​​

2024: In a case report of a cat with type 2 diabetes, adding CBD to her regimen reduced glycemia, improved sleep cycles, decreased thirst & urination as well as increasing physical activity

Use of cannabidiol-dominant extract as co-adjuvant therapy for type 2 diabetes mellitus treatment in feline: case report

https://karger.com/mca/article-pdf/doi/10.1159/000541034/4278247/000541034.pdf

​

2024: In dogs with pain, full spectrum hemp extracts lowered their pain scores, increased their ability to use stairs, improved daily activity & lowered blood levels of proinflammatory cytokines

Efficacy and tolerability of full spectrum hemp oil in dogs living with pain in common household settings

https://pubmed.ncbi.nlm.nih.gov/39071787/

​

2024: In dogs with mobility disorders, a double-blind placebo study found that those receiving CBD oil improved on both subjective & objective outcome measures & that it combined safely with NSAIDs, though a third of the dogs experienced liver enzyme elevations

Evaluation of the Effect of Cannabidiol Administration with and without Nonsteroidal Anti-inflammatory Drugs in Dogs with Mobility Disorders: A Prospective, Double-blind, Crossover, Placebo-controlled Study

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-1786230

​

2024: In dogs having their ovaries removed, CBD helped with pain & also changed pupil size

Assessment of the nociceptive response to the use of cannabidiol alone and in combination with meloxicam through infrared pupillometry in female dogs undergoing elective ovariohysterectomy

https://www.frontiersin.org/articles/10.3389/fvets.2024.1380022/abstract

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2024: In dogs undergoing hysterectomies, CBD worked as well as meloxicam (an NSAID commonly used for arthritis) for managing acute pain

Assessment of the nociceptive response to the use of cannabidiol alone and in combination with meloxicam through infrared pupillometry in female dogs undergoing elective ovariohysterectomy

https://pubmed.ncbi.nlm.nih.gov/39027908/

​

2024: In dogs with flea allergy dermatitis, nutraceuticals containing both CBD & PEA worked to lower itching, skin lesions & discomfort

The Beneficial Effect of Two Nutraceuticals in Flea Allergy Dermatitis Itch Control: A Comparative Study

https://www.researchgate.net/publication/381018612_The_Beneficial_Effect_of_Two_Nutraceuticals_in_Flea_Allergy_Dermatitis_Itch_Control_A_Comparative_Study

​

2024: In dogs with osteoarthritis, two weeks of CBD combined well with krill oil to reduce pain & inflammation

Cannabidiol plus krill oil supplementation improves chronic stifle osteoarthritis in dogs: A double-blind randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/39179145/

​

2024: For chronic pain in a frail dog, a combination of PEA & quercetin improved pain & quality of life

Combining co-ultramicronized palmitoylethanolamide and quercetin with physical therapy and acupuncture for chronic pain in a frail patient: a case report in a dog

https://www.cureus.com/abstracts/1323-combining-co-ultramicronized-palmitoylethanolamide-and-quercetin-with-physical-therapy-and-acupuncture-for-chronic-pain-in-a-frail-patient-a-case-report-in-a-dog

​

2024: In dogs living in a municipal shelter, one week of small amounts of CBD oil did not change behavioral parameters but did modulate cortisol levels

Assessing the effectiveness of cannabidiol additive supplementation on canine behavior and cortisol levels

https://pubmed.ncbi.nlm.nih.gov/38803908/

​

2024: In dogs, a pharmacokinetic comparison of three oils & one semi-solid CBD preparation

Pharmacokinetics behavior of four cannabidiol preparations following single oral administration in dogs

https://pubmed.ncbi.nlm.nih.gov/38725584/

​

2024: In dogs, the tolerability of 36 weeks of CBD

Tolerability of long-term cannabidiol supplementation to healthy adult dogs
https://pubmed.ncbi.nlm.nih.gov/38009749/
A dose of 5 mg/kg/day was well tolerated. At 10 mg/kg/day, this group had a higher frequency of soft feces. And in all treatment groups, they had high ALP liver enzyme activity, but that was the only difference found in the blood work.

