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Mental
Health

Best reviews

2022: This review looks at the use of CBD for psychiatric disorders & finds the strongest evidence for psychotic symptoms & anxiety

A scoping review of the use of cannabidiol in psychiatric disorders

https://pubmed.ncbi.nlm.nih.gov/34952255/

2022: A review of cannabis for anxiety

A Comparative Review of Cannabis-Based Medication and First-Line Pharmacotherapy Treatments for Anxiety Disorders

https://ijrpr.com/uploads/V3ISSUE1/IJRPR2280.pdf

2021: This insightful review of the literature suggests the mechanisms by which CBD exerts its promising effects on PTSD

Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder

https://www.sciencedirect.com/science/article/pii/S2667242121000324

2021: This review discusses targeting the ECS for treatment of PTSD

Targeting the endocannabinoid system in the treatment of PTSD: A promising case of preclinical-clinical translation?

https://www.sciencedirect.com/science/article/pii/S0006322321014724

2021: This review looks at how the endocannabinoids regulate your metabolism, stress response & development

Lipid endocannabinoids in energy metabolism, stress and developmental programming

https://pubmed.ncbi.nlm.nih.gov/34843899/

2021: This review looks at targeting the ECS for social anxiety disorder – with a focus on CBD

The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics

https://pubmed.ncbi.nlm.nih.gov/34468550/

2021: A review of how the cannabinoids relate to our fear & anxiety systems

Cannabinoids: revealing their complexity and role in central networks of fear and anxiety

https://pubmed.ncbi.nlm.nih.gov/34487746/

2021: CV Sciences medical adviser Dr. Jamie Corroon on using CBD to lessen the anxiety that can be caused by THC

https://uproxx.com/life/how-to-smoke-weed-without-paranoia-guide/

2021: This expert panel of Colombian psychiatrists suggested CBD for the treatment of the major mental disorders

Colombian consensus of treatment with pure cannabidiol (CBD) in Psychiatry

https://europepmc.org/article/ppr/ppr381442

2021: This in-depth review looks at targeting the endocannabinoid system for serious mental health disorders

The Endocannabinoidome in Neuropsychiatry: Opportunities and Potential Risks

https://pubmed.ncbi.nlm.nih.gov/34119623/

2021: A review of the endocannabinoid system as a guardian of mental health

Endocannabinoid system in trauma and psychosis: distant guardian of mental stability

https://pubmed.ncbi.nlm.nih.gov/33656307/

2021: In this review of aggression, they find that activating the CB1 receptor helps suppress impulsive aggression

Regulation of stress-provoked aggressive behavior using endocannabinoids

https://www.sciencedirect.com/science/article/pii/S235228952100045X

2021: This meta-review of clinical trials looks at CBD's reducing psychotic symptoms of THC as well as effects on schizophrenia & cannabis addiction (10 trials)

Efficacy of Cannabidiol for Δ-9-Tetrahydrocannabinol-Induced Psychotic Symptoms, Schizophrenia, and Cannabis Use Disorders: A Narrative Review

https://www.mdpi.com/2077-0383/10/6/1303/htm

2020: A review of essential oils & the ECS

A Systematic Review of Essential Oils and the Endocannabinoid System: A Connection Worthy of Further Exploration

https://pubmed.ncbi.nlm.nih.gov/32508955/

2020: A review suggesting targeting the ECS for treating Borderline Personality Disorder

Targeting the Endocannabinoid System in Borderline Personality Disorder

https://www.ncbi.nlm.nih.gov/pubmed/32351183

2020: A review looking at how THC & CBD affect the recognition of emotions in facial expressions

The effects of Cannabidiol (CBD) and Delta-9-Tetrahydrocannabinol (THC) on the recognition of emotions in facial expressions: A systematic review of randomized controlled trials

https://pubmed.ncbi.nlm.nih.gov/32745478/

2020: A review of CBD during neurodevelopment for schizophrenia & autism

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?

https://pubmed.ncbi.nlm.nih.gov/33613289/

2020: A review of why CBD & fish oil can be helpful for mental health via their effects on the PPAR receptors (nuclear receptors that control genetic transcription)

