Research Roundup: May 6, 2025
- Lex Pelger
- May 6
- 3 min read
Updated: May 13
Best of cannabinoid science this week...
In 50 children with drug-resistant epilepsy, CBD caused 8 of them to become seizure-free & reduced seizures in the majority
Cannabidiol in Drug‑Resistant Epilepsy in Children: A Retrospective Study
And in a multi-center analysis of pediatric drug-resistant epilepsy, CBD significantly reduced seizures & allowed some to become seizure free & for others to reduce their anti-epileptic drug burden
Adjunctive Use of Cannabidiol in Pediatric Drug‑Resistant Epilepsy: A Retrospective Multicenter Analysis
For chronic pain, a cost-effectiveness analysis of cannabis vs opioids found cannabis to have similar costs & quality-adjusted life years (QALYs) without the risk of overdose
Cost‑Effectiveness of Medical Cannabis Versus Opioids for Chronic Non‑Cancer Pain
In meditators, cannabis use was linked to increased meditation quality but lowered intrapersonal communication & concentration
Mental Clarity and Cannabis: A Mixed‑Method Study on Meditation, Intrapersonal Communication, Concentration and Cosmos
In burn survivors, a survey found cannabis use to be common & more likely among those who had visible burns
Marijuana Use in a Nationwide Survey of Burn Survivors
In people with systemic sclerosis (a group of rare diseases of the hardening & tightening of the skin), a CBD/THC oil increased sleep duration & decreased sleep disturbance, sleep medication use & daytime dysfunction (though not statistically significant)
Efficacy of Cannabis Oil in Improving Subjective Sleep Quality in Systemic Sclerosis
On CBD drug interactions, an analysis of 136 reports
Evidence of Potential Drug Interactions Between Cannabidiol and Other Drugs: A Scoping Review to Guide Pharmaceutical Care
In CBD for breast cancer, a systematic review found significant anti-cancer effects including inhibition of cell proliferation, suppression of metastasis, modulation of the tumor microenvironment & induction of apoptosis (programmed cellular suicide)
Cannabidiol as a Novel Therapeutic Agent in Breast Cancer: Evidence From Literature
And for cancer, a review of beta-caryophyllene & the d-limonene terpenes
Anticancer Properties of β‑Caryophyllene and Its Mechanistic Pathways
For neuropathic pain, a review of 11 clinical trials found cannabinoids reduced pain perception, improved patient quality of life & mitigated other related symptoms
Cannabinoids in Neuropathic Pain Treatment: Pharmacological Insights and Clinical Outcomes From Recent Trials
For the tuberculosis bacteria, a review found two preclinical studies on the antibacterial activity of CBD
Antibacterial activity of cannabinoids on the bacteria that cause tuberculosis: a systematic review
In chronic rhinosinusitis (inflamed & swollen sinuses), a review of five preclinical studies found the endocannabinoid system regulates the related inflammatory pathways
Cannabinoids and the Endocannabinoid System in the Treatment of Chronic Rhinosinusitis
For the endocannabinoid & paracannabinoid (related mediators such as PEA, OEA & SEA) systems, a review of how they shape survival behaviors such as food, mating & social interaction (one super sexy chart)
The Endocannabinoid and Paracannabinoid Systems in Natural Reward Processes: Possible Pharmacological Targets?
In a mouse model of sickle cell disease, PEA reduced pain, improved red blood cell & hemoglobin levels, reduced liver size & lowered markers of inflammation
Levagen+ Ameliorates Hyperalgesia in a Mouse Model of Sickle Cell Disease
In a rat model of obesity, various mixtures of THC & CBD showed antihypertensive properties & benefits for the liver
Effects of Five Cannabis Oils With Different CBD:THC Ratios and Terpenes on Hypertension, Dyslipidemia, Hepatic Steatosis, Oxidative Stress, and CB1 Receptor
In a rat model of sleep disorders following general anesthesia, CBD significantly increased sleep time at night via the hypothalamus (a key regulator of bodily functions)
Cannabidiol Regulates Circadian Rhythm to Improve Sleep Disorders Following General Anesthesia in Rats
In human skin stem cells, cannabis extracts reduced inflammation via the NF-κB pathway, with CBD, THC & CBG being the most active
Beyond Cannabidiol: The Contribution of Cannabis sativa Phytocomplex to Skin Anti-Inflammatory Activity in Human Skin Keratinocytes
In fat cells resistant to insulin, nano-CBD enhanced glucose uptake, reduced lipid content, lowered triglycerides & total cholesterol & increased HDL levels
Enhanced Metabolic Syndrome Management Through Cannabidiol‑Loaded PLGA Nanoparticles: Development and In Vitro Evaluation
Comments