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Research Roundup: Nov 29, 2021



Best of the Week...


This survey looks at people's CBD use & anxiety

Expectancies about the effects of cannabidiol products on anxiety symptoms

https://www.tandfonline.com/doi/abs/10.1080/14659891.2021.2006341

A survey finds that people who smoke recreational cannabis also tend to use more CBD

Patterns and correlates of cannabidiol product and marijuana co-use in a sample of U.S. young adults

https://www.sciencedirect.com/science/article/abs/pii/S0306460321003701


A remarkable case series showing the power of small amounts of oral THC (dronabinol) for neuropathic itch

Neuropathic itch treated with oral cannabinoids: A case series

https://pubmed.ncbi.nlm.nih.gov/34692966/

In rats with spinal cord injuries, PEA alleviated the injury, inhibited inflammation, mitigated oxidative stress, reduced cell death & promoted motor function recovery

PPARα agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

https://pubmed.ncbi.nlm.nih.gov/34799468/

In stressed rats, inhibiting the FAAH enzyme (a function of CBD) caused antistress effects in their brains, reduced stress hormones & promoted a return to baseline

Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats

https://pubmed.ncbi.nlm.nih.gov/34794150/

The source of stress for the rats is listed as ‘chronic unpredictable stress’. They didn’t explain exactly what that meant - but we assume it involved taking their pups through the mall on Black Friday.

A new drug delivery system to get cannabis oil onto the skin for the treatment of wounds

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

https://pubmed.ncbi.nlm.nih.gov/34827358/

Speaking of, this survey looks at why people use cannabis topicals in Canada

A Survey of Topical Cannabis Use in Canada

https://pubmed.ncbi.nlm.nih.gov/34798780/


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This review looks at CBD as a new fixture in pediatric neurology

Cannabidiol - A new fixture in childhood neurology

https://pubmed.ncbi.nlm.nih.gov/34808574/

This review looks at how the cannabinoid receptors help to control bone growth & remodeling

Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human studies

https://pubmed.ncbi.nlm.nih.gov/34800625/

This review looks at how the ECS alters over the course of Parkinson’s disease

Parkinson's Disease related alterations in cannabinoid transmission

https://pubmed.ncbi.nlm.nih.gov/34808322/

In mice with neurotoxicity from treatment with the chemotherapy drug oxaliplatin, activating their CB1 receptor reduced the associated peripheral neuropathic pain

Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors

https://pubmed.ncbi.nlm.nih.gov/34792764/

This review looks at the cannabinoids for nociplastic pain (where the nervous system gets overly sensitized to pain signals, such as fibromyalgia)

Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain

https://pubmed.ncbi.nlm.nih.gov/34800285/

A review of targeting the ECS for the treatment of autism - with lessons from animal models

The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: lessons from behavioral studies on mouse models

https://pubmed.ncbi.nlm.nih.gov/34813825/



Preclinical Research & Cannabinoid Chemistry

In sensory pain neurons, CBD & CBG reduced responses to the ‘spicy’ molecule capsaicin

Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons

https://www.dovepress.com/dose-related-inhibition-of-capsaicin-responses-by-cannabinoids-cbg-cbd-peer-reviewed-fulltext-article-JPR

How to create nano-encapsulated CBD balls for delivery into the eyeball

Cannabidiol-Loaded Mixed Polymeric Micelles of Chitosan/Poly(Vinyl Alcohol) And Poly(Methyl Methacrylate) For Trans-Corneal Delivery

https://www.preprints.org/manuscript/202111.0364/v1

In a mouse model of Dravet syndrome, the state of the ECS affects the seizures

The endocannabinoid system impacts seizures in a mouse model of Dravet syndrome

https://pubmed.ncbi.nlm.nih.gov/34822817

A look at how activating the CB2 receptor reduces morphine tolerance

Cannabinoid Receptor Type 2 Agonist Reduces Morphine Tolerance via Mitogen Activated Protein Kinase Phosphatase Induction and Mitogen Activated Protein Kinase Dephosphorylation

https://pubmed.ncbi.nlm.nih.gov/34774714/

How does the CB2 receptor modulate inflammation? These scientists did so much work - and then said, “We still don’t know!”

Delineating the interactions between the cannabinoid CB 2 receptor and its regulatory effectors; β-arrestins and G protein-coupled receptor kinases

https://pubmed.ncbi.nlm.nih.gov/34811740/