a rat model of neuropathic pain, a drug to inhibit the FAAH enzyme (also a function of CBD) reduced their pain

Fatty acid amide hydrolase activity in the dorsal PAG attenuates neuropathic pain and associated dysautonomia

https://pubmed.ncbi.nlm.nih.gov/36154489

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2022: In a mouse model of neuropathic pain, the levels of 2-AG in various parts of the brain indicate that it might be involved in pain control

Expression and Kinetics of Endogenous Cannabinoids in the Brain and Spinal Cord of a Spare Nerve Injury (SNI) Model of Neuropathic Pain

https://pubmed.ncbi.nlm.nih.gov/36552893/

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2022: In a mouse model of neuropathic pain, preventing the degradation of 2-AG reduced the pain via normalizing the reactivity of the microglia (immune cells of the brain)

Attenuation of allodynia and microglial reactivity by inhibiting the degradation of 2-arachidonoylglycerol following injury to the trigeminal nerve in mice

https://pubmed.ncbi.nlm.nih.gov/35991988

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2022: In rats with spinal cord injuries, the increased expression of CB2 receptors helped to reduce neuropathic pain by lowering the transmission of pain signals into the spinal cord

Cannabinoid CB2 receptors are upregulated via bivalent histone modifications and control primary afferent input to the spinal cord in neuropathic pain

https://pubmed.ncbi.nlm.nih.gov/35500651/

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2022: In a rat model of neuropathic pain, electrical brain stimulation created painkilling via the opioids & endocannabinoids

Electrical stimulation of the posterior insular cortex induces opioid and cannabinoid-dependent antinociception and regulates glial cells in the spinal cord

https://www.scielo.br/j/brjp/a/GVw6yTfC9RB3jdSChXfCbjr

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2021: In rats with nerve injuries, CBD helped with pain & symptoms of depression via the serotonin receptors & CB1 receptors

Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT 1A and CB 1 receptors

https://pubmed.ncbi.nlm.nih.gov/34192579/

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2021: In a rat model of neuropathic pain, CBD helped on several different measures of pain & anxiety

Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors

https://pubmed.ncbi.nlm.nih.gov/34274349/

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2021: In a mouse model of neuropathic pain, THC & CBD both helped with pain - though they displayed less synergy than expected

Oral efficacy of Δ(9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model

https://pubmed.ncbi.nlm.nih.gov/33741405/

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2021: In a mouse model of neuropathic pain, three of the main cannabis terpenes helped to reduce pain, possibly via the cannabinoid receptors

Evaluation of the Terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the Mouse Chronic Constriction Injury Model of Neuropathic Pain: Possible Cannabinoid Receptor Involvement

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2021.35.S1.01643

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2021: In rats with depression from traumatic nerve pain, the injury seems to lower the levels of cannabinoids & lead to behavioral depression

Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression after Neuropathic Pain

https://pubmed.ncbi.nlm.nih.gov/34244365/

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2021: In rats with nerve injuries, the ability of exercise to lower their pain seems to be at least partially mediated by the endocannabinoid system lowering their inflammatory response

Exercise-Induced Hypoalgesia Profile in a Rat Neuropathic Pain Model Predicts Pain Severity Following Infraorbital Nerve Injury and Is Associated with Local Cytokine Levels, Systemic Endocannabinoids, and Endogenous Opioids

https://pubmed.ncbi.nlm.nih.gov/34398938/

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2021: In a mouse model of neuropathic pain, the pain-relieving properties of gabapentin are mediated by the endocannabinoid system

Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation

https://pubmed.ncbi.nlm.nih.gov/33331440/

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2020: In mice, full-spectrum hemp oil was effective for chronic neuropathic pain

The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model

https://www.mdpi.com/2075-1729/10/5/69

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2020: In mice, oral cannabinoids helpful for neuropathic pain

Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain

https://www.nature.com/articles/s41386-019-0585-3

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2019: CBD helps with mental effects of neuropathic pain in rats via serotonin receptors

Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319597/

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2019: In a model of neuropathic pain, the effects of CBD

Insights on cannabidiol's antiallodynic and anxiolytic mechanisms of action in a model of neuropathic pain

https://pubmed.ncbi.nlm.nih.gov/32766463/

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2013: In rats, when a nerve is severed, CBD protected it & it reduced the reaction of the glial cells

Neuroprotection and reduction of glial reaction by cannabidiol treatment after sciatic nerve transection in neonatal rats

https://www.ncbi.nlm.nih.gov/pubmed/23981015

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2008: In mice, PEA helped with pain via CB1, TRPV1 and PPARγ

The Endogenous Fatty Acid Amide, Palmitoylethanolamide, Has Anti-Allodynic and Anti-Hyperalgesic Effects in a Murine Model of Neuropathic Pain: Involvement of CB(1), TRPV1 and PPARgamma Receptors and Neurotrophic Factors

https://pubmed.ncbi.nlm.nih.gov/18602217/

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