Best of cannabinoid science this week...
In patients with recurrent mouth ulcers, a topical 0.1% CBD cream reduced the ulcer size, accelerated the ulcer healing & exerted anti-inflammatory & painkilling effects Efficacy and safety of topical 0.1% cannabidiol for managing recurrent aphthous ulcers: a randomized controlled trial https://pubmed.ncbi.nlm.nih.gov/36803360/
In a mouse model of seizures, the researchers propose CBD lowers seizures by blocking the fatty acid LPI from the GPR55 receptor (which may one day be known as CB3) Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity https://pubmed.ncbi.nlm.nih.gov/36787750/
In retinal cells of the eyes, PEA protected them from reactive oxygen species & cell death Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinal https://pubmed.ncbi.nlm.nih.gov/36816211/
For sleep, a review of CBD & THC for insomnia, sleep apnea & restless leg syndrome
CBD and THC - influence on insomnia, sleep apnea and restless leg syndrome - review based on recent advances
A review of 107 papers on oral health find that activating the cannabinoid receptors can help with inflammation, bone healing & the treatment of periodontitis (a serious gum infection) Activation of cannabinoid receptors promotes periodontal healing by regulating periodontal inflammation and bone remodeling https://www.cjter.com/EN/10.12307/2023.530
A review of the crosstalk between the estrogen system & the endocannabinoid system as seen through the rodent estrus cycle Molecular and cellular mechanisms underlying brain region-specific endocannabinoid system modulation by estradiol across the rodent estrus cycle https://pubmed.ncbi.nlm.nih.gov/36707154/