Research Roundup: Nov 18, 2025
- Nov 18, 2025
- 5 min read
Best of cannabinoid science this week...
For high blood pressure, 5 weeks of CBD reduced blood pressure levels
The effects of chronic cannabidiol dosing on cardiovascular parameters in primary hypertension: A summary of findings from a randomized controlled trial
In older adults, public health data found current cannabis use not linked to harms in cognition & past use was linked to better performance & slower decline in some cognitive domains
History of cannabis use and cognitive function in older adults: findings from the UK biobank
In people with Alzheimer's disease, a low-dose cannabis extract improved mental state & dementia
A randomized clinical trial of low-dose cannabis extract in Alzheimer's disease
In people with cancer, those taking CBD had improved anxiety scores & those taking cannabis products had improved depression scores
Measuring the Effects of Cannabis on Anxiety and Depression Among Cancer Patients
For multiple sclerosis, the UK Medical Cannabis Registry found that treatment with cannabis-based medicinal products was associated with improvements in health-related quality of life
UK Medical Cannabis Registry: An Updated Analysis of Cannabis-Based Medicinal Products for Multiple Sclerosis
For chronic musculoskeletal pain, a meta-analysis of 5 trials found cannabis caused a significant reduction in pain intensity
Effectiveness of oromucosal medical Cannabis versus placebo in reducing chronic musculoskeletal pain: a systematic review and meta-analysis
In people with fibromyalgia, THC significantly reduced spontaneous pain ratings
The impact of tetrahydrocannabinol on central pain modulation in chronic pain: a randomized clinical comparative study of offset analgesia and conditioned pain modulation in fibromyalgia
In people with rare seizure disorders, CBD was effective & well-tolerated
Real‐world efficacy and safety of cannabidiol in developmental and epileptic encephalopathies
In a case series of tuberous sclerosis complex (benign tumors that lead to seizures), for the two patients receiving CBD, one had a 50% reduction in seizures & the other became seizure-free after two months
Syndromic Manifestation of Tuberous Sclerosis: A Case Series
In people with HIV, the cannabis users had a higher integrity of their default mode network
Neural Compensation in Persons with HIV and Marijuana use: Insights from a Reorganized DMN
In people with Crohn's disease, public health data showed that cannabis users had lower odds of hospital readmissions, smaller hospital costs & a shorter length of stay than the opioid users
Marijuana Use Is Associated With Reduced Health Care Burden Compared to Opioid Use in Inflammatory Bowel Disease: A Nationwide Study
In people with acute pancreatitis, public health data showed cannabis use could be protective, with decreased rates of mortality, ICU admission, respiratory distress, kidney injury & sepsis
Cannabis Use Is Associated With Better Outcomes in Patients With Acute Pancreatitis: A Propensity-Matched Analysis
In people with chronic gastrointestinal diseases, public health data found cannabis use linked to lower odds of sepsis (an overactive immune response to infection)
Association Between Marijuana Use and Sepsis in Patients With Chronic Gastrointestinal Diseases: A Cross-Sectional Analysis From All of Us
On PEA, a comprehensive review of its biochemistry & clinical evidence
Palmitoylethanolamide: A Comprehensive Review of Its Biochemistry, Therapeutic Applications, and Clinical Evidence
2025: And for pain, a review on PEA (nice charts on how it works)
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
For chemotherapy-induced nausea & vomiting, a review of 32 studies found significant benefits from cannabinoids
Cannabinoids for the prevention of chemotherapy-induced nausea and vomiting in oncological therapy: a systematic review
In prostate cancer, a review of 12 studies on cannabinoids for pain & quality of life
Cannabinoids and Chemotherapy in Prostate Cancer: A Scoping Review of Evidence on Pain and Quality of Life
For palliative care, a review on the potential of cannabinoids
Use of cannabinoids in palliative care: an integrative review and bioethical view
For diseases of the immune system, a review on the use of cannabinoids (nice charts)
Cannabinoids in immune system-related diseases: From bench to clinic
https://journals.lww.com/cmj/fulltext/9900/cannabinoids_in_immune_system_related_diseases_.1774.aspx
For Parkinson's disease, a review of CBD
Cannabidiol and Parkinson's disease: Investigating receptor interactions and their therapeutic implications
For ADHD, a review on the potential of cannabinoids
Cannabinoids and ADHD: a New Frontier in Neuropharmacology?
For skin conditions & CBD, a review found evidence for acne, dermatitis, psoriasis & potentially cosmetic purposes (nice charts)
The Therapeutic Potential of Cannabidiol in Skin Conditions
For dentistry & CBD, a review of 57 studies found anti-inflammatory properties & help for pain
Therapeutic Potential of Cannabidiol in Dentistry: A Systematic Review From Cellular Mechanisms to Clinical Trials
And on CBD as an antibiotic in dentistry, a review of 10 studies found CBD showed promise against a range of oral bacteria & fungi
Potential Antimicrobial Use of Cannabidiol in Dentistry: A Scoping Review
In a mouse model of Alzheimer's disease, CBD altered over 750 markers related to disease onset
Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment
In a mouse model of heart failure, CBD lowered scarring via the AGE-RAGE axis & genetic regulation of extracellular matrix collagen fibers
Abstract 4370383: Cannabidiol alleviates fibrosis through AGE-RAGE axis inhibition in a Non-Ischemic Mouse Model of Heart Failure
In a mouse model of type 2 diabetes, hemp extracts reduced fasting blood glucose, improved glucose tolerance, reduced oxidative damage, regulated lipid metabolism & effectively alleviated damage to the liver, pancreas & kidneys
Preparation of cannabinoid extracts from hemp and their hypoglycemic effects
In a female mouse model of breast cancer, cannabinoids lowered neuropathic pain & caused anti-tumor activity
Multifaced Roles of Cannabinoid Therapy in Cancer: Balancing Analgesia, Antitumor Potential, and Systemic Toxicity
In a female rat model of migraines, on the benefits from various combinations of CBD, THC & CBG
Efficacy of different cannabinoid compounds on migraine-like responses in female rats
In a mouse model of migraines, a 100:1 CBD:THC treatment improved light aversion, resting time & pain behaviors via CGRP levels
Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice
In a rat model of schizophrenia, CBDV improved cognition & social deficits
The phytocannabinoid cannabidivarin alleviates cognitive and social behaviour deficits in the sub-chronic phencyclidine rat model of relevance for schizophrenia
In a rat model of blood-brain loss due to stroke, the terpene beta-caryophyllene improved neurological functions & cognitive recovery via decreases in neutrophil extracellular traps, inflammation & oxidative stress
β-Caryophyllene modulates the JAK2/STAT3 signaling pathway to downregulate neutrophil extracellular traps and alleviate cerebral ischemia-reperfusion injury
In a tissue model of Parkinson's disease, cannabis extracts reduced alpha-synuclein formation
Cannabis sativa extracts reduce inclusion formation in a cell model of alpha-synuclein aggregation
In innate immune cells, CBD caused anti-inflammatory effects via several pathways
Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators
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