​​

2024: In cats, an oral dose of 1:20 THC:CBD did not show adverse effects at 2 milligrams or 5 milligrams per kg & absorption was increased when given with a meal
Pharmacokinetic of two oral doses of a 1:20 THC:CBD cannabis herbal extract in cats
https://pubmed.ncbi.nlm.nih.gov/38585296/

​

2024: On using PEA for chronic pain in geriatric cats [Portuguese]
Desenvolvimento de uma pasta veterinária enriquecida com palmitoiletanolamida destinada ao manejo da dor crônica em felinos geriátricos
https://ojs.observatoriolatinoamericano.com/ojs/index.php/olel/article/view/4168

​

2024: In a cat with advanced cancer, a full spectrum cannabis product (4:1 CBD:THC) relieved their symptoms within a week & gave them six more months of good health & energy until ultimately euthanized for blindness
The Use of Medical Cannabis as Palliative Care in a Feline With Advanced Cancer
https://greennile.org/wp-content/uploads/2024/03/Vol-74-Medical-Cannabis.Feline.copyright-LR.pdf

​

2024: Cats well tolerated daily feeding of CBD at a dosage of 4 mg/kg
Healthy cats tolerate long-term daily feeding of Cannabidiol
https://pubmed.ncbi.nlm.nih.gov/38327816/

​

2024: In cats, CBD seemed effective for easing separation anxiety
Is cannabidiol (CBD) effective to ease separation anxiety?
https://pubmed.ncbi.nlm.nih.gov/38356586/
 

2024: A case report of a dog using CBD-rich full spectrum oil to treat the common autoimmune skin disease discoid lupus erythematosus
Case report: Cannabinoid therapy for discoid lupus erythematosus in a dog
https://pubmed.ncbi.nlm.nih.gov/38406630/

​

2024: A survey of Argentinian cannabis veterinarians they found pain, seizures & behavior disorders to be the most common treatments for dogs & for cats, conditions treated included pain, behavior, an autoimmune disease, skin diseases, gingivostomatitis & as a palliative for cancer
Cannabis and pathologies in dogs and cats: first survey of phytocannabinoid use in veterinary medicine in Argentina
https://pubmed.ncbi.nlm.nih.gov/38031164/

 

2024: The National Animal Supplement Council releases a study on the safety of 90 days of CBD in dogs
Safety study of cannabidiol products in healthy dogs
https://www.frontiersin.org/articles/10.3389/fvets.2024.1349590/full
National Animal Supplement Council Announces Publication of Landmark Safety Study of Cannabidiol Products in Healthy Dogs
https://www.businesswire.com/news/home/20240305878251/en/National-Animal-Supplement-Council-Announces-Publication-of-Landmark-Safety-Study-of-Cannabidiol-Products-in-Healthy-Dogs

​

2024: In dogs exposed to the stress of repeated car travel, CBD lowered their stress
Daily dosing of cannabidiol (CBD) demonstrates a positive effect on measures of stress in dogs during repeated exposure to car travel
https://pubmed.ncbi.nlm.nih.gov/38244994/
 

2024: In dogs with separation anxiety, two weeks of 2 mg CBD/kg /day led to significantly less vocalization during separations
Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers
https://pubmed.ncbi.nlm.nih.gov/38322918/

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2024: In a survey of Danish dog owners (where cannabis products for dogs are unlicensed), the majority confirmed the use of cannabinoids, most especially for pain, behavioral issues & allergy, with the most efficacy being for pain
Danish dog owners' use and the perceived effect of unlicensed cannabis products in dogs
https://pubmed.ncbi.nlm.nih.gov/38295012/

​

2024: In dogs, giving them CBD rich extracts reduced their necessary anesthetic dosage of propofol by 23%
Full spectrum cannabidiol-rich extract reduced propofol dosage required for anesthetic induction in dogs—a pilot study
https://www.frontiersin.org/articles/10.3389/fvets.2024.1352314/full

​

2024: Cats well tolerated daily feeding of CBD at a dosage of 4 mg/kg
Healthy cats tolerate long-term daily feeding of Cannabidiol
https://pubmed.ncbi.nlm.nih.gov/38327816/

​

2023: In cats with gingivostomatitis (severe inflammatory gum infection), a placebo-controlled study found that 15 days of CBD (4 mg/kg) twice a day significantly improved disease scores
Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis
https://pubmed.ncbi.nlm.nih.gov/37684980/

​

2023: In a group of 40 cats exposed to a simulated thunderstorm, CBD caused significant reductions on the Cat-Stress-Score
Possible Anxiolytic Effects of Cannabidiol (Cbd) Administration on Feline Response to a Fear Response Test
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4480358
As always, it’s hard to get dosing info for cats, so the use of 4 mg/kg/day is helpful.

