Best of cannabinoid science this week...
In an observational study of people beginning medical cannabis, after one year they had significant reductions in pain scores, less interference of pain on daily function & improvements to sleep & mental health (depression, anxiety, stress)
Changes in Pain and Mental Health Symptoms Associated with Prescribed Medicinal Cannabis Use: A One-Year Longitudinal Study
And in an economic analysis of treating chronic pain, because cannabinoid based medicines had similar efficacy to other treatments but were less expensive, they were found to be “significantly more cost-effective”
An early economic analysis of medical cannabis for the treatment of chronic pain
In people with fibromyalgia, analysis of different cannabis products found improvements in anxiety, sleep, fibromyalgia symptom severity & quality of life with no differences across the formulations
Comparison of Cannabis-Based Medicinal Product Formulations for Fibromyalgia: A Cohort Study
In people being treated with CBD for their drug-resistant focal epilepsy, they also experienced improvements to their psychiatric comorbidities, depression & anxiety
Psychiatric comorbidities before and after cannabidiol treatment in adult patients with drug resistant focal epilepsy
And in a rat model of seizures, vaporized CBD & oral THC reduced their seizure-induced increases in anxiety & fear responses, probably via serotonin receptors
Phytocannabinoids restore seizure-induced alterations in emotional behaviour in male rats
In public health data, cannabis use in early pregnancy not associated with childhood autism
Maternal Prenatal Cannabis Use and Child Autism Spectrum Disorder
In six cases of dogs with accidental THC ingestion, they were primarily treated with transmucosal CBD & their clinical signs resolved with 45 minutes
Case Report: Treatment of non-medical tetrahydrocannabinol toxicosis with transmucosal cannabidiol-infused dissolving sheets in six dogs
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1448123/abstract
In Alzheimer's disease, a review of 22 studies on how CBD disrupts the formation of the Aβ plaques, reduced the release of pro-inflammatory molecules, prevented the formation of reactive oxygen species, inhibited oxidation of lipids & protected the neurons from apoptosis (programmed cellular suicide)
A systematic study of molecular targets of cannabidiol in Alzheimer’s disease
For psoriasis, a review of treating with CBD oil
Exploring the Potential of Cannabidiol (CBD) Oil as an Adjunct Therapy for Psoriasis: Efficacy, Mechanisms, and Regulatory Challenges
A review of the benefits of PEA
Palmitoylethanolamide, an endogenous fatty acid amide, and its pleiotropic health benefits: A narrative review
Or read my article from last year on ProjectCBD: PEA: Anti-Inflammatory Superstar
For organ fibrosis (scarring), a review on targeting the CB2 receptors (with two great charts!)
Therapeutic potential of agents targeting cannabinoid type 2 receptors in organ fibrosis
In a mouse model of fever, CBD suppressed fever & pro-inflammatory cytokine levels via the HPA axis & inflammatory reflex
Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever
In a mouse model of depression, cannabis extract improved depressive behaviors & reduced systemic inflammation probably via the mast cells (immunoregulatory cells)
Antidepressant-like Effects of Cannabis sativa L. Extract in an Lipopolysaccharide Model: Modulation of Mast Cell Activation in Deep Cervical Lymph Nodes and Dura Mater
In the offspring of mice with maternal obesity, CBD helped to lessen the associated neuroinflammation, anxiety, social disturbances & endocannabinoid signaling
Cannabidiol partially rescues behavioral, neuroinflammatory and endocannabinoid dysfunctions stemming from maternal obesity in the adult offspring
In a mouse model of opioid tolerance, PEA delayed the formation of tolerance & potentiated its painkilling effects via downregulation of VEGF-A & sFLT-1
New insights in the mechanisms of opioid analgesia and tolerance: Ultramicronized palmitoylethanolamide down-modulates vascular endothelial growth factor-A in the nervous system
In a mouse model of alcohol use disorder, oleoylethanolamide (the “anti-hunger” endocannabinoid) reduced alcohol self-administration, addiction cue behaviors & the number of sessions needed for the extinction of alcohol seeking
Region-Specific Gene Expression Changes Associated with Oleoylethanolamide-Induced Attenuation of Alcohol Self-Administration
In a tissue & mouse model of asthma, CBD extracts inhibited inflammation & down regulated proinflammatory & pro-asthmatic cytokines as well as modulating immune cell behavior
High-CBD Extract (CBD-X) in Asthma Management: Reducing Th2-Driven Cytokine Secretion and Neutrophil/Eosinophil Activity
In skin stem cells, CBD enhanced their antioxidant properties to protect from UVB radiation
3-O-Ethyl Ascorbic Acid and Cannabigerol in Modulating the Phospholipid Metabolism of Keratinocytes
For candida, the antifungal effects of CBD
Effect of Cannabidiol (CBD), a cannabis plant derivative, against Candida albicans growth and biofilm formation
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