Research Roundup: Sept 9, 2025
- Lex Pelger
- Sep 9
- 3 min read
Best of cannabinoid science this week...
For complex regional pain syndrome, the UK Medical Cannabis Registry found the initiation of medical cannabis to be associated with reduced pain levels, improvements in anxiety, sleep quality & general health-related quality of life
UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Complex Regional Pain Syndrome
In people with chronic pain, a full-spectrum cannabis extract reduced pain, anxiety, insomnia & lowered or discontinued the use of other painkillers & anti-inflammatory drugs
Effectiveness of Full Spectrum Cannabis Extracts in the Treatment of Chronic Pain: An Open Label Study
In French people with Parkinson's disease, a survey found CBD very effective for sleep disorders, pain & rigidity/cramps
Patterns of Use and Patient-Reported Effects of Cannabinoids in People With PD: A Nationwide Survey
In people with temporomandibular disorders, a CBD topical improved pain, sleep, muscle tension & migraine scores
Expanding the Therapeutic Profile of Topical Cannabidiol in Temporomandibular Disorders: Effects on Sleep Quality and Migraine Disability in Patients with Bruxism-Associated Muscle Pain
For epidermolysis bullosa (a rare genetic skin blistering disease), a survey found some reported pain & itch relief from cannabinoids & the majority reported increased well-being, with the ingestion methods being inhalation, topicals & ingestion
64760 Cannabinoids for Epidermolysis Bullosa Symptom Management: A Survey
In people with endometriosis, a survey found they used it most for pain control & the bothersome side effects of other medications, with their primary source being the black market
'In the weeds': navigating the complex concerns, challenges and choices associated with medicinal cannabis consumption for endometriosis
In pain & anxiety patients, they substituted cannabis for some or all of their prescription medications
Beyond substitution: How medical cannabis patients manage health with cannabis and prescription medications
In people taking HIV antiretroviral therapy, adding cannabinoids increased their serotonin, β-hydroxybutyrate & Ahr signaling while reducing bile acids & acylcholines (signs of lower inflammation & less metabolic dysfunction)
Supplementing HIV-ART with cannabinoids increases serotonin, BHB, and Ahr signaling while reducing secondary bile acids and acylcholines
In people with rare seizure disorders, this cohort study found CBD reduced seizures, with some becoming seizure-free
Use of cannabidiol for off-label treatment of patients with refractory focal, genetic generalised and other epilepsies
For female orgasmic difficulty, a review of 16 studies on the efficacy of cannabis
Cannabis for female orgasmic disorder/difficulty: a systematic review
And this thesis project found cannabis use linked to improved sexual functioning
A Mixed-Methods Investigation of the Relationship between Cannabis and Sexual Functioning Using Incentive Motivational Models
For immune responses, a review on the effects of cannabis (nice charts)
Cannabis and the immune response: A comprehensive review of therapeutic potential and concerns
For autoimmune & rheumatic disorders, a review on the potential of cannabis
Exploring therapeutic potential of Cannabis based therapy in autoimmune and rheumatic disorders
For targeting the cannabinoid receptors, a review of emerging tactics for improving clinical translation
Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success
In a rat model of hernia repair, a CBD-impregnated surgical mesh prevented infections
The Effect of Cannabinoid-Impregnated Mesh on Infection Prevention in Hernia Repair: An Experimental Study in Rats
In a mouse model of rheumatoid arthritis, a high-CBD extract reduced inflammation & modulated immune responses
High CBD extract (CBD-X) modulates inflammation and immune cell activity in rheumatoid arthritis
In a mouse model of obesity from a high-fat diet, dietary CBD reduced body weight & fat gain, lowered glucose & triglyceride concentrations & promoted thermogenesis in fat tissue
Dietary cannabidiol oil mitigates metabolic dysfunction in mice with high-fat diet-induced obesity
In a mouse model of schizophrenia, CBD reversed activation of the microglia (guardian immune cells of the brain) & deficits of the interneurons
Cannabidiol reverses microglia activation and deficits of parvalbumin interneurons and their perineuronal nets in a MK-801-induced mouse model of schizophrenia
In a rat model of methamphetamine use disorder, CBD helped to extinguish their conditioned place preference (a sign of addiction) via dopamine receptors in the hippocampus (memory center of the brain)
D1-like dopamine receptors in the dentate gyrus mediate cannabidiol's facilitation of extinction and prevention of reinstatement in methamphetamine-induced conditioned place preference
In rats, cannabis extracts from the São Francisco valley region of Brazil caused painkilling, anti-inflammatory & anti-dysmenorrheal effects
Antinociceptive, anti-inflammatory, and anti-dysmenorrheal activities of aerial parts of Cannabis sativa L. from the sub-middle region of the Vale do São Francisco
In a tissue model of Parkinson's disease, CBD increased cell viability & decreased apoptosis (programmed cellular suicide) via regulation of genetic transcription & the Nrf2 signaling pathway
Cannabidiol Extracted from Cannabis sativa L. Plant Shows Neuroprotective Impacts Against 6-HODA-Induced Neurotoxicity via Nrf2 Signal Transduction Pathway
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