​

2023: In pets, a survey of CBD use finds most pet owners see an improvement in their pets condition with mild to no side effects
Assessment of cannabidiol use in pets according to a national survey in the USA
https://pubmed.ncbi.nlm.nih.gov/37203420/

​

2023: In dogs with osteoarthritis, injections of CBD reduced pain & increased well-being
Pharmacokinetics and therapeutic efficacy of liposomal cannabidiol (CBD) injection: A pilot clinical study in dogs with naturally-occurring osteoarthritis
https://onlinelibrary.wiley.com/doi/10.1111/jvp.13257

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2023: In dogs with drug resistant epilepsy, 9 mg/kg/day of CBD effectively reduced seizures, though the liver enzyme activities should be monitored & side effects of decreased appetite & increased vomiting should be watched for
The efficacy and safety of cannabidiol as adjunct treatment for drug-resistant idiopathic epilepsy in 51 dogs: A double-blinded crossover study
https://pubmed.ncbi.nlm.nih.gov/37889215/

​

2023: In dogs with osteoarthritis, one injection of liposomal CBD reduced pain & increased well-being for 6 weeks
Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis
https://pubmed.ncbi.nlm.nih.gov/37680386/

​

2023: Here’s a study of how CBD moves through healthy dogs that shows how giving CBD twice a day lessens variations in CBD blood levels
Cannabidiol plasma determination and pharmacokinetics conducted at beginning, middle and end of long-term supplementation of a broad-spectrum hemp oil to healthy adult dogs
https://pubmed.ncbi.nlm.nih.gov/37841465/

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2023: In dogs with osteoarthritis, an analysis of the endocannabinoid system at their joints indicates a therapeutic use for cannabinoid medicines
Endocannabinoid System Receptors at the Hip and Stifle Joints of Middle-Aged Dogs: A Novel Target for the Therapeutic Use of Cannabis sativa Extract in Canine Arthropathies
https://pubmed.ncbi.nlm.nih.gov/37760233/

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2023: In dogs, the long-term use of CBD did not appear to affect their eye health or tear production
Long-term effect of oral cannabidiol administration to healthy adult dogs on tear production, intraocular pressure, and tear concentrations
https://pubmed.ncbi.nlm.nih.gov/38032014/

​

2023: In dogs stressed out by car travel or separation, one dose of CBD significantly lowered their stress-related measures

A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel
https://pubmed.ncbi.nlm.nih.gov/36908527/

​

2023: A case study of a cat with osteoarthritis where full spectrum cannabis oil for 30 days helped with the pain
A case report of CBD and THC as analgesic therapy in a cat with chronic osteoarthritic pain
https://pubmed.ncbi.nlm.nih.gov/37002652/

​

2023: For a 3 year old dog with intense jaw pain from a nerve sheath tumor, using CBD oil & gabapentin to relieve the pain
Cannabinoid oil with gabapentin for the treatment of chronic neuropathic pain – case repor
https://www.researchgate.net/publication/367537234_Cannabinoid_oil_with_gabapentin_for_the_treatment_of_chronic_neuropathic_pain_-_case_report

​

2023: In canine epilepsy, an analysis of the changes to the CB1 receptors in the hippocampus (memory center of the brain)
Hippocampal expression of the cannabinoid receptor type 1 in canine epilepsy
https://pubmed.ncbi.nlm.nih.gov/36823232/

​

2023: In a dog with compulsive disorder, using cannabis & melatonin lowered their compulsive episodes
Combining cannabis and melatonin treatment with a rehabilitation program improved symptoms in a dog with compulsive disorder: A case report
https://pubmed.ncbi.nlm.nih.gov/37245289/

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2023: In dogs, the use of oral transmucosal CBD did not change the bioavailability compared to oral treatments
Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs
https://pubmed.ncbi.nlm.nih.gov/36686155/

​

2022: A study of giving increasing doses of CBD to cats was safe
Pharmacokinetics of escalating single-dose administration of cannabidiol to cats
https://pubmed.ncbi.nlm.nih.gov/36300854

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2022: In teddy dogs, hemp oil helped with nutrient digestibility, blood metabolism, immunity & antioxidant capacity
Dietary supplementation of hemp oil in teddy dogs: Effect on apparent nutrient digestibility, blood biochemistry and metabolomics
https://pubmed.ncbi.nlm.nih.gov/35200081/

