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Research Roundup: June 27, 2023



Best of cannabinoid science this week...



In people with anxiety who use cannabis, a survey finds that on the days they use cannabis, they reported better sleep quality that night, with the strongest effects among those who use high CBD edibles Daily associations with cannabis use and sleep quality in anxious cannabis users https://pubmed.ncbi.nlm.nih.gov/37255232/


In pediatric epilepsy patients, a study of CBD's effect on anxiety, seizures & endocannabinoid levels Effects of Cannabidiol Treatment on Anxiety, Seizure Frequency, and Plasma Endocannabinoid Concentrations in Pediatric Epilepsy Patients: A Pilot Study https://www.biologicalpsychiatryjournal.com/article/S0006-3223(23)00495-X/fulltext


In children with fragile X syndrome (a genetic developmental disorder that causes intellectual disability) & children with 22q11.2 deletion syndrome (the second most common chromosomal disorder after Down syndrome), a transdermal CBD gel caused a host of clinical improvements Long-term Safety and Sustained Efficacy of ZYN002 Cannabidiol Transdermal Gel in the Treatment of Behavioral Symptoms in Children and Adolescents with Fragile X Syndrome (ZYN2-CL-017) http://www.zynerba.com/wp-content/uploads/2023/05/2023-ASCP_Tich-and-OQuinn_ZYN2-CL-017-Long-term-Safety-Poster_05-24-23_FINAL.pdf An Open-Label Trial Assessing Short- and Long-Term Tolerability and Efficacy of ZYN002 (Cannabidiol) Administered as a Transdermal Gel to Children and Adolescents with 22q11.2 Deletion Syndrome (INSPIRE) http://www.zynerba.com/wp-content/uploads/2023/05/2023-ASCP_Heussler_and-OQuinn-INSPIRE-Poster_05-24-23-FINAL.pdf


In adults receiving CBD-dominant cannabis oil, females had significantly greater metabolites in their plasma Sex Differences in the Pharmacokinetics of Cannabidiol and Metabolites Following Oral Administration of a Cannabidiol-Dominant Cannabis Oil in Healthy Adults https://pubmed.ncbi.nlm.nih.gov/37267269/


Profound anti-aging benefits from a gel of CBD & eicosapentaenoic acid (EPA) In vitro, ex vivo, and clinical evaluation of anti-aging gel containing EPA and CBD https://pubmed.ncbi.nlm.nih.gov/37264742/


In a survey of rheumatology patients, they reported a significant reduction in average pain & stiffness via cannabis

POS1573-PARE Patient-Reported Outcome Measures of Pain Alleviation With Cannabinoid Usage in Rheumatoid and Psoriatic Arthritis: a Cross-Sectional Study


In two mouse models & tissue samples of osteoarthritis, THC reduced cartilage degeneration, pain response & knee inflammation OP0200 ORAL DELIVERY OF DELTA-9-TETRAHYDROCANNABINOL PROVIDES SYMPTOM AND DISEASE MODIFICATION USING TWO MODELS OF KNEE OSTEOARTHRITIS https://ard.bmj.com/content/82/Suppl_1/132


Several tests of CBD found no genetic toxicity Genotoxicity evaluation of cannabidiol https://pubmed.ncbi.nlm.nih.gov/37271419/


For Parkinson's disease, a review of 13 studies on the benefits of THC & CBD

Cannabinoids in Treating Parkinson's Disease Symptoms: A Systematic Review of Clinical Studies


For substance use disorders, a review of 10 trials on using cannabinoids to treat them Cannabinoids for Substance Use Disorder Treatment: What Does the Current Evidence Say? https://pubmed.ncbi.nlm.nih.gov/37262132/


A review of using cannabinoids for endometriosis

Potential of Cannabinoids for the Treatment of Endometriosis


In non-human primates, the distribution patterns of the CB1 receptor across their prefrontal cortex Laminar Distribution of Cannabinoid Receptor 1 in the Prefrontal Cortex of Nonhuman Primates https://assets.researchsquare.com/files/rs-2984659/v1/532c21db-6052-49b3-b726-859294eedfeb.pdf?c=1685631591


In a mouse model of autism, CBD & cannabis terpene blends caused prosocial behaviors Cannabidiol and cannabis-inspired terpene blends have acute prosocial effects in the BTBR mouse model of autism spectrum disorder https://www.frontiersin.org/articles/10.3389/fnins.2023.1185737/full


In a rat model of neuropathic pain & tolerance to morphine, a single dose of THC lowered pain transmission signals Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine https://pubmed.ncbi.nlm.nih.gov/37257771/


In rats, CBD protected the liver via anti-inflammatory & antioxidant effects The Promising Role of the Potential Medical Benefits of Cannabidiol Derived from an Herbal Plant to Enhance the Hepatic Defense in Adult Male Rats https://www.advetresearch.com/index.php/AVR/article/view/1237


In a rat model of irritable bowel syndrome, CBD microemulsions with berberine decreased intestinal permeability, blocked inflammatory cytokines from the serum & displayed synergistic advantages & pharmacokinetics Cannabidiol-Decorated Berberine-Loaded Microemulsions Improve IBS-D Therapy Through Ketogenic Diet-Induced Cannabidiol Receptors Overexpression https://pubmed.ncbi.nlm.nih.gov/37273286/


In a roundworm model of Alzheimer's disease, CBD modulated the cellular stress response via SKN-1 (a regulator of innate immunity) SKN-1, NRF HOMOLOG, MEDIATES CANNABIDIOL CELLULAR STRESS RESPONSIVE EFFECTS IN


In a mouse model of epilepsy, both the cannabinoids & the terpenes help to reduce seizures EFFETTI ANTICONVULSIVANTI DEI COMPOSTI PRESENTI IN CANNABIS SATIVA L. IN MODELLI SPERIMENTALI CON RODITORI: REGIONI IPPOCAMPALI COINVOLTE E POSSIBILI MEDIATORI https://iris.unimore.it/handle/11380/1305587


In a mouse model of colitis, a mixture of CBD, CBG, CBC, & CBDV helped with visceral pain Non-Psychotropic cannabinoids attenuate visceral pain in colitis https://prism.ucalgary.ca/server/api/core/bitstreams/108e4508-f57b-47fe-862a-bd38d3de981f/content


How CBD modulates ion channels & the excitability of neurons Cannabidiol modulation of ion channels and neuronal excitability https://dash.harvard.edu/bitstream/handle/1/37375641/HZhang%20thesis%200508%20409pm.pdf?sequence=1


The pharmacology of CBDV The In Vitro Pharmacology of Cannabidivarin (CBDV) https://harvest.usask.ca/bitstream/handle/10388/14711/LE-THESIS-2023.pdf?sequence=1&isAllowed=y

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