Functional interactions between cannabinoids, omega-3 fatty acids and peroxisome proliferator-activated receptors: Implications for mental health pharmacotherapies

https://pubmed.ncbi.nlm.nih.gov/33108021/

2020: CBD & suicidality

Suicidality and Cannabidiol: Opportunities and Challenges

https://pubmed.ncbi.nlm.nih.gov/33059579/

2020: A review of CBD for mental health

The Impact of Cannabidiol on Psychiatric and Medical Conditions

https://pubmed.ncbi.nlm.nih.gov/32655732/

2020: The ECS as biomarkers for mental health

Endocannabinoid System Components as Potential Biomarkers in Psychiatry

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197485/

2020: A review of mental disorders & the cannabinoids 

Cannabinoids and their therapeutic applications in mental disorders

https://www.dialogues-cns.org/wp-content/uploads/2020/09/DialoguesClinNeurosci-22-271.pdf

2020: A review of the importance of synapses in mental disorders & how cannabinoids can help

Cannabis points to the synaptic pathology of mental disorders: how aberrant synaptic components disrupt the highest psychological functions

https://www.dialogues-cns.org/wp-content/uploads/2020/09/DialoguesClinNeurosci-22-251.pdf

2020: Di Marzo on the ECS & how its healing of the guts can lead to healing of the mind

The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders

https://www.dialogues-cns.org/wp-content/uploads/2020/09/DialoguesClinNeurosci-22-259.pdf

2020: Review of what we know about how the ECS is disordered in psychotic and mood disorders

Endocannabinoid system in psychotic and mood disorders: A review of human studies

https://pubmed.ncbi.nlm.nih.gov/32898588/

2020: A review of CBD for mental health

The therapeutic role of Cannabidiol in mental health: a systematic review

https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-019-0012-y

2020: A review of the studies of CBD and schizophrenia

Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies

https://www.ncbi.nlm.nih.gov/pubmed/32073423

2019: A review of the ECS & bipolar disorder

Bipolar disorder and the endocannabinoid system

https://www.ncbi.nlm.nih.gov/pubmed/31159897

2019: A review of the ECS & OCD: charts of circuits & CB1 distribution

The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?

https://pubmed.ncbi.nlm.nih.gov/32656342/

2019: A review of the clinical studies of CBD for psychosis & addiction

The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review

https://www.ncbi.nlm.nih.gov/pubmed/31330972

2019: A review of CBD & psychosis

Cannabidiol as a potential treatment for psychosis

https://www.ncbi.nlm.nih.gov/pubmed/31741731

2019: A review of PET scans of ECS signaling in psychiatric disorders

Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies

https://pubmed.ncbi.nlm.nih.gov/30166624/

2019: CBD in psychiatry

Cannabidiol (CBD) use in psychiatric disorders: A systematic review

https://www.ncbi.nlm.nih.gov/pubmed/31412258

2019: A review finds cannabis terpenes and terpenoids "may be an important potential source for new medications for the treatment of mood and anxiety disorders."

The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/

2019: A review about CBD and psychiatric conditions

Preclinical and Clinical Evidence Supporting Use of Cannabidiol in Psychiatry

https://pubmed.ncbi.nlm.nih.gov/31558911/

2019: A review of CBD and psychiatric disorders

Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings

https://www.ncbi.nlm.nih.gov/pubmed/31601406

2019: CBD and psychiatry

Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment

https://www.ncbi.nlm.nih.gov/pubmed/30910646

2018: Pharmacology of CBD and psychiatry

Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview

https://www.ncbi.nlm.nih.gov/pubmed/29789034

2018: A review of glial cells & the cannabinoids in schizophrenia

Cannabinoids and glial cells: possible mechanism to understand schizophrenia

https://www.ncbi.nlm.nih.gov/pubmed/29392440

2018: CBD & recent-onset psychosis

The Potential of Cannabidiol Treatment for Cannabis Users With Recent-Onset Psychosis

https://www.ncbi.nlm.nih.gov/pubmed/29083450

2017: CBD & cognitive function with relevance to schizophrenia

A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia

https://www.ncbi.nlm.nih.gov/pubmed/27884751

2017: The effects of the ECS on emotions, consciousness and dreams

The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents

https://www.ncbi.nlm.nih.gov/pubmed/28240187

2017: Mechanisms of CBD for psychiatry

Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

https://www.ncbi.nlm.nih.gov/pubmed/28588483/

2016: CBD and motivational disorders

Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?

https://www.ncbi.nlm.nih.gov/pubmed/27023732

2013: Mechoulam on how the huge swathe of FAAHs may be key to personality

The endocannabinoid system and the brain

http://www.ncbi.nlm.nih.gov/pubmed/22804774

2012: Mechanisms of  CBD for mental disorders

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

https://www.ncbi.nlm.nih.gov/pubmed/23108553/

2009: The ECS & emotional homeostasis

Functional role of the endocannabinoid system in emotional homeostasis

https://pubmed.ncbi.nlm.nih.gov/19145562/

Timeline of Research

2022: In a mouse model of approach & avoidance to fearful stimuli, the ECS worked with the immune system to control inflammation in the amygdala (a central brain hub for emotional processing, especially fear) as well as modulating synaptic plasticity & neuronal metabolism

Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits

https://www.mdpi.com/1422-0067/23/5/2538

2022: In humans with borderline & antisocial personality disorders, the strength of the binding of their FAAH enzymes was correlated with neuroticism

Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders

https://pubmed.ncbi.nlm.nih.gov/35064143/.

