Research Roundup: May 26, 2026
- 2 hours ago
- 4 min read
Best of cannabinoid science this week...
Among people using cannabis for sleep, the majority reported that it helped improve sleep quality & duration, though they had an association with cannabis use disorder
1034 Racial/Ethnic Differences in Cannabis Use Disorder Among Sleep-Motivated Cannabis Consumers Across Two Age-Distinct Cohorts
In people with sciatica-related back pain, PEA caused significant reductions in pain & improvements to daily functioning
Water-Dispersible Palmitoylethanolamide (PEA) Supplementation for Functional Improvement in Adults With Chronic Sciatica-Related Back Pain: A Pilot Clinical Trial
For neuropathic facial pain, a case report of 2 females with a balanced THC:CBD formulation who experienced a marked painkilling response, improved functional performance & improved scores in physical domains & psychological well-being
Cannabinoid Therapy for Refractory Trigeminal Neuropathic Pain: Quantification of Somatosensory Alterations (QualST) by 3D Stereophotogrammetry—Two Case Reports
In people with arthritis, a survey found that they used cannabis to help with their pain & replace their painkilling medications
Perceptions regarding the use of cannabis in orthopaedics for treating musculoskeletal joint pain: A survey of arthritis patients
In children & adults with epilepsy, a combination of CBD & a ketogenic diet had a 30-40% responder rate, with more improved outcomes associated with starting CBD before the ketogenic diet
Concurrent use of ketogenic diet therapy and cannabidiol in children and adults with epilepsy: A multicenter retrospective cohort study
For people microdosing cannabis, psychedelics & MDMA, a survey on their reasons (for cannabis, it was pain)
Prevalence and Reasons for Microdosing Cannabis, Psilocybin, LSD, and MDMA Among US Adults
For intraocular pressure, a meta-analysis of 5 studies found THC reduced it via the oral or topical route
Intraocular pressure-lowering effects of tetrahydrocannabinol drugs: a systematic review and meta-analysis
For non-fatal opioid poisonings, in public health data from US people with employer-sponsored insurance, medical cannabis dispensaries & adult-use cannabis laws were associated with reduced non-fatal opioid poisonings
The association between state cannabis legalization and non-fatal opioid poisonings among adults with employer-sponsored insurance in the United States
For feline gingivostomatitis (a mouth & gum infection of swelling & sores), a case report where broad-spectrum CBD oil caused reduced inflammation, fewer ulcers & a marked improvement in the oral cavity, with the main negatives being sleepiness, diarrhea & decreased food intake
Cannabidiol Oil for Feline Gingivostomatitis Complex: A Case Report
In people with gastroparesis (delayed gastric emptying), a review of 38 studies found cannabinoids improved total symptom scores & caloric intake even while paradoxically slowing gastric emptying
Cannabis-Based Medicines in Gastroparesis and Related Syndromes
In wound healing, a review of 18 studies found topical cannabis or CBD hydrogels improved collagen formation, the development of new blood vessels & wound closure
Cannabis sativa (Vijaya) in Wound Healing: A Systematic Review of Preclinical and Clinical Evidence
For autoimmune diseases, a review of the potential of cannabinoids
Cannabinoids in autoimmune diseases: mechanistic insights and translational challenges
For adolescent psychiatry, a review on using CBD
Integrating Cannabidiol into Adolescent Psychiatry: Clinical Applications and Safety-Risk Profile for Treatment of Anxiety, Depression, and Post-traumatic Stress Disorder
For neurodegenerative diseases, a review of the cannabinoids helping via the microglia (guardian immune cells of the brain)
Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration
In traumatic brain injury, a review on modulating the endocannabinoid system
Molecular and Genetic Mechanisms of Traumatic Brain Injury: The Endocannabinoid System as a Modulatory Axis
In sepsis (an immune system overreaction to an infection), a review of targeting the endocannabinoid system for the dysfunctions of the microvascular system (small blood vessels)
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review
In a rat model of phantom limb pain, the combination of CBD, THC & beta-caryophyllene lowered immune system reactivity, lessened inflammation & decreased pain via inhibition of GABA (the brain's most common inhibitory neurotransmitter) in the spinal cord
Targeting Phantom Limb Pain with Cannabinoids in a Rat Model
In a mouse model of diet-induced obesity, THC as well as cannabis extracts reduced body weight & fat mass & normalized adipokines (cytokines from fat cells), while cannabis extracts (but not THC) also normalized glucose clearance
Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity
In a mouse model of intestinal stem cells damaged by radiation (as in cancer treatment), CBD rescued the dysregulation of their fatty acids & enhanced their proliferation
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation
In a mouse model of diet-induced obesity, THC as well as cannabis extracts reduced body weight & fat mass & normalized adipokines (cytokines from fat cells), while cannabis extracts (but not THC) also normalized glucose clearance
Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity
In a mouse model of intestinal stem cells damaged by radiation (as in cancer treatment), CBD rescued the dysregulation of their fatty acids & enhanced their proliferation
Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation
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