​

2022: In canine kidney cells, hemp leaf extract reduced their inflammation, especially CBN
Phytochemical differences of hemp ( Cannabis sativa L.) leaves from different germplasms and their regulatory effects on lipopolysaccharide-induced inflammation in Matin-Darby canine kidney cell lines
https://pubmed.ncbi.nlm.nih.gov/35938104/

​

2022: A case study of injecting CBD for a dog with severe pain
A Case Report of Subcutaneously Injected Liposomal Cannabidiol Formulation Used as a Compassion Therapy for Pain Management in a Dog
https://pubmed.ncbi.nlm.nih.gov/35573415/

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2022: In healthy dogs, CBD capsules for 6 months was well-tolerated & saw no biochemistry or liver changes asides from a passing elevation in ALP liver levels in half the dogs
Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
https://pubmed.ncbi.nlm.nih.gov/36213402

​

2022: In dogs with osteoarthritis, this thesis project found that both CBD & water-soluble CBD helped control pain with no difference between the methods
Comparison of Water-Soluble CBD and CBD Oil as an Anti-Inflammatory in Canines with Osteoarthritis
https://digitalcommons.murraystate.edu/scholarsweek/Fall2022/HON/3

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2022: In dogs with eczema, the inflammatory skin cells contained CB2, GPR55, TRPV1 & TRPA receptors
Cannabinoid receptors in the inflammatory cells of canine atopic dermatitis
https://pubmed.ncbi.nlm.nih.gov/36187821

​

2022: On using CBD/CBDA paste to treat seizures in dogs
Safety and efficacy of cannabidiol-cannabidiolic acid rich hemp extract in the treatment of refractory epileptic seizures in dogs
https://pubmed.ncbi.nlm.nih.gov/35967998
 

2022: In dogs with osteoarthritis, a combination of cannabis extract & frankincense reduced inflammation, oxidative stress & chronic pain
Long-term effects of a diet supplement containing Cannabis sativa oil and Boswellia serrata in dogs with osteoarthritis following physiotherapy treatments: a randomized, placebo-controlled and double-blind clinical trial
https://pubmed.ncbi.nlm.nih.gov/36067506

​

2022: In dogs with itchy skin, they had higher levels of CB2 receptors in their skin, suggesting targeting the ECS in the skin as a treatment
Distribution of Cannabinoid Receptors in Keratinocytes of Healthy Dogs and Dogs With Atopic Dermatitis
https://pubmed.ncbi.nlm.nih.gov/35873682

​

2022: In dogs, how CBD & CBDA moves through their system
Twenty-Four Hour and One-Week Steady State Pharmacokinetics of Cannabinoids in Two Formulations of Cannabidiol and Cannabidiolic Acid Rich Hemp in Dogs
https://esmed.org/MRA/mra/article/view/2907

 

2022: In dogs, a study of how CBD moves through their body when taking it nasally, rectally or orally
Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs
https://pubmed.ncbi.nlm.nih.gov/35754531

​

2022: In dogs with atopic dermatitis (red itchy skin), a CBD/CBDA oil helped with their itchiness but not their lesions
The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis
https://pubmed.ncbi.nlm.nih.gov/35644533

​

2022: In dogs with red, itchy skin, CBD oil (with no THC in it) was well-tolerated & decreased the itchiness
Effects of cannabidiol without delta-9-tetrahydrocannabinol on canine atopic dermatitis: A retrospective assessment of 8 cases
https://pubmed.ncbi.nlm.nih.gov/35368394/

​

2022: In dogs, CBG & CBGA caused no ill effects & CBGA was found to be much more bioavailable

Single dose and chronic oral administration of cannabigerol and cannabigerolic acid-rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation

https://pubmed.ncbi.nlm.nih.gov/35246858/

​

2022: In dogs being fed CBD treats, it did not lower their immune response to a novel antigen

Feeding treats containing cannabidiol (CBD) did not alter canine immune response to immunization with a novel antigen

https://pubmed.ncbi.nlm.nih.gov/34953408/

​

2021: In cow & dog heart cells, TRPV1 receptors found
TRPV1 Receptor Identification in Bovine and Canine Mitral Valvular Interstitial Cells
https://pubmed.ncbi.nlm.nih.gov/34564577/

​

2021: In dogs with skin allergies, a mixture including cannabinoids downregulated their inflammatory genes
Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis
https://pubmed.ncbi.nlm.nih.gov/33763461/

