Research Roundup: June 10, 2025
- Lex Pelger
- Jun 10
- 3 min read
Best of cannabinoid science this week...
For pediatric drug-resistant epilepsy, an observational study across 19 Thai hospitals found that CBD reduced seizure rates
National Multicenter Cohort Study: Adjunctive Cannabidiol-Enriched Cannabis Oil for Pediatric Drug-Resistant Epilepsy Treatment in Thailand
In people with neuropathic pain from their chemotherapy cancer treatments, the combination of CBD & exercise improved handgrip strength, lowered neurotoxic symptoms, & improved gait speed, manual dexterity & perceived physical function
Cannabidiol and multi-modal exercise for chemotherapy-induced peripheral neuropathy in cancer survivors
In Minnesota's obstructive sleep apnea program, a survey found that almost 40% of patients experienced significant improvements within four months of starting medical cannabis
Sleep Apnea Report Medical Cannabis Program / Division of Medical Cannabis
In tests of sleep latency (time until falling asleep), there was a non-significant trend of cannabis users falling asleep faster but having a greater rate of severe sleepiness & narcolepsy
Impact of Cannabis Smoking on Multiple Sleep Latency Test Outcomes
In people living with HIV, regular cannabis use had a normalizing effect on their neural oscillations involved with motor control, suggesting therapeutic utility
Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV
In a case report of post-operative neuropathic pain, 75 mg of CBG, 60 mg of CBD & 3 mg of THC reduced pain & improved mobility
Cannabinoids for treatment of postoperative neuropathic pain: a case report
In dogs with pain from a hysterectomy, CBD was as effective as meloxicam in managing acute pain
Facial action units as biomarkers of postoperative pain in ovariohysterectomized bitches treated with cannabidiol and meloxicam
For rehabilitation of musculoskeletal injury, a systematic review of 24 studies found that cannabis had a moderate painkilling effect & CBD reduced inflammation with overall improvements found in mobility & therapy adherence
Cannabis in Acute Injury Rehabilitation: Analgesic Efficacy, Functional Outcomes and Dependency Risks
For motor neuron diseases (a group of rare neurodegenerative disorders with muscle weakness), a literature review on the benefits of CBD (good charts)
Study of the Relationship between Cannabidiol and Motor Neuron Disease
For orofacial pain, this systematic review found cannabinoids helped for pain & oral inflammation
Cannabinoids: Therapeutic Perspectives for Management of Orofacial Pain, Oral Inflammation and Bone Healing—A Systematic Review
For anti-seizure activity, a review of CBD & the potential interaction with microRNA (aka miRNA, regulators of genetic transcription)
Cannabidiol and microRNAs: shared cellular targets and new insights for developing anti-seizure modalities
In veterinary medicine, a review of its therapeutic use & cardiovascular effects [Spanish]
Therapeutic use and cardiovascular effects of Cannabis spp. in veterinary medicine
In a mouse model of Alzheimer's disease, PEA restored metabolic changes including the rebalancing of lactate-glutamate metabolism, increased taurine synthesis & transport, upregulated receptor expression & the mitigation of neurodegenerative processes
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer’s disease
In a rat model of kidney damage, Lebanese cannabis oil extract decreased biomarkers of kidney toxicity, reduced renal vascular dilation & protected against kidney damage
Therapeutic Effect of Lebanese Cannabis Oil Extract in the Management of Sodium Orthovanadate-Induced Nephrotoxicity in Rats
In a rat model of buprenorphine-induced respiratory depression, CBD increased the painkilling power & attenuated the respiratory depression
Combination of Cannabidiol and Low-Dose Buprenorphine Suggests Synergistic Analgesia and Attenuates Buprenorphine-Induced Respiratory Depression
In a rat model of obesity & insulin resistance, CBG reduced excessive levels of ceramide & helped with homeostasis in skeletal muscle
Cannabigerol – A potent regulator of insulin sensitivity in rat’s skeletal muscle via targeting the sphingolipid metabolism and PI3K/Akt/mTOR pathway?
Against the pathogenic fungus Cryptococcus neoformans, CBD & CBDV acted as a fungicide & prevented formation of biofilm (a city-like assembly of microorganisms that are harder to treat)
Uncovering the antifungal potential of Cannabidiol and Cannabidivarin
In E. coli bacteria, CBD had antimicrobial & anti-biofilm properties
Cannabidiol as a potential anti-biofilm and anti-quorum sensing agent against Escherichia coli O157:H7
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