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Research Roundup: Mar 7, 2022



A great study of women in cannabis features many of the important names as well as insights into female fans of this female plant

https://www.womenincannabis.study/view-report


Best of the Week...


In two patients with hyperhidrosis (excessive sweating), CBD immediately improved their symptoms

Unexpected improvement of hyperhidrosis with cannabidiol

https://pubmed.ncbi.nlm.nih.gov/35170710/


Zynerba Pharmaceuticals completes enrollment for a transdermal CBD trial for 22q deletion syndrome (a serious developmental disorder resulting from missing DNA)

https://www.benzinga.com/markets/cannabis/22/02/25869015/zynerba-pharmaceuticals-completes-enrollment-for-cbd-transdermal-trial-for-22q-deletion-syndrome


The headline you’ve been waiting for: hemp extract given to a bottlenose dolphin for the treatment of an eye disease

An Ocular Case Study of an Atlantic Bottlenose Dolphin (Tursiops truncatus) Using A Medical Regime of Various Topical, Oral, and Alternative Modalities Including Crystalline Hemp Extract

https://www.vin.com/apputil/content/defaultadv1.aspx?id=10200586&pid=27093&


In a mouse model of depression, LSD combined with CBD to help alleviate depression more than either substance alone

Synergistic effects of lysergic acid diethylamide (LSD) and cannabidiol (CBD)

https://www.researchgate.net/publication/357426416_P0835_Synergistic_effects_of_lysergic_acid_diethylamide_LSD_and_cannabidiol_CBD


In a mouse model of obesity, treatment with CBD & omega 3 (fish oil) improved the gut microbiome as well as reducing anxiety & memory impairment

High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies

https://www.scirp.org/journal/paperinformation.aspx?paperid=115157


In a mouse model of dementia, CBD helped to maintain their spatial memory, reduce their anxiety & lessen fear-associated freezing

Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice

https://pubmed.ncbi.nlm.nih.gov/35202719/

Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In the treatment of tuberous sclerosis complex (the formation of many noncancerous tumors), this study finds that CBD starts to help with seizures in 6-10 days

Time to Onset of Cannabidiol (CBD) Treatment Effect and Resolution of Adverse Events in Tuberous Sclerosis Complex: Post Hoc Analysis of Randomized Controlled Phase 3 Trial GWPCARE6

https://pubmed.ncbi.nlm.nih.gov/35175622/


A survey of Parkinson’s patients finds that they use cannabis to help with improvements to motor function, sleep & pain

Cannabis use in Parkinson's disease-A nationwide online survey study

https://pubmed.ncbi.nlm.nih.gov/35178701/


A survey of pain patients found that cannabis causes a significant improvement in quality of life as well as reduced anxiety

Measuring the Change in Health-Related Quality of Life in Patients Using Marijuana for Pain Relief

https://pubmed.ncbi.nlm.nih.gov/35224431/


In humans, a study of how CBD enters the system via the various ingestion methods

Pharmacokinetic Profile of Δ9-Tetrahydrocannabinol, Cannabidiol, and Metabolites in Blood Following Vaporization and Oral Ingestion of Cannabidiol Products

https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkab124/6529814


In humans with opioid use disorder, a report on using cannabis for withdrawal

Biological (Testosterone and Oxytocin) Approach for the Impact of Naturalistic Cannabis use on Self-reported Opioid Withdrawal

https://www.primescholars.com/articles/biological-testosterone-and-oxytocin-approach-for-the-impact-of-naturalistic-cannabis-use-on-selfreported-opioid-withdra-107252.html



Recent Reviews


A review of using cannabinoids to treat multiple sclerosis

Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis

https://link.springer.com/article/10.1007/s11033-022-07223-5


A review of CBD & cannabis for sports

Cannabis, cannabidiol and tetrahydrocannabinol in sport: An overview

https://pubmed.ncbi.nlm.nih.gov/35191178/


This review finds CBD effective for treating epilepsy

Use of cannabidiol in the treatment of epilepsy

https://pubmed.ncbi.nlm.nih.gov/35211946


A review of cannabis for anxiety

A Comparative Review of Cannabis-Based Medication and First-Line Pharmacotherapy Treatments for Anxiety Disorders

https://ijrpr.com/uploads/V3ISSUE1/IJRPR2280.pdf


On targeting the ECS for treating migraines

The endocannabinoid system and related lipids as potential targets for the treatment of migraine-related pain

https://pubmed.ncbi.nlm.nih.gov/35179780/


A review of 5 studies find potential for using the cannabinoids to treat GI diseases in pediatric patients

THERAPEUTIC EFFECTS OF MEDICINAL CANNABINOIDS ON THE GASTROINTESTINAL SYSTEM IN PEDIATRIC PATIENTS: A SYSTEMATIC REVIEW

https://academic.oup.com/jcag/article/5/Supplement_1/78/6532896


A review of the transdermal delivery of cannabinoids

The Transdermal Delivery of Therapeutic Cannabinoids

https://pubmed.ncbi.nlm.nih.gov/35214170/


A network pharmacology study looks at how the protein targets of the cannabinoids help with human diseases

Network-Based Pharmacology Study Reveals Protein Targets for Medical Benefits and Harms of Cannabinoids in Humans

https://www.mdpi.com/2076-3417/12/4/2205


A review of the ECS in zebrafish suggests that it can be a model organism to study the effects of cannabis in humans

The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

https://pubmed.ncbi.nlm.nih.gov/35193700/



Preclinical Research & Cannabinoid Chemistry


In a mouse model of epileptic seizures being worsened during phases of the menstrual cycle, CBD protected from seizures & neuroinflammation

Partial protective effects of cannabidiol against PTZ-induced acute seizures in female rats during the proestrus-estrus transition

https://pubmed.ncbi.nlm.nih.gov/35217387/


In mice with cancer, a combination of CBD & naltrexone helped the chemotherapy to work better

Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy in vitro and in vivo

https://pubmed.ncbi.nlm.nih.gov/35179218/


In human brain cells, CBD activated potassium channels

Cannabidiol activates neuronal Kv7 channels

https://pubmed.ncbi.nlm.nih.gov/35179483/


In a mouse model of pain, combining an activator of the CB1 receptor & the mu-opioid receptor inhibited visceral pain without the development of side effects or tolerance

COMBINED CANNABINOID RECEPTOR 1 AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT VISCERAL PAIN IN VIVO WITHOUT ADVERSE SIDE EFFECTS OR TOLERANCE

https://academic.oup.com/jcag/article/5/Supplement_1/131/6533032


In a rat model of stroke, cannabinoids improved a number of measures & protected the brain

Effect of cannabinoids in global cerebral Ischemia in vivo

https://ejchem.journals.ekb.eg/article_221459.html


In a mouse model of memory impairment, fatty acid binding proteins (you might call them the vehicles that the endocannabinoids use to move around) have a key role in interacting with the environment during adolescence, though the lack of them seem to be worse for males than females

Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor

https://pubmed.ncbi.nlm.nih.gov/35202717/


In mice with alcohol use disorder, 2-AG modulates their sensitivity to pain & its supplementation could be a potential treatment for alcohol withdrawal

2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

https://www.biorxiv.org/content/10.1101/2022.02.15.480609v1.full


In mice, the CB1 receptor is necessary for the development of important dopamine neurons in the brain

Cannabinoid receptor 1 is required for neurodevelopment of striosome-dendron bouquets

https://europepmc.org/article/ppr/ppr448340