Research Roundup: Mar 3, 2026
- Mar 2
- 3 min read
Best of cannabinoid science this week...
For chronic lower back, a center’s analysis of 10 years of data found that cannabis reduced pain intensity, functional disability & opioid use
Ten-Year Outcomes of Medical Cannabis for Chronic Low Back Pain: Opioid Reduction, Pain Relief, and Functional Improvement in 1,000 Patients
In cancer patients, 12 weeks of guided cannabis care caused significant improvements to pain, sleep, anxiety & GI symptoms
Guided cannabis care and improvements in PROMIS metrics among cancer patients: a prospective assessment
In people with chronic orofacial pain from temporomandibular disorder (a cluster of jaw problems), a 1:1 THC:CBD extract improved pain, muscle sensitivity & mouth function
Effect of Δ9-tetrahydrocannabinol and cannabidiol on myofascial pain modulation in patients with temporomandibular disorder: a prospective crossover study
In people with mutations in their syntaxin-binding protein-1 (STXBP1, which leads to a wide range of neurodevelopmental disorders), CBD lowered seizure levels & helped with movement disorders
STXBP1 encephalopathy: Cannabidiol as a treatment option and expansion of the genotype-phenotype spectrum- Case reports
In people with obesity, oleoylethanolamide (the endocannabinoid of satiation) altered the gut microbiome, improved the intestinal barrier & reduced inflammation
Oleoylethanolamide supplementation enriches Akkermansia muciniphila and modulates intestinal barrier in adults with obesity: A randomized, double-blind, placebo-controlled trial
In men with a swollen prostate & chronic pelvic pain syndrome, the combination of CBD & hyaluronic acid suppositories reduced pain & improved urination
Cannabidiol-hyaluronic acid combination delivered rectally for attenuating abacterial prostatitis symptoms: Single-arm open-label pilot clinical trial
For sedentary behavior, cannabis use was associated with less sitting time
Ethnic variations in sedentary behavior and marijuana use among U.S. adults: A cross-sectional analysis
For the pharmacokinetics of THC (how they move through the body), a model based on an analysis of 16 studies & various routes of ingestion
A Multi-route, Multi-formulation Population Pharmacokinetic Framework for THC and 11-OH-THC Reflecting Real-World Use
For neuropathic pain from diabetes, a review of 4 studies found pain relief from rather small amounts of THC (16 to 18 mg)
Medical Cannabis for the Treatment of Peripheral Neuropathy due to Diabetes: A Systematic Review
For less common disorders, a review of the efficacy of the cannabinoids
Cannabinoid Therapies in Less-Common Disorders: Clinical Evidence and Formulation Strategies
For oral medicine, a review of the cannabinoids (with a nice timeline of historical cannabis use)
Cannabis in oral medicine: what should we know? -a narrative review
In a female rat model of blunt force trauma to the chest, CBD lowered inflammation & lessened the injuries to the heart & reproductive tissue
Cannabidiol mitigates secondary genital injury after thoracic trauma by regulating systemic inflammation and hormone receptor signaling
In a rat model of neuropathic pain, CBD reduced the self-administration of oxycodone
Cannabidiol reduces oxycodone self-administration while preserving its analgesic efficacy in a rat model of neuropathic pain
In a tissue model of myocarditis (heart inflammation), CBD lowered inflammatory cytokines at low doses but increased them at high doses
The Potential Anti-Inflammatory Effect of Cannabidiol in Autoimmune Myocarditis
In a mouse model of fertility damage due to the chemotherapy treatment paclitaxel, the terpene beta caryophyllene restored antioxidant capacity, suppressed inflammation & apoptosis (programmed cellular suicide) & protected testicular architecture & reproductive function
β-Caryophyllene Protects Male Fertility and Testicular Function Against Paclitaxel-Induced Damage in a Murine Model
For inhibiting voltage-gated sodium channels (vital for the brain’s action potentials & excitability), on the mechanisms of how CBD stabilizes them in their inactive state, thereby suppressing high-frequency firing
From cannabis to conductance: Cannabinoid-inspired strategies for state-selective Nav inhibition
In bone cells, CBD enhanced their differentiation & mineralization
Involvement of AKT/β-catenin in Enhanced Osteogenesis by Cannabidiol in Bone Stromal Cells Harvested from Human Tori
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