Research Roundup: July 1, 2025
- Lex Pelger
- 43 minutes ago
- 5 min read
Best of cannabinoid science this week...
In women with sexual dysfunction, those who used cannabis before sex reported significantly higher lubrication scores & trends towards higher arousal & sexual function scores
Cannabis Use in Women and Sexual Dysfunction
For sleep, a 1:1 THC:CBD or 1:16 THC:CBD significantly increased subjective sleepiness
Same-Day Sedative and Night-Time Sleep Effects Following Combined Cannabinoid Formulations: A Randomised-Controlled Trial
For people with neurotoxicity from methamphetamine, CBD inhibited the oxidative stress & neural cell death
Cannabidiol attenuates methamphetamine-induced oxidative neurotoxicity via regulating transient receptor potential vanilloid type 1
For dementia, a conference abstract reported that both a 15-day & 6-month trial of CBD resulted in very positive effects
The role of Cannabinoids in Dementia
In people with gastrointestinal symptoms, a survey of 1 year of cannabis use reported a significant decrease in GI symptom severity
Relief in Gastrointestinal Symptoms With Medical Marijuana Over 1 Year
In a survey of women with fibromyalgia, this thesis found they described cannabis as transformative, helping with pain, sleep & quality of life but that they experienced stigma, lack of medical guidance, high cost & difficulties in determining dosage
EXPERIENCES OF CANADIAN WOMEN USING CANNABIS FOR FIBROMYALGIA SYMPTOM MANAGEMENT: A QUALITATIVE DESCRIPTION STUDY
In interviews of caregivers of neurologically disabled children, they reported that medical cannabis improved symptoms & quality of life in their children
Caregiver experiences of children living with a diagnosed neurological disability and using medical cannabis
In children with Rett Syndrome & CDKL5 Deficiency Disorder (two severe neurodevelopmental disorders that often include drug-resistant epilepsy), an open-label study found CBD reduced the incidence of seizures (sometimes dramatically) & improved other symptoms such as sleep & attention
Is highly purified cannabidiol a treatment opportunity for drug‐resistant epilepsy in subjects with typical Rett syndrome and CDKL5 deficiency disorder?
In young people with Rett syndrome (a rare neurodevelopmental disorder), a low-dose THC extract improved clinical scores, communication skills, mental alertness, socialization/eye contact, attentiveness, anxiety, general mood ,breathing problems, repetitive face movements, fear/anxiety, the ability to communicate choices, cognition & quality of life
Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open-Label Study
In people with chronic pain, an industry study of a 1:1 THC:CBD extract found decreased pain intensity & pain interference as well as improved physical & mental health
How to ESCAPE from Pain? An Observational Study on Improving Pain and Quality of Life with the Cannamedical® Hybrid Cannabis Extract
For the blood levels of the eicosanoids—lipid mediators that regulate inflammation such as lipoxygenase (LOX), cyclooxygenase (COX) & cytochrome P450 (CYP450), high-CBD cannabis led to a rise in their levels, especially lipoxins, while high-THC cannabis did not
Effect of Cannabidiol and Δ9-tetrahydrocannabinol on Anti-Inflammatory Lipid Mediator Synthesis in Humans
For fibromyalgia, a review found CBD reduced pain, improved sleep quality, promoted self-care & performance of usual activities, reduced fatigue, increased memory, decreased anxiety & depression, increased libido & improved mood
Medicinal benefits of cannabidiol in patients with fibromyalgia integrative review
For autism, a review found that CBD reduced seizures, stereotypical behaviors, anxiety, irritability & sleep disorders [Portuguese]
Canabidiol no tratamento do transtorno do espectro autista: revisão integrativa e perspectivas farmacêuticas
For chronic pain, a positive Italian report on using medical cannabis
Medical cannabis for chronic pain management: questions and answers between clinical and medico-legal issues
For PTSD in youth, limited evidence suggests help from cannabis-based medicinal products
Cannabis-Based Medicinal Products in the Treatment of Post-Traumatic Stress Disorder in Children and Young People: A Literature Review
