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Research Roundup: Mar 7, 2022



A great study of women in cannabis features many of the important names as well as insights into female fans of this female plant


Best of the Week...


In two patients with hyperhidrosis (excessive sweating), CBD immediately improved their symptoms

Unexpected improvement of hyperhidrosis with cannabidiol


Zynerba Pharmaceuticals completes enrollment for a transdermal CBD trial for 22q deletion syndrome (a serious developmental disorder resulting from missing DNA)


The headline you’ve been waiting for: hemp extract given to a bottlenose dolphin for the treatment of an eye disease

An Ocular Case Study of an Atlantic Bottlenose Dolphin (Tursiops truncatus) Using A Medical Regime of Various Topical, Oral, and Alternative Modalities Including Crystalline Hemp Extract


In a mouse model of depression, LSD combined with CBD to help alleviate depression more than either substance alone

Synergistic effects of lysergic acid diethylamide (LSD) and cannabidiol (CBD)


In a mouse model of obesity, treatment with CBD & omega 3 (fish oil) improved the gut microbiome as well as reducing anxiety & memory impairment

High Fat Diet Alteration of Gut Microbiota Impacts Learning, Memory and Anxiety Response in Mice: Cannabidiol and Omega 3 Possible Remedies


In a mouse model of dementia, CBD helped to maintain their spatial memory, reduce their anxiety & lessen fear-associated freezing

Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice

Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In the treatment of tuberous sclerosis complex (the formation of many noncancerous tumors), this study finds that CBD starts to help with seizures in 6-10 days

Time to Onset of Cannabidiol (CBD) Treatment Effect and Resolution of Adverse Events in Tuberous Sclerosis Complex: Post Hoc Analysis of Randomized Controlled Phase 3 Trial GWPCARE6


A survey of Parkinson’s patients finds that they use cannabis to help with improvements to motor function, sleep & pain

Cannabis use in Parkinson's disease-A nationwide online survey study


A survey of pain patients found that cannabis causes a significant improvement in quality of life as well as reduced anxiety

Measuring the Change in Health-Related Quality of Life in Patients Using Marijuana for Pain Relief


In humans, a study of how CBD enters the system via the various ingestion methods

Pharmacokinetic Profile of Δ9-Tetrahydrocannabinol, Cannabidiol, and Metabolites in Blood Following Vaporization and Oral Ingestion of Cannabidiol Products


In humans with opioid use disorder, a report on using cannabis for withdrawal

Biological (Testosterone and Oxytocin) Approach for the Impact of Naturalistic Cannabis use on Self-reported Opioid Withdrawal



Recent Reviews


A review of using cannabinoids to treat multiple sclerosis

Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis


A review of CBD & cannabis for sports

Cannabis, cannabidiol and tetrahydrocannabinol in sport: An overview


This review finds CBD effective for treating epilepsy

Use of cannabidiol in the treatment of epilepsy


A review of cannabis for anxiety

A Comparative Review of Cannabis-Based Medication and First-Line Pharmacotherapy Treatments for Anxiety Disorders


On targeting the ECS for treating migraines

The endocannabinoid system and related lipids as potential targets for the treatment of migraine-related pain


A review of 5 studies find potential for using the cannabinoids to treat GI diseases in pediatric patients

THERAPEUTIC EFFECTS OF MEDICINAL CANNABINOIDS ON THE GASTROINTESTINAL SYSTEM IN PEDIATRIC PATIENTS: A SYSTEMATIC REVIEW


A review of the transdermal delivery of cannabinoids

The Transdermal Delivery of Therapeutic Cannabinoids


A network pharmacology study looks at how the protein targets of the cannabinoids help with human diseases

Network-Based Pharmacology Study Reveals Protein Targets for Medical Benefits and Harms of Cannabinoids in Humans


A review of the ECS in zebrafish suggests that it can be a model organism to study the effects of cannabis in humans

The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans



Preclinical Research & Cannabinoid Chemistry


In a mouse model of epileptic seizures being worsened during phases of the menstrual cycle, CBD protected from seizures & neuroinflammation

Partial protective effects of cannabidiol against PTZ-induced acute seizures in female rats during the proestrus-estrus transition


In mice with cancer, a combination of CBD & naltrexone helped the chemotherapy to work better

Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy in vitro and in vivo


In human brain cells, CBD activated potassium channels

Cannabidiol activates neuronal Kv7 channels


In a mouse model of pain, combining an activator of the CB1 receptor & the mu-opioid receptor inhibited visceral pain without the development of side effects or tolerance

COMBINED CANNABINOID RECEPTOR 1 AND MU-OPIOID RECEPTOR AGONISTS SYNERGISTICALLY INHIBIT VISCERAL PAIN IN VIVO WITHOUT ADVERSE SIDE EFFECTS OR TOLERANCE


In a rat model of stroke, cannabinoids improved a number of measures & protected the brain

Effect of cannabinoids in global cerebral Ischemia in vivo


In a mouse model of memory impairment, fatty acid binding proteins (you might call them the vehicles that the endocannabinoids use to move around) have a key role in interacting with the environment during adolescence, though the lack of them seem to be worse for males than females

Environmental enrichment sex-dependently rescues memory impairment in FABP5 KO mice not mediated by brain-derived neurotrophic factor


In mice with alcohol use disorder, 2-AG modulates their sensitivity to pain & its supplementation could be a potential treatment for alcohol withdrawal

2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice


In mice, the CB1 receptor is necessary for the development of important dopamine neurons in the brain

Cannabinoid receptor 1 is required for neurodevelopment of striosome-dendron bouquets

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