Best of cannabinoid science this week...
For moderate PTSD, a cost-utility analysis found cannabis to be a cost-effective adjunctive therapy
The Cost Effectiveness of Adjunctive Medical Cannabis Therapy in the Treatment of Moderate Post-Traumatic Stress Disorder
In people with chronic pain using unregulated opioids, daily cannabis use was associated with higher odds of opioid cessation
Cannabis use and illicit opioid cessation among people who use drugs living with chronic pain
In people with gingivitis, a rinse of tea tree oil, CBD & spilanthol ( a spicy fatty acid) reduced bleeding & plaque
Evaluation of the Effectiveness of a Mouthwash Containing Spilanthol and Cannabidiol on Improving Oral Health in Patients with Gingivitis—Clinical Trial
For sickle cell disease, a review of using the cannabinoids for pain management, inflammation & cardiac complications
Modulation of the endocannabinoid system in chronic conditions: a potential therapeutic intervention yet to be explored in sickle cell disease
For HIV, a review on the promise of cannabis for managing inflammation, gut dysbiosis & immune system dysfunction
Cannabis Use in HIV: Impact on Inflammation, Immunity and the Microbiome
For depression, a review on targeting the CB2 receptor in the microglia (guardian immune cells of the brain) (nice charts)
Microglial cannabinoid receptor 2 and epigenetic regulation: Implications for the treatment of depression
For orofacial pain, a review of using cannabinoids (Portuguese)
Canabinoides na Dor Orofacial - Uma Revisão de Escopo
In adolescent squirrel monkeys, six months of low-dose THC injections increased functional connectivity in the central executive network
Central Executive Network drives delta-9-tetrahydrocannabinol (THC)-induced nonlinear changes in large-scale functional connectivity in adolescent nonhuman primates
In 3 different mouse models of migraines, a 100:1 CBD:THC combination reduced the most bothersome symptoms (thanks to Dr. Erik Zorrilla for alerting me to his new study)
Combined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice
In a rat model of neuropathic pain & depression, a comparison of CBD versus fluoxetine found that while both help with the depression-like behavior, only CBD also helped with the pain
Comparison between Cannabidiol and Fluoxetine effects on chronic neuropathic pain and depression comorbid in rats
In a mouse model of colitis, on the entourage effect for pain reduction by combining CBD, CBG, CBC & CBDV
Entourage effects of nonpsychotropic cannabinoids on visceral sensitivity in experimental colitis
In a rat model of liver dysfunction caused by a high fat diet, CBD prevented ceramide deposition & improved insulin signaling via the sphingolipid pathway
Cannabidiol and sphingolipid metabolism – an unexplored link offering a novel therapeutic approach against high-fat diet-induced hepatic insulin resistance
In a mouse model of a high fat diet, gut bacteria that produce the endocannabinoid oleoylethanolamide led to significant weight loss, the increase of beneficial gut bacteria & improved metabolic dysfunction, depression, anxiety & gut barrier function
Oleoylethanolamide-producing Lactobacillus paracasei F19 improves metabolic and behavioral disorders by restoring intestinal permeability and microbiota-gut-brain axis in high-fat diet-induced obese male mice
Another series of tests that found CBD to not be genotoxic, to not cause DNA damage & to not influence genomic stability
Assessment of the genotoxic and mutagenic potential of a CBD isolate and a Cannabis sativa extract in vitro
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