Research Roundup: May 20, 2025
- Lex Pelger
- May 20
- 2 min read
Best of cannabinoid science this week...
In a Uruguayan center for pediatric treatment-resistant epilepsy, treatment with medical cannabis caused a >50% reduction in seizure frequency in all 15 children & adolescents & half reported a reduction in the duration of seizures
Medicinal Cannabis Derivatives in the Treatment of Children and Adolescents With Refractory Epilepsy in Uruguay, 2021-2024
In older adults, a daily diary study found that medical cannabis improved their pain, anxiety & depression with indirect benefits for sleep quality
Daily Impact of Medical Cannabis on Anxiety and Sleep Quality in Older Adults
In people with chronic musculoskeletal pain, the vast majority agreed that medical cannabis improves their primary symptoms with topical formulations being the most commonly used
Patterns, Efficacy, and Cognitive Effects of Medical Cannabis Use in Chronic Musculoskeletal Pain Patients
For cardiometabolic health & oleoylethanolamide (OEA, the endocannabinoid of satiety), a meta-analysis of 10 trials found OEA supplementation led to a significant improvement in antioxidant capacity, body weight, body mass index, waist circumference, fat mass, body fat percentage, fasting glucose levels, insulin & a number of other benefits for metabolic markers
Oleoylethanolamide Supplementation on Cardiometabolic Health: A Systematic Review and Meta-Analysis
For CBD, a huge review of its many mechanisms of action (excellent charts!)
Beyond the Hype: A Comprehensive Exploration of CBD's Biological Impacts and Mechanisms of Action
For people with cancer, a review on using medical cannabis for their symptoms of nausea, vomiting, anorexia & pain
Use of Medicinal Cannabis in the Treatment of Symptoms in Cancer Patients
For Alzheimer's disease, a review & computer analysis of CBD’s therapeutic effects
Cannabidiol and Alzheimer disease: A Comprehensive Review and In Silico Insights into Molecular Interactions
In a rat model of stroke, oleoylethanolamide (OEA) protected the blood-brain barrier, reduced the infiltration of macrophages, neutrophils, T-cells & B-cells as well as caused therapeutic effects via the PPARα nuclear receptors (regulators of genetic transcription) in the microglia (guardian immune cells of the brain)
Oleoylethanolamide Exerts Neuroprotection Following Ischemic Stroke Through Microglial PPARα Signal
In a mouse model of epilepsy to test different CBD delivery methods, the most effective was broad-spectrum CBD via inhalation
Optimization of Seizure Prevention by Cannabidiol (CBD)
In a mouse model & computer analysis of depression, CBC showed antidepressant effects
Cannabichromene in Treatment of Major Depressive Disorder: In Silico and In Vivo Explorations
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