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Research Roundup: May 9, 2022



Best of cannabinoid science this week...


In mice, PEA helps with inflammation in a variety of situations via Toll receptors Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammation https://pubmed.ncbi.nlm.nih.gov/35485445/ In a number of different animals, CBD demonstrated a “very low abuse potential and [that it] is unlikely to produce physical dependence” Preclinical assessment of the abuse potential of purified botanical cannabidiol: self-administration, drug discrimination, and physical dependence https://pubmed.ncbi.nlm.nih.gov/35489780/

In cervical cancer, a review of enhancing conventional treatment with CBD Enhancement of Conventional and Photodynamic Therapy for Treatment of Cervical Cancer with Cannabidiol https://pubmed.ncbi.nlm.nih.gov/35481367/ In mice with heart failure, CBD “significantly prevented cardiac dysfunction and the development of fibrosis” Cannabidiol Therapy For Chronic Heart Failure Prevents Cardiac Hypertrophy And Contractile Dysfunction By Reducing Mitochondrial Ros Generation In A Murine Model https://www.sciencedirect.com/science/article/abs/pii/S1071916422003669

In a mouse model of oral mucositis (mouth ulcers from chemotherapy), nano-CBD balls accelerated healing & decreased inflammation Inflammation-targeted cannabidiol-loaded nanomicelles for enhanced oral mucositis treatment https://pubmed.ncbi.nlm.nih.gov/35467472/ In patients with severe neuropathic back pain, this industry study found that nabiximols (ie Sativex – a pharmaceutical 1:1 CBD:THC spray) was superior to a long-acting opioid analgesics in terms of pain control & side effects Effectiveness, Safety, and Tolerability of Nabiximols Oromucosal Spray vs Typical Oral Long-Acting Opioid Analgesics in Patients with Severe Neuropathic Back Pain: Analysis of 6-Month Real-World Data from the German Pain e-Registry https://pubmed.ncbi.nlm.nih.gov/34480564/ A review of medical cannabis in Canada found that it helped patients with anxiety & depression Medical cannabis use in Canada and its impact on anxiety and depression: a retrospective study https://www.sciencedirect.com/science/article/abs/pii/S0165178122001834 This review about using cannabis for rheumatic diseases (joint pain & inflammation) says that the number of positive observational & survey studies points to the need for controlled clinical trials Cannabis for Rheumatic Disease Pain: a Review of Current Literature https://pubmed.ncbi.nlm.nih.gov/35486218/ In a computer analysis of cannabinoids against the COVID-19 virus, they found the strongest to be CBN, CBNA, cannabichromanon & cannabicyclolic acid The Role of Cannabis sativa L. as a Source of Cannabinoids against Coronavirus 2 (SARS-CoV-2): An In Silico Study to Evaluate Their Activities and ADMET Properties https://www.mdpi.com/1420-3049/27/9/2797