Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)
In people with multiple sclerosis, THC & CBD helped with inflammation via the Toll receptors
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
https://www.mdpi.com/1420-3049/27/6/1763/htm
In pain patients, cannabis oil reduced the use of opioids
Long-term Cannabis-based oil therapy and pain medications prescribing patterns: an Italian observational study
https://pubmed.ncbi.nlm.nih.gov/35253178/
& a survey finds that medical cannabis patients reported it helped their pain, sleep & overall function
Medical Marijuana Efficacy: A Survey
https://www.scirp.org/journal/paperinformation.aspx?paperid=115717
In some people with Tourette syndrome, medical cannabis helped to control tics
Medical Cannabis for Gilles de la Tourette Syndrome: An Open-Label Prospective Study
https://www.hindawi.com/journals/bn/2022/5141773/
In patients with anal fissures, a topical hemp blend significantly improved pain & quality of life
Management of Chronic Anal Fissure With A Novel Topical Hemp-Herbal Based Ointment - A Pilot Study
In dogs, CBG & CBGA caused no ill effects & CBGA was found to be much more bioavailable
Single dose and chronic oral administration of cannabigerol and cannabigerolic acid-rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation
https://pubmed.ncbi.nlm.nih.gov/35246858/
In horses being transported, CBD reduced stress
Cannabidiol Supplementation and Physiological Response in Transported Horses
https://academic.oup.com/jas/article/100/Supplement_1/33/6544471?login=true
In steers, feeding them hemp rich in CBDA helped with stress & inflammation
Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers
https://pubmed.ncbi.nlm.nih.gov/35256692/
Recent Reviews
On the role of cannabis in neurology
Neurology - to be or not to be of the cannabis-based medicine?
https://pubmed.ncbi.nlm.nih.gov/35233759/
& on the role of cannabis in psychiatry
The Construct of Medical and Non-Medical Marijuana-Critical Review
https://pubmed.ncbi.nlm.nih.gov/35270462/
& a review of the ECS in mood disorders
Endocannabinoid system in psychotic and mood disorders, a review of human studies
https://pubmed.ncbi.nlm.nih.gov/32898588/
& an editorial on why cannabis might be excellent for psychotic disorders
Commentary on: it might be a wonderful opportunity when patients with a psychotic disorder use cannabis
Cannabinoids for migraines
Clinical Evidence of Cannabinoids in Migraine: A Narrative Review
https://www.mdpi.com/2077-0383/11/6/1479/htm
A review of the effects of THC on obesity at different stages of life
Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review
https://www.mdpi.com/1660-4601/19/6/3174/html
A review of the cannabinoids for treating cancer
Plant-derived cannabinoids as anticancer agents
https://pubmed.ncbi.nlm.nih.gov/35260379/
& a review focused on pancreatic cancer
Targeting the Endocannabinoid System: From the Need for New Therapies to the Development of a Promising Strategy. What About Pancreatic Cancer?
https://pubmed.ncbi.nlm.nih.gov/35241505/
Preclinical Research & Cannabinoid Chemistry
In mice, CBD helps to promote new bone growth via the lowering of inflammation & the activation of bone stem cells
Cannabidiol Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in the Inflammatory Microenvironment via the CB2-dependent p38 MAPK Signaling Pathway
https://pubmed.ncbi.nlm.nih.gov/35220282/
In a mouse model of glaucoma, a stabilized nanoemulsion of CBD reduced ocular inflammation & at some dosages, helped decrease intraocular pressure
The dose-dependent effect of a stabilized cannabidiol nanoemulsion on ocular surface inflammation and intraocular pressure
https://pubmed.ncbi.nlm.nih.gov/35245638/
In a mouse model of multiple sclerosis, activating the CB2 receptor reduced inflammation & improved symptoms
A CB2 Receptor Agonist Reduces the Production of Inflammatory Mediators and Improves Locomotor Activity in Experimental Autoimmune Encephalomyelitis
http://rbmb.net/article-1-819-en.pdf
In a tissue model of Alzheimer’s disease, some cannabis terpenes provided neuroprotection against the toxic neurofibrillary tangles
Cannabis terpenes display variable protective and anti-aggregatory actions against neurotoxic β amyloid in vitro: highlighting the protective bioactivity of α-bisabolol in motorneuronal-like NSC-34 cells