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2021: In dogs with irritated intestines, the levels of endocannabinoids such as 2AG, PEA & OEA may be a diagnostic marker
Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study
https://pubmed.ncbi.nlm.nih.gov/34124221/

​

2021: In the blood of dogs, they measured the absorption of CBD & found it to be anti-inflammatory & immuno-modulating

Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood
https://pubmed.ncbi.nlm.nih.gov/34564578

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2021: In dogs, no drug-drug interactions found between CBD & phenobarbital

Drug-drug interaction between cannabidiol and phenobarbital in healthy dogs

https://pubmed.ncbi.nlm.nih.gov/34727050

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2021: In canines, the researchers looked at how 3 weeks of CBD treats altered the dog’s metabolomics

Alteration of the Canine Metabolome After a 3-Week Supplementation of Cannabidiol (CBD) Containing Treats: An Exploratory Study of Healthy Animals

https://pubmed.ncbi.nlm.nih.gov/34336977/

 

2021: In dogs, feeding them CBD treats had no effect on their daily voluntary activity in this well-designed study & might have helped with their itchy skin

Feeding Cannabidiol (CBD)-Containing Treats Did Not Affect Canine Daily Voluntary Activity

https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1042&context=animalsci_facpub

​

2021: In 20 healthy adult beagles, a month of CBD was safe & well-tolerated

Randomized, placebo-controlled, 28-day safety and pharmacokinetics evaluation of repeated oral cannabidiol administration in healthy dogs

https://pubmed.ncbi.nlm.nih.gov/33904801/

​

2021: In dogs living in a shelter, cannabis helped to lower aggressive behavior towards humans

Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs

https://pubmed.ncbi.nlm.nih.gov/33531559/

​

2021: This study looking at the safety of CBD & THC in cats found both to be safe - and CBD to be especially safe

Safety and tolerability of escalating cannabinoid doses in healthy cats

https://pubmed.ncbi.nlm.nih.gov/33769105/

​

2020: After looking in the mouths of cats with chronic gingivostomatitis (a disease with intense oral pain), the upregulation of cannabinoid receptors suggest the ECS as a therapeutic target

Expression of cannabinoid and cannabinoid-related receptors in the oral mucosa of healthy cats and cats with chronic gingivostomatitis

https://pubmed.ncbi.nlm.nih.gov/33174485/

​

2020: In the guts of cats, where the cannabinoid receptors are located

Localization of cannabinoid and cannabinoid related receptors in the cat gastrointestinal tract

https://www.ncbi.nlm.nih.gov/pubmed/32095931

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2020: In dogs with colon problems being treated by probiotics, they had decreased numbers of mast cell & increased levels of CB1 & CB2
Enterocolic increase of cannabinoid receptor type 1 and type 2 and clinical improvement after probiotic administration in dogs with chronic signs of colonic dysmotility without mucosal inflammatory changes
https://pubmed.ncbi.nlm.nih.gov/31495983/

​

2020: A safety study of CBD & THC levels in dogs found only the usual mild adverse events with the CBD being the most tolerated
Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs
https://pubmed.ncbi.nlm.nih.gov/32118071/

​

2020: In dogs a 1:20 THC:CBD extract & the pharmacokinetics examined – tolerance seemed to develop to neurological effects
Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Cannabis Herbal Extract in Dogs
https://pubmed.ncbi.nlm.nih.gov/33134364/

​

2020: In dogs, CBD treats helped with their fear response to loud noises

The Impact of Feeding Cannabidiol (CBD) Containing Treats on Canine Response to a Noise-Induced Fear Response Test

https://pubmed.ncbi.nlm.nih.gov/33195551/

​

2020: Great pilot study in 32 dogs with osteoarthritis finds that CBD-rich hemp extracts help almost all of them with their pain & allowed almost all of them taking gabapentin to reduce or eliminate that drug

The Use of Cannabidiol-Rich Hemp Oil Extract to Treat Canine Osteoarthritis-Related Pain: A Pilot Study

https://www.semanticscholar.org/paper/The-Use-of-Cannabidiol-Rich-Hemp-Oil-Extract-to-A-Kogan-Hellyer/94d216f37b94965863e33bda278cb31adcf1f5ea?p2df

​

2020: A placebo-controlled study of arthritic dogs found that CBD oil significantly helped with pain & quality of life

Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/32858828/

​

2020: In applying cannabinoids topically to beagles, the THCA & CBDA were absorbed better through the skin than the THC & CBD