2022: In a mouse model of memory, the ability of certain serotonin receptors to regulate spatial memory is dependent on a pathway using CB1 & GABA

5-HT3A receptors maintain hippocampal LTP in a CB1 and GABAA receptor- dependent manner for spatial memory

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.15793

2022: An analysis of medical cannabis patients finds that it helps them with generalized anxiety disorder

UK Medical Cannabis Registry: an analysis of clinical outcomes of medicinal cannabis therapy for generalized anxiety disorder

https://pubmed.ncbi.nlm.nih.gov/34937473/

2022: An analysis of the patients in the UK’s Medical Cannabis Registry, they found “treatment to be associated with a relatively low incidence of severe adverse events” & “positive changes following treatment were observed in general, as well as anxiety and sleep-specific, HRQoL [health-related quality of life] outcomes”

An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry

https://pubmed.ncbi.nlm.nih.gov/35073160/

2022: Endocannabinoids & endovanilloids balance each other’s actions in the release of stress hormones

Cannabinoid and vanilloid pathways mediate opposing forms of synaptic plasticity in corticotropin-releasing hormone neurons

https://pubmed.ncbi.nlm.nih.gov/35034400/

2022: A study of anxiety in humans finds that 2-AG levels change in response to stress

Endocannabinoid system reactivity during stress processing in healthy humans

https://pubmed.ncbi.nlm.nih.gov/35090896/

2022: In a mouse model of fear and anxiety, using orexin to increase 2-AG levels in the amygdala & hippocampus led to less extinction of fearful memories

Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1

https://d197for5662m48.cloudfront.net/documents/publicationstatus/73681/preprint_pdf/44a84b235014a31389144200587050ce.pdf

2022: In female mice with early life stress, CBD reverses their anxiety & depression behaviors via a modulation of brain energy metabolism

Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol

https://pubmed.ncbi.nlm.nih.gov/34973413/

2022: In female mice with early life stress, CBD reverses their anxiety & depression behaviors via a modulation of brain energy metabolism

Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol

https://pubmed.ncbi.nlm.nih.gov/34973413/

2022: In a mouse model of depression, LSD combined with CBD to help alleviate depression more than either substance alone

Synergistic effects of lysergic acid diethylamide (LSD) and cannabidiol (CBD)

https://www.researchgate.net/publication/357426416_P0835_Synergistic_effects_of_lysergic_acid_diethylamide_LSD_and_cannabidiol_CBD

2022: In a mouse model of depression, CBD prevented depressive behaviors by modulating the differentiation of neural stem cells into less stressful configurations

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

https://pubmed.ncbi.nlm.nih.gov/35212887/

2022: In humans with PTSD, CBD significantly lowered their stress levels while recalling traumatic events

Effects of cannabidiol on symptoms induced by the recall of traumatic events in patients with posttraumatic stress disorder

https://pubmed.ncbi.nlm.nih.gov/35029706/

2021: In mice with no CB2 receptor, they had an impaired social memory

Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus

https://pubmed.ncbi.nlm.nih.gov/34413398/

2021: In a mouse model of PTSD & aversive memories, this study looks at how CBD works in the brain to help

Medial prefrontal cortex mechanisms of cannabidiol-induced aversive memory reconsolidation impairmentshttps://pubmed.ncbi.nlm.nih.gov/34864001/

2021: In humans consuming CBD, they saw no negative effects on working memory

Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task

https://www.mdpi.com/1424-8247/14/11/1165

2021: In older mice, THC worked better alone for reversing spatial learning deficits than when combined with CBD because the presence of CBD caused more rapid clearance of the THC

Efficacy of Δ 9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice

https://pubmed.ncbi.nlm.nih.gov/34526890/

2021: In mice with memory impairment from the calcium channel blocker verapamil, a blocker of the CB1 receptor (similar to CBD) helps to counter the negative memory effects

The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat

https://pubmed.ncbi.nlm.nih.gov/34845169/

2021: In mice, the link between gut microbiome & mental health is mediated by the endocannabinoid system

