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Research Roundup: May 16, 2023

Best of cannabinoid science this week...

In patients with Parkinson's disorder, the majority using a 1:1 THC:CBD tincture saw an improvement in their cramping/dystonia, pain, spasticity, lack of appetite, dyskinesia & tremor while half lowered or stopped their opioid usage Medical Cannabis in the Treatment of Parkinson's Disease And another Parkinson’s clinical study focused on safety found formulas of THC/CBD to be well tolerated A Phase Ib, Double Blind, Randomized Study of Cannabis Oil for Pain in Parkinson's Disease

In adults with treated & untreated hypertension, chronic administration of CBD reduced blood pressure with a noted lack of serious adverse events Chronic Effects of Oral Cannabidiol Delivery on 24-h Ambulatory Blood Pressure in Patients with Hypertension (HYPER-H21-4): A Randomized, Placebo-Controlled, and Crossover Study

In adults with PTSD, low levels of THC helped with fear learning & memory in the corticolimbic system Cannabinoid modulation of corticolimbic activation during extinction learning and fear renewal in adults with posttraumatic stress disorder

A review of 120 studies on anxiety finds positive results for CBD Anxiolytic effects of endocannabinoid enhancing compounds: A systematic review and meta-analysis

In confirmation of the entourage effect, certain cannabis terpenes synergized with THC to increase CB1 receptor activation Selected cannabis terpenes synergize with THC to produce increased CB1 receptor activation

In a mouse model of alcohol withdrawal, CBD reduce their anxiety, their behavioral symptoms of withdrawal & and cause remarkable changes in the genetic expression of the brain targets studied

Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal

In mice with pain from a bacterial infection, CBD reduced the transmission of pain signals & inflammation via Toll receptor

Cannabidiol reduces lipopolysaccharide-induced nociception via endocannabinoid system activation

And for a mouse housed with another mouse in extreme chronic pain, CBD helped lessen their anxiety, sensitivity pain & depressive behaviors

Cannabidiol Treatment Shows Therapeutic Efficacy in a Rodent Model of Social Transfer of Pain in Pair-Housed Male Mice

In a mouse model of osteoporosis, CBD enhanced bone metabolism as well as bone healing after a break Non-psychoactive Cannabidiol Prevents Osteoporosis in an Animal Model and Increases Cell Viability, Proliferation, and Osteogenic Gene Expression in Human Skeletal Stem and Progenitor Cells

In an animal model of kidney disease, CBGA & CBD strongly reduced inflammation & kidney scarring partially via TRPM7 inhibition CBGA ameliorates inflammation and fibrosis in nephropathy

In a rat model of addiction to methamphetamine, CBD helped to inhibit the rewarding properties via dopamine receptors in the hippocampus The inhibitory effect of cannabidiol on the rewarding properties of methamphetamine in part mediates by interacting with the hippocampal D1-like dopamine receptors


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