Serum cannabidiol, tetrahydrocannabinol (THC), and their native acid derivatives after transdermal application of a low-THC Cannabis sativa extract in beagles

https://pubmed.ncbi.nlm.nih.gov/32735381/

​

2020: In dogs, a case study suggests combing CBD with NSAIDs for osteoarthritis

Does the addition of cannabidiol alongside current drug treatments reduce pain in dogs with osteoarthritis?

https://veterinaryrecord.bmj.com/content/186/15/493.abstract

​

2020: This double-blind study in dogs finds CBD helpful for the pain of osteoarthritis

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

https://www.ncbi.nlm.nih.gov/pubmed/32345916

​

2020: In dogs, a look at how Sativex (the 1:1 THC/CBD drug) enters the body

Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders

https://www.ncbi.nlm.nih.gov/pubmed/32054131

​

2019: In dogs with itchy allergic skin from dust mites, a topical endocannabinoid membrane transporter inhibitor caused significant protection from itchiness & allergic flares
Double blinded, vehicle controlled, crossover study on the efficacy of a topical endocannabinoid membrane transporter inhibitor in atopic Beagles
https://pubmed.ncbi.nlm.nih.gov/31446453/

​

2019: In cats & dogs, a positive 12-week safety study on CBD0rich hemp extracts

Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats

https://pubmed.ncbi.nlm.nih.gov/31635105/

​

2019: In the cervical ganglia of the sympathetic nervous system in dogs, they had CB1, CB2, TRPV1, GPR55 & PPARα receptors
Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia
https://pubmed.ncbi.nlm.nih.gov/31608295/

​

2019: In cats with sensitive itchy skin, PEA lowered their itchiness
Effect of dietary supplementation with ultramicronized palmitoylethanolamide in maintaining remission in cats with nonflea hypersensitivity dermatitis: a double-blind, multicentre, randomized, placebo-controlled stud
https://pubmed.ncbi.nlm.nih.gov/31237065/

​

2019: A case study of using CBD for a dog with anxiety & a cat with epilepsy
CBD case studies: anxiety and epilepsy
https://ivcjournal.com/CBD-case-studies

​

2019: In dogs with seizures, 12 weeks of CBD lessened seizures (26 dogs in randomized blinded controlled clinical trial)

Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy

https://pubmed.ncbi.nlm.nih.gov/31067185/

​

2019: In dogs being fed a high fat diet, blocking the CB1 receptor increased genes related to fat beiging & the improvement of metabolic homeostasis
Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs
https://pubmed.ncbi.nlm.nih.gov/31237449/

​

2019: In three dogs with epilepsy, CBD helped two of them

Cannabidiol as a potential anti-epileptic dietary supplement in dogs with suspected epilepsy: three case reports

https://www.researchgate.net/publication/332361943_Cannabidiol_as_a_potential_anti-epileptic_dietary_supplement_in_dogs_with_suspected_epilepsy_three_case_reports

​

2018: TRPV1 receptors found in canine skin stem cells
Expression of functional TRPV1 receptor in primary culture of canine keratinocytes
https://pubmed.ncbi.nlm.nih.gov/30043987/

​

2018: in the guts of dogs, a wide distribution of CB1, CB2, GPR55 & PPARα
Localization of cannabinoid receptors CB1, CB2, GPR55, and PPARα in the canine gastrointestinal tract
https://pubmed.ncbi.nlm.nih.gov/29882158/
 

2018: In dogs & cats with skin allergies, they had higher levels of CB1 & CB2 as well as PPARα
Cannabinoid receptor types 1 and 2 and peroxisome proliferator-activated receptor-α: distribution in the skin of clinically healthy cats and cats with hypersensitivity dermatitis
https://pubmed.ncbi.nlm.nih.gov/29920828/

​

2018: Efficacy of CBD for arthritis in dogs

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

https://pubmed.ncbi.nlm.nih.gov/30083539/

​

2018: Pharmacokinetics of CBD in healthy dogs

Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs

https://pubmed.ncbi.nlm.nih.gov/30026641/

​

2017: In cats, the CB1 receptors play an important role in the neuromodulation of bladder overactivity
Role of cannabinoid receptor type 1 in tibial and pudendal neuromodulation of bladder overactivity in cats
https://pubmed.ncbi.nlm.nih.gov/27927655/

