Research Roundup: June 16, 2026
- Jun 12
- 1 min read
Best of cannabinoid science this week...
In people with chronic low back pain, 5 years of inhaled cannabis was associated with "large, sustained, and statistically robust improvements in pain, disability, and pain interference, accompanied by near-total displacement of opioids, NSAIDs, antidepressants, and gabapentinoids"
Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients
For people with pain after a knee replacement, a 25:1 CBD:THC oil reduced levels of moderate to severe pain over the next 26 weeks
Cannabis to Reduce Chronic Postsurgical Pain Following Total Knee Arthroplasty: A Pilot Randomized Controlled Trial
For inflammatory bowel diseases, a review of 8 trials on THC-rich cannabis
Effectiveness of THC-containing cannabis for inflammatory bowel disease: a systematic review
In a rat model of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as fatty liver disease), cannabis oil lessened the inflammation, liver scarring & other negative effects
Cannabis oil prevents early hepatic fibrosis, inflammation and endothelial dysfunction in a sucrose-rich dietinduced MASLD model: role of cannabinoid receptors
In a rat model of Alzheimer's disease, CBD improved spatial learning, memory & levels of tau in the hippocampus (a memory center of the brain)
Cannabidiol attenuates tau hyperphosphorylation and cognitive deficits in an experimental model of Alzheimer's disease and is associated with restoration of PP2A expression
In a rat model of obesity, CBG lowered the influx of fatty acids, protected against excess lipids & improved antioxidant defenses in the mitochondria (powerhouse of the cell)
Cannabigerol Alleviates Obesity-Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling
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