Mental
Health
Best reviews
2022: This review looks at the use of CBD for psychiatric disorders & finds the strongest evidence for psychotic symptoms & anxiety
A scoping review of the use of cannabidiol in psychiatric disorders
https://pubmed.ncbi.nlm.nih.gov/34952255/
2022: A review of cannabis for anxiety
A Comparative Review of Cannabis-Based Medication and First-Line Pharmacotherapy Treatments for Anxiety Disorders
https://ijrpr.com/uploads/V3ISSUE1/IJRPR2280.pdf
2021: This insightful review of the literature suggests the mechanisms by which CBD exerts its promising effects on PTSD
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
https://www.sciencedirect.com/science/article/pii/S2667242121000324
2021: This review discusses targeting the ECS for treatment of PTSD
Targeting the endocannabinoid system in the treatment of PTSD: A promising case of preclinical-clinical translation?
https://www.sciencedirect.com/science/article/pii/S0006322321014724
2021: This review looks at how the endocannabinoids regulate your metabolism, stress response & development
Lipid endocannabinoids in energy metabolism, stress and developmental programming
https://pubmed.ncbi.nlm.nih.gov/34843899/
2021: This review looks at targeting the ECS for social anxiety disorder – with a focus on CBD
The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics
https://pubmed.ncbi.nlm.nih.gov/34468550/
2021: A review of how the cannabinoids relate to our fear & anxiety systems
Cannabinoids: revealing their complexity and role in central networks of fear and anxiety
https://pubmed.ncbi.nlm.nih.gov/34487746/
2021: CV Sciences medical adviser Dr. Jamie Corroon on using CBD to lessen the anxiety that can be caused by THC
https://uproxx.com/life/how-to-smoke-weed-without-paranoia-guide/
2021: This expert panel of Colombian psychiatrists suggested CBD for the treatment of the major mental disorders
Colombian consensus of treatment with pure cannabidiol (CBD) in Psychiatry
https://europepmc.org/article/ppr/ppr381442
2021: This in-depth review looks at targeting the endocannabinoid system for serious mental health disorders
The Endocannabinoidome in Neuropsychiatry: Opportunities and Potential Risks
https://pubmed.ncbi.nlm.nih.gov/34119623/
2021: A review of the endocannabinoid system as a guardian of mental health
Endocannabinoid system in trauma and psychosis: distant guardian of mental stability
https://pubmed.ncbi.nlm.nih.gov/33656307/
2021: In this review of aggression, they find that activating the CB1 receptor helps suppress impulsive aggression
Regulation of stress-provoked aggressive behavior using endocannabinoids
https://www.sciencedirect.com/science/article/pii/S235228952100045X
2021: This meta-review of clinical trials looks at CBD's reducing psychotic symptoms of THC as well as effects on schizophrenia & cannabis addiction (10 trials)
Efficacy of Cannabidiol for Δ-9-Tetrahydrocannabinol-Induced Psychotic Symptoms, Schizophrenia, and Cannabis Use Disorders: A Narrative Review
https://www.mdpi.com/2077-0383/10/6/1303/htm
2020: A review of essential oils & the ECS
A Systematic Review of Essential Oils and the Endocannabinoid System: A Connection Worthy of Further Exploration
https://pubmed.ncbi.nlm.nih.gov/32508955/
2020: A review suggesting targeting the ECS for treating Borderline Personality Disorder
Targeting the Endocannabinoid System in Borderline Personality Disorder
https://www.ncbi.nlm.nih.gov/pubmed/32351183
2020: A review looking at how THC & CBD affect the recognition of emotions in facial expressions
The effects of Cannabidiol (CBD) and Delta-9-Tetrahydrocannabinol (THC) on the recognition of emotions in facial expressions: A systematic review of randomized controlled trials
https://pubmed.ncbi.nlm.nih.gov/32745478/
2020: A review of CBD during neurodevelopment for schizophrenia & autism
Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?