​

2017: The location of CB1 & FAAH in the ovaries of cats
Spatial distribution of cannabinoid receptor 1 and fatty acid amide hydrolase in the cat ovary and oviduct
https://pubmed.ncbi.nlm.nih.gov/28478955/

​

2017: In dogs with osteoarthritis, they had all the major endocannabinoids in their knee joints & a significant increase of oleamide & 2AG
Characterization of endocannabinoids and related acylethanolamides in the synovial fluid of dogs with osteoarthritis: a pilot study
https://pubmed.ncbi.nlm.nih.gov/29110674/

​

2017: In a canine model of ALS, they had higher CB2 levels in their astrocytes
Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis
https://pubmed.ncbi.nlm.nih.gov/28069688/

​

2017: In a canine model of itchy skin, PEA reduced mast cells & histamine as well as reducing vasodilation

Ultramicronized palmitoylethanolamide counteracts the effects of compound 48/80 in a canine skin organ culture model
https://pubmed.ncbi.nlm.nih.gov/28585337/

​

2017: A map of the CB1 receptors of a dog’s nervous system
Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system
https://pubmed.ncbi.nlm.nih.gov/28700706/
 

2016: In a canine skin stem cell model of skin allergies, adelmidrol (a PEA analog) increases the concentration of endocannabinoids & lowered inflammation
Adelmidrol increases the endogenous concentrations of palmitoylethanolamide in canine keratinocytes and down-regulates an inflammatory reaction in an in vitro model of contact allergic dermatitis
https://pubmed.ncbi.nlm.nih.gov/26639824/

​

2016: In dogs with chronic inflammation, adelmidrol (a PEA analog) reduced pain and inflammation via the PPARγ receptor
Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of acute and chronic inflammation
https://pubmed.ncbi.nlm.nih.gov/27599446/

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2016: In dogs, CB1 receptors & FAAH enzymes are found in the claustrum (wall of the brain)
Immunohistochemical distribution of the cannabinoid receptor 1 and fatty acid amide hydrolase in the dog claustrum
https://pubmed.ncbi.nlm.nih.gov/26907575/

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2015: In dogs being fed fats, blocking their CB1 receptor enhanced their liver insulin clearance as well as changing gene expression of adiponectin receptors
CB1R antagonist increases hepatic insulin clearance in fat-fed dogs likely via upregulation of liver adiponectin receptors
https://pubmed.ncbi.nlm.nih.gov/26306598/

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2015: In dogs with itchy skin, oral ultra-micronized PEA decreased itchiness & skin lesions
Efficacy of ultra-micronized palmitoylethanolamide in canine atopic dermatitis: an open-label multi-centre study
https://pubmed.ncbi.nlm.nih.gov/26283633/

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2015: In canine embryos, they had CB1 receptors in their epithelial. nervous system, inner ear, olfactory epithelium, eye & thyroid
Preferential epithelial expression of type-1 cannabinoid receptor (CB1R) in the developing canine embryo
https://pubmed.ncbi.nlm.nih.gov/26702393/

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2014: In dogs with itchy skin, they had higher levels of PEA & mast cells
Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis
https://pubmed.ncbi.nlm.nih.gov/24423192/

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2013: In dogs with seizures, they had higher levels of anandamide with a severity response linked to endocannabinoid concentrations
Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder
https://pubmed.ncbi.nlm.nih.gov/24370333/

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2013: In dog eyes, a THC solution reduced their intraocular pressure
Effects of a topically applied 2% delta-9-tetrahydrocannabinol ophthalmic solution on intraocular pressure and aqueous humor flow rate in clinically normal dogs
https://pubmed.ncbi.nlm.nih.gov/23363354/

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2012: In obese dogs being fed a high fat diet, blocking the CB1 receptor restored their sensitivity to insulin but not to reduced fat mass
CB(1) antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs
https://pubmed.ncbi.nlm.nih.gov/22374758/

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2012: Finding CB1 in dog hair follicles
Identification of cannabinoid type 1 receptor in dog hair follicles
https://pubmed.ncbi.nlm.nih.gov/21414652/

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2012: In dogs with skin allergies, they had higher levels of CB1 & CB2
Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis
https://pubmed.ncbi.nlm.nih.gov/22738050/

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2012: In dogs with skin allergies, PEA reduced wheals (red marks) & inflammation markers
Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs
https://pubmed.ncbi.nlm.nih.gov/21601500/

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2012: In dogs with skin allergies, the PEA analog adelmidrol reduced wheals (swollen marks) & reduced mast cells
Inhibitory effect of topical adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis
https://pubmed.ncbi.nlm.nih.gov/23181761/

