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Research Roundup: May 2, 2022

Best of cannabinoid science this week...

A small study of CBD users finds that it might be impossible to use a ‘one size fits all’ approach to CBD dosing because of the wide range of people’s absorption rates Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development

To help with the loss of smell from COVID, a combination of PEA with luteolin (a flavonoid) helped to enhance the effectiveness of olfactory training Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo-Controlled Clinical Trial

In a rat model of temporal lobe epilepsy, CBD increased the brain levels of PPARγ (a nuclear receptor that controls genetic transcription) & reduced or abolished their seizures Antiseizure Effects of Cannabidiol Leading to Increased Peroxisome Proliferator-Activated Receptor Gamma Levels in the Hippocampal CA3 Subfield of Epileptic Rats

Temporal lobe epilepsies can cause fascinating effects in the human brain - including religious epiphanies. See this essay by Oliver Sacks.

In roundworms (a common model for aging research), CBD increased longevity & brain health by increasing the efficiency of autophagy (cellular recycling) Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity

In rats with a Vitamin D3 deficiency, CBD helped to improve the availability of Vitamin D3 which caused improvements in memory, pain tolerance, inflammation & aging Effects of Cannabidiol Interactions with CYP2R1, CYP27B1, CYP24A1, and Vitamin D 3 Receptors on Spatial Memory, Pain, Inflammation, and Aging in Vitamin D 3 Deficiency Diet-Induced Rats

CBD shows promising combination with the antibiotic polymyxin B against Gram-negative bacteria, especially the Klebsiella pneumoniae which causes pneumonia Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli

In a model of intracerebral hemorrhage (bleeding in the brain – the second most common cause of stroke), PEA lowered neuroinflammation & improved motor function via the PPAR-α receptors (nuclear receptors that control genetic transcription) in microglial cells (the immune cells of the brain)

Palmitoylethanolamide ameliorates neuroinflammation via modulating PPAR-α to promote the functional outcome after intracerebral hemorrhage

A nice article on alternative supplements that boost the endocannabinoid system

A review of cannabis for the treatment of anxiety Medicinal Cannabis for the Treatment of Anxiety Disorders: a Narrative Review

This collection of studies finds cannabis helpful for a number of different types of non-cancer pain Long-term observational studies with cannabis-based medicines for chronic non-cancer pain: A systematic review and meta-analysis of effectiveness and safety

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