https://pubmed.ncbi.nlm.nih.gov/33613289/
2020: A review of why CBD & fish oil can be helpful for mental health via their effects on the PPAR receptors (nuclear receptors that control genetic transcription)
Functional interactions between cannabinoids, omega-3 fatty acids and peroxisome proliferator-activated receptors: Implications for mental health pharmacotherapies
https://pubmed.ncbi.nlm.nih.gov/33108021/
2020: CBD & suicidality
Suicidality and Cannabidiol: Opportunities and Challenges
https://pubmed.ncbi.nlm.nih.gov/33059579/
2020: A review of CBD for mental health
The Impact of Cannabidiol on Psychiatric and Medical Conditions
https://pubmed.ncbi.nlm.nih.gov/32655732/
2020: The ECS as biomarkers for mental health
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197485/
2020: A review of mental disorders & the cannabinoids
Cannabinoids and their therapeutic applications in mental disorders
https://www.dialogues-cns.org/wp-content/uploads/2020/09/DialoguesClinNeurosci-22-271.pdf
2020: A review of the importance of synapses in mental disorders & how cannabinoids can help
Cannabis points to the synaptic pathology of mental disorders: how aberrant synaptic components disrupt the highest psychological functions
https://www.dialogues-cns.org/wp-content/uploads/2020/09/DialoguesClinNeurosci-22-251.pdf
2020: Di Marzo on the ECS & how its healing of the guts can lead to healing of the mind
The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders
https://www.dialogues-cns.org/wp-content/uploads/2020/09/DialoguesClinNeurosci-22-259.pdf
2020: Review of what we know about how the ECS is disordered in psychotic and mood disorders
Endocannabinoid system in psychotic and mood disorders: A review of human studies
https://pubmed.ncbi.nlm.nih.gov/32898588/
2020: A review of CBD for mental health
The therapeutic role of Cannabidiol in mental health: a systematic review
https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-019-0012-y
2020: A review of the studies of CBD and schizophrenia
Cannabidiol as a treatment option for schizophrenia: recent evidence and current studies
https://www.ncbi.nlm.nih.gov/pubmed/32073423
2019: A review of the ECS & bipolar disorder
Bipolar disorder and the endocannabinoid system
https://www.ncbi.nlm.nih.gov/pubmed/31159897
2019: A review of the ECS & OCD: charts of circuits & CB1 distribution
The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?
https://pubmed.ncbi.nlm.nih.gov/32656342/
2019: A review of the clinical studies of CBD for psychosis & addiction
The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review
https://www.ncbi.nlm.nih.gov/pubmed/31330972
2019: A review of CBD & psychosis
Cannabidiol as a potential treatment for psychosis
https://www.ncbi.nlm.nih.gov/pubmed/31741731
2019: A review of PET scans of ECS signaling in psychiatric disorders
Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies
https://pubmed.ncbi.nlm.nih.gov/30166624/
2019: CBD in psychiatry
Cannabidiol (CBD) use in psychiatric disorders: A systematic review
https://www.ncbi.nlm.nih.gov/pubmed/31412258
2019: A review finds cannabis terpenes and terpenoids "may be an important potential source for new medications for the treatment of mood and anxiety disorders."
The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/
2019: A review about CBD and psychiatric conditions
Preclinical and Clinical Evidence Supporting Use of Cannabidiol in Psychiatry
https://pubmed.ncbi.nlm.nih.gov/31558911/
2019: A review of CBD and psychiatric disorders
Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings
https://www.ncbi.nlm.nih.gov/pubmed/31601406
2019: CBD and psychiatry
Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment
https://www.ncbi.nlm.nih.gov/pubmed/30910646
2018: Pharmacology of CBD and psychiatry
Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview
https://www.ncbi.nlm.nih.gov/pubmed/29789034
2018: A review of glial cells & the cannabinoids in schizophrenia
Cannabinoids and glial cells: possible mechanism to understand schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/29392440
2018: CBD & recent-onset psychosis
The Potential of Cannabidiol Treatment for Cannabis Users With Recent-Onset Psychosis
https://www.ncbi.nlm.nih.gov/pubmed/29083450
2017: CBD & cognitive function with relevance to schizophrenia
A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia
https://www.ncbi.nlm.nih.gov/pubmed/27884751
2017: The effects of the ECS on emotions, consciousness and dreams
The Endocannabinoid System Modulating Levels of Consciousness, Emotions and Likely Dream Contents
https://www.ncbi.nlm.nih.gov/pubmed/28240187
2017: Mechanisms of CBD for psychiatry
Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders
https://www.ncbi.nlm.nih.gov/pubmed/28588483/
2016: CBD and motivational disorders
Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?
