Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)
In people with multiple sclerosis, THC & CBD helped with inflammation via the Toll receptors
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
In pain patients, cannabis oil reduced the use of opioids
Long-term Cannabis-based oil therapy and pain medications prescribing patterns: an Italian observational study
& a survey finds that medical cannabis patients reported it helped their pain, sleep & overall function
Medical Marijuana Efficacy: A Survey
In some people with Tourette syndrome, medical cannabis helped to control tics
Medical Cannabis for Gilles de la Tourette Syndrome: An Open-Label Prospective Study
In patients with anal fissures, a topical hemp blend significantly improved pain & quality of life
Management of Chronic Anal Fissure With A Novel Topical Hemp-Herbal Based Ointment - A Pilot Study
In dogs, CBG & CBGA caused no ill effects & CBGA was found to be much more bioavailable
Single dose and chronic oral administration of cannabigerol and cannabigerolic acid-rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation
In horses being transported, CBD reduced stress
Cannabidiol Supplementation and Physiological Response in Transported Horses
In steers, feeding them hemp rich in CBDA helped with stress & inflammation
Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers
Recent Reviews
On the role of cannabis in neurology
Neurology - to be or not to be of the cannabis-based medicine?
& on the role of cannabis in psychiatry
The Construct of Medical and Non-Medical Marijuana-Critical Review
& a review of the ECS in mood disorders
Endocannabinoid system in psychotic and mood disorders, a review of human studies
& an editorial on why cannabis might be excellent for psychotic disorders
Commentary on: it might be a wonderful opportunity when patients with a psychotic disorder use cannabis
Cannabinoids for migraines
Clinical Evidence of Cannabinoids in Migraine: A Narrative Review
A review of the effects of THC on obesity at different stages of life
Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review
A review of the cannabinoids for treating cancer
Plant-derived cannabinoids as anticancer agents
& a review focused on pancreatic cancer
Targeting the Endocannabinoid System: From the Need for New Therapies to the Development of a Promising Strategy. What About Pancreatic Cancer?
Preclinical Research & Cannabinoid Chemistry
In mice, CBD helps to promote new bone growth via the lowering of inflammation & the activation of bone stem cells
Cannabidiol Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in the Inflammatory Microenvironment via the CB2-dependent p38 MAPK Signaling Pathway
In a mouse model of glaucoma, a stabilized nanoemulsion of CBD reduced ocular inflammation & at some dosages, helped decrease intraocular pressure
The dose-dependent effect of a stabilized cannabidiol nanoemulsion on ocular surface inflammation and intraocular pressure
In a mouse model of multiple sclerosis, activating the CB2 receptor reduced inflammation & improved symptoms
A CB2 Receptor Agonist Reduces the Production of Inflammatory Mediators and Improves Locomotor Activity in Experimental Autoimmune Encephalomyelitis
In a tissue model of Alzheimer’s disease, some cannabis terpenes provided neuroprotection against the toxic neurofibrillary tangles
Cannabis terpenes display variable protective and anti-aggregatory actions against neurotoxic β amyloid in vitro: highlighting the protective bioactivity of α-bisabolol in motorneuronal-like NSC-34 cells