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Research Roundup: Oct 3, 2022



Best of cannabinoid science this week...


A review confirms the efficacy of CBD for social anxiety Systematic literature review of human studies assessing the efficacy of cannabidiol for social anxiety https://www.sciencedirect.com/science/article/pii/S2772598722000551

In patients with diabetes experiencing neuropathic body pain, 600 mg of PEA lowered their pain & inflammation scores significantly as well as improving their sleep & mood A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain

https://pubmed.ncbi.nlm.nih.gov/36057884


In patients with lower back pain from lumbar spinal stenosis (narrowing of the spinal channel), the use of CBD gel caps for 6 months resulted in “significant improvements in pain scores & several quality-of-life measures” The Use of Cannabidiol in Patients With Low Back Pain Caused by Lumbar Spinal Stenosis: An Observational Study https://www.cureus.com/articles/106551-the-use-of-cannabidiol-in-patients-with-low-back-pain-caused-by-lumbar-spinal-stenosis-an-observational-study


A diary study of using cannabis for PTSD & to help with sleep with CBD-rich products helping the most to lower early awakenings Posttraumatic stress disorder, sleep and medical cannabis treatment: A daily diary study https://www.sciencedirect.com/science/article/abs/pii/S0887618522001050


A survey of people with substance use disorder who used CBD found that it helped them to sleep better, relax, reduce pain & feel less anxious Cannabidiol use among patients with substance use disorders https://www.tandfonline.com/doi/abs/10.1080/14659891.2022.2120425


An overview of the studies on using CBD to treat Alzheimer’s disease

Cannabidiol in the treatment and prevention of Alzheimer’s disease – a comprehensive overview of in vitro and in vivo studies

https://apcz.umk.pl/JEHS/article/view/39922


A review of using CBD for strokes via aneurysm Cannabidiol's Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review https://pubmed.ncbi.nlm.nih.gov/36109476


On using PEA to reduce the tolerance to opiates & enhance their painkilling abilities Role of PEA in Reduction of Opiate Tolerance https://www.jbclinpharm.org/articles/role-of-pea-in-reduction-of-opiate-tolerance.pdf


In heart cells exposed to typical chemotherapy drugs, PEA protected them from cell death & inflammation via the PPAR-α pathway (nuclear receptors that on & off genetic transcription) & the NLRP3-related pathways (related to inflammation) The analgesic compound palmitoylethanolamide reduces inflammation in human cardiomyocytes and vascular endothelial cells exposed to doxorubicin and anti-HER2 monoclonal antibody through PPAR-α and NLRP3-related pathways https://www.annalsofoncology.org/article/S0923-7534(22)01894-4/fulltext


In teens rats withdrawing from an alcohol binge, CBD increased their social exploration, reduced stress hormone levels, restored dopamine transmission & helped to strengthen & remodel their brain connections Social stress under binge-like alcohol withdrawal in adolescence: evidence of cannabidiol effect on maladaptive plasticity in rats https://pubmed.ncbi.nlm.nih.gov/36065905


In rats with traumatic spinal cord injuries, injection with CBD hydrogels caused increased repair, decreased cell death & better function of the mitochondria (powerhouse of the cell) Cannabidiol-loaded injectable chitosan-based hydrogels promote spinal cord injury repair by enhancing mitochondrial biogenesis https://pubmed.ncbi.nlm.nih.gov/36075309


In macrophages (mobile white blood cells), CBD lowered inflammation as well as the standard treatment of the steroid dexamethasone Comparison of the in vitro Anti-Inflammatory Effect of Cannabidiol to Dexamethasone https://pubmed.ncbi.nlm.nih.gov/36159203


In a roundworm model of neurodegeneration, both THC & CBD oil helped to protect their neurons Neuroprotective potential of Cannabis sativa-based oils in Caenorhabditis elegans https://pubmed.ncbi.nlm.nih.gov/36100636


In a roundworm model of Parkinson’s, CBD protected the neurons that produce dopamine, decreased their food-sensing disabilities, reduced oxidation & increased their lifespan Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease https://pubmed.ncbi.nlm.nih.gov/36108815


CBD extract works well with antibiotics to kill salmonella Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella typhimurium https://www.preprints.org/manuscript/202209.0143/v1


A combination of lidocaine & CBD for the topical treatment of pain Design of Liposomal Lidocaine/Cannabidiol Fixed Combinations for Local Neuropathic Pain Treatment https://www.mdpi.com/1999-4923/14/9/1915/html