Research Roundup: July 6, 2026
- Jul 6
- 3 min read
Best of cannabinoid science this week...
In people with mental health problems from tuberous sclerosis complex (a disease of many benign tumors), 6 months of CBD improved eating, sleeping, irritability & manic behavior as well as took the number of people with severe behavior problems from 50% to 0%
Tuberous Sclerosis Complex (TSC)-Associated Neuropsychiatric Disorders (TAND) Outcomes Following Adjunctive Cannabidiol (CBD) Treatment: 6-Month Intermediate Analysis of the EpiCom Trial (S5.005)
In people with fibromyalgia, a 1:1 THC:CBD oil reduced pain, improved sleep quality & reduced fibromyalgia impact
Feasibility, Safety and Preliminary Efficacy of 1:1 THC:CBD Cannabis Oil for Fibromyalgia Symptoms: Results From a Randomised, Double-Blind, Placebo-Controlled Pilot Trial
In the real-world use of cannabis oil, people reported better quality of life & sleep
Real-World Quality of Life and Sleep Outcomes in Patients Treated With THC-and CBD-Rich Cannabis Oil: A Cross-Sectional Study
In the largest study from a state-run medical cannabis program on pain symptoms: people in Minnesota who used medical cannabis for four months reported improvements to life enjoyment, activity interference & pain scores
Benefits of Medical Cannabis in Patients With Pain Registered in the Minnesota Medical Cannabis Program
In people with cancer, a blinded study comparing 4 days of sublingual THC, CBD or placebo found that half getting cannabinoids achieved their primary outcome: Patient Global Impression of Change (predominantly sleep, tiredness & anxiety)
Comparing cannabinoid extracts for treating cancer-related symptoms: a randomized placebo-controlled, triple-blind aggregate n-of-1 clinical trial
For Parkinson's disease, self-titrated medical cannabis oil caused improvements on the non-motor symptoms scale, the pain scale, the sleep scale, the urinary scale & the quality of life scale, with decreased nighttime urinary frequency
Exploratory Prospective Study of Self-Titrated Medical Cannabis for Nonmotor Symptoms in Parkinson’s Disease
In children with drug-resistant epilepsy, a French observational study found significant improvements to behavior, well-being, cognition, physical activities & social interaction as well as a 50+% seizure reduction in two-thirds of patients
Impact of Cannabidiol on Quality of Life and Seizure Control in Children with Drug-Resistant Epilepsy: A Retrospective Observational Study
In treatment-resistant epilepsies, a meta-analysis found CBD significantly improved the rates of seizure freedom & responder rates
Cannabidiol in Refractory Epilepsy: Meta-analysis of Seizure Freedom and Responder Rates Across Syndromes (P8-11.001)
In kids with epilepsy, CBD isolate not only reduced their seizure frequency but also their anxiety symptoms, with greater blood levels of the endocannabinoid 2-AG associated with greater reductions in anxiety symptoms
Preliminary Prospective Study of Pharmaceutical-grade Cannabidiol for Seizure Frequency and Comorbid Anxiety Symptoms in Pediatric Epilepsy: Associations with Circulating Endocannabinoids and Related Lipid Biomarkers (P3-8.005)
In people with epilepsy, CBD combined well with a ketogenic diet & was more effective when CBD was initiated first
Combination Cannabidiol and Ketogenic Diet Therapy in Epilepsy (P3-10.005)
For arthritis & CBD, a review of the clinical & preclinical evidence of its painkilling potential being “comparable to other types of medications with low to no detrimental effects”
Therapeutic Potential of Cannabidiol for Pain Management in Arthritis: Evidence from Clinical and Preclinical Studies
For CBD & inflammation, a great review on how it targets the NLRP3 inflammasome (love the charts!)
Cannabidiol as a modulator of NLRP3 inflammasome: Mechanistic insights and therapeutic potential
In bruxism (tooth grinding, mostly at night), a review on the potential of targeting the endocannabinoid system
ENDOCANNABINOID SYSTEM MODULATION IN BRUXISM: A NEUROBIOLOGICAL HYPOTHESIS AND TRANSLATIONAL MODEL OF ECS-TARGETED INTERVENTION
In a male rat model of sexual inhibition, CBD acutely caused sexually satiated rats to increase their sexual motivation & reverse their sexual inhibition, while chronically, CBD had no negative effects on male sexual behavior (#sex)
Cannabidiol has facilitative effects on sexual motivation of sexually inhibited male rats
In a mouse model of age-associated cognitive decline, CBD reversed the mood & memory deficits, restored levels of cannabinoid receptors, lessened inflammatory signaling & normalized neurotransmitter balance in the medial prefrontal cortex
Cannabidiol rescues age-associated cognitive decline in mouse model
In a rat model of Alzheimer's disease, THC improved cognitive performance, prevented cell loss & increased markers of neurogenesis (the creation of new brain cells)
Delta-9-tetrahydrocannabinol delineates D-galactose and aluminium chloride-induced cognitive dysfunction and neurodegeneration in the hippocampus of the Wistar rat model
In a mouse model of a drug-resistant severe childhood epilepsy, CBD reduced seizures & infantile spasms
Cannabidiol reduces atypical absence seizures and epileptic spasms in a Gabrb3+/D120N mouse model of Lennox-Gastaut syndrome
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