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Research Roundup: June 6, 2023



Best of cannabinoid science this week...


Among daily nicotine e-cigarette users, 320 milligrams of CBD reduced withdrawal symptoms & anxiety during abstinence Cannabidiol Reduces Nicotine Withdrawal Severity and State Anxiety During an Acute E-cigarette Abstinence Period: A Novel, Open-Label Study https://pubmed.ncbi.nlm.nih.gov/37167367/


For sleep, chronic use of a low dose of CBD is safe & effective The Safety and Comparative Effectiveness of Non-Psychoactive Cannabinoid Formulations for the Improvement of Sleep: A Double-Blinded, Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/37162192/


In dementia patients, six months of 3% CBD solution improved all of their neurological measurements & the researchers suggested it as a more effective & safe choice than the typical intervention The Effect of Cannabidiol 3% on Neuropsychiatric Symptoms in Dementia - Six-Month Follow-Up https://pubmed.ncbi.nlm.nih.gov/37153956/


In patients with multiple sclerosis, sprays of 1:1 THC:CBD helped with urinary disturbances & hyperactive bladders as well as decreased spasms, pain & tremors & an improved quality of life Nabiximols oromucosal spray in patients with multiple sclerosis-related bladder dysfunction: A prospective study https://pubmed.ncbi.nlm.nih.gov/37062198/


In patients with recent onset psychosis, one month of 600 milligrams of CBD significantly increased functional connectivity in the default mode network The impact of cannabidiol treatment on resting state functional connectivity, prefrontal metabolite levels and reward processing in recent-onset patients with a psychotic disorder https://pubmed.ncbi.nlm.nih.gov/37207437/


In 10 people with opioid use disorder, one dose of 600 milligrams of isolated CBD significantly reduced cue-induced craving as well as attentional bias towards drug related cues

Impact of cannabidiol on reward- and stress-related neurocognitive processes among individuals with opioid use disorder: A pilot, double-blind, placebo-controlled, randomized cross-over trial


A review of using CBD to treat the sleep disturbances of alcohol use disorder Cannabidiol as a candidate pharmacotherapy for sleep disturbance in alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/37139966/


In a mouse model of morphine withdrawal, CBD cause anti-anxiety effects via a serotonin receptor Cannabidiol attenuates the expression of conditioned place aversion induced by naloxone-precipitated morphine withdrawal through the activation of 5-HT1A receptors https://pubmed.ncbi.nlm.nih.gov/37209879/


Dr. Franjo Grotenhermen interviews a patient about their positive experience with cannabis for acne inversa (an autoinflammatory skin condition that attacks hair follicles & causes painful recurring abscesses in sweaty areas of the body) Case in Context: Acne Inversa (Hidradenitis Suppurativa) https://pubmed.ncbi.nlm.nih.gov/37074343/


On using CBD oil against the bacteria of acne Antibacterial Effect of Cannabidiol Oil against Propionibacterium Acnes, Staphylococcus Aureus, Staphylococcus Epidermidis and Level of Toxicity against Artemia Salina https://journalspress.com/LJMHR_Volume23/Antibacterial-Effect-of-Cannabidiol-Oil-Against-Propionibacterium-Acnes-Staphylococcus-Aureus-Staphylococcus-Epidermidis-and-level-of-Toxicity-against-Artemia-Salina.pdf


For fibromyalgia patients in the UK Medical Cannabis Registry, cannabinoid medicines improved sleep, anxiety & quality of life Assessment of clinical outcomes in patients with fibromyalgia: Analysis from the UK Medical Cannabis Registry https://pubmed.ncbi.nlm.nih.gov/37199833/


In a long term follow up of 25 patients with Tourette syndrome, a subset of them found cannabis to help improve control of their symptoms Licensed Medical Cannabis Use in Gilles de la Tourette Syndrome: A Retrospective Long-term Follow-Up https://pubmed.ncbi.nlm.nih.gov/37172308/


In pets, a survey of CBD use finds most pet owners do you see an improvement in their pets condition with mild to no side effects Assessment of cannabidiol use in pets according to a national survey in the USA https://pubmed.ncbi.nlm.nih.gov/37203420/


