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Research Roundup: Sep 6, 2022



Best of cannabinoid science this week...


In an analysis of pediatric epilepsy patients using pharmaceutical (isolated) CBD vs artisanal (full-spectrum), the isolated CBD did cause them to have higher levels in the blood, but this only increased side effects while having no effect on seizure frequency Variability in Serum Concentrations and Clinical Response in Artisanal Versus Pharmaceutical Cannabidiol Treatment of Pediatric Pharmacoresistant Epilepsy https://meridian.allenpress.com/jppt/article-abstract/27/6/558/485210/Variability-in-Serum-Concentrations-and-Clinical


A survey found that for people with arthritis & joint pain, they said CBD helped with pain, physical function & sleep as well as a reduction in other medications Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study https://pubmed.ncbi.nlm.nih.gov/35999581


A review of CBD for movement disorders Cannabinoids in movement disorders https://pubmed.ncbi.nlm.nih.gov/36038457


What does PEA do at our synapses that make it effective for neurodegeneration & neuroinflammation? Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders https://pubmed.ncbi.nlm.nih.gov/36009055


In a mouse model of neuropathic pain, CBD caused the morphine’s painkilling to work better & lowered the buildup of tolerance to opioids Cannabidiol enhances the antinociceptive effects of morphine and attenuates opioid-induced tolerance in the chronic constriction injury model https://pubmed.ncbi.nlm.nih.gov/36028000


In rats with a traumatic spinal cord injury, CBD lowered their oxidative stress, reduced their hypersensitivity & lessened pain levels Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury in rats https://pubmed.ncbi.nlm.nih.gov/36028005


In a mouse model of PTSD, CBD helped to lower their fear response & anxiety Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance https://pubmed.ncbi.nlm.nih.gov/36012600


In a mouse model of osteoarthritis, both CBD oil & CBG oil helped with pain & inflammation as well as improved gait & locomotion Distinctive Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis https://pubmed.ncbi.nlm.nih.gov/35994012


In a mouse model of fibromyalgia, low-THC cannabis oil reduced sensitivity to pressure & heat as well as reducing depressive behaviors Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice https://pubmed.ncbi.nlm.nih.gov/35988425


In rats who had spinal fusion surgery, THC increased their fusion rates while CBD had no adverse effect Effects of cannabinoids on spinal fusion in a rat model https://www.sciencedirect.com/science/article/abs/pii/S1529943022004053


In a rat model of nausea from chemotherapy, they experienced benefit from THC,CBD & CBD Acid with no detectable differences between the sexes Evaluation of Sex Differences in the Potential of Δ 9-Tetrahydrocannabinol, Cannabidiol, Cannabidiolic Acid, and Oleoyl Alanine to Reduce Nausea-Induced Conditioned Gaping Reactions in Sprague-Dawley Rats https://pubmed.ncbi.nlm.nih.gov/35984924


Figuring out how THC modifies the glycine receptors – key for motor coordination & pain sensation Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs https://pubmed.ncbi.nlm.nih.gov/35982060