Research Roundup: Mar 17, 2026
- 14 minutes ago
- 2 min read
Best of cannabinoid science this week...
In older people with chronic pain, a comparison of CBD-rich full-spectrum extracts versus dronabinol (pharmaceutical THC isolate) found that while both caused symptom relief, there were greater improvements & less adverse effects from the full-spectrum extracts
CARE – A Retrospective, Dual-Cohort, 24-Week Real-World Study from the German Pain eRegistry on the Effectiveness and Safety of CBDDominant Oral Cannabis Extracts versus THC/ Dronabinol in Older Patients with Chronic Pain
On substituting cannabis for opioids in chronic pain, the majority of participants decreased their opioid intake by more than half, with additional improvements to sleep quality & physical function
Assessing the efficacy of medical Cannabis as a substitution therapy for opioids in chronic pain management: A comprehensive investigation
In people with anxiety & sleep-related problems, a month of CBD caused majority to have a decrease in anxiety symptoms & two-thirds saw an improvement in their sleep quality
Cannabidiol effects on Anxiety and Insomnia
In people with HIV, the cannabis users had less global neurocognitive deficits & a more anti-inflammatory immunometabolic-phenotype, including less pro-inflammatory cytokines, more anti-inflammatory upregulation, more mitochondria (powerhouse of the cell) & more BDNF (a key brain growth factor)
Cannabis Use by People with HIV is Associated with an Anti-Inflammatory Immunometabolic Phenotype in Monocyte-Derived Macrophages
For people doing aerobic exercise (but not yoga), they had higher blood levels of anandamide, with increases correlated to changes in positive affect
Contributions of yoga and aerobic exercise to acute changes in state affect, circulating BDNF and eCB concentrations, and memory
For pain, a review of cannabis & the endocannabinoid control of pain (good charts)
Beyond the high: Therapeutic insights into Cannabis sativa and endocannabinoid control of pain
For electroacupuncture, on how the endocannabinoids mediated the help for pain & itching
[Progress on the mechanism of endocannabinoids involved in electroacupuncture for analgesia and itch relief]
In veterinary medicine, on the potential uses of CBD
Cannabidiol in veterinary medicine: Therapeutic potential and quality assurance challenges in therapeutic trend products
In a mouse model of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly fatty liver disease), CBD or CBG improved glycemic control, reduced liver fats & normalized blood lipid levels
Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration
In a mouse model of a broken bone, CBC reduced pain but impaired bone healing
Cannabichromene attenuates fracture pain but impairs bone repair in a murine tibial fracture model
In a mouse model of non-alcoholic fatty liver disease, the terpene beta-caryophyllene reduced liver injury markers, oxidative stress, inflammation & scarring via the CB2 receptor
β-caryophyllene mitigates oxidative stress, inflammation and fibrosis by activating cannabinoid-2 receptors in murine model of high-fat diet/streptozotocin-induced nonalcoholic fatty liver disease
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