Research Roundup: June 2, 2026
- Jun 1
- 2 min read
Best of cannabinoid science this week...
In people with multiple sclerosis using cannabinoids, a meta-analysis of 20 studies found significant reductions in pain intensity, spasticity severity & disability
Efficacy of Sativex® on pain, spasticity, and disability in patients with multiple sclerosis: A systematic review and meta-analysis
In people with chronic pain using methadone for their opioid use disorder, CBD helped with pain at lower doses
An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol
For CBD & drug-resistant epilepsy, a meta-analysis of 7 trials found it caused clinically meaningful reductions in seizures with an acceptable safety profile
Adjunctive Cannabidiol for Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
And in pediatric epilepsy, CBD reduced epilepsy severity, seizures, medication use, emergency visits & hospitalizations
Effectiveness and tolerability of cannabidiol in paediatric epilepsy: a one-year multisite prospective study
For chronic pain due to fibromyalgia or arthritis, 12 weeks of different combinations of cannabinoids (including CBD, THC, CBDA, CBG & CBC) had beneficial effects
Assessing the Efficacy of Cannabinoid Compositions for Treating 3 Classes of Chronic Pain: A Real-World Evidence Study
For cannabis use among couples, interviews with South Asian people on the effects on their relationship
And they lived happily ever after? Experiences of couples affected by marijuana use explored using Rogers’ tentative law of interpersonal relationships
For neuroinflammation, a review of the effects of various cannabinoids
Effects of phytocannabinoids, synthetic and semi-synthetic cannabinoids on microglia and astrocytes: Review of neuroinflammatory mechanisms
For gum disease & CBD, a review found that it modulated inflammatory signaling, reduced bone loss & caused antimicrobial & antibiofilm (slimy aggregations that resist treatment) effects against oral microorganisms
Cannabidiol in Periodontal Therapy—Is There Hope or Just a Bias? A Systematic Review
For different types of pain, a review on targeting the endocannabinoid system
Endocannabinoid system modulation in acute, chronic, and neuropathic pain: reviewing experimental models, clinical evidence, and nanotechnology delivery
In a rat model of inflammatory pain, CBD, CBN & THCV reduced the hypersensitivity
Effect of cannabidiol, cannabinol and tetrahydrocannabivarin in managing inflammatory pain
In a mouse model of muscle atrophy, CBD lessened the muscle mass loss, reduced the oxidative stress & restored markers of the mitochondria (powerhouse of the cell)
Protective Effects of the Phytocannabinoid Cannabidiol on Disuse-Induced Muscle Atrophy through Modulation of Proteolysis and Mitochondrial Regulation
In a rat model of testicular dysfunction due to a high-fat diet, the terpene beta-caryophyllene restored sperm count & sperm motility as well as elevating testosterone levels
β-caryophyllene mitigates high fat diet-induced testicular dysfunctions by targeting JNK/ERK-1 and JAK-1/STAT-3 pathways in rats
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