Research Roundup: Feb 24, 2026
- 1 day ago
- 4 min read
Best of cannabinoid science this week...
In people with insomnia, 300 mg of CBN increased NREM sleep & subjective sleep quality while reducing the time to get to sleep & nighttime arousal
Cannabinol for Acute Treatment of Insomnia Disorder in a Randomized Placebo‐Controlled Crossover Trial
In people taking THC before bed, they had increased sleep latency (time to sleep), slow wave sleep & reduced heart rate variability
Delta‐9‐Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity
In people with elevated levels of worrying, CBD decreased sleep disturbances
The effects of cannabidiol on sleep disturbances within a sample of high trait worriers: A double-blind, randomized placebo controlled trial
For burning mouth syndrome, cannabis oil caused significant improvements & also reduced anxiety & depression
Evaluating the Suitability and Potential Efficiency of Cannabis sativa Oil for Patients with Primary Burning Mouth Syndrome: A Prospective, Open-Label, Single-Arm Pilot Study
In people with CDKL5 Deficiency Disorder (a severe neurodevelopmental disease of brain swelling, problems in synaptic maturation & persistent motor, cognitive & behavioral impairments), a year of CBD isolate caused the majority to experience a 50+% seizure reduction & for some to show improvements in vigilance, motor performance, sleep & constipation
Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open‐label prospective study
And in a mouse model of CDKL5 Deficiency Disorder, inhibition of the enzyme MAGL (which breaks down the endocannabinoid 2-AG) increased blood levels of 2-AG, caused limited behavioral improvements & partially restored dendritic spine maturation & neuronal survival, with dose-dependent effects on the microglia (guardian immune cells of the brain)
Endocannabinoid Enhancement via MAGL Inhibition in CDKL5 Deficiency: Selective Cellular Benefits and Constrained Functional Impact in Cdkl5 KO Mice
In people with focal drug-resistant epilepsy, those who responded to CBD treatment had improvements in verbal memory, visual memory, language, sustained attention & alternating attention
Analysis of Cognitive Status Before and After Cannabidiol Treatment in Adult Patients with Focal Drug-Resistant Epilepsy
For tobacco use disorder, a meta-analysis of 18 studies found cannabis use associated with 35% lower odds of stopping tobacco smoking, but preclinical evidence that blocking the CB1 receptor reduced nicotine use & CBD use lowered both nicotine use & withdrawal
Cannabis Co-Use and Endocannabinoid System Modulation in Tobacco Use Disorder: A Translational Systematic Review and Meta-Analysis
In people with fibromyalgia, cannabis oil helped with pain
Letter to Editor: real-world use of cannabis oil for pain management in fibromyalgia
For PEA & diabetic neuropathic pain, a meta-analysis of 3 studies found significant reductions in pain scores as well as improvements in sleep quality, depressive symptoms, nerve conduction velocity & vibration perception threshold
Efficacy, safety, and tolerability of palmitoylethanolamide in the management of diabetic neuropathic pain: a systematic review and meta-analysis
For the effects of employee after-work cannabis use, a daily diary study found no link with next-day executive functioning, cognitive engagement or daily task performance
From fried to focused? A daily diary study of after‐work cannabis use and downstream performance effects
In traumatic brain injury, a review on the ability of CBD to protect against neuronal damage, restore the blood-brain barrier & improve cognitive dysfunction
Effect of cannabidiol on traumatic brain injury related neuronal damage pathways: Brain injury and cannabidiol
In cardiac remodeling (heart changes in response to disease) & fibrosis (scarring) after a heart attack or heart disease, a review on cannabinoids helping to reduce fibrosis
The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence
In headache, a review of targeting the endocannabinoid system (with a good chart)
Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies
In autism, a meta-analysis of the reduced endocannabinoid signaling, specifically anandamide, 2-AG & oleoylethanolamide (the endocannabinoid of satiation)
Reduced Endocannabinoid Signaling in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
In the ability of exercise to protect against depression, a review of the endocannabinoid system as a unifying mechanism
Bridging Reward and Resilience: The Endocannabinoid System as a Unifying Mechanism in Exercise-Induced Protection Against Major Depressive Disorder
In a rat model of cognitive impairment & neuropathic pain, cannabis extract lowered pain & combined well with donepezil or tramadol for neuroprotective effects, especially in the hippocampus (a memory center of the brain)
Therapeutic relevance of an EU-GMP certified Cannabis sativa L. strain in a dual in vivo model of cognitive impairment and chronic neuropathic pain
In obese male rats, a combination of exercise & cannabis extracts improved PI3K/Akt/mTOR signaling in the pancreas
The Effect of Resistance Training and Cannabis Extract Supplementation on the Expression of PI3K/Akt/mTOR Signaling Pathway Genes in the Pancreas of Obese Male Rats
In a female mouse model of alcohol binging due to social stress, oleoylethanolamide (the endocannabinoid of satiation) reduced alcohol consumption to baseline levels & lowered neuroinflammation, particularly in the hippocampus (a memory center of the brain)
OLEOYLETHANOLAMIDE MITIGATES BINGE-LIKE ETHANOL CONSUMPTION AND NEUROINFLAMMATION INDUCED BY SOCIAL STRESS IN FEMALE MICE
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