Research Roundup: July 8, 2025
- Lex Pelger
- Jul 8
- 2 min read
Best of cannabinoid science this week...
In peripheral neuropathy induced by the cancer treatment taxane, 8 weeks of 100mg of CBD + 5mg of THC caused significantly better ratings on pain measurements, sleep & functional well-being but worse on sleep
Oral Cannabis for Taxane-Induced Neuropathy: A Pilot Randomized Placebo-Controlled Study
For endometriosis, a thesis surveying people found many self-medicate with cannabis for pain relief
Weed Out the Pain: Using Cannabis to Manage Endometriosis
In opioid maintenance therapy, close to half used cannabis & the majority met criteria for cannabis dependence, with the most common reasons for use being mood change, enhancements & a reduction in cravings for other substances
Cannabis Use in Opioid Maintenance Therapy: Prevalence, Clinical Correlates and Reasons for Use
For autism, a review of targeting the endocannabinoid-microbiome-brain axis (great chart!)
The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder
For orthopedic conditions & pain, a review of the therapeutic evidence for cannabinoids
The Efficacy and Safety of Use of Cannabis and Cannabinoid Products for Pain Relief in Orthopaedic Conditions and Trauma
On pain & the terpenoids, a review using a Traditional Chinese medicine lens
Terpenoids: A promising traditional chinese medicine for neuropathic pain relief
In a rat model of glaucoma, a nano CBD eye drop lowered intraocular pressure, caused antioxidant effects & protected the retinal ganglion cells (neuronal eye cells)
Neuroprotective Effects of Topical Nano-Formulated CBD Eye Drops in a Glaucoma Rat Model
In a mouse model of developmental & epileptic encephalopathy (a rare drug-resistant pediatric epilepsy with developmental delays), CBD reduced seizure severity & frequency while also lowering the expression of pro-inflammatory genes
Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1
In 2 mouse models of seizures, CBD significantly reduced seizure frequency & severity
Assessing the Impact of Cannabidiol on Seizure Frequency and Severity in Animal Models of Epilepsy
In a tissue model of Parkinson's disease, a water infusion of cannabis had a high CBD content & protected from cell death
Chemical Profiling of Polyphenolic Fraction of Cannabis sativa L. vr. Kompolti Industrial Inflorescences: Insights into Cannabidiol Neuroprotective Effects in a Cellular Model of Parkinson's Disease
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