Research Roundup: Nov 11, 2025
- Lex Pelger
- 4 days ago
- 3 min read
Best of cannabinoid science this week...
In people with Parkinson's disease, CBD improves the efficacy of the levodopa treatment for tremors, rigidity, slowed movements, depression, motivation & sleep
Investigating the synergistic and modulatory effects of cannabidiol with levodopa and dietary protein in Parkinson's disease
For the sleep of cancer patients, high CBD was associated with improvements in sleep, but with no consistent changes from THC
The effects of tetrahydrocannabinol and cannabidiol on sleep in cancer patients
For psychological symptoms in people with cancer, this review found people used cannabis for sleep disturbances & anxiety
Use of cannabis in psychological symptom management among patients with cancer: A narrative review
For drug-resistant epilepsy in children older than two, CBD caused a >50% reduction in 58% of them & 15% became seizure-free
Cannabidiol as Adjunctive Treatment in Drug-Resistant Epilepsy With Epileptic Spasms Beyond Two Years of Age
In people with Lennox-Gastaut syndrome, CBD was associated with an improved Caregiver Global Impression of Change score
Clinically Meaningful Reduction in Drop Seizures in Patients with Lennox–Gastaut Syndrome Treated with Cannabidiol: Post Hoc Analysis of Phase 3 Clinical Trials
In people with inflammatory bowel disorder, cannabis was associated with a 30% reduction in 30-day readmission
Cannabis Use and 30-Day Readmission in Inflammatory Bowel Disease: A Nationwide Analysis
In a case series of Stiff Person Syndrome (a rare, progressive autoimmune neurological disorder of severe, fluctuating muscle rigidity & painful muscle spasms), cannabinoid oils were one of the helpful treatments
3700 Stiff person syndrome: a single centre’s experience
In people with HIV, cannabis users had less activation of the NLRP3 inflammasome
Cannabis use is associated with alterations in NLRP3 inflammasome related gene expression in monocyte-derived macrophages from people living with HIV
In cats with osteoarthritic pain, a CBD/CBDA paste effectively reduced pain but had a high dropout rate
Field safety and efficacy study with a cannabidiol/cannabidiol acid-rich hemp paste in cats with osteoarthritic pain
In dogs with osteoarthritis, a cannabis extract caused a small reduction in pain & was well tolerated
Cannabis-Based Extract for Managing Pain in Dogs with Osteoarthritis: Efficacy and Safety Assessment
In mental health & cannabis, a holistic review of its risks & benefits
A Holistic Review of Cannabis and Its Potential Risks and Benefits in Mental Health
For anxiety & sleep disturbances, a review of 29 studies found help from the cannabinoids, particularly CBD
CANNABINOIDS FOR ANXIETY AND SLEEP DISTURBANCES: A SCOPING REVIEW
For sepsis, a review of the involvement of the endocannabinoid system (nice charts)
Endocannabinoid System in Sepsis: A Scoping Review
In a rat model of methamphetamine use disorder, CBD shortened extinction duration & inhibited methamphetamine reinstatement, partially through dopamine receptors in the dentate gyrus (a hippocampus brain region of memory encoding & spatial learning)
Modulatory function of cannabidiol on the extinction and reinstatement of methamphetamine-seeking behavior through the D2-like dopamine receptors in the dentate gyrus
In a mouse model of pain, CBD & the terpene beta-caryophyllene had synergistic pain-killing effects
Cannabidiol and Beta-Caryophyllene: chronic inflammatory pain.
In a mouse model of inflammatory bowel disease, THC reduced colitis severity in females, CBD showed modest help for males & the terpene beta-caryophyllene showed the most robust protective effects in both genders
Medical Cannabis for IBD: Differential Responses to Cannabinoids in IL-10 Deficient Model of IBD
In a rat model of arthritis, CBG lowered inflammation & modulated the immune system response
Regulation of inflammatory pathways by cannabigerol in the collagen induced arthritis model in rats
For antioxidant, anti-inflammatory & antimicrobial effects, a comparison of cannabis extracts rich in CBD, CBG & CBC
Targeting the antioxidant, antimicrobial and anti-inflammatory activity of non-psychotropic Cannabis sativa L.: a comparison with chemotype V
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