https://www.ncbi.nlm.nih.gov/pubmed/27023732
2013: Mechoulam on how the huge swathe of FAAHs may be key to personality
The endocannabinoid system and the brain
http://www.ncbi.nlm.nih.gov/pubmed/22804774
2012: Mechanisms of CBD for mental disorders
Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
https://www.ncbi.nlm.nih.gov/pubmed/23108553/
2009: The ECS & emotional homeostasis
Functional role of the endocannabinoid system in emotional homeostasis
https://pubmed.ncbi.nlm.nih.gov/19145562/
Timeline of Research
2022: In a mouse model of approach & avoidance to fearful stimuli, the ECS worked with the immune system to control inflammation in the amygdala (a central brain hub for emotional processing, especially fear) as well as modulating synaptic plasticity & neuronal metabolism
Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits
https://www.mdpi.com/1422-0067/23/5/2538
2022: In humans with borderline & antisocial personality disorders, the strength of the binding of their FAAH enzymes was correlated with neuroticism
Higher trait neuroticism is associated with greater fatty acid amide hydrolase binding in borderline and antisocial personality disorders
https://pubmed.ncbi.nlm.nih.gov/35064143/.
2022: In a mouse model of memory, the ability of certain serotonin receptors to regulate spatial memory is dependent on a pathway using CB1 & GABA
5-HT3A receptors maintain hippocampal LTP in a CB1 and GABAA receptor- dependent manner for spatial memory
https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.15793
2022: An analysis of medical cannabis patients finds that it helps them with generalized anxiety disorder
UK Medical Cannabis Registry: an analysis of clinical outcomes of medicinal cannabis therapy for generalized anxiety disorder
https://pubmed.ncbi.nlm.nih.gov/34937473/
2022: An analysis of the patients in the UK’s Medical Cannabis Registry, they found “treatment to be associated with a relatively low incidence of severe adverse events” & “positive changes following treatment were observed in general, as well as anxiety and sleep-specific, HRQoL [health-related quality of life] outcomes”
An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry
https://pubmed.ncbi.nlm.nih.gov/35073160/
2022: Endocannabinoids & endovanilloids balance each other’s actions in the release of stress hormones
Cannabinoid and vanilloid pathways mediate opposing forms of synaptic plasticity in corticotropin-releasing hormone neurons
https://pubmed.ncbi.nlm.nih.gov/35034400/
2022: A study of anxiety in humans finds that 2-AG levels change in response to stress
Endocannabinoid system reactivity during stress processing in healthy humans
https://pubmed.ncbi.nlm.nih.gov/35090896/
2022: In a mouse model of fear and anxiety, using orexin to increase 2-AG levels in the amygdala & hippocampus led to less extinction of fearful memories
Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1
2022: In female mice with early life stress, CBD reverses their anxiety & depression behaviors via a modulation of brain energy metabolism
Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol
https://pubmed.ncbi.nlm.nih.gov/34973413/
2022: In female mice with early life stress, CBD reverses their anxiety & depression behaviors via a modulation of brain energy metabolism
Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol
https://pubmed.ncbi.nlm.nih.gov/34973413/
2022: In a mouse model of depression, LSD combined with CBD to help alleviate depression more than either substance alone
Synergistic effects of lysergic acid diethylamide (LSD) and cannabidiol (CBD)
2022: In a mouse model of depression, CBD prevented depressive behaviors by modulating the differentiation of neural stem cells into less stressful configurations
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
https://pubmed.ncbi.nlm.nih.gov/35212887/
2022: In humans with PTSD, CBD significantly lowered their stress levels while recalling traumatic events