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2011: In dogs the safety of a CB1 antagonist/inverse agonist that decreased weight gain without affecting appetite or causing adverse health effects
Safety evaluation and treatment affect of LY2190416, a CB-1 antagonist/inverse agonist in growing beagle dogs
https://pubmed.ncbi.nlm.nih.gov/21323931/

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2011: Finding the CB2 receptor in dogs
Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor
https://pubmed.ncbi.nlm.nih.gov/21871882/

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2010: In obese dogs being fed a high fat diet, blocking the CB1 receptor led to acute weight loss
CB-1 antagonism with LY2190416 results in acute weight loss in obese adult dogs fed a high-fat diet
https://pubmed.ncbi.nlm.nih.gov/21108507/

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2010: In dogs, finding CB1 in their salivary glands with a possible control of salivary secretion
Immunohistochemical localization of CB1 receptor in canine salivary glands
https://pubmed.ncbi.nlm.nih.gov/20437096/

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2010: In dog skin mast cells, PEA reduced histamine & inflammatory cytokines
Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells
https://pubmed.ncbi.nlm.nih.gov/19625089/

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2009: In dogs & humans, THC reduced acid reflux rates & spontaneous swallowing as well as significantly reducing lower throat sphincter pressure
Effect of delta9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans
https://pubmed.ncbi.nlm.nih.gov/19068079/

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2009: In dogs being fed a high fat diet, blocking the CB1 receptor caused a reduction in body weight but no changes in metabolic rate or food intake
Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs
https://pubmed.ncbi.nlm.nih.gov/19366874/

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2008: On dog skins, a PEA analog improved wound healing via the mast cells
Mast cell morphometry and densitometry in experimental skin wounds treated with a gel containing adelmidrol: a placebo controlled study
https://pubmed.ncbi.nlm.nih.gov/25942520/

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2006: In canine kidney cells, anandamide raised calcium levels
Effect of anandamide on cytosolic Ca(2+) levels and proliferation in canine renal tubular cells
https://pubmed.ncbi.nlm.nih.gov/16623868/

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2005: On the TRPV1 in dogs
Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1)
https://pubmed.ncbi.nlm.nih.gov/15878709/

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2002: In a dog model of acid reflux, activating the cannabinoids receptor inhibits their relaxations probably via the brainstem
Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs
https://pubmed.ncbi.nlm.nih.gov/12360475/

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2001: In a cat bone marrow cell model of HIV, activating the cannabinoid receptors inhibited nitric oxide production
Cannabinoids inhibit nitric oxide production in bone marrow derived feline macrophages
https://pubmed.ncbi.nlm.nih.gov/11587735/

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2001: In cats with skin lesions, an analog of PEA caused skin improvements & a lower number of granules but no change in mass cell numbers
Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study
https://pubmed.ncbi.nlm.nih.gov/11301536/

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1999: In the artery muscles of a cat’s brain, activating the CB1 receptor lowered calcium channel activity & increased blood flow to the brain
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current
https://pubmed.ncbi.nlm.nih.gov/10362691/

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1995: First identification of 2-AG in dog guts
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
https://pubmed.ncbi.nlm.nih.gov/7605349/

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1991: In dogs, rats & man, the difference in metabolizing CBD
Comparative metabolism of cannabidiol in dog, rat and man
https://pubmed.ncbi.nlm.nih.gov/1806942/

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1991: Looking at CBD metabolites in dog, rat & man
Urinary metabolites of cannabidiol in dog, rat and man and their identification by gas chromatography-mass spectrometry
https://pubmed.ncbi.nlm.nih.gov/2026700/

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1990: In dogs, the metabolites of CBD
Identification of urinary metabolites of cannabidiol in the dog
https://pubmed.ncbi.nlm.nih.gov/1981704/

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1988: On how CBD is absorbed by dogs

Pharmacokinetics of cannabidiol in dogs

https://www.ncbi.nlm.nih.gov/pubmed/2900742

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1986: Cats & CBD’s central motor neuron effects

Cannabidiol-caused depression of spinal motoneuron responses in cats

https://pubmed.ncbi.nlm.nih.gov/3018797/

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1975: In anesthetized dogs, the heart & lung effects of CBD
Cardiopulmonary effects of cannabidiol in anesthetized mongrel dogs
https://pubmed.ncbi.nlm.nih.gov/238308/

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