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

https://www.nature.com/articles/s41467-020-19931-2

2021: In humans, this cohort analysis found that the diversity of your gut microbiome was related to your happiness & motivation via the endocannabinoid system, especially via PEA (an endocannabinoid)

Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort

https://pubmed.ncbi.nlm.nih.gov/34002020/

2021: In humans, a trial of the effect of CBD & THC on emotions, cognition & attention

Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers

https://pubmed.ncbi.nlm.nih.gov/33304282/

2020: In patients with borderline personality disorder, they tended to have more FAAH enzyme in their prefrontal cortex

Elevated Fatty Acid Amide Hydrolase in the Prefrontal Cortex of Borderline Personality Disorder: A [ 11 C]CURB Positron Emission Tomography Study

https://pubmed.ncbi.nlm.nih.gov/32521537/

2020: In humans with OCD, THC & CBD did not lower the tics but they did lessen anxiety (12 participants in a randomized, placebo-controlled, human laboratory study)

Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study

https://pubmed.ncbi.nlm.nih.gov/32383271/

2020: In humans, yoga & meditation are good for your ECS

Inner Engineering Practices and Advanced 4-day Isha Yoga Retreat Are Associated with Cannabimimetic Effects with Increased Endocannabinoids and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293737/

2020: In prairie voles (a model organism of sociality), increasing anandamide levels caused female prairie voles to spend more time with males, both friends & strangers

Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster)

https://pubmed.ncbi.nlm.nih.gov/33130926/

2020: In humans who attempt suicide, they have higher serum levels of AEA & PEA than similar cases in psychiatric care

Serum endocannabinoid levels in suicide attempters: A pilot study

https://pubmed.ncbi.nlm.nih.gov/32994115/

2020: In rats separated from their mothers & then isolated in adolescence, the dopamine & endocannabinoid systems of their brains were rewired & increased their tendency to alcoholism

Maternal separation plus social isolation during adolescence reprogram brain dopamine and endocannabinoid systems and facilitate alcohol intake in rats

https://pubmed.ncbi.nlm.nih.gov/32784005/

2020: In mice, sociability is partially regulated by the ECS in the amygdala

An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability

https://pubmed.ncbi.nlm.nih.gov/31874107/

2020: In the brain regions related to social attachment in voles, the density of CB1 receptors were higher in the monogamous prairie voles than in the promiscuous meadow voles

Cannabinoid Receptor Type 1 Densities Reflect Social Organization in Microtus

https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.24996

2020: In rats, the relationship of the CB1 receptor to memory formation

Effect of the Endocannabinoid System in Memory Updating and Forgetting

https://pubmed.ncbi.nlm.nih.gov/32739508/

2020: In rat brains, the ECS contributes to long-term depression (the downregulation of neural signals)

Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus

https://pubmed.ncbi.nlm.nih.gov/32817304/

2020: From slices of rat brain, they found how the ECS controls the synapses involved in memory formation

Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation

https://pubmed.ncbi.nlm.nih.gov/32163129/

2020: In mice, the activation of CB1 during exercise helps to enhance learning & memory via glutamate, BDNF and an increased number of dendrites

The endocannabinoid system regulates the moderate exercise-induced enhancement of learning and memory in mice

https://pubmed.ncbi.nlm.nih.gov/31974335/

2020: In tissue samples, we learn how 2-AG helps to regulate the brain plasticity via the dopamine pathway

Cyclic AMP-dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase-α and synaptic 2-arachidonoyl glycerol signaling

https://www.ncbi.nlm.nih.gov/pubmed/31985073

2020: In rats addicted to meth, CBD protected from the memory loss of the drug

Neuroprotective effect of chronic administration of cannabidiol during the abstinence period on methamphetamine-induced impairment of recognition memory in the rats

https://www.ncbi.nlm.nih.gov/pubmed/32032100

2020: In humans, THC affected various emotional & attentional scores while CBD did not

Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers

https://pubmed.ncbi.nlm.nih.gov/33304282/

2020: In mice, exercise enhances learning & memory via the ECS's effect on glutamate & BDNF (a brain growth factor)

Exercise enhances learning and memory: the role of endogenous cannabinoid system

https://www.ncbi.nlm.nih.gov/pubmed/31974335

2020: In rat brains, the interplay of GABA and cannabinoids mediate the amnesia effects of morphine

