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Research Roundup: June 7, 2021




Best of the Week...


This meta-review of 11 studies finds support for using CBD for anxiety

Anxiolytic and antidepressant effects of cannabidiol: a systematic review

https://pdfs.semanticscholar.org/e601/695e15ca2d6a523a183f9918cbc74ab4b298.pdf

This survey finds that many survivors of cancer use CBD for sleep, anxiety & easing pain

Cannabidiol (CBD) use among cancer survivors

https://ascopubs.org/doi/abs/10.1200/JCO.2021.39.15_suppl.12096

In guinea pigs with lung inflammation, CBD & CBG both worked to lower inflammation

The anti-inflammatory effects of cannabidiol and cannabigerol alone, and in combination

https://pubmed.ncbi.nlm.nih.gov/34082108/

In mice with a movement disorder, CBD helped to alleviate the facial tics from the treatment drug haloperidol as well as lowering proinflammatory cytokines in the striatum & hippocampus of the brain via the PPARγ nuclear receptors

PPARγ receptors are involved in the effects of cannabidiol on orofacial dyskinesia and cognitive dysfunction induced by typical antipsychotic in mice

https://pubmed.ncbi.nlm.nih.gov/34048863/

At Mass General, a review of their epilepsy patients found that CBD maintained its efficacy for controlling seizures for up to 60 months

The long-term efficacy of cannabidiol in the treatment of refractory epilepsy

https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.16936


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This analysis of childhood gliomas (very aggressive brain cancer) suggests CBD as a treatment

ID1 IS A KEY TRANSCRIPTIONAL REGULATOR OF DIPG INVASION AND IS TARGETABLE WITH CANNABIDIOL

link

In humans, one dose of 150 mg of CBD did not alter their emotional reactivity to stimuli

Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters

https://www.scielo.br/j/rbp/a/Mpgdyp83HNptcTWyPr7bxHK/?format=pdf&lang=en This review of female pelvic medicine & reconstructive surgery suggests PEA as a treatment Cannabinoid Therapy in Female Pelvic Medicine and Reconstructive Surgery: Current Evidence and Future Directions https://link.springer.com/article/10.1007/s11884-021-00632-5 In humans with nerve pain from rheumatic diseases, PEA combined well with acetyl-l-carnitine (ALC) to lower inflammation & to increase clinical scores Efficacy of a fixed combination of Palmitoylethanolamide and acetyl-l-carnitine (PEA + ALC FC) in the treatment of Neuropathies secondary to Rheumatic Diseases https://pubmed.ncbi.nlm.nih.gov/34056884/

In humans, a certain genetic variant of FAAH (the enzyme that breaks down anandamide) is linked to how much people process fear & their susceptibility to PTSD

A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults https://pubmed.ncbi.nlm.nih.gov/34051704/

Remember, one function of CBD is the inactivation of FAAH, which is probably why you hear about it so often for fear & anxiety.

This review looks at endocannabinoid signaling in Parkinson's disease

Endocannabinoid Signaling in Parkinson’s Disease

https://encyclopedia.pub/item/revision/a21a5a173ced7e50fc908382e44f64ff

This review looks at the endocannabinoids & how they regulate the immune system as well as treat immune system disorders

Endocannabinoids in immune regulation and immunopathologies https://pubmed.ncbi.nlm.nih.gov/34053085/


This review looks at targeting the CB2 receptor for arthritis progression & pain

Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB 2 receptor in the arthritis progression and pain: an updated review

https://pubmed.ncbi.nlm.nih.gov/34050525/

Here’s an interesting review of using fluorescent cells to look at how the cannabinoids modulate the immune system

Real-Time Imaging of Immune Modulation by Cannabinoids Using Intravital Fluorescence Microscopy

https://pubmed.ncbi.nlm.nih.gov/34042507/

And another one on the history of using fluorescent probes to examine the CB1 & CB2 receptors

Imaging Cannabinoid Receptors: A Brief Collection of Covalent and Fluorescent Probes for CB1 and CB2 Receptors

https://www.publish.csiro.au/CH/CH21007

Preclinical Research & Cannabinoid Chemistry

In a rat model of cocaine addiction, CBD helped with anxiety & depressive-like behaviors

Antidepressant-like effects of cannabidiol in a rat model of early-life stress with or without adolescent cocaine exposure

https://pubmed.ncbi.nlm.nih.gov/34076862/

In rats, the ability of 2-AG to reduce fear & stress behaviors is mediated by CB1 & CB2

Anti-aversive effect of 2-arachidonoylglycerol in the dorsolateral periaqueductal gray of male rats in contextual fear conditioning and Vogel tests

https://pubmed.ncbi.nlm.nih.gov/34074811/

In mice with kidney disease, there’s an overexpression of CB1 receptors & the damage to the kidneys might be reduced by using blockers of the CB1 receptor

Role of endocannabinoid CB1 receptors in Streptozotocin-induced uninephrectomised Wistar rats in diabetic nephropathy

https://bjbas.springeropen.com/articles/10.1186/s43088-021-00121-y

In a mouse model of arthritis, blocking the MAGL enzyme (which raises levels of 2-AG) reduced inflammation

Monoacylglycerol Lipase Inhibition Using JZL184 Attenuates Paw Inflammation and Functional Deficits in a Mouse Model of Inflammatory Arthritis

https://pubmed.ncbi.nlm.nih.gov/34042520/

In diabetic mice, injections of 2-AG protected their hearts from the cardiac pathology of the disease

2-Arachidonoylglycerol Attenuates Fibrosis in Diabetic Mice via the TGF-β1/Smad Pathway

https://europepmc.org/article/ppr/ppr344998

In mice, a neutral antagonist of the CB1 receptor caused them to drink less alcohol

CB1 Receptor Neutral Antagonist Treatment Epigenetically Increases Neuropeptide Y Expression and Decreases Alcohol Drinking

https://pubmed.ncbi.nlm.nih.gov/34048869/

In rats, the ability of cocaine to increase motivation requires 2-AG & CB1 in the brain’s ventral tegmental area (an area of reward circuitry associated with dopamine)

Cocaine-induced increases in motivation require 2-arachidonoylglycerol mobilization and CB1 receptor activation in the ventral tegmental area

https://pubmed.ncbi.nlm.nih.gov/34058192/

In rodents, an extract of cannabis roots helped to control pain & inflammation as well as causing antiasthmatic activity

Investigation of antinociceptive, antipyretic, antiasthmatic and spasmolytic activities of Brazilian Cannabis sativa L. roots in rodents

https://pubmed.ncbi.nlm.nih.gov/34058314/

The use of cannabis roots for healing goes way back.