Best of the Week...
This survey looks at people's CBD use & anxiety
Expectancies about the effects of cannabidiol products on anxiety symptoms
A survey finds that people who smoke recreational cannabis also tend to use more CBD
Patterns and correlates of cannabidiol product and marijuana co-use in a sample of U.S. young adults
A remarkable case series showing the power of small amounts of oral THC (dronabinol) for neuropathic itch
Neuropathic itch treated with oral cannabinoids: A case series
In rats with spinal cord injuries, PEA alleviated the injury, inhibited inflammation, mitigated oxidative stress, reduced cell death & promoted motor function recovery
PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway
In stressed rats, inhibiting the FAAH enzyme (a function of CBD) caused antistress effects in their brains, reduced stress hormones & promoted a return to baseline
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats
The source of stress for the rats is listed as ‘chronic unpredictable stress’. They didn’t explain exactly what that meant - but we assume it involved taking their pups through the mall on Black Friday.
A new drug delivery system to get cannabis oil onto the skin for the treatment of wounds
Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
Speaking of, this survey looks at why people use cannabis topicals in Canada
A Survey of Topical Cannabis Use in Canada
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
This review looks at CBD as a new fixture in pediatric neurology
Cannabidiol - A new fixture in childhood neurology
This review looks at how the cannabinoid receptors help to control bone growth & remodeling
Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies
This review looks at how the ECS alters over the course of Parkinson’s disease
Parkinson's Disease related alterations in cannabinoid transmission
In mice with neurotoxicity from treatment with the chemotherapy drug oxaliplatin, activating their CB1 receptor reduced the associated peripheral neuropathic pain
Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors
This review looks at the cannabinoids for nociplastic pain (where the nervous system gets overly sensitized to pain signals, such as fibromyalgia)
Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain
A review of targeting the ECS for the treatment of autism - with lessons from animal models
The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models
Preclinical Research & Cannabinoid Chemistry
In sensory pain neurons, CBD & CBG reduced responses to the ‘spicy’ molecule capsaicin
Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons
How to create nano-encapsulated CBD balls for delivery into the eyeball
Cannabidiol-Loaded Mixed Polymeric Micelles of Chitosan/Poly(Vinyl Alcohol) And Poly(Methyl Methacrylate) For Trans-Corneal Delivery
In a mouse model of Dravet syndrome, the state of the ECS affects the seizures
The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome
A look at how activating the CB2 receptor reduces morphine tolerance
Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation
How does the CB2 receptor modulate inflammation? These scientists did so much work - and then said, “We still don’t know!”
Delineating the interactions between the cannabinoid CB 2 receptor and its regulatory effectors; β-arrestins and G protein-coupled receptor kinases