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Research Roundup: May 2, 2022



Best of cannabinoid science this week...


A small study of CBD users finds that it might be impossible to use a ‘one size fits all’ approach to CBD dosing because of the wide range of people’s absorption rates Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development https://pubmed.ncbi.nlm.nih.gov/35443784/

To help with the loss of smell from COVID, a combination of PEA with luteolin (a flavonoid) helped to enhance the effectiveness of olfactory training Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo-Controlled Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35450527/

In a rat model of temporal lobe epilepsy, CBD increased the brain levels of PPARγ (a nuclear receptor that controls genetic transcription) & reduced or abolished their seizures Antiseizure Effects of Cannabidiol Leading to Increased Peroxisome Proliferator-Activated Receptor Gamma Levels in the Hippocampal CA3 Subfield of Epileptic Rats https://www.mdpi.com/1424-8247/15/5/495/htm

Temporal lobe epilepsies can cause fascinating effects in the human brain - including religious epiphanies. See this essay by Oliver Sacks.

In roundworms (a common model for aging research), CBD increased longevity & brain health by increasing the efficiency of autophagy (cellular recycling) Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity https://pubmed.ncbi.nlm.nih.gov/35445360/

In rats with a Vitamin D3 deficiency, CBD helped to improve the availability of Vitamin D3 which caused improvements in memory, pain tolerance, inflammation & aging Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D 3 Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D 3 Deficiency Diet-Induced Rats https://pubmed.ncbi.nlm.nih.gov/35443806/

CBD shows promising combination with the antibiotic polymyxin B against Gram-negative bacteria, especially the Klebsiella pneumoniae which causes pneumonia Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli https://pubmed.ncbi.nlm.nih.gov/35440801/

In a model of intracerebral hemorrhage (bleeding in the brain – the second most common cause of stroke), PEA lowered neuroinflammation & improved motor function via the PPAR-α receptors (nuclear receptors that control genetic transcription) in microglial cells (the immune cells of the brain)

Palmitoylethanolamide ameliorates neuroinflammation via modulating PPAR-α to promote the functional outcome after intracerebral hemorrhage https://www.sciencedirect.com/science/article/pii/S0304394022002051

Dr. Trina Hazzah on using cannabis for our animal friends https://www.ganjapreneur.com/dr-trina-hazzah-expanding-veterinary-care-with-medical-cannabis/

A nice article on alternative supplements that boost the endocannabinoid system https://fullscript.com/blog/supplements-for-the-endocannabinoid-system

A review of cannabis for the treatment of anxiety Medicinal Cannabis for the Treatment of Anxiety Disorders: a Narrative Review https://link.springer.com/article/10.1007/s40501-022-00260-8

This collection of studies finds cannabis helpful for a number of different types of non-cancer pain Long-term observational studies with cannabis-based medicines for chronic non-cancer pain: A systematic review and meta-analysis of effectiveness and safety https://pubmed.ncbi.nlm.nih.gov/35467781/