Research Roundup: July 15, 2025
- Lex Pelger
- 58 minutes ago
- 2 min read
Best of cannabinoid science this week...
In lung cancer patients, a double-blind trial found that CBD helped with pain & insomnia
IPElife: Phase III, double-blind trial of cannabis sativa extract in pain management and quality of life in patients with metastatic lung cancer
In adolescents with Tourette syndrome, a ratio of 10:15 THC:CBD cannabis improved tic levels, behavioral & emotional issues & quality of life
Medicinal cannabis for tics in adolescents with Tourette syndrome
In people with anxiety and/or depression, initiating medical cannabis use was associated with significant decreases in anxiety & depression levels, “with mean scores dropping below clinically significant levels within three months of initiation”
Acute and chronic effects of medicinal cannabis use on anxiety and depression in a prospective cohort of patients new to cannabis
In young children with drug-resistant epilepsy, CBD reduced seizure frequency & improved social & environmental participation, but some were non-responders
Efficacy and Safety of Cannabidiol in a Single-Center Pediatric Drug-Resistant Epilepsy Cohort: A Retrospective Study
But in two case reports of epilepsy, cannabis increased seizure frequency & severity as well as reducing the effectiveness of anti-seizure medication
The role of cannabis in epilepsy illustrated by two case reports
For anxiety, a review of combining CBD with Cognitive Behavioral Therapy (CBT) [Portuguese]
CANABIDIOL: UMA PROMESSA PARA A ANSIEDADE? EXPLORANDO EFICÁCIA, IMPACTOS PSICOLÓGICOS E EVIDÊNCIAS CIENTÍFICAS
For psychopathology in young people, a review of targeting the endocannabinoid system
Research Review: What we have learned about the endocannabinoid system in developmental psychopathology
For neurodegenerative disorders, a review of the combination of acupuncture & targeting the endocannabinoid system
Therapeutic Potential of the Cannabinoid System and Acupuncture in Neurodegenerative Brain Disorders: a Comprehensive Review
In a mouse model of polycystic ovary syndrome, CBD improved their metabolic profile & lessened liver inflammation & fibrosis (scarring)
Cannabidiol improves metabolic profiles and alleviates liver inflammation and fibrosis in conditions of androgenic obesity and polycystic ovary syndrome
In a mouse model of alcohol use disorder, CBD reduced alcohol-self-administration, motivation for alcohol, somatic withdrawal signs, withdrawal-induced anxiety-like behaviors & mechanical sensitivity via the amygdala (a processing center of emotional responses)
Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum
In a rat model of schizophrenia, CBD lessened cognitive deficits such as memory impairment & enhanced dopamine signaling
Cannabidiol Attenuates Behavioral and Electrophysiological Changes in the Mam Model of Schizophrenia in Male and Female Rats
In a mouse model of chronic sleep deprivation, CBD, CBG & CBC lessened memory impairment & depression as well as lowered activation of the microglia (guardian immune cells of the brain) & lessened their shift towards a more pro-inflammatory polarization
Long-term cannabinoid therapy can ameliorate chronic sleep deprivation-induced behavioral and neuroinflammatory changes in mice
In a gerbil model of stroke, the terpene beta caryophyllene caused neuroprotection & improved memory function as well as improvements to the gut microbiome
Neuroprotective Effects of SELFormer-Selected β-Citronellol and β-Caryophyllene in Vagotomized Ischemic Stroke Model Through Direct Brain Protection and Gut Microbiota Modulation
An analysis of the antiviral effects of the terpene beta caryophyllene
Insights into the antiviral mechanisms of β-caryophyllene: inhibiting viral spread and its synergy with acyclovir
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