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Research Roundup: June 6, 2022



Best of cannabinoid science this week...


In a double-blind study of children with autism, CBD-rich hemp extracts increased social interaction & concentration while decreasing anxiety & psychomotor agitation & led to less caregiver distress Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial https://pubmed.ncbi.nlm.nih.gov/35617670

In Alzheimer’s patients, 12 weeks of THC:CBD extract reduced agitation, apathy, irritability, sleep disturbances, eating disturbances, cognitive impairments & aggressive behaviors, leading to less caregiver distress Oral Thc: Cbd Cannabis Extract in Main Symptoms of Alzheimer Disease: Agitation and Weight Loss https://assets.researchsquare.com/files/rs-1672277/v1/4a190d8f-58a7-4c82-8e6f-86a9708493a9.pdf

In patients with arthritis of the thumb, two weeks of topical CBD treatment caused significant improvements in their pain measures A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis https://pubmed.ncbi.nlm.nih.gov/35637038


3 case studies of cannabis for palliative care A Case Series of the Role of Cannabis Based Medicine in the Palliative Care Setting https://olh.ie/education-research/wp-content/uploads/2022/03/A-Case-Series-of-the-Role-of-Cannabis-Based-Medicine-in-the-Palliative-Care-Setting.pdf In a survey of rheumatoid & psoriatic arthritis patients, medical cannabis gave them significant relief from short & long-term pain as well as reduced stiffness – and for some patients, total pain relief PARE Patient-Reported Outcome Measures of Pain Alleviation With Cannabinoid Usage in Rheumatoid and Psoriatic Arthritis: a Cross-Sectional Study https://ard.bmj.com/content/81/Suppl_1/1132.3.abstract A survey of patients with restless leg syndrome found that some found relief with cannabis Prevalence of Cannabis Use in Patients with Restless Leg Syndrome for Symptomatic Relief https://academic.oup.com/sleep/article/45/Supplement_1/A246/6593000 A survey of Canadian cannabis users found these conditions at the top of the list: anxiety (70%), insomnia (56%), pain (53%), depression (37%) A description of self-medication with cannabis among adults with legal access to cannabis in Quebec, Canada https://pubmed.ncbi.nlm.nih.gov/35619155 A study of patients with neurological disorders saw that 50% found cannabis helpful for treating symptoms & that 25% found it helped improve quality of life Cannabis-based medicinal products for neurological disorders: a study of 75 patients https://jnnp.bmj.com/content/93/6/A115.3.abstract In a double-blind study, 600 mg of CBD did not cause any alterations in brain responses to emotional faces (hattip to Stuart Tomc) The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study https://pubmed.ncbi.nlm.nih.gov/35445839

In a rat model of oral mucosal (mouth tissue swelling) problems from chemotherapy, CBD “improved survival, decreased body weight loss, reduced ulcer sizes, and improved clinical scores”, “restored epithelial thickness and normal structure in tongue tissues”, suppressed the inflammatory response & lowered reactive oxygen creation Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways https://www.hindawi.com/journals/omcl/2022/4619760/

In mice being fed a high-fat diet to simulate nonalcoholic fatty liver disease, the addition of CBD increased food intake, improved glucose tolerance, reduced some of the inflammatory response & partially mitigated the microbiome problems while TC produced a similar but much weaker response THC and CBD affect metabolic syndrome parameters including microbiome in mice fed high fat-cholesterol diet https://pubmed.ncbi.nlm.nih.gov/35644678

In a tissue model of Alzheimer’s disease, PEA & luteolin (a flavonoid commonly paired with PEA) reduces neuronal inflammation & astrocyte reactivity while restoring homeostasis of the oligodendrocytes via the PPAR nuclear receptors (controllers of genetic transcription) Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer’s Disease https://www.mdpi.com/2227-9059/10/6/1236


On treating addiction disorders by targeting the endocannabinoid system Targeting the endocannabinoid system in the treatment of addiction disorders https://www.researchgate.net/publication/360685011_Targeting_the_endocannabinoid_system_in_the_treatment_of_addiction_disorders

A systematic review of the effect of CBD on cancer cells Biological Effects of Cannabidiol on Human Cancer Cells: Systematic Review of the Literature https://pubmed.ncbi.nlm.nih.gov/35643249

A review of CBD in cancer treatment Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review https://www.mdpi.com/2079-7737/11/6/817