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Research Roundup: Mar 21, 2022



Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In people with multiple sclerosis, THC & CBD helped with inflammation via the Toll receptors

Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis

https://www.mdpi.com/1420-3049/27/6/1763/htm

In pain patients, cannabis oil reduced the use of opioids

Long-term Cannabis-based oil therapy and pain medications prescribing patterns: an Italian observational study

https://pubmed.ncbi.nlm.nih.gov/35253178/

& a survey finds that medical cannabis patients reported it helped their pain, sleep & overall function

Medical Marijuana Efficacy: A Survey

https://www.scirp.org/journal/paperinformation.aspx?paperid=115717

In some people with Tourette syndrome, medical cannabis helped to control tics

Medical Cannabis for Gilles de la Tourette Syndrome: An Open-Label Prospective Study

https://www.hindawi.com/journals/bn/2022/5141773/

In patients with anal fissures, a topical hemp blend significantly improved pain & quality of life

Management of Chronic Anal Fissure With A Novel Topical Hemp-Herbal Based Ointment - A Pilot Study

https://assets.researchsquare.com/files/rs-1389433/v1/1340a238-aa36-4e95-831f-71312e1b0ed5.pdf?c=1646671134

In dogs, CBG & CBGA caused no ill effects & CBGA was found to be much more bioavailable

Single dose and chronic oral administration of cannabigerol and cannabigerolic acid-rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation

https://pubmed.ncbi.nlm.nih.gov/35246858/

In horses being transported, CBD reduced stress

Cannabidiol Supplementation and Physiological Response in Transported Horses

https://academic.oup.com/jas/article/100/Supplement_1/33/6544471?login=true

In steers, feeding them hemp rich in CBDA helped with stress & inflammation

Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers

https://pubmed.ncbi.nlm.nih.gov/35256692/



Recent Reviews


On the role of cannabis in neurology

Neurology - to be or not to be of the cannabis-based medicine?

https://pubmed.ncbi.nlm.nih.gov/35233759/

& on the role of cannabis in psychiatry

The Construct of Medical and Non-Medical Marijuana-Critical Review

https://pubmed.ncbi.nlm.nih.gov/35270462/

& a review of the ECS in mood disorders

Endocannabinoid system in psychotic and mood disorders, a review of human studies

https://pubmed.ncbi.nlm.nih.gov/32898588/

& an editorial on why cannabis might be excellent for psychotic disorders

Commentary on: it might be a wonderful opportunity when patients with a psychotic disorder use cannabis

https://www.cambridge.org/core/journals/psychological-medicine/article/commentary-on-it-might-be-a-wonderful-opportunity-when-patients-with-a-psychotic-disorder-use-cannabis/5730A5478D4D93DF90977BFBBF2B8062

Cannabinoids for migraines

Clinical Evidence of Cannabinoids in Migraine: A Narrative Review

https://www.mdpi.com/2077-0383/11/6/1479/htm

A review of the effects of THC on obesity at different stages of life

Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review

https://www.mdpi.com/1660-4601/19/6/3174/html

A review of the cannabinoids for treating cancer

Plant-derived cannabinoids as anticancer agents

https://pubmed.ncbi.nlm.nih.gov/35260379/

& a review focused on pancreatic cancer

Targeting the Endocannabinoid System: From the Need for New Therapies to the Development of a Promising Strategy. What About Pancreatic Cancer?

https://pubmed.ncbi.nlm.nih.gov/35241505/



Preclinical Research & Cannabinoid Chemistry


In mice, CBD helps to promote new bone growth via the lowering of inflammation & the activation of bone stem cells

Cannabidiol Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in the Inflammatory Microenvironment via the CB2-dependent p38 MAPK Signaling Pathway

https://pubmed.ncbi.nlm.nih.gov/35220282/

In a mouse model of glaucoma, a stabilized nanoemulsion of CBD reduced ocular inflammation & at some dosages, helped decrease intraocular pressure

The dose-dependent effect of a stabilized cannabidiol nanoemulsion on ocular surface inflammation and intraocular pressure

https://pubmed.ncbi.nlm.nih.gov/35245638/

In a mouse model of multiple sclerosis, activating the CB2 receptor reduced inflammation & improved symptoms

A CB2 Receptor Agonist Reduces the Production of Inflammatory Mediators and Improves Locomotor Activity in Experimental Autoimmune Encephalomyelitis

http://rbmb.net/article-1-819-en.pdf

In a tissue model of Alzheimer’s disease, some cannabis terpenes provided neuroprotection against the toxic neurofibrillary tangles

Cannabis terpenes display variable protective and anti-aggregatory actions against neurotoxic β amyloid in vitro: highlighting the protective bioactivity of α-bisabolol in motorneuronal-like NSC-34 cells

https://pubmed.ncbi.nlm.nih.gov/35278524/