GABA-cannabinoid interplays in the dorsal hippocampus and basolateral amygdala mediate morphine-induced amnesia

https://www.ncbi.nlm.nih.gov/pubmed/31981675

2020: In rats, CBD helps protects against the cognitive impairment of ketamine

Cannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats

https://www.ncbi.nlm.nih.gov/pubmed/31823199

2020: In rats, how running on a treadmill repairs memory impairment via the ECS

Treadmill exercise improves LPS-induced memory impairments via endocannabinoid receptors and cyclooxygenase enzymes

https://pubmed.ncbi.nlm.nih.gov/31863846/

2019: In mice, CBD caused no detrimental effects on memory, motor performance or anxiety

Prolonged Cannabidiol Treatment Lacks on Detrimental Effects on Memory, Motor Performance and Anxiety in C57BL/6J Mice

https://pubmed.ncbi.nlm.nih.gov/31133833/

2019: In stressed rats, CB1 modulates the effects of polyunsaturated fatty acids on the memory

Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats

https://www.ncbi.nlm.nih.gov/pubmed/31637966

2019: In songbirds, CBD helps their recovery of singing abilities after a brain injury

Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model

https://pubmed.ncbi.nlm.nih.gov/31325430/

2019: In aged mice, CB2 activation by β-caryophyllene (the most common terpene in cannabis) improves memory

The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice

https://www.ncbi.nlm.nih.gov/pubmed/31173795

2019: In mice, memory deficits from chronic CB1 activation is prevented by a blocker of adenosine

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A 2A R receptor antagonism

https://pubmed.ncbi.nlm.nih.gov/31103616/

2018: In regular cannabis users, 200 mg of CBD per day caused less depressive & psychotic symptoms as well as improved scores in attentional switching, verbal learning & memory

Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/29607408/

2017: In humans, CBD does not dampen emotional responses

Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults

https://www.ncbi.nlm.nih.gov/pubmed/28861510

2016: In mice, CB1 helps to regulate habit formation

Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation

https://pubmed.ncbi.nlm.nih.gov/27238866/

2016: In rats, anandamide mediates optimistic judgements

Anandamide mediates cognitive judgement bias in rats

https://pubmed.ncbi.nlm.nih.gov/26363193/

2015: In rodents, blocking MAGL and raising 2AG inhibits learning and memory – but produces painkilling effects

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

https://www.ncbi.nlm.nih.gov/pubmed/25560837

2015: in humans, THC impairs the recognition of facial emotions while combining THC with CBD caused no impairment

Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users

https://www.ncbi.nlm.nih.gov/pubmed/25534187

2014: In mice with induced OCD, CBD decreased marble-burying behavior

Cannabidiol reverses the mCPP-induced increase in marble-burying behavior

https://pubmed.ncbi.nlm.nih.gov/24118015/

2013: In stressed rats, cannabinoids help prevents the harms to plasticity and short-term memory

Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory

https://www.ncbi.nlm.nih.gov/pubmed/23426383/

2013: In monkeys, CBD protects from deficits of THC on memory, learning and motor skills

Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ(9) tetrahydrocannabinol

https://www.ncbi.nlm.nih.gov/pubmed/23550724

2012: In rats, a single dose of CBD rescued the memory after impairment from an iron overload

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

https://www.ncbi.nlm.nih.gov/pubmed/21870037

2012: In rats & mice, a look at the effects of CBD & other cannabinoids on OCD

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour.

https://www.ncbi.nlm.nih.gov/pubmed/21796370

2010: In mice, CBD causes less OCD behavior via the CB1 receptor

Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors

https://www.ncbi.nlm.nih.gov/pubmed/20695034

2010: in two patients, high levels of CBD for ~30 days was well tolerated but not effective for their bipolar disorder

Cannabidiol was ineffective for manic episode of bipolar affective disorder

https://www.ncbi.nlm.nih.gov/pubmed/18801823

2010: In humans, CBD protected from the amnesia effects of THC

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected]

https://pubmed.ncbi.nlm.nih.gov/20884951/

2010: comment

Does cannabidiol protect against the negative effects of THC?

https://pubmed.ncbi.nlm.nih.gov/20884945/

2010: In testing of human cannabis smokers, CBD seemed to attenuate memory deficits caused by THC

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study

https://www.ncbi.nlm.nih.gov/pubmed/20884951

2009: Brain scans of the effects from THC & CBD

Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing

https://www.ncbi.nlm.nih.gov/pubmed/19124693/

2006: In mice, CBD extracts did not reverse memory deficits caused by cholinergic  (scopolamine) or glutamatergic (MK801) insults

Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

https://pubmed.ncbi.nlm.nih.gov/16406104/

2004: In rats, THC extracts caused problems for spatial working/short-term memory but CBD extracts did not

Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats

https://www.ncbi.nlm.nih.gov/pubmed/15567426