Research Roundup: Oct 14, 2025
- Lex Pelger
- Oct 14
- 4 min read
Best of cannabinoid science this week...
For lower back pain, this phase 3 trial of VER 01 (a proprietary cannabis extract) provided better pain relief, sleep & GI tolerability than opioids
VER-01 Shows Enhanced Gastrointestinal Tolerability, Superior Pain Relief, and Improved Sleep Quality Compared to Opioids in Treating Chronic Low Back Pain: A Randomized Phase 3 Clinical Trial
For people with insomnia, data from Project Twenty21 found cannabinoid treatment associated with a large & clinically significant improvement in sleep quality & a reduction in sleep medications, with the improvement maintained for up to 12 months
Changes in sleep quality among patients prescribed medicinal cannabis: Real-world evidence from Project Twenty 21
In people with Parkinson's disease, CBD synergized with the treatment levodopa & this was only enhanced with a protein-controlled diet for improvements in motor control, depression, motivation & sleep
Investigating the synergistic and modulatory effects of cannabidiol with levodopa and dietary protein in Parkinson's disease
In people with vestibulodynia (vulval sensations of burning, irritation & the need to urinate), a 5% CBD gel with the terpene myrcene reduced pain scores & urination sensations
Efficacy and Safety of Topical 5% Cannabidiol Plus Myrcene for the Treatment of Vestibulodynia: A Multi-Centric Randomized Controlled Trial
In people with breast cancer with pain from aromatase inhibitors, CBD improved joint pain
Pilot Study of Cannabidiol for Treatment of Aromatase Inhibitor-Associated Musculoskeletal Symptoms in Breast Cancer
In cats, CBD increased scores for sedation, compliance & temperament
Evaluation of Cannabidiol Oil's Effects on Sedation, Behavioral Responses to Handling, and Nociceptive Thresholds in Healthy Cats
For dogs taking CBD long-term, they had shifts of 584 metabolites
The long-term effect of cannabidiol on the circulating metabolome of healthy adult dogs
For cannabinoids & cancer, a review of their antioxidant activity as well as treatment & prevention effects (great charts!)
Unveiling the Antioxidant Role of Hemp Oils in Cancer Prevention and Treatment
In disorders of oral pain & inflammation, this review of 7 cannabinoid studies found benefits for reducing pain, muscle tension, gum inflammation, bacterial load & ulcer symptoms
Therapeutic potential of cannabidiol in oral disorders: A systematic review of clinical evidence
In PTSD, a review of the involvement of the endocannabinoids, GABA (the brain’s primary inhibitory neurotransmitter) & glutamate (the brain’s primary excitatory neurotransmitter) (great charts!)
The Involvement of the Endocannabinoid, Glutamatergic, and GABAergic Systems in PTSD
For CBD & anxiety, a review of 64 studies found that it worked primarily via the CB1 & 5-HT1A serotonin receptors
Efficacy and Safety of Cannabidiol for Anxiety: A Bibliometric Analysis and Systematic Review
For CBD & adolescent psychiatric, neurological & substance use disorders, a review of 33 papers
Evidence for Cannabidiol as a Medication for the Treatment of Neurological, Psychiatric, Behavioral and Substance Use Disorders in Adolescents
For migraines, a review of how phytocannabinoids utilize the endocannabinoid system
Treatment of Migraine With Phytocannabinoids, the Involvement of Endocannabinoids in Migraine, and Potential Mechanisms of Action
For older adults with dementia, this review of 10 studies found cannabinoids helped to reduce agitation & nocturnal disturbances (nice graphical abstract)
Can cannabinoids alleviate behavioral symptoms in older adults with dementia? A systematic review
In young people with dystonia (involuntary muscle contractions), a review of 6 studies found symptomatic relief with cannabinoid treatment
Therapeutic Potential of Cannabinoids in Pediatric Dystonia: Insights from a Systematic Review and Clinical Cases
From metabolic syndrome, a review on using ALIAmides such as the endocannabinoids palmitoylethanolamide (PEA) & oleoylethanolamide (OEA)
Targeting metabolic syndrome with ALIAmides: A novel multi-mechanistic approach
In a rat model of neuropathy from chemotherapy, CBD prevented their mechanical & thermal sensitivity
Prevention of Allodynia and Hyperalgesia by Cannabidiol in a Rat Model of Chemotherapy-Induced Peripheral Neuropathy
In a rat model of HIV-associated neurocognitive impairment, THC-enhanced learning but impaired decision-making, with little effects from CBD
Investigating the therapeutic potential of phytocannabinoids on HIV-associated neurocognitive impairment in the HIV-1 transgenic rat
In a female mouse model of Rett syndrome, CBDV lessened motor coordination impairments & preserved cognitive function
Cannabidivarin mitigates motor and cognitive impairments in a female mouse model of Rett syndrome
In a rat model of pancreatitis, CBD reduced damage & oxidative stress in the pancreas & liver
The effect of cannabinoids on liver injury associated with acute pancreatitis
In a mouse model of intestinal inflammation, CBD oil reduced inflammatory processes via the modulation of PPAR nuclear receptors (which regulate genetic transcription)
PPARα Expression Analysis in a Murine Model of Sepsis-like Inflammation Intestinal Tissue Treated with a Cannabidiol-Enriched Broad Spectrum Cannabis Oil
In a tissue model of intestinal inflammation, CBD & CBG inhibited inflammatory chemokines
Efficacy of non-psychotropic Cannabis sativa L. standardized extracts in a model of intestinal inflammation
In a rat model of colitis from a high-fat, high-sugar diet, CBG reduced inflammation possibly via restoration of insulin signaling & modulation of sphingolipid metabolism
Sphingolipid metabolism and insulin resistance – Does cannabigerol protect against experimental colitis induced by high-fat high-sucrose diet
In mice microbiomes, on the effects of CBD
Effect of intraperitoneal cannabidiol (CBD) injection on intestine microbiome profile in a mouse model
For inflammatory skin diseases, thyme essential oil synergized with a CBD/CBG formulation to cause antioxidant & anti-inflammatory effects
Valorization of Thyme Combined with Phytocannabinoids as Anti-Inflammatory Agents for Skin Diseases
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