In a mouse model of ALS, CBDA proved the most effective (compared to CBD, CBDV, THC & THCV) at improving motor coordination, reducing neuronal cell death & reducing inflammation & it outperformed the standard treatment of riluzole
Preclinical evaluation of cannabidiolic acid as a neuroprotective agent in TDP-43 transgenic mice, an experimental model of amyotrophic lateral sclerosis
In a rat model of multiple concussions, high doses of CBD protected the brain by inhibition of apoptosis (programmed cellular suicide) & stress to the endoplasmic reticulum (protein processing center)
[Cannabidiol inhibits neuronal endoplasmic reticulum stress and apoptosis in rats with multiple concussions by regulating the PERK-eIF2α-ATF4-CHOP pathway]
In a female mouse model of metabolic dysfunction-associated steatohepatitis (MASH, formerly known as fatty liver disease), CBG improved liver health & decreased scarring, oxidative stress & inflammation
Cannabigerol Alleviates Liver Damage in Metabolic Dysfunction-Associated Steatohepatitis Female Mice via Inhibition of Transforming Growth Factor Beta 1
In two different mouse models of acute pain, cannabis ethanol extracts caused antioxidant effects, lowered inflammation & reduced symptoms of pain
Oral Administration of Moroccan Cannabis sativa L. Extract and Cannabidiol: A Comparative Study in Acute Pain Models
In a rat model of trigeminal neuralgia (severe orofacial pain), CBD showed strong efficacy for pain killing with gendered effects
Sex-related differences in cannabidiol's antinociceptive efficacy in a trigeminal neuralgia rodent model
In a rat model of anxiety & panic, a CBD nanoemulsion reduced anxiety & panic via serotonin neurons in the dorsal raphe (a regulator of sleep-wake cycles, mood & cognition)
A cannabidiol (CBD) lipid-based nanoemulsion induces anxiolytic- and panicolytic-like effects and increases FosB/deltaFosB immunoreactivity in serotonergic cells of the dorsal raphe
For immune diseases like graft-versus-host disease or lichen planus (an inflammatory skin & mucous membrane condition) or head-and-neck cancer, CBD-rich cannabis extracts reduced inflammation as good or better than conventional treatments like dexamethasone & tacrolimus as well as having potent anti-tumor effects
From Immune Dysregulation to Cancer: The Therapeutic Potential of CBD-Rich Cannabis Extracts in Lichen Planus, GVHD, and HNSCC
In a mouse model of graft-versus-host disease (such as a rejection of bone marrow transplantation), the endocannabinoid PEA reduced clinical disease severity, reduced the activation of immune cells & protected the intestines & liver from damage
Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8+ Cells and TNF-α Levels in Target Organs, and Protects Mice From Graft-Versus-Host Disease-Related Mortality Through PPAR Activation Without Compromising the Graft-Versus-Tumour Response
In human cartilage, CBD reduced ferroptosis (iron-dependent regulated cell death), which could be the mechanism for slowing orthopedic diseases such as osteoarthritis
Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes
In a tissue model of type 2 diabetes, the phytocannabinoids THC, CBD, THCV, CBC & CBG protected the β-cells from functional impairment & apoptosis (programmed cellular suicide)
The Impact of Major and Minor Phytocannabinoids on the Maintenance and Function of INS-1 β-Cells Under High-Glucose and High-Lipid Conditions
In a mouse model of obesity, oleoylethanolamide (the endocannabinoid of satiety) lowered the inflammatory response in the fat tissue via several mechanisms
Anti-Inflammatory Effect of Oleoylethanolamide-Based Dietary Supplement in Adipose Tissue in Alimentary-Induced Obesity in Mice
In a rat model of the antidepressant effects of exercise, the effects appeared to be mediated by increased CB1 receptor levels in the medial prefrontal cortex & the prevention of the loss of astrocytes (the most predominant brain support cell)
Medial Prefrontal Cortical CB1Rs and Astrocytes Are Involved in Depression and the Antidepressant Effects of Running Exercise
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