Best of the Week...
This survey looks at people's CBD use & anxiety
Expectancies about the effects of cannabidiol products on anxiety symptoms
https://www.tandfonline.com/doi/abs/10.1080/14659891.2021.2006341
A survey finds that people who smoke recreational cannabis also tend to use more CBD
Patterns and correlates of cannabidiol product and marijuana co-use in a sample of U.S. young adults
https://www.sciencedirect.com/science/article/abs/pii/S0306460321003701
A remarkable case series showing the power of small amounts of oral THC (dronabinol) for neuropathic itch
Neuropathic itch treated with oral cannabinoids: A case series
https://pubmed.ncbi.nlm.nih.gov/34692966/
In rats with spinal cord injuries, PEA alleviated the injury, inhibited inflammation, mitigated oxidative stress, reduced cell death & promoted motor function recovery
PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway
https://pubmed.ncbi.nlm.nih.gov/34799468/
In stressed rats, inhibiting the FAAH enzyme (a function of CBD) caused antistress effects in their brains, reduced stress hormones & promoted a return to baseline
Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats
https://pubmed.ncbi.nlm.nih.gov/34794150/
The source of stress for the rats is listed as ‘chronic unpredictable stress’. They didn’t explain exactly what that meant - but we assume it involved taking their pups through the mall on Black Friday.
A new drug delivery system to get cannabis oil onto the skin for the treatment of wounds
Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil
https://pubmed.ncbi.nlm.nih.gov/34827358/
Speaking of, this survey looks at why people use cannabis topicals in Canada
A Survey of Topical Cannabis Use in Canada
https://pubmed.ncbi.nlm.nih.gov/34798780/
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
This review looks at CBD as a new fixture in pediatric neurology
Cannabidiol - A new fixture in childhood neurology
https://pubmed.ncbi.nlm.nih.gov/34808574/
This review looks at how the cannabinoid receptors help to control bone growth & remodeling
Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies
https://pubmed.ncbi.nlm.nih.gov/34800625/
This review looks at how the ECS alters over the course of Parkinson’s disease
Parkinson's Disease related alterations in cannabinoid transmission
https://pubmed.ncbi.nlm.nih.gov/34808322/
In mice with neurotoxicity from treatment with the chemotherapy drug oxaliplatin, activating their CB1 receptor reduced the associated peripheral neuropathic pain
Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors
https://pubmed.ncbi.nlm.nih.gov/34792764/
This review looks at the cannabinoids for nociplastic pain (where the nervous system gets overly sensitized to pain signals, such as fibromyalgia)
Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain
https://pubmed.ncbi.nlm.nih.gov/34800285/
A review of targeting the ECS for the treatment of autism - with lessons from animal models
The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models
https://pubmed.ncbi.nlm.nih.gov/34813825/
Preclinical Research & Cannabinoid Chemistry
In sensory pain neurons, CBD & CBG reduced responses to the ‘spicy’ molecule capsaicin
Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons
How to create nano-encapsulated CBD balls for delivery into the eyeball
Cannabidiol-Loaded Mixed Polymeric Micelles of Chitosan/Poly(Vinyl Alcohol) And Poly(Methyl Methacrylate) For Trans-Corneal Delivery
https://www.preprints.org/manuscript/202111.0364/v1
In a mouse model of Dravet syndrome, the state of the ECS affects the seizures
The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome
https://pubmed.ncbi.nlm.nih.gov/34822817
A look at how activating the CB2 receptor reduces morphine tolerance
Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation
https://pubmed.ncbi.nlm.nih.gov/34774714/
How does the CB2 receptor modulate inflammation? These scientists did so much work - and then said, “We still don’t know!”
Delineating the interactions between the cannabinoid CB 2 receptor and its regulatory effectors; β-arrestins and G protein-coupled receptor kinases