Research Roundup: Jan 27, 2026
- Lex Pelger
- 6 days ago
- 4 min read
Best of cannabinoid science this week...
In women who had surgery for their endometriosis uses, 10 weeks of CBD oil reduced pain & improved psychological symptoms & quality of life measures
Cannabidiol-Enriched Extract Oil for Postoperative Management of Chronic Pelvic Pain Secondary to Endometriosis: A Randomized Clinical Trial—DREAMLAND Study
In children with autism, CBD-rich cannabis significantly improved “anxious-shyness, perfectionism, ADHD index, emotional lability, and hyperactivity-impulsivity” with trends towards improvement in oppositional behavior, cognitive inattention, hyperactivity & inattention scores
CBD-Rich Cannabis Therapy in Children with Autism Spectrum Disorder May Improve Symptoms of Hyperactivity and Attention Deficit: An Open-Label Study
In people with newly diagnosed advanced pancreatic cancer, cannabis substantially improved insomnia, pain & appetite loss
Pilot Randomized Trial of Medical Cannabis to Reduce Symptom Burden in Patients With Newly Diagnosed Advanced Pancreatic Cancer (CanPan)
And in Maine cancer healthcare providers, a survey about cannabis found the majority agreed it can be effective for managing symptoms
Survey of MaineHealth Cancer Care Network Providers on Cannabis Use: Preparation for Studies Sponsored by the National Cancer Institute
For depression, the UK Medical Cannabis Registry found that the initiation of cannabis-based medicinal products to be associated with improvements in severe anxiety & depression severity
UK Medical Cannabis Registry: A two-year case series of clinical outcomes in depression
For cannabis & health-related quality of life, data from the UK Medical Cannabis Registry found over 70% experienced improvements to health quality & 50+% had clinically significant improvements on anxiety & sleep scores
Clinical Outcomes and Patient Profiles in the UK Medical Cannabis Registry: A k-Means Clustering Analysis
In veterans with Gulf War Illness, 10 weeks of 400 mg of oleoylethanolamide (the endocannabinoid of satiation) reduced fatigue & improved mood disturbance scores with participants reporting increased energy, emotional well-being & social functioning
Oleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial
In people with olfactory dysfunction from COVID, a meta-analysis of PEA & luteolin (a flavonoid commonly paired with PEA) found significant improvements in olfactory scores
P-1648. Efficacy of Co-Ultramicronized Palmitoylethanolamide With Luteolin for Managing Post-COVID-19 Persistent Olfactory Dysfunction: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
For restless leg syndrome, a case report of treating it with PEA
Palmitoylethanolamide (PEA) in the treatment of restless legs syndrome: Rationale and case report
For adults substituting cannabis beverages for alcohol, a survey on their reduction of alcohol-related harms
The Exploration of Cannabis Beverage Substitution for Alcohol: A Novel Harm Reduction Strategy
In dogs & cats with joint pain, 6 weeks of PEA caused significant improvements in multiple pain domains, with more help for dogs
Levagen+ (Palmitoylethanolamide) alleviates joint pain and reduces the impact of joint pain in canines and felines: A Double-Blind, Placebo-Controlled, Randomised Clinical Trial
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1703143/abstract
In canine drug-resistant epilepsy, a case report of a dog named Jack using CBD
Cannabidiol in Canine Drug-Resistant Epilepsy. A Comprehensive Case Study of Jack's Journey
On CBD & status epilepticus (seizures of 5+ minutes), a review of 11 papers
Cannabidiol in the treatment of status epilepticus
Abd for complex epilepsies & CBD, a review of 57 studies on reduced seizures, prolonged seizure freedom & mild adverse events & drug interactions
A systematic review of highly purified cannabidiol in developmental and epileptic encephalopathies and complex treatment-resistant epilepsies: Changes in seizure frequency and adverse events
And for CBD & epilepsy, a review on the effects on neuroinflammation
Epilepsy, neuroinflammation and cannabidiol What do we know thus far?
For neurodegenerative diseases, a review on the potential benefits of the cannabinoid, terpenes & flavonoids
Therapeutic Applications of Secondary Metabolites From Cannabis Sativa in Neurodegenerative Diseases
For the acidic cannabinoids, a review on their therapeutic potential
Therapeutic potential of acidic cannabinoids: an update
In a rat model of cerebral vasospasm (intense constriction of brain arteries), CBD reduced severity & improved outcomes
The Effects of Cannabidiol on Vasospasm Induced by Subarachnoid Hemorrhage in Rats
In a mouse model of weight loss from the chemotherapy treatment doxorubicin, THC reduced weight loss & increase the length of the small intestine
Delta-9-Tetrahydrocannabinol alleviates doxorubicin-induced weight loss but does not affect dextran sodium sulphate-induced colitis
In a zebrafish model of amyotrophic lateral sclerosis, a novel cannabinoid formulation altered the transcription of 1576 genes “related to cytokine signaling, extracellular matrix organization, steroid metabolism, calcium-mediated signaling, and PI3K-Akt signaling, suggesting multi-target neuroprotective mechanisms”
Transcriptomic Analysis of a Cannabis-Derived Neuroprotective Therapy in a Zebrafish Model of ALS
In a mouse model of HIV exposure, infection via their mucosal membranes was inhibited by CBD
Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells
In a mouse model of Alzheimer’s disease, PEA lowered neurodegeneration via metabolism of the neurons & astrocytes (the brain’s most common support cell)
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease
In a rat model of autism, the flavonoid cannflavin B lowered most of the behavioral & neuronal alterations
Cannflavin B ameliorates behavioural and neuronal systems alterations in adolescent rats exposed to prenatal valproic acid
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