Research Roundup: June 24, 2025
- Lex Pelger
- Jun 22
- 3 min read
Best of cannabinoid science this week...
In breast cancer survivors, a survey found they reported cannabis improved mood, sleep, pain, neuropathy & appetite
Chronic cannabis use in breast cancer survivors: A questionnaire study of Israeli patients
In people with chronic pain taking buprenorphine/naloxone for opioid use disorder, a capsule of 1:1 CBD:THC cause significant decreases in pain severity & pain interference, as well as increases in pain-related self-efficacy, sleep & quality of life
Clinical and psychosocial changes in adults with opioid use disorder and chronic pain using medical cannabis: a brief report
In people with fibromyalgia, this case series found that 1:1 THC:CBD for three months cause significant improvement in pain scores, stiffness levels, sleep quality & fibromyalgia symptom scores
ABS1022 USE OF CANNABIS LIQUID PLANT EXTRACT 10 mg/ml Δ9-TETRAHYDROCANNABINOL AND 10 mg/ml CANNABIDIOL IN PATIENTS WITH FIBROMYALGIA SYNDROME
As is often the case, the people who responded well to the treatment were the ones with the highest initial baseline scores for higher pain & worse sleep.
In people with inflammatory bowel disease, a survey found the majority believed cannabis & CBD oil had a somewhat or extremely beneficial effect in relieving symptoms with over half reporting relief from abdominal pain, other pain, stress, anxiety, depression & nausea/vomiting, 19% reporting decreased opioid use, 14% reporting remission & Crohn's patients experiencing significantly more relief than ulcerative colitis patients
Inflammatory bowel disease patients believe cannabis and cannabidiol oil relieve symptoms
In autism, a meta-analysis of 21 studies on the alterations to the endocannabinoid system with less anandamide in the blood & hippocampus (memory center of the brain) as well as decreased levels of 2-AG in the prefrontal cortex (highest area of the brain)
Alterations of the endocannabinoid system in autism spectrum disorder: a systematic review and meta-analysis
For atopic dermatitis (eczema), 12 weeks of an emollient with CBD & ginger extract led to sustained improvements of itchiness, redness, dryness & patient-reported outcomes
Long-term Progressive Improvement of Atopic Dermatitis by an Herbal Emollient Plus Combination in a 12-week Clinical Trial
In dogs, a gel-based CBD produced similar effects to oil-based CBD including lowering of post-stress cortisol levels
A Preliminary Evaluation of the Comparative Efficacy of Gel-Based and Oil-Based CBD on Hematologic and Biochemical Responses in Dogs
For dogs in a shelter, giving them CBD + CBDA for 4 weeks caused significant increases in resting time & decreases in physical activity with a possible reduction of stress/anxiety stereotypic behaviors such as pacing or circling (which may explain the lower activity)
CBD/CBDA rich hemp extract and Shelter Dogs: A New Look at Canine Activity and Welfare
For Alzheimer's disease, this review found “that the combination of THC and CBD can significantly reduce agitation and aggression” & “CBD demonstrated neuroprotective potential, attenuating neuroinflammation and β-amyloid plaque formation”
Exploring the Role of Cannabis in Modulating Pathological Mechanisms of Alzheimer's Disease
For epilepsy, a review of the endocannabinoid system in pathogenesis & treatment
The role of the endocannabinoid system in the pathogenesis and treatment of epilepsy
In an adolescent rat model of depression, CBD caused antidepressant effects without causing long-term changes to cognitive performance or effective behavior
Adolescent cannabidiol treatment produces antidepressant-like effects without compromising long-term cognition in rats
In a mouse model of social stress, oleoylethanolamide (the endocannabinoid of satiety) restored their deficits in pre-pulse inhibition (a measure of propensity to schizophrenia) with gendered effects on anxiety & depressive-like behaviors via the striatum (a brain region of the motor & reward systems) & hippocampus (memory center of the brain)
Oleoylethanolamide restores stress-induced prepulse inhibition deficits and modulates inflammatory signaling in a sex-dependent manner
In a mouse model of radiation-induced skin wounds, a hydrogel with CBD reduced inflammation & increased collagen production
A novel antioxidant and anti-inflammatory carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol promotes the healing of radiation-combined wound skin injury in the 60Co γ-irradiated mice
Comments