Effects of cannabidiol on symptoms induced by the recall of traumatic events in patients with posttraumatic stress disorder
https://pubmed.ncbi.nlm.nih.gov/35029706/
2021: In mice with no CB2 receptor, they had an impaired social memory
Cannabinoid receptor 2 deletion influences social memory and synaptic architecture in the hippocampus
https://pubmed.ncbi.nlm.nih.gov/34413398/
2021: In a mouse model of PTSD & aversive memories, this study looks at how CBD works in the brain to help
Medial prefrontal cortex mechanisms of cannabidiol-induced aversive memory reconsolidation impairmentshttps://pubmed.ncbi.nlm.nih.gov/34864001/
2021: In humans consuming CBD, they saw no negative effects on working memory
Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
https://www.mdpi.com/1424-8247/14/11/1165
2021: In older mice, THC worked better alone for reversing spatial learning deficits than when combined with CBD because the presence of CBD caused more rapid clearance of the THC
Efficacy of Δ 9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice
https://pubmed.ncbi.nlm.nih.gov/34526890/
2021: In mice with memory impairment from the calcium channel blocker verapamil, a blocker of the CB1 receptor (similar to CBD) helps to counter the negative memory effects
The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat
https://pubmed.ncbi.nlm.nih.gov/34845169/
2021: In mice, the link between gut microbiome & mental health is mediated by the endocannabinoid system
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system
https://www.nature.com/articles/s41467-020-19931-2
2021: In humans, this cohort analysis found that the diversity of your gut microbiome was related to your happiness & motivation via the endocannabinoid system, especially via PEA (an endocannabinoid)
Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort
https://pubmed.ncbi.nlm.nih.gov/34002020/
2021: In humans, a trial of the effect of CBD & THC on emotions, cognition & attention
Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers
https://pubmed.ncbi.nlm.nih.gov/33304282/
2020: In patients with borderline personality disorder, they tended to have more FAAH enzyme in their prefrontal cortex
Elevated Fatty Acid Amide Hydrolase in the Prefrontal Cortex of Borderline Personality Disorder: A [ 11 C]CURB Positron Emission Tomography Study
https://pubmed.ncbi.nlm.nih.gov/32521537/
2020: In humans with OCD, THC & CBD did not lower the tics but they did lessen anxiety (12 participants in a randomized, placebo-controlled, human laboratory study)
Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study
https://pubmed.ncbi.nlm.nih.gov/32383271/
2020: In humans, yoga & meditation are good for your ECS
Inner Engineering Practices and Advanced 4-day Isha Yoga Retreat Are Associated with Cannabimimetic Effects with Increased Endocannabinoids and Short-Term and Sustained Improvement in Mental Health: A Prospective Observational Study of Meditators
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293737/
2020: In prairie voles (a model organism of sociality), increasing anandamide levels caused female prairie voles to spend more time with males, both friends & strangers
Effects of systemic endocannabinoid manipulation on social and exploratory behavior in prairie voles (Microtus ochrogaster)
https://pubmed.ncbi.nlm.nih.gov/33130926/
2020: In humans who attempt suicide, they have higher serum levels of AEA & PEA than similar cases in psychiatric care
Serum endocannabinoid levels in suicide attempters: A pilot study
https://pubmed.ncbi.nlm.nih.gov/32994115/
2020: In rats separated from their mothers & then isolated in adolescence, the dopamine & endocannabinoid systems of their brains were rewired & increased their tendency to alcoholism
Maternal separation plus social isolation during adolescence reprogram brain dopamine and endocannabinoid systems and facilitate alcohol intake in rats
https://pubmed.ncbi.nlm.nih.gov/32784005/
2020: In mice, sociability is partially regulated by the ECS in the amygdala
