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2024: In a survey of 1300+ people from a tertiary headache center, they reported using cannabis to treat their headaches & sleep concerns with the majority reporting improvements in migraine intensity, duration & frequency as well as nausea, sleep disturbances, anxiety & depression

Characterizing Cannabis Use and Perceived Benefit in a Tertiary Headache Center Patient Sample

https://pubmed.ncbi.nlm.nih.gov/38455123/

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2024: In people with migraines, 600 mg of PEA resolved headaches, lowered pain & reduced rescue medication significantly more than a placebo with no adverse events

Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy Participants—A Double-Blind Randomised Controlled Study

https://www.mdpi.com/1424-8247/17/2/145

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2024: For migraines, a vaped THC/CBD mixture caused sustained pain relief
Vaporized Cannabis versus Placebo for Acute Migraine: A Randomized Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/38405890/

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2024: For refractory migraine (resistant to treatment), a case report of one month of CBD resolving the symptoms

Cannabidiol in the treatment of migraine: studies and future perspectives

https://headachemedicine.com.br/index.php/hm/article/view/1270

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2022: In a survey of people with persistent headaches, the majority of cannabis users reported it helped with the severity of their headaches & a quarter of them said it reduced their frequency
Cannabinoid Use in a Tertiary Headache Clinic: A Cross-Sectional Survey
https://pubmed.ncbi.nlm.nih.gov/34511153

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2022: In migraine patients, oral cannabinoids helped reduce pain intensity & to lower acute medication intake

Oral Cannabinoid Preparations for the Treatment of Chronic Migraine: A Retrospective Study

https://pubmed.ncbi.nlm.nih.gov/34347088/

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2022: In humans with tension headaches, PEA worked almost as well as ibuprofen for moderate headaches & for severe headaches, PEA worked faster
Efficacy of Palmitoylethanolamide (Levagen+TM) Compared to Ibuprofen for Reducing Headache Pain Severity and Duration in Healthy Adults: A Double-Blind, Parallel, Randomized Clinical Trial
https://www.scirp.org/journal/paperinformation.aspx?paperid=118715

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2022: In patients with episodic migraines, a small pilot study finds that PEA helps decrease the frequency of migraines & the amount of medication needed for pain
Palmitoylethanolamide-based nutraceutical Calmux® in preventive treatment of migraine
https://pubmed.ncbi.nlm.nih.gov/35598579

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2021: In this case study, vaping a small amount of THC helped a patient with her headaches resulting from brain surgery

Significant reduction of symptomatic headache by medical marijuana – Case report

http://www.jpccr.eu/Significant-reduction-of-symptomatic-headache-by-medical-marijuana-Case-report,142773,0,2.html

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2020: A survey finds cannabis helpful for migraines

Experience of Migraine, its Severity, and Perceived Efficacy of Treatments among Cannabis Users

https://www.sciencedirect.com/science/article/pii/S0965229920318860

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2020: A real-world study finds smoked cannabis flower effective for migraines & headache

Alleviative effects of Cannabis flower on migraine and headache

https://www.sciencedirect.com/science/article/abs/pii/S2095496420300741

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2020: A study finds that cannabis treatment decreased migraine frequency

Migraine Frequency Decrease Following Prolonged Medical Cannabis Treatment: A Cross-Sectional Study

https://www.mdpi.com/2076-3425/10/6/360

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2016: A retrospective chart review of migraine patients shows cannabis decreased migraine frequency

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population

https://www.ncbi.nlm.nih.gov/pubmed/26749285

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