A great study of women in cannabis features many of the important names as well as insights into female fans of this female plant
https://www.womenincannabis.study/view-report
Best of the Week...
In two patients with hyperhidrosis (excessive sweating), CBD immediately improved their symptoms
Unexpected improvement of hyperhidrosis with cannabidiol
https://pubmed.ncbi.nlm.nih.gov/35170710/
Zynerba Pharmaceuticals completes enrollment for a transdermal CBD trial for 22q deletion syndrome (a serious developmental disorder resulting from missing DNA)
The headline you’ve been waiting for: hemp extract given to a bottlenose dolphin for the treatment of an eye disease
An Ocular Case Study of an Atlantic Bottlenose Dolphin (Tursiops truncatus) Using A Medical Regime of Various Topical, Oral, and Alternative Modalities Including Crystalline Hemp Extract
https://www.vin.com/apputil/content/defaultadv1.aspx?id=10200586&pid=27093&
In a mouse model of depression, LSD combined with CBD to help alleviate depression more than either substance alone
Synergistic effects of lysergic acid diethylamide (LSD) and cannabidiol (CBD)
In a mouse model of obesity, treatment with CBD & omega 3 (fish oil) improved the gut microbiome as well as reducing anxiety & memory impairment
High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies
https://www.scirp.org/journal/paperinformation.aspx?paperid=115157
In a mouse model of dementia, CBD helped to maintain their spatial memory, reduce their anxiety & lessen fear-associated freezing
Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice
https://pubmed.ncbi.nlm.nih.gov/35202719/
Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)
In the treatment of tuberous sclerosis complex (the formation of many noncancerous tumors), this study finds that CBD starts to help with seizures in 6-10 days
Time to Onset of Cannabidiol (CBD) Treatment Effect and Resolution of Adverse Events in Tuberous Sclerosis Complex: Post Hoc Analysis of Randomized Controlled Phase 3 Trial GWPCARE6
https://pubmed.ncbi.nlm.nih.gov/35175622/
A survey of Parkinson’s patients finds that they use cannabis to help with improvements to motor function, sleep & pain
Cannabis use in Parkinson's disease-A nationwide online survey study
https://pubmed.ncbi.nlm.nih.gov/35178701/
A survey of pain patients found that cannabis causes a significant improvement in quality of life as well as reduced anxiety
Measuring the Change in Health-Related Quality of Life in Patients Using Marijuana for Pain Relief
https://pubmed.ncbi.nlm.nih.gov/35224431/
In humans, a study of how CBD enters the system via the various ingestion methods
Pharmacokinetic Profile of Δ9-Tetrahydrocannabinol, Cannabidiol, and Metabolites in Blood Following Vaporization and Oral Ingestion of Cannabidiol Products
https://academic.oup.com/jat/advance-article-abstract/doi/10.1093/jat/bkab124/6529814
In humans with opioid use disorder, a report on using cannabis for withdrawal
Biological (Testosterone and Oxytocin) Approach for the Impact of Naturalistic Cannabis use on Self-reported Opioid Withdrawal
Recent Reviews
A review of using cannabinoids to treat multiple sclerosis
Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis
https://link.springer.com/article/10.1007/s11033-022-07223-5
A review of CBD & cannabis for sports
Cannabis, cannabidiol and tetrahydrocannabinol in sport: An overview
https://pubmed.ncbi.nlm.nih.gov/35191178/
This review finds CBD effective for treating epilepsy
Use of cannabidiol in the treatment of epilepsy
https://pubmed.ncbi.nlm.nih.gov/35211946
A review of cannabis for anxiety
A Comparative Review of Cannabis-Based Medication and First-Line Pharmacotherapy Treatments for Anxiety Disorders
https://ijrpr.com/uploads/V3ISSUE1/IJRPR2280.pdf
On targeting the ECS for treating migraines
The endocannabinoid system and related lipids as potential targets for the treatment of migraine-related pain
https://pubmed.ncbi.nlm.nih.gov/35179780/
A review of 5 studies find potential for using the cannabinoids to treat GI diseases in pediatric patients
THERAPEUTIC EFFECTS OF MEDICINAL CANNABINOIDS ON THE GASTROINTESTINAL SYSTEM IN PEDIATRIC PATIENTS: A SYSTEMATIC REVIEW
https://academic.oup.com/jcag/article/5/Supplement_1/78/6532896
A review of the transdermal delivery of cannabinoids
The Transdermal Delivery of Therapeutic Cannabinoids
https://pubmed.ncbi.nlm.nih.gov/35214170/
A network pharmacology study looks at how the protein targets of the cannabinoids help with human diseases
Network-Based Pharmacology Study Reveals Protein Targets for Medical Benefits and Harms of Cannabinoids in Humans
https://www.mdpi.com/2076-3417/12/4/2205
A review of the ECS in zebrafish suggests that it can be a model organism to study the effects of cannabis in humans
The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans
https://pubmed.ncbi.nlm.nih.gov/35193700/
Preclinical Research & Cannabinoid Chemistry
In a mouse model of epileptic seizures being worsened during phases of the menstrual cycle, CBD protected from seizures & neuroinflammation
Partial protective effects of cannabidiol against PTZ-induced acute seizures in female rats during the proestrus-estrus transition
https://pubmed.ncbi.nlm.nih.gov/35217387/
In mice with cancer, a combination of CBD & naltrexone helped the chemotherapy to work better
Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy in vitro and in vivo
https://pubmed.ncbi.nlm.nih.gov/35179218/
In human brain cells, CBD activated potassium channels
Cannabidiol activates neuronal Kv7 channels
https://pubmed.ncbi.nlm.nih.gov/35179483/
In a mouse model of pain, combining an activator of the CB1 receptor & the mu-opioid receptor inhibited visceral pain without the development of side effects or tolerance
COMBINED CANNABINOID RECEPTOR 1 AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT VISCERAL PAIN IN VIVO WITHOUT ADVERSE SIDE EFFECTS OR TOLERANCE
https://academic.oup.com/jcag/article/5/Supplement_1/131/6533032
In a rat model of stroke, cannabinoids improved a number of measures & protected the brain
Effect of cannabinoids in global cerebral Ischemia in vivo
https://ejchem.journals.ekb.eg/article_221459.html
In a mouse model of memory impairment, fatty acid binding proteins (you might call them the vehicles that the endocannabinoids use to move around) have a key role in interacting with the environment during adolescence, though the lack of them seem to be worse for males than females
Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor
https://pubmed.ncbi.nlm.nih.gov/35202717/
In mice with alcohol use disorder, 2-AG modulates their sensitivity to pain & its supplementation could be a potential treatment for alcohol withdrawal
2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice
https://www.biorxiv.org/content/10.1101/2022.02.15.480609v1.full
In mice, the CB1 receptor is necessary for the development of important dopamine neurons in the brain
Cannabinoid receptor 1 is required for neurodevelopment of striosome-dendron bouquets