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Research Roundup: Oct 3, 2022

Best of cannabinoid science this week...

A review confirms the efficacy of CBD for social anxiety Systematic literature review of human studies assessing the efficacy of cannabidiol for social anxiety

In patients with diabetes experiencing neuropathic body pain, 600 mg of PEA lowered their pain & inflammation scores significantly as well as improving their sleep & mood A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain

In patients with lower back pain from lumbar spinal stenosis (narrowing of the spinal channel), the use of CBD gel caps for 6 months resulted in “significant improvements in pain scores & several quality-of-life measures” The Use of Cannabidiol in Patients With Low Back Pain Caused by Lumbar Spinal Stenosis: An Observational Study

A diary study of using cannabis for PTSD & to help with sleep with CBD-rich products helping the most to lower early awakenings Posttraumatic stress disorder, sleep and medical cannabis treatment: A daily diary study

A survey of people with substance use disorder who used CBD found that it helped them to sleep better, relax, reduce pain & feel less anxious Cannabidiol use among patients with substance use disorders

An overview of the studies on using CBD to treat Alzheimer’s disease

Cannabidiol in the treatment and prevention of Alzheimer’s disease – a comprehensive overview of in vitro and in vivo studies

A review of using CBD for strokes via aneurysm Cannabidiol's Multifactorial Mechanisms Has Therapeutic Potential for Aneurysmal Subarachnoid Hemorrhage: a Review

On using PEA to reduce the tolerance to opiates & enhance their painkilling abilities Role of PEA in Reduction of Opiate Tolerance

In heart cells exposed to typical chemotherapy drugs, PEA protected them from cell death & inflammation via the PPAR-α pathway (nuclear receptors that on & off genetic transcription) & the NLRP3-related pathways (related to inflammation) The analgesic compound palmitoylethanolamide reduces inflammation in human cardiomyocytes and vascular endothelial cells exposed to doxorubicin and anti-HER2 monoclonal antibody through PPAR-α and NLRP3-related pathways

In teens rats withdrawing from an alcohol binge, CBD increased their social exploration, reduced stress hormone levels, restored dopamine transmission & helped to strengthen & remodel their brain connections Social stress under binge-like alcohol withdrawal in adolescence: evidence of cannabidiol effect on maladaptive plasticity in rats

In rats with traumatic spinal cord injuries, injection with CBD hydrogels caused increased repair, decreased cell death & better function of the mitochondria (powerhouse of the cell) Cannabidiol-loaded injectable chitosan-based hydrogels promote spinal cord injury repair by enhancing mitochondrial biogenesis

In macrophages (mobile white blood cells), CBD lowered inflammation as well as the standard treatment of the steroid dexamethasone Comparison of the in vitro Anti-Inflammatory Effect of Cannabidiol to Dexamethasone

In a roundworm model of neurodegeneration, both THC & CBD oil helped to protect their neurons Neuroprotective potential of Cannabis sativa-based oils in Caenorhabditis elegans

In a roundworm model of Parkinson’s, CBD protected the neurons that produce dopamine, decreased their food-sensing disabilities, reduced oxidation & increased their lifespan Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease

CBD extract works well with antibiotics to kill salmonella Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella typhimurium

A combination of lidocaine & CBD for the topical treatment of pain Design of Liposomal Lidocaine/Cannabidiol Fixed Combinations for Local Neuropathic Pain Treatment


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