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Research Roundup: Nov 29, 2021

Best of the Week...

This survey looks at people's CBD use & anxiety

Expectancies about the effects of cannabidiol products on anxiety symptoms

A survey finds that people who smoke recreational cannabis also tend to use more CBD

Patterns and correlates of cannabidiol product and marijuana co-use in a sample of U.S. young adults

A remarkable case series showing the power of small amounts of oral THC (dronabinol) for neuropathic itch

Neuropathic itch treated with oral cannabinoids: A case series

In rats with spinal cord injuries, PEA alleviated the injury, inhibited inflammation, mitigated oxidative stress, reduced cell death & promoted motor function recovery

PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

In stressed rats, inhibiting the FAAH enzyme (a function of CBD) caused antistress effects in their brains, reduced stress hormones & promoted a return to baseline

Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats

The source of stress for the rats is listed as ‘chronic unpredictable stress’. They didn’t explain exactly what that meant - but we assume it involved taking their pups through the mall on Black Friday.

A new drug delivery system to get cannabis oil onto the skin for the treatment of wounds

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Speaking of, this survey looks at why people use cannabis topicals in Canada

A Survey of Topical Cannabis Use in Canada

Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review looks at CBD as a new fixture in pediatric neurology

Cannabidiol - A new fixture in childhood neurology

This review looks at how the cannabinoid receptors help to control bone growth & remodeling

Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies

This review looks at how the ECS alters over the course of Parkinson’s disease

Parkinson's Disease related alterations in cannabinoid transmission

In mice with neurotoxicity from treatment with the chemotherapy drug oxaliplatin, activating their CB1 receptor reduced the associated peripheral neuropathic pain

Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors

This review looks at the cannabinoids for nociplastic pain (where the nervous system gets overly sensitized to pain signals, such as fibromyalgia)

Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain

A review of targeting the ECS for the treatment of autism - with lessons from animal models

The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models

Preclinical Research & Cannabinoid Chemistry

In sensory pain neurons, CBD & CBG reduced responses to the ‘spicy’ molecule capsaicin

Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons

How to create nano-encapsulated CBD balls for delivery into the eyeball

Cannabidiol-Loaded Mixed Polymeric Micelles of Chitosan/Poly(Vinyl Alcohol) And Poly(Methyl Methacrylate) For Trans-Corneal Delivery

In a mouse model of Dravet syndrome, the state of the ECS affects the seizures

The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome

A look at how activating the CB2 receptor reduces morphine tolerance

Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation

How does the CB2 receptor modulate inflammation? These scientists did so much work - and then said, “We still don’t know!”

Delineating the interactions between the cannabinoid CB 2 receptor and its regulatory effectors; β-arrestins and G protein-coupled receptor kinases


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