An endocannabinoid-regulated basolateral amygdala-nucleus accumbens circuit modulates sociability
https://pubmed.ncbi.nlm.nih.gov/31874107/
2020: In the brain regions related to social attachment in voles, the density of CB1 receptors were higher in the monogamous prairie voles than in the promiscuous meadow voles
Cannabinoid Receptor Type 1 Densities Reflect Social Organization in Microtus
https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.24996
2020: In rats, the relationship of the CB1 receptor to memory formation
Effect of the Endocannabinoid System in Memory Updating and Forgetting
https://pubmed.ncbi.nlm.nih.gov/32739508/
2020: In rat brains, the ECS contributes to long-term depression (the downregulation of neural signals)
Endocannabinoid receptors contribute significantly to multiple forms of long-term depression in the rat dentate gyrus
https://pubmed.ncbi.nlm.nih.gov/32817304/
2020: From slices of rat brain, they found how the ECS controls the synapses involved in memory formation
Temporal Gating of Synaptic Competition in the Amygdala by Cannabinoid Receptor Activation
https://pubmed.ncbi.nlm.nih.gov/32163129/
2020: In mice, the activation of CB1 during exercise helps to enhance learning & memory via glutamate, BDNF and an increased number of dendrites
The endocannabinoid system regulates the moderate exercise-induced enhancement of learning and memory in mice
https://pubmed.ncbi.nlm.nih.gov/31974335/
2020: In tissue samples, we learn how 2-AG helps to regulate the brain plasticity via the dopamine pathway
Cyclic AMP-dependent protein kinase and D1 dopamine receptors regulate diacylglycerol lipase-α and synaptic 2-arachidonoyl glycerol signaling
https://www.ncbi.nlm.nih.gov/pubmed/31985073
2020: In rats addicted to meth, CBD protected from the memory loss of the drug
Neuroprotective effect of chronic administration of cannabidiol during the abstinence period on methamphetamine-induced impairment of recognition memory in the rats
https://www.ncbi.nlm.nih.gov/pubmed/32032100
2020: In humans, THC affected various emotional & attentional scores while CBD did not
Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers
https://pubmed.ncbi.nlm.nih.gov/33304282/
2020: In mice, exercise enhances learning & memory via the ECS's effect on glutamate & BDNF (a brain growth factor)
Exercise enhances learning and memory: the role of endogenous cannabinoid system
https://www.ncbi.nlm.nih.gov/pubmed/31974335
2020: In rat brains, the interplay of GABA and cannabinoids mediate the amnesia effects of morphine
GABA-cannabinoid interplays in the dorsal hippocampus and basolateral amygdala mediate morphine-induced amnesia
https://www.ncbi.nlm.nih.gov/pubmed/31981675
2020: In rats, CBD helps protects against the cognitive impairment of ketamine
Cannabidiol Improves Cognitive Impairment and Reverses Cortical Transcriptional Changes Induced by Ketamine, in Schizophrenia-Like Model in Rats
https://www.ncbi.nlm.nih.gov/pubmed/31823199
2020: In rats, how running on a treadmill repairs memory impairment via the ECS
Treadmill exercise improves LPS-induced memory impairments via endocannabinoid receptors and cyclooxygenase enzymes
https://pubmed.ncbi.nlm.nih.gov/31863846/
2019: In mice, CBD caused no detrimental effects on memory, motor performance or anxiety
Prolonged Cannabidiol Treatment Lacks on Detrimental Effects on Memory, Motor Performance and Anxiety in C57BL/6J Mice
https://pubmed.ncbi.nlm.nih.gov/31133833/
2019: In stressed rats, CB1 modulates the effects of polyunsaturated fatty acids on the memory
Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats
https://www.ncbi.nlm.nih.gov/pubmed/31637966
2019: In songbirds, CBD helps their recovery of singing abilities after a brain injury
Cannabidiol improves vocal learning-dependent recovery from, and reduces magnitude of deficits following, damage to a cortical-like brain region in a songbird pre-clinical animal model
https://pubmed.ncbi.nlm.nih.gov/31325430/
