Search

Research Roundup: Nov 15, 2022



Best of cannabinoid science this week...


In a review of 933 patients using PEA for neuropathic pain, it helped with pain reduction & quality of life Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence https://pubmed.ncbi.nlm.nih.gov/36015298


In a survey of patients with inflammatory bowel disease, those who started using cannabis had less visits to the ER & less impact of symptoms on daily life Medical Cannabis Use Patterns and Adverse Effects in Inflammatory Bowel Disease https://pubmed.ncbi.nlm.nih.gov/36227025


When people used 1:1 THC:CBD flower, they had less anxiety than using high-THC cannabis Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis https://pubmed.ncbi.nlm.nih.gov/36227352


In a mouse model of Alzheimer’s, an ultra-low dose of THC lessened cognitive impairments An Ultra-Low Dose of ∆9-Tetrahydrocannabinol Alleviates Alzheimer's Disease-Related Cognitive Impairments and Modulates TrkB Receptor Expression in a 5XFAD Mouse Model https://pubmed.ncbi.nlm.nih.gov/36012711


In a mouse model of facial pain, CBD reduced transmission through the pain pathway via the TRPV1 receptors Efficacy and mechanism of the antinociceptive effects of cannabidiol on acute orofacial nociception induced by Complete Freund's Adjuvant in male Mus musculus mice https://pubmed.ncbi.nlm.nih.gov/36265395


In rats with loss of blood flow to their brains, CBD lowered cell death & protected against dysfunction of the mitochondria (powerhouse of the cell) Mitofusin-2 mediates cannabidiol-induced neuroprotection against cerebral ischemia in rats https://pubmed.ncbi.nlm.nih.gov/36229600


In a rat model of diabetes type 2 with high levels of insulin, THC decreased the levels of inflammatory cytokines & regulated antioxidant potential Anti-inflammatory potential of delta-9-tetrahydrocannabinol in hyperinsulinemia: an experimental study https://pubmed.ncbi.nlm.nih.gov/36239881


In a female mouse model of neuropsychiatric disorders, cannabis oil lowered depressive behaviors, significantly reduced social avoidance & promoted social interaction Potential Therapeutic Effects of Lebanese Cannabis oil in Female Mouse Models of Neuropsychiatric Disorders https://laur.lau.edu.lb:8443/xmlui/handle/10725/14202


In rats conditioned to a scheduled drinking of alcohol, THC helped to delay their acquisition of the drinking habit Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects https://pubmed.ncbi.nlm.nih.gov/34436650


A review of what we know about the minor cannabinoids Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research https://pubmed.ncbi.nlm.nih.gov/36008978


In an animal & cellular model, THCV lowered neuroinflammation & improved the ability of morphine to lower pain Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia https://pubmed.ncbi.nlm.nih.gov/36032146


In a cellular model of Parkinson’s disease, THC protected the dopamine producing neurons by antioxidant effects, decreasing cell death & protecting the mitochondria (powerhouse of the cell)

Neuroprotective Effects of Delta-9-Tetrahydrocannabinol against FeSO4- and H2O2-Induced Cell Damage on Dopaminergic Neurons in Primary Mesencephalic Cell Culture

https://www.thieme-connect.com/products/ejournals/html/10.1055/a-1516-4182