Research Roundup: Dec 8, 2025
- Lex Pelger
- Dec 8
- 3 min read
Best of cannabinoid science this week...
In elite Canadian athletes, a survey found that they used CBD to improve sleep, relax & reduce pain from training
Cannabidiol Use Among Elite-Level Canadian Athletes: The Pursuit of Improved Sleep, Pain Relief, and Enhanced Recovery
In people with autism, cannabis reduced overall symptom severity by ~73%
Acute effects of cannabis on core and co-occurring features associated with autism spectrum disorder in adults
And for autism, a survey of families found that most reported benefits from cannabis, especially for anxiety, sleep & irritability
Autism Spectrum Disorder and Use of Medical Cannabis
And in children with autism, CBD-rich oil helped them taper off other medications
Retrospective Observations from a Pilot Study on the Feasibility and Safety of Medication Reduction or Withdrawal in Children with Autism Spectrum Disorder Taking Cannabidiol-Rich Oil
And for autism, a review on the efficacy of CBD
Use of cannabidiol in the signs and comorbidities in children with Autism Spectrum Disorder: An integrative review
For hypermobile Ehlers-Danlos syndrome & hypermobility spectrum disorder, data from Project Twenty21 found cannabis-based medical products improved symptoms, quality of life & functionality as well as reducing opioid usage
Medicinal cannabis in the treatment of hypermobile Ehlers-Danlos syndrome & hypermobility spectrum disorder: Real-world evidence from Project Twenty21
For people with muscle spasticity, CBD & THC products caused an improvement in sleep disturbance, fatigue, pain interference & pain intensity
Investigating the effectiveness and adverse events of medicinal cannabis for patients with muscle spasticity or spasms
In people undergoing opioid withdrawal due to naloxone, vaped cannabis reduced the severity of withdrawal
The effects of vaped cannabis on the severity of naloxone-precipitated opioid withdrawal
In heavy alcohol drinkers, smoking cannabis reduced their urge to drink & the level of their alcohol consumption
Acute Effects of Cannabis on Alcohol Craving and Consumption: A Randomized Controlled Crossover Trial
After a tooth extraction, higher levels of CBD were as effective for pain relief as the standard non-opioid therapy
Oral Cannabidiol for Acute Post-Extraction Pain: A Randomized Pilot Study
In people with kidney failure, six weeks of CBD reduced symptoms such as pain, anxiety, restless leg syndrome & pruritus (intense itchiness) A Phase 1B Trial of Cannabidiol for Symptom Management in Kidney Failure https://www.sciencedirect.com/science/article/pii/S2468024925007077/
For people with a clinical high-risk for psychosis, 12 weeks of PEA reduced psychotic symptoms, possibly via immune & inflammatory modulations Effects of palmitoylethanolamide in clinical high-risk for psychosis: A nonrandomized open-label trial https://www.sciencedirect.com/science/article/pii/S2666354625001991
For PTSD, ultramicronized PEA reduced PTSD & anxiety symptoms over 18 months via neuroinflammatory & endocannabinoid mechanisms
Targeting PTSD with ultramicronized palmitoylethanolamide: Results from a randomized trial integrating pharmacotherapy and cognitive behavioral therapy
In Alzheimer’s disease, dronabinol (pharmaceutical THC) decreased agitation
A randomized controlled trial of the safety and efficacy of dronabinol for agitation in Alzheimer’s disease
For temporal mandibular disorders (problems of the jaw), a review of 13 studies on the efficacy of cannabinoids
Effects of Cannabinoids Use in Temporomandibular Disorders: A Scoping Review
For obsessive compulsive disorder, a review of the potential of psychedelics & cannabinoids
New treatments for OCD? Evidence for cannabinoids and psychedelics
For endometriosis, a review of THC & CBD
Cannabidiol and ∆9-Tetrahydrocannabinol in Endometriosis: A Literature Review on Therapeutic Applications and Mechanisms
In dentistry, a review on the potential of cannabinoids
Cannabinology in Dentistry: Therapeutic Applications and Future Directions
Comments