2019: In aged mice, CB2 activation by β-caryophyllene (the most common terpene in cannabis) improves memory
The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice
https://www.ncbi.nlm.nih.gov/pubmed/31173795
2019: In mice, memory deficits from chronic CB1 activation is prevented by a blocker of adenosine
Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A 2A R receptor antagonism
https://pubmed.ncbi.nlm.nih.gov/31103616/
2018: In regular cannabis users, 200 mg of CBD per day caused less depressive & psychotic symptoms as well as improved scores in attentional switching, verbal learning & memory
Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/29607408/
2017: In humans, CBD does not dampen emotional responses
Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults
https://www.ncbi.nlm.nih.gov/pubmed/28861510
2016: In mice, CB1 helps to regulate habit formation
Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
https://pubmed.ncbi.nlm.nih.gov/27238866/
2016: In rats, anandamide mediates optimistic judgements
Anandamide mediates cognitive judgement bias in rats
https://pubmed.ncbi.nlm.nih.gov/26363193/
2015: In rodents, blocking MAGL and raising 2AG inhibits learning and memory – but produces painkilling effects
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents
https://www.ncbi.nlm.nih.gov/pubmed/25560837
2015: in humans, THC impairs the recognition of facial emotions while combining THC with CBD caused no impairment
Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users
https://www.ncbi.nlm.nih.gov/pubmed/25534187
2014: In mice with induced OCD, CBD decreased marble-burying behavior
Cannabidiol reverses the mCPP-induced increase in marble-burying behavior
https://pubmed.ncbi.nlm.nih.gov/24118015/
2013: In stressed rats, cannabinoids help prevents the harms to plasticity and short-term memory
Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory
https://www.ncbi.nlm.nih.gov/pubmed/23426383/
2013: In monkeys, CBD protects from deficits of THC on memory, learning and motor skills
Cannabidiol attenuates deficits of visuospatial associative memory induced by Δ(9) tetrahydrocannabinol
https://www.ncbi.nlm.nih.gov/pubmed/23550724
2012: In rats, a single dose of CBD rescued the memory after impairment from an iron overload
Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
https://www.ncbi.nlm.nih.gov/pubmed/21870037
2012: In rats & mice, a look at the effects of CBD & other cannabinoids on OCD
Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour.
https://www.ncbi.nlm.nih.gov/pubmed/21796370
2010: In mice, CBD causes less OCD behavior via the CB1 receptor
Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors
https://www.ncbi.nlm.nih.gov/pubmed/20695034
2010: in two patients, high levels of CBD for ~30 days was well tolerated but not effective for their bipolar disorder
Cannabidiol was ineffective for manic episode of bipolar affective disorder
https://www.ncbi.nlm.nih.gov/pubmed/18801823
2010: In humans, CBD protected from the amnesia effects of THC
Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected]
https://pubmed.ncbi.nlm.nih.gov/20884951/
2010: comment
Does cannabidiol protect against the negative effects of THC?
https://pubmed.ncbi.nlm.nih.gov/20884945/
2010: In testing of human cannabis smokers, CBD seemed to attenuate memory deficits caused by THC
Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study
https://www.ncbi.nlm.nih.gov/pubmed/20884951
2009: Brain scans of the effects from THC & CBD
Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing
https://www.ncbi.nlm.nih.gov/pubmed/19124693/
2006: In mice, CBD extracts did not reverse memory deficits caused by cholinergic (scopolamine) or glutamatergic (MK801) insults
Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts
https://pubmed.ncbi.nlm.nih.gov/16406104/
2004: In rats, THC extracts caused problems for spatial working/short-term memory but CBD extracts did not
Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats
https://www.ncbi.nlm.nih.gov/pubmed/15567426