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Research Roundup: May 23, 2022



Best of cannabinoid science this week...


In humans, 8 weeks of CBD had no negative effects on the levels of blood immune cells or natural killer cells

Eight Weeks of Daily Cannabidiol Ingestion Does Not Alter Peripheral Blood Mononuclear Cell Profile or Natural Killer Cell Cytotoxicity https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.0R810 In humans exposed to a threat, their blood levels of anandamide & 2-AG increased Acquisition of threat responses are associated with elevated plasma concentration of endocannabinoids in male humans https://pubmed.ncbi.nlm.nih.gov/35562542/ We know that endocannabinoid levels in the blood rise to help us stop responding to a threat – but now it appears that they also help us to learn to respond to a threat. In male mice, low doses of CBD increases social interaction Acute Low Dose Cannabidiol Treatment Boosts Social Interaction Preference in Male Mice https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fasebj.2022.36.S1.R3304 #CBDforIntroverts! In mice with chronic pain from the chemotherapy drug cisplatin, CBD helped with their pain & this seems to be mediated by the CB1 & CB2 receptors working via the TRPV1 receptors & in females only, a serotonin receptors The Role of Cannabidiol (CBD) in a Cisplatin-Induced Model of Chronic Neuropathic Pain https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.R5197 In a rat model of obesity, synthetic CBD reduced body weight & fat levels but not blood pressure Synthetic Cannabidiol Reduced Body Mass and Visceral Adiposity but Not Blood Pressure in Rats With Advanced Metabolic Syndrome https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2022.36.S1.R2910 In Parkinson’s patients, nabilone (a pharmaceutical THC analog) had beneficial effects on sleep outcomes Effects of nabilone on sleep outcomes in patients with Parkinson's disease: a post-hoc analysis of NMS-Nab study https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mdc3.13471 In a rat stressed out by the smell of a predator, CBD helped to lower unconditioned – but not conditioned - fear The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats https://pubmed.ncbi.nlm.nih.gov/31133832 In mice, CBG lowers blood pressure Acute Cannabigerol Administration Lowers Blood Pressure in Mice https://www.frontiersin.org/articles/10.3389/fphys.2022.871962/full A review of cannabinoids for addiction Cannabinoids as Potential Molecules for Addiction Disorders https://pubmed.ncbi.nlm.nih.gov/35538819/ A review of using the cannabinoids for pain Cannabis, cannabinoids, and cannabis-based medicines: future research directions for analgesia https://pubmed.ncbi.nlm.nih.gov/35534020 This computer simulation study looked at the ability of THC, CBD, AEA & 2-AG to bind to the endoplasmic reticulum (final processing center for proteins) & how this helps to increase the breakdown of misfolded proteins Promising action of cannabinoids on ER stress mediated neurodegeneration: An In Silico Investigation https://www.dl.begellhouse.com/references/0ff459a57a4c08d0,forthcoming,40055.html The great Appendino with a takedown on how much CBD actually gets produced in Nature outside the cannabis plant Cannabidiol (CBD) From Non-Cannabis Plants: Myth or Reality? https://journals.sagepub.com/doi/full/10.1177/1934578X221098843