On the effects of CBD in the amygdala (brain region associated with fight or flight, anxiety & PTSD) Cannabidiol Differentially Modulates Synaptic Release and Cellular Excitability in Amygdala Subnuclei https://pubmed.ncbi.nlm.nih.gov/37163725/


In microglia (brain immune cells) infected with HIV, CBD reduced the production of a large number of inflammatory cytokines & chemokines (more than THC), reduced genes related to the inflammasome cascade (NLRP3) & significantly reduced the expression of HIV

Anti-inflammatory effects of CBD in human microglial cell line infected with HIV-1


In a rat model of high blood pressure, chronic CBD administration reduced scarring & inflammatory factors Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway in monocrotaline-induced pulmonary hypertension in rats https://pubmed.ncbi.nlm.nih.gov/37187449/


In a mouse model of neuropathic pain, CBD extract with a high content of terpenes outperformed the same extract without terpenes in causing rapid & long lasting relief of pain hypersensitivity via the CB2 receptor & neuroinflammatory factors of the microglial cells (guardian immune cells of the brain) Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation https://iris.unimore.it/handle/11380/1304106 #EntourageEffect


In a rat model of periodontitis (chronic inflammation & destruction of the mouth’s soft & hard tissues), CBD significantly inhibited bone loss, downregulated pro-inflammatory mediators & in a human tissue model, it inhibited inflammation Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF-κB pathway https://pubmed.ncbi.nlm.nih.gov/37143211/


In a rat model of acute & chronic migraines, CBD significantly reduced pain & inflammation levels in the acute model & CBD caused a significant decrease in inflammatory cytokines in the chronic model Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine https://pubmed.ncbi.nlm.nih.gov/37138206/


In a rat model of diabetes with neuropathic pain, CBD combined additively with tramadol for pain reduction Pharmacological Interaction Between Cannabidiol and Tramadol on Experimental Diabetic Neuropathic Pain: An Isobolographic Analysis https://pubmed.ncbi.nlm.nih.gov/37205869/


In a tissue & animal model of neuropathic pain, CBD lowered pain & neuroinflammation via FKBP5 (an immunoregulation protein) Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5 https://pubmed.ncbi.nlm.nih.gov/37196785/


A review of using CBD for chronic musculoskeletal disorders Cannabidiol for musculoskeletal regenerative medicine https://pubmed.ncbi.nlm.nih.gov/37158062/ And a review of how the endocannabinoids & other lipids are involved in exercise induced muscle damage repair The Involvement of Lipid Mediators in the Mechanisms of Exercise-Induced Muscle Damage https://www.mdpi.com/2673-9488/3/2/22


A review of the anti-inflammatory effects of the cannabinoids Anti-inflammatory effects of cannabinoids https://www.scielo.br/j/brjp/a/kJFVFMnvSMw9K5BpymRfNyC/?lang=en


A review of using CBD in dentistry Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry https://www.researchgate.net/publication/370563008_Cannabidiol_for_Oral_Health_A_New_Promising_Therapeutical_Tool_in_Dentistry


In rodents, GMP toxicity studies of EU certified cannabis Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-Certified Cannabis sativa L. in Rodents https://www.mdpi.com/1424-8247/16/5/694


In fruit flies, cannabis had little effect on their neural function but CBD displayed significant neuroprotective properties following a traumatic injury The Influence of Cannabinoids on Drosophila Behaviors, Longevity, and Traumatic Injury Responses of the Adult Nervous System https://pubmed.ncbi.nlm.nih.gov/37158809/


In young stallions, 70 days of CBD did not lower their libido & it decreased aggressive behaviors at semen collection time 24 Effects of Oral Supplementation of Cannabidiol on Young Stallion Behavior https://academic.oup.com/jas/article/101/Supplement_1/27/7151489 And in older horses, CBD was well accepted, caused no banned substances to be detectable in the blood & had no adverse effects on blood chemistry parameters 85 Evaluation of an Oral Supplemental Cannabidiol Product for Acceptability in Mature Horses https://academic.oup.com/jas/article/101/Supplement_1/62/7151471



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