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Research Roundup: Oct 11, 2021



Best of the Week...


According to this survey, about 20% of people caring for a child with autism give their child CBD

http://www.autismparentingmagazine.com/autism-cbd-products/?msID=2a1b4913-c633-491a-9c8f-504d0051ef0e

See our CVResearch autism page for much more on this important topic.

A review of CBD for schizophrenia finds that it helps to lower scores for positive symptoms (these includes delusions, conceptual disorganization, hallucinatory behavior, excitement, grandiosity, persecution & hostility)

Effect of cannabidiol on schizophrenia based on randomized controlled trials: A meta-analysis

https://www.sciencedirect.com/science/article/abs/pii/S0003448721003048

In 8 children with West syndrome (a constellation of symptoms including epileptic spasms & intellectual disability), CBD-rich medical cannabis caused half of them to see a 50% reduction in seizures

Cannabidiol-enriched medical cannabis as add-on therapy in children with treatment-resistant West syndrome: A study of eight patients

https://pubmed.ncbi.nlm.nih.gov/34624613/

A review of the positives of CBD-rich hemp extracts for dogs

Current review of hemp-based medicines in dogs

https://pubmed.ncbi.nlm.nih.gov/34605042/

An editorial on ‘Combating Periodontal Diseases With Cannabidiol’

https://dimensionsofdentalhygiene.com/amp/article/combating-periodontal-diseases-cannabidiol/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

In Brazil, a study found that the “daily administration of 300 mg CBD for 14 days failed to alter the clinical evolution of COVID-19”

Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/34619044/

In human females, this study looked at the dysregulation of the endocannabinoid system in endometriosis

Implications of dysregulated endogenous cannabinoid family members in the pathophysiology of endometriosis

https://www.sciencedirect.com/science/article/abs/pii/S2666335X21000707

This survey finds patients using CBG-rich products report for anxiety, chronic pain, depression & insomnia

Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms

https://pubmed.ncbi.nlm.nih.gov/34569849/

A chapter by Dr. Idris on the roles of cannabinoid receptors in bone cancers

Chapter 23 - Role of classical cannabinoid receptors in cancer-associated bone disease

https://www.sciencedirect.com/science/article/pii/B9780128216668000499



Preclinical Research & Cannabinoid Chemistry

In mice with skin wounds who had no CB1 or CB2 receptors, researchers find that both receptors help to regulate inflammation & that the CB1 receptor is important in wound repair

Genetic deletion of the cannabinoid receptors CB1 and CB2 enhances inflammation with diverging effects on skin wound healing in mice

https://pubmed.ncbi.nlm.nih.gov/34624321/

In a mouse model of Parkinson’s disease, the combination of exercise & a FAAH inhibitor (a function of CBD) had a positive effect on all parameters measured

The effect of URB597, exercise or their combination on the performance of 6-OHDA mouse model of Parkinson disease in the elevated plus maze, tail suspension test and step-down task

https://pubmed.ncbi.nlm.nih.gov/34599739/

In a mouse model of acute respiratory distress syndrome (a severe clinical complication of COVID-19), an inhaled version of the phytocannabinoid CBC reduced proinflammatory cytokines in the blood & lungs, increased oxygen levels in the blood & protected the lungs – probably via the TRP channels

A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome

https://pubmed.ncbi.nlm.nih.gov/34598736/

In skeletal muscle cells, the CB1 receptors help to control the signaling of the nuclear receptors that modulate genetic transcription

The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells

https://www.mdpi.com/1873-149X/28/4/29

In mice engineered to be obese, researchers find altered endocannabinoid levels that may be caused by changes in the gut microbiome

Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota

https://pubmed.ncbi.nlm.nih.gov/34606993/

In mice engineered to have no CB1 in their microglia (brain immune cells that regulate neuroinflammation), the results showed separate effects for males & females

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner

https://pubmed.ncbi